The N‐terminal domain of gasdermin D induces liver fibrosis by reprogrammed lipid metabolism by Xue Wang, Chunyou Ning, Xingyi Cheng, Zhengzhong Wu, Dongbo Wu, Xuemei Ding, Cunxiang Ju, Zhihang Zhou, Lingfeng Wan, Wei Zhao, Peiliang Shi

“…RNA‐sequencing showed that upregulated differentially expressed genes were involved in inflammatory responses, cell activation, and metabolic processes. Treatment with OCA alleviated the liver fibrosis, with reduced ALT and AST levels seen in the GSDMD‐NTki/wt × Alb‐creki/wt mice. …”
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Computerised cognitive training tools and online nutritional group counselling for people with mild cognitive impairment: study protocol of a completely digital, randomised, contro... by Stephanie Book, Elmar Graessel, Julia Schneider, Michael Jeitler, Petra Scheerbaum, Michael Jank, Etienne Hanslian, Melanie DellO’ro, Julia-Sophia Scheuermann, Sophia Bösl, Christian Kessler

“…Additionally, there are two kinds of active control measures (CCT: ‘basic’ CCT; nutrition: a healthy diet following the current guidelines of the German Nutrition Society). …”
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Primary multiple cancer in practice of urological oncologist by M. D. Ter-Ovanesov, D. M. Yagudaev, A. A. Gritskevich, E. V. Anikanova, K. I. Medvedev

“…Exogenous factors are represented by lifestyle and environmental factors such as smoking and alcohol, low physical activity, as well as prolonged exposure to ultraviolet radiation and industrial pollution. …”
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Comparative the effect of bisphenol A and bisphenol S on the development and spectral sensitivity of cone photoreceptors in zebrafish larvae (Danio rerio) by Liguo Qiu, Peng Yu, Qiang Li, Cuiping Wen, Haiyang Wang, Dongying Zhao, Tianyu Zhang, Chenghui Wang, Lixia Liu, Dongxue Li, Shiyong Wen, Yinghui Sun

“…In contrast to BPA exposure, BPS exposure resulted in significant activation of key genes involved in the phototransduction pathway. …”
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Evaluation of the transmission-blocking potential of Plasmodium vivax antigen Pvg37 using transgenic rodent parasites and clinical isolates by Di Zhang, Yan Zhao, Dongyan Liu, Fei Liu, Pengbo Liu, Biying Zhang, Zifang Wu, Wanlapa Roobsoong, Sirasate Bantuchai, Sataporn Thongpoon, Piyarat Sripoorote, Meilian Wang, Liwang Cui, Yaming Cao

“…Furthermore, in direct membrane feeding experiments using four clinical P. vivax isolates, the anti-Pvg37 antibodies significantly reduced oocyst density by 28.6–50.4%.ConclusionPvg37 is a promising candidate for P. vivax TBV development, deserving further research and optimization to enhance its immunogenicity and transmission-blocking activity.…”
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Association of patellofemoral osteoarthritis on patient-reported outcomes after medial unicompartmental knee arthroplasty: a retrospective cohort study by Jonathan Winther Olsen, Christian Bredgaard Jensen, Kristine Ifigenia Bunyoz, Anders Flygenring Bagge, Kirill Gromov, Anders Troelsen

“…All patients completed the Oxford Knee Score (OKS), Activity and Participation Questionnaire (APQ), and Forgotten Joint Score (FJS), preoperatively and 3, 12, and 24 months postoperatively. …”
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Environmental pollution evaluation and spatiotemporal distribution of different forms of phosphorus in a phosphate mining area in Western Hubei, China by Lei Kou, Junwei Zhang, Liyue Huang, Guanyu Chen, Shupeng Jiang, Ding Han, Dayuan Jiang

“…The soil total phosphorus content was closely related to phosphate mining activities. The migration and transformation of phosphorus sources were mainly through soil leaching, scouring and mine drainage into surface water, and there may be migration of surface water to groundwater in monitoring wells. …”
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A Study on the Line of Sight to Galaxies Detected at Gamma-Ray Energies by Amy Furniss, Josepf N. Amador, Olivier Hervet, Ollie Jackson, David A. Williams

“…We measure the fraction of the line of sight that intersects voids for active galactic nuclei (AGN) detected by Fermi Large Area Telescope (LAT) and quasars from the Sloan Digital Sky Survey (SDSS). …”
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Analysis of tumoral, stromal and glycolitic markers in the response basal cell carcinoma and Bowen disease to photodynamic therapy in real life by L Bernal-Masferrer, T Gracia-Cazaña, L Najera-Botello, MC Gomez-Mateo, P Cerro, MC Matei, M Gallego-Rentero, S González, A Juarranz, Y Gilaberte

“…On the other hand, the metabolic profile of the tumors indicated that tumors with higher glycolytic activity were less responsive to treatment, therefore, using metformin, a glycolytic inhibitor, as a potential adjuvant therapy to improve outcomes in resistant tumors should be considered. …”
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AKT1-Mediated NOTCH1 phosphorylation promotes gastric cancer progression via targeted regulation of IRS-1 transcription by Lingshan Zhou, Yuan Yang, Qian Qiao, Yingying Mi, Yuling Gan, Ya Zheng, Yuping Wang, Min Liu, Yongning Zhou

“…Conclusion AKT1 induces the Notch1 phosphorylation and promotes the activation and nuclear translocation of Notch1-IC by targeting the regulation of IRS-1, thereby advancing the progression of GC.…”
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The Construction of Heterothallic Strains of <i>Komagataella kurtzmanii</i> Using the I-SceI Meganuclease by Daria D. Sokolova, Philipp I. Akentyev, Kristina O. Petrova, Lyudmila V. Lyutova, Aleksei A. Korzhenkov, Irek I. Gubaidullin, Stepan V. Toshchakov, Dmitry G. Kozlov

“…In the present study, we constructed heterothallic strains of <i>K. kurtzmanii</i>, ensuring a constant mating type by unifying the genetic sequences in the active and silent MAT loci. To obtain such strains, we performed site-directed inactivation of one of the two yeast MAT loci, replacing its sequence with a selective HIS4 gene surrounded by I-SceI meganuclease recognition sites. …”
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Preferences of people with type 2 diabetes for telemedical lifestyle programmes in Germany: protocol of a discrete choice experiment by Veronika Gontscharuk, Andrea Icks, Michael Roden, Markus Vomhof, Sandra Grobosch, Jana Sommer, Jan Dyczmons

“…This study aims to examine the preferences of people with T2DM with respect to telemedical lifestyle programmes, to analyse whether these preferences predict programme success and to explore the changes that may occur during a telemedical lifestyle intervention.Methods and analysis We outline the protocol of the development and assessment of a discrete choice experiment (DCE) to examine patient preferences in a telemedical lifestyle programme with regard to the functions of the online portal, communication, responsibilities, group activities and time requirements. To develop the design of the DCE, we conducted pilot work involving healthcare experts and in particular people with T2DM using cognitive pretesting. …”
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Ceria nanoparticles ameliorate renal fibrosis by modulating the balance between oxidative phosphorylation and aerobic glycolysis by Mengling Wang, Feng Zeng, Fengling Ning, Yinhang Wang, Shilin Zhou, Jiaqi He, Cong Li, Cong Wang, Xiaolin Sun, Dongliang Zhang, Jisheng Xiao, Ping Hu, Svetlana Reilly, Hong Xin, Xudong Xu, Xuemei Zhang

“…Ceria nanoparticles (CeNP-PEG) with strong ROS scavenging and anti-inflammatory activities have been applied for mitochondrial oxidative stress and inflammatory diseases. …”
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Isolation, purification, structural characteristic and antioxidative property of polysaccharides from A. cepa L. var. agrogatum Don by Hongcheng Liu, Hongxiu Fan, Jing Zhang, Shanshan Zhang, Wenting Zhao, Tingting Liu, Dawei Wang

“…The monosaccharide composition, structural and antioxidative properties of ALAP-21 were investigated by GC–MS chromatography, FT-IR and NMR spectroscopies and three antioxidative activity tests in vitro. The results showed that ALAP-21 was a heteropolysaccharide composed of glucose, galacturonic acid, mannose, galactose, arabinose, rhamnose, xylose, fructose and glucuronic acid with a relative molar ratio of 26.282: 27.546: 11.400: 4.781: 2.467: 2.445: 3.622: 1.106: 1.753, owning (1→4)-α-d-Glcp, (1→4)-α-d-GalAp6Me3OA, (1→4)-β-d-Galp6OMe, (1→2)-α-l-Rhap, (1→4)-β-d-Manp glycosidic linkages. (1→4)-α-d-Glcp and (1→4)-α-d-GalAp6Me3OA residues might be the main components of the sugar chain backbone of ALAP-21. …”
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Combination of rapamycin and adipose-derived mesenchymal stromal cells enhances therapeutic potential for osteoarthritis by Damien Veret, Gautier Tejedor, Esther Perez, Alison Chomette, Maylis Farno, Rosanna Ferreira-Lopez, Louis Dagneaux, Yves-Marie Pers, Christian Jorgsensen, Claire Gondeau, Jean-Marc Brondello

“…Next, the in vitro differentiation capacities of AD-MSCs, their regulatory immune functions on activated immune cells and their regenerative effects on OA chondrocyte signature were assessed in the presence of rapamycin. …”
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Development and validation of an integrated model for the diagnosis of liver cirrhosis with portal vein thrombosis combined with endoscopic characters and blood biochemistry data:... by Jie Yang, Xu Zhang, Jia Chen, Xianghong Hou, Minghong Shi, Longlong Yin, Longchun Hua, Cheng Wang, Xiaolong Han, Shuyan Zhao, Guolan Kang, Ping Mai, Rui Jiang, Hongwei Tian

“…The model identified 7 factors, including splenectomy, blood urea nitrogen (BUN), serum sodium, activated partial thromboplastin time (APTT), thrombin time (TT), D-dimer, and degree of oesophageal varices. …”
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Economic burden of musculoskeletal disorders in Tanzania: results from a community-based survey by Stefan Siebert, Emma McIntosh, Manuela Deidda, Richard Walker, Ping-Hsuan Hsieh, Blandina Mmbaga, Clive Kelly, Kajiru Kilonzo, Eleanor Grieve, Elizabeth F Msoka, Kiula Kiula, Nateiya Yongolo, Sanjura Mandela Biswaro, Stefanie Krauth, Jo Halliday

“…The difference in terms of out-of-pocket expenses was economically substantial in magnitude, although not statistically significant.Conclusion The evidence will be used to inform policies addressing MSK disorders, by promoting the design of interventions, service provision, health promotion and awareness activities at local, regional and national level.…”
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User-Centric Radio Access Technology Selection: A Survey of Game Theory Models and Multi-Agent Learning Algorithms by Giuseppe Caso, Ozgu Alay, Guido Carlo Ferrante, Luca De Nardis, Maria-Gabriella Di Benedetto, Anna Brunstrom

“…Finally, open challenges are discussed, in light of ongoing research and standardization activities.…”
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Radiation dose and fraction in immunotherapy: one-size regimen does not fit all settings, so how does one choose? by Marka Crittenden, Sandra Demaria, C Norman Coleman, Jonathan Schoenfeld, Arta Monjazeb, Samir Khleif, Seema Gupta, Andrew Sikora, Zachary Morris, Chandan Guha, Stephen Shiao, Silvia Chiara Formenti, Bhadrasain Vikram, Mansoor M Ahmed

“…Other novel delivery options may also affect immune responses, including T-cell activation and tumor-antigen presentation changes. However, there is limited understanding of the immunological impact of hypofractionated and unique multifractionated radiotherapy regimens, as these observations are relatively recent. …”
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Arsenic inducible islet β-cell dysfunction and ferroptosis through m6A-YTHDF2-dependent CHAC1 enhancement by Tianming Qiu, Jingyuan Zhang, Jinwei Song, Chenbing Wu, Xiaofeng Yao, Ningning Wang, Guang Yang, Jie Bai, Li Lv, Xiance Sun

“…However, the underlying molecular mechanisms remain unclear. GPX4 activity is significantly modulated by glutathione levels. …”
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