The Reduced Expression of EOLA1 May Be Related to Refractory Diabetic Foot Ulcer by Mingxia Wu, Weiling Leng, Hang Pan, Xiaotian Lei, Liu Chen, Xinshou Ouyang, Ziwen Liang

“…The refractory wounds in patients with DFU may be closely related to the uncontrolled activation of inflammatory pathways in cells caused by the reduced expression of negative regulators of inflammation (e.g., EOLA1), and such decreased expression may be also strongly linked to the persistent state of inflammation.…”
Get full text

Significance of Linked Color Imaging for Predicting the Risk of Clinical Relapse in Ulcerative Colitis by Shuji Kanmura, Akihito Tanaka, Kazuki Yutsudou, Kosuke Kuwazuru, Fukiko Komaki, Yuga Komaki, Hiromichi Iwaya, Shiho Arima, Fumisato Sasaki, Shiroh Tanoue, Shinichi Hashimoto, Akio Ido

“…Our previous study emphasized the redness and yellowness of the lesion using LCI observation, which was useful for the evaluation of histological mucosal activity in UC. In this study, we aimed to evaluate the correlation between LCI observation and clinical relapse rate in UC patients. …”
Get full text

Liver transplantation for homozygous familial hypercholesterolemia: a retrospective analysis from Chinese experience by Hao-Su Zhan, Lin Wei, Wei Qu, Zhi-Gui Zeng, Ying Liu, Yu-Le Tan, Jun Wang, Liang Zhang, En-Hui He, Guang-Peng Zhou, Hai-Ming Zhang, Zhi-Jun Zhu, Li-Ying Sun

“…Results Xanthoma and decreased activity tolerance were the primary clinical manifestations in the 7 HoFH children initially assessed (one child died suddenly prior to surgery due to cardiac arrest). …”
Get full text

Dual-frequency ultrasonic-assisted enzymolysis for synthesis of microstructure regulated biomass-derived porous carbon for high-performance supercapacitors by Zhaocai Teng, Kuihua Han, Meimei Wang, Jianhui Qi, Jiangwei Liu, Yingjie Li

“…In this paper, a dual-frequency ultrasonic-assisted enzymolysis strategy combined with carbonization-activation method was proposed to prepare high-performance garlic peel-derived PC (DUGPC) for supercapacitors. …”
Get full text

Tiny clue reveals the general trend: a bibliometric and visualized analysis of renal microcirculation by Bing Wang, Mengting Xu, Sunjing Fu, Yingyu Wang, Hao Ling, Yuan Li, Bingwei Li, Xueting Liu, Qin Ouyang, Xiaoyan Zhang, Ailing Li, Xu Zhang, Mingming Liu

“…The United States, Mayo Clinic, and Lerman Lilach O emerged with the highest publication count, indicating their active collaborations. ‘Type 2 diabetes’ was the most significant keyword cluster, and ‘diabetic kidney disease’ was the largest cluster of cited references. …”
Get full text

The Effect of Exosomes Derived from Human Umbilical Cord Mesenchymal Stromal/Stem Cells on the Regeneration of Human Pulpectomized Tooth: A Case Report by Nazanin Jafari, Mina Seyed Habashi, Alireza Afshar, Mohammad Ghasemi, Madina A. Kurmanalina, Nadiar M. Mussin, Asset A. Kaliyev, Shahrokh Zare, Zahra Khodabandeh, Nader Tanideh, Amin Tamadon

“…Radiographic assessments indicated periapical radiolucency and periodontal ligament widening, suggesting active healing. Despite these radiographic changes, the absence of clinical symptoms indicated successful tissue regeneration and integration. …”
Get full text

Chemical Fingerprint Analysis for Discovering Markers and Identifying Saussurea involucrata by HPLC Coupled with OPLS-DA by Qingdong Ma, Xiaoxiang Chen, Ke Zhang, Dahong Yao, Lu Yang, Hangyu Wang, Santai Bulemasi, Jian Huang, Jinhui Wang

“…Additionally, peaks 19 and 20 were identified as linolenic acid and linoleic acid with anti-inflammatory activity, and they were isolated from the herb for the first time. …”
Get full text

Effect of prolonged starvation on nutrition utilization and transcriptional responses in Pacific oyster (Crassostrea gigas) by Mingkun Liu, Chenchen Wei, Wenwen Xu, Lintao Tan, Li Li, Guofan Zhang

“…Combined with the correlation between gene expression and symbiotic microbiota, these findings indicated that oysters, due to limited energy, activated insufficient immune responses, leading to increased pathogen abundance and higher mortality during prolonged starvation. …”
Get full text

Synergistic Antibacterial Action of Norfloxacin-Encapsulated G4 Hydrogels: The Role of Boronic Acid and Cyclodextrin by Monica-Cornelia Sardaru, Irina Rosca, Simona Morariu, Elena-Laura Ursu, Alexandru Rotaru

“…In this present study, we developed and characterized a series of supramolecular G4 hydrogels by integrating <i>β</i>-cyclodextrin (<i>β</i>-CD) and boronic acid linkers into a supramolecular matrix to enhance antibacterial activity against <i>Staphylococcus aureus</i> (<i>S. aureus</i>). …”
Get full text

Identification and validation of CDK1 as a promising therapeutic target for Eriocitrin in colorectal cancer: a combined bioinformatics and experimental approach by Jiemiao Shen, Xing Gong, Haili Ren, Xia Tang, Hairong Yu, Yilu Tang, Shen Chen, Minghui Ji

“…Furthermore, Eriocitrin emerged as a potential inhibitor, exerting its anti-tumor effects by targeting and inhibiting CDK1 activity. Conclusion CDK1 plays a critical role in CRC prognosis. …”
Get full text

Gene Therapy for Inflammatory Cascade in Intrauterine Injury with Engineered Extracellular Vesicles Hybrid Snail Mucus‐enhanced Adhesive Hydrogels by Xiaotong Peng, Tao Wang, Bo Dai, Yiping Zhu, Mei Ji, Pusheng Yang, Jiaxin Zhang, Wenwen Liu, Yaxin Miao, Yonghang Liu, Shuo Wang, Jing Sun

“…Upon injection of FA‐EVs hybrid GS hydrogel into the uterine cavity, a protective hydrogel layer forms on the surface of injury sites and sustains the release of STAT1‐siRNA‐loaded FA‐EVs to curtail M1 macrophages generation through inhibiting STAT1 phosphorylation, resulting in reduction of myofibroblasts activation and collagen deposition. In addition, the pregnancy rate and the number of fetuses in rats treated with this hydrogel were much higher than those in other groups, suggesting that the hydrogel could promote functional endometrial regeneration and restore fertility. …”
Get full text

A Data-Driven Approach to Engineering Instruction: Exploring Learning Styles, Study Habits, and Machine Learning by Lauren Genith Isaza Dominguez, Antonio Robles-Gomez, Rafael Pastor-Vargas

“…They completed the Learning Styles Index questionnaire on the first day of class, and each week, teaching methods and class activities were aligned with one of the four learning dimensions of the Felder-Silverman Learning Styles Model. …”
Get full text

Influence of Synthesis Conditions on the Capacitance Performance of Hydrothermally Prepared MnO₂ for Carbon Xerogel-Based Solid-State Supercapacitors by Vania Ilcheva, Victor Boev, Mariela Dimitrova, Borislava Mladenova, Daniela Karashanova, Elefteria Lefterova, Natalia Rey-Raap, Ana Arenillas, Antonia Stoyanova

“…These two-phase (α-MnO₂/K_1.39Mn₃O₆) materials, synthesized at the lowest and highest temperatures, respectively, and containing an appropriate amount of carbon xerogel, were tested as active mass for positive electrodes in a solid-state supercapacitor, using a Na₊-form Aquivion^® membrane as the polymer electrolyte. …”
Get full text

Establishment of a Southern catfish (Silurus meridionalis) spermatogonial stem cell line capable of sperm production in vitro by Jianeng Li, Changle Zhao, Lei Liu, Shuqing Zheng, Deshou Wang, Changwei Shao, Jing Wei

“…This cell line has exhibited continuous growth for more than one year, showing significant alkaline phosphatase activity, and maintaining a diploid karyotype. It exhibited expression of germ cell markers, including glial cell-derived neurotrophic factor family receptor alpha-1 (gfrα1) a and b, pou5f3, nanog, and vasa, but no expression of somatic cell markers such as amh, wt1a, and wt1b. …”
Get full text

Dwelling overheating in risk in cool climates: Assessing the risk in the context of retrofit and climate change in Ireland by M. Mulville, S. Harrington, C. Li, K. Raushan, E. Essien-Thompson, C. Ahern

“…Key contributory factors to overheating, including typology and characteristics, specification and design (including the role of retrofit), internal factors and occupant activities and external conditions are reviewed and existing regulatory frameworks assessed, to highlight potential limitations. …”
Get full text

Arterial Thromboembolism in Patients With Advanced Lung Cancer: Secondary Analyses of the Rising‐VTE/NEJ037 Study by Naoki Furuya, Yukari Tsubata, Takamasa Hotta, Toshihide Yokoyama, Masahiro Yamasaki, Nobuhisa Ishikawa, Kazunori Fujitaka, Tetsuya Kubota, Kunihiko Kobayashi, Takeshi Isobe

“…Objectives To evaluate the risk factors and the clinical activity of edoxaban (EDO) for the prevention of ATE in patients with advanced lung cancer. …”
Get full text

Brain function abnormalities and inflammation in HIV-positive men who have sex with men with depressive disorders by Yang Zhang, Yang Zhang, Yihui He, Yihui He, Yuan Fang, Yuan Fang, Miaotian Cai, Guangqiang Sun, Guangqiang Sun, Rui Wang, Rui Wang, Jiaxin Zhen, Jiaxin Zhen, Yulin Zhang, Zhen Li, Zhen Li, Yundong Ma, Yundong Ma, Tong Zhang, Tong Zhang

“…These imaging results were significantly correlated with peripheral blood indicators and clinical variables.ConclusionThis rs-fMRI study provides considerable evidence for abnormal intrinsic brain activity in people with HADD. Furthermore, our data also indicate the detrimental effects of depression-related inflammation on PWH. …”
Get full text

The cancer-associated fibroblasts interact with malignant T cells in mycosis fungoides and promote the disease progression by Yige Zhao, Yong Li, Yong Li, Panpan Wang, Mengyan Zhu, Jiaqi Wang, Bo Xie, Chenyu Tang, Yangyang Ma, Shiwen Wang, Sha Jin, Jinhui Xu, Zhao Li, Xiaoyan Zhang, Liuyu Li, Xiuzu Song, Ping Wang

“…The cancer-associated fibroblasts (CAFs) showed active role in TME. The occurrence of inflammatory CAFs (iCAFs) may represent the advanced-stage MF. …”
Get full text

Synergistic Effect of Sugarcane Bagasse and Zinc Oxide Nanoparticles on Eco-Remediation of Cadmium-Contaminated Saline Soils in Wheat Cultivation by Emad M. Hafez, Khadiga Alharbi, Hany S. Gharib, Alaa El-Dein Omara, Essam Elatafi, Maha M. Hamada, Emadelden Rashwan, Tarek Alshaal

“…These amendments enhanced antioxidant enzyme activity, with catalase (CAT) increasing by 35.3% and ascorbate peroxidase (APX) by 54.9%. …”
Get full text

Effects of the Vivifrail-B multicomponent exercise program based on society ecosystems theory on physical function in community-dwelling frail older adults: A randomized controlled... by Yue Li, Shasha Li, Xu Weng, Xinyu Yang, Jianyi Bao, Shufang Liao, Yingxue Xi, Xiaofang Song, Guojing Guo

“…The Tilburg Frailty Indicator (TFI), the Short Physical Performance Battery (SPPB), Handgrip strength (HGS), the Physical Self-Maintenance Scale (PSMS), and the Instrumental Activities of Daily Living Scale (IADL) were assessed at baseline, 6 weeks, 12 weeks, 18 weeks, and 24 weeks. …”
Get full text