Wearable Sensors Measure Ankle Joint Changes of Patients with Parkinson’s Disease before and after Acute Levodopa Challenge by Zhuang Wu, Xu Jiang, Min Zhong, Bo Shen, Jun Zhu, Yang Pan, Jingde Dong, Pingyi Xu, Wenbin Zhang, Li Zhang

“…Previous studies found levodopa could improve the activity of the ankle joints of patients with Parkinson’s disease (PD). …”
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Disturbances of Modulating Molecules (FOXP3, CTLA-4/CD28/B7, and CD40/CD40L) mRNA Expressions in the Orbital Tissue from Patients with Severe Graves’ Ophthalmopathy by Przemyslaw Pawlowski, Natalia Wawrusiewicz-Kurylonek, Anja Eckstein, Joanna Reszec, Wlodzimierz Luczynski, Kristian Johnson, Adam Kretowski, Alina Bakunowicz-Lazarczyk, Maria Gorska, Jacek Szamatowicz, Lech Chyczewski, Janusz Mysliwiec

“…The enhanced mRNA expression of CD40 in severe GO and negative correlation to CRP mRNA may suggest their role in the active and inactive GO.…”
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Nutrient Formulation—A Sustainable Approach to Combat PRSV and Enhance Productivity in Papaya by Kavitha Chinnasamy, Naveen Kumar Krishnan, Moganapathi Balasubramaniam, Reena Balamurugan, Pugalendhi Lakshmanan, Kalarani M. Karuppasami, Manoranjitham S. Karuppannan, Elaiyabharathi Thiyagarajan, Senthil Alagarswamy, Saraladevi Muthusamy

“…Metabolomics study indicates that foliar spray of nutrient formulation enhanced the activators and precursors of defense enzymes, viz., peroxidase (PO), polyphenol oxidase (PPO), phenyl ammonia lyase (PAL), catalase (CAT) and nitrate reductase (NRase) in the sprayed plants over unsprayed control. …”
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Thermodynamic qualification of knitted spacer fabrics for use as insulation box insert in the context of refrigerated transport containers in the logistics sector by Julia Klausmann, Thomas Mutschler, Prisca Holderied, Dominik Güther, Thomas Freitag, Matthias Hummel, Martin Zeitler, Oliver van Neerven, Marcus Oliver Weber, Christof Breckenfelder

“…The knitted box performs as insulation when the transported goods are actively cooled inside the box, which is more sustainable and flexible than recent insulation solutions. …”
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From bench to bedside: Developing CRISPR/Cas-based therapy for ocular diseases by Qing Zhao, Linxin Wei, Youxin Chen

“…Recent advancements have demonstrated the technology's potential to restore cellular homeostasis and alleviate disease phenotypes, thereby prompting a variety of clinical trials. To date, active trials include treatments for primary open angle glaucoma with MYOC mutations, refractory herpetic viral keratitis, CEP290-associated inherited retinal degenerations, neovascular age-related macular degeneration, and retinitis pigmentosa with RHO mutations. …”
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Vernolactone Promotes Apoptosis and Autophagy in Human Teratocarcinomal (NTERA-2) Cancer Stem-Like Cells by Nuwanka K. Abeysinghe, Ira Thabrew, Sameera R. Samarakoon, Meran K. Ediriweera, Kamani H. Tennekoon, Varuni P. C. Pathiranage, Anuka S. Mendis

“…Effects of vernolactone on the expression of autophagy-related genes (LC3, Beclin 1, PI3K, Akt, and mTOR) were evaluated using real-time PCR. 2,2-Diphenyl-1-2,2-diphenyl-picrylhydrazyl (DPPH) radical scavenging assay, 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging, and ferric reducing antioxidant power (FRAP) assays were also carried out to evaluate the antioxidant activity of vernolactone. Overall results confirm that vernolactone can exert antiproliferative effects, induce apoptosis and autophagy, and decrease NTERA-2 cell migration in a dose- and time-dependent manner with a very small antioxidant property.…”
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Geodynamics of basins above subducted slabs: An integrated modelling study of tectonics, sedimentation, and magmatism in the Timok Magmatic Complex by Stojadinović Uroš, Toljić Marinko, Trivić Branislav, Pantović Radoje, Srećković-Batoćanin Danica, Krstekanić Nemanja, Kostić Bojan, Velojić Miloš, Stefanović Jelena, Ranđelović Nikola, Maleš Maja

“…The new model of the TMC basin’s geodynamic evolution will quantitatively advance the strategy of prospecting and exploration of world‐class porphyry copper‐ gold deposits, which have been actively exploited in this region for more than a century. …”
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Feasibility of an indocyanine green-hyaluronic acid mixture (LuminoMark™) for targeting suspicious axillary lymph nodes in patients with breast cancer by Jeeyeon Lee, Byeongju Kang, Jin Hyang Jung, Hye Jung Kim, Won Hwa Kim, Jung Dug Yang, Joon Seok Lee, Yee Soo Chae, Soo Jung Lee, In Hee Lee, Ji-Young Park, Nora Jee-Young Park, Ho Yong Park

“…Methods A total of 13 patients with breast cancer (mean age 56.5 years; 92.3% female) and suspicious ALNs underwent targeted axillary surgery (TAS) with activated charcoal and LuminoMark™ injected into the LNs in the surgical field. …”
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CCL4 Affects Eosinophil Survival via the Shedding of the MUC1 N-Terminal Domain in Airway Inflammation by Yoshiki Kobayashi, Chu Hong Hanh, Naoto Yagi, Nhi Kieu Thi Le, Yasutaka Yun, Akihiro Shimamura, Kenta Fukui, Akitoshi Mitani, Kensuke Suzuki, Akira Kanda, Hiroshi Iwai

“…Although eosinophils are activated and coincubation with airway epithelial cells prolongs their survival, the interaction mechanism between eosinophils and epithelial cells is unclear. …”
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Novel Perspectives for Sensory Analysis Applied to Piperaceae and Aromatic Herbs: A Pilot Study by Isabella Taglieri, Alessandro Tonacci, Guido Flamini, Pierina Díaz-Guerrero, Roberta Ascrizzi, Lorenzo Bachi, Giorgia Procissi, Lucia Billeci, Francesca Venturi

“…Furthermore, the present investigation, performed on 12 individuals, outlines the administration of a pilot study, merging the typical sensory analysis with emotional data collection and the innovative contribution related to the study around the Autonomic and Central Nervous System activation in consumers, performed using wearable technologies and related signal processing. …”
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Single‐cell RNA‐sequencing and spatial transcriptomic analysis reveal a distinct population of APOE− cells yielding pathological lymph node metastasis in papillary thyroid cancer... by Guohui Xiao, Rongli Xie, Jianhua Gu, Yishu Huang, Min Ding, Dongjie Shen, Jiqi Yan, Jianming Yuan, Qiong Yang, Wen He, Siyu Xiao, Haizhen Chen, Dan Xu, Jian Wu, Jian Fei

“…APOE overexpression significantly reduced tumor cell proliferation and invasion, both in vitro and in vivo, by activating the ABCA1‐LXR axis. APOE− tumor cells may promote tumor growth by interacting with dendritic cells and CD4+ T cells via CD99‐ rather than CD6‐regulated signaling. …”
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Pre-Season Precipitation and Temperature Have a Larger Influence on Vegetation Productivity than That of the Growing Season in the Agro-Pastoral Ecotone in Northern China by Yuanyuan Zhang, Qingtao Wang, Xueyuan Zhang, Zecheng Guo, Xiaonan Guo, Changhui Ma, Baocheng Wei, Lei He

“…Climate change and human activities are reshaping the structure and function of terrestrial ecosystems, particularly in vulnerable regions such as agro-pastoral ecotones. …”
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Diet with high content of advanced glycation end products induces oxidative stress damage and systemic inflammation in experimental mice: protective effect of peanut skin procyanid... by Li Zhao, Xingxing Zhang, Langzhi He, Yubing Li, Yue Yu, Qun Lu, Rui Liu

“…Molecular docking technique was used to confirm that the parent compound of procyanidins and its main metabolites, such as 3-hydroxyphenylacetic acid, could interact with RAGE, which might inhibit the activation of nuclear transcription factor (NF-κB), and ultimately reduce oxidative stress and inflammation in mice.…”
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Concomitant Usage of H1‐Antihistamines and Immune Checkpoint Inhibitors on Cancer Patient Survival by Yin Leung, Terry Cheuk‐Fung Yip, Grace Lai‐Hung Wong, Vincent Wai‐Sun Wong, Vicki Wing‐Ki Hui, Tony Shu‐Kam Mok, Henry Lik‐Yuen Chan, Stephen Lam Chan, Rashid Nok‐Shun Lui

“…ABSTRACT Purpose Recent research (Li et al. 2021) suggests an upregulated expression and activation of H1 receptors on macrophages in the tumor microenvironment, and concomitant H1‐antihistamine use is associated with improved overall survival in patients with lung and skin cancers receiving immunotherapy. …”
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Neuroprotective Potential of <i>Origanum majorana</i> L. Essential Oil Against Scopolamine-Induced Memory Deficits and Oxidative Stress in a Zebrafish Model by Ion Brinza, Razvan Stefan Boiangiu, Iasmina Honceriu, Ahmed M. Abd-Alkhalek, Samir M. Osman, Omayma A. Eldahshan, Elena Todirascu-Ciornea, Gabriela Dumitru, Lucian Hritcu

“…We also investigated acetylcholinesterase (AChE) activity and the brain’s oxidative stress status. In parallel, we performed in silico predictions (research conducted using computational models) of the pharmacokinetic properties of the main compounds identified in OmEO, using platforms such as SwissADME, pKCSM, ADMETlab 2.0, and ProTox-II. …”
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NLRP3 deficiency aggravated DNFB-induced chronic itch by enhancing type 2 immunity IL-4/TSLP-TRPA1 axis in mice by Si-Ting Huang, Zuo-Ming Chen, Zhe Peng, Yu Wang, Fan Yang, Yang Tang, Zi Li, Li Wan, Li Wan

“…Flow cytometry was performed to quantify the frequency of type 2 immune cells.ResultsThis study revealed that the NLRP3 inflammasome was activated in the skin of DNFB-induced chronic itch mice. …”
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Examining the impacts of input factor application, production efficiency, and inefficiency model on maize yield: employing the stochastic frontier model in search of more efficient... by Muslim Salam, Ayu Anisa Amir, A Nixia Tenriawaru, Muhammad Hatta Jamil, Letty Fudjaja, Muhammad An-Nashrullah K Samma, Ahmad Imam Muslim, Hamed Noralla Bakheet Ali, Muhammad Ridwan

“…On the local government side, reviewing the price of certified seeds, subsidizing the price of maize seeds, ensuring the availability of urea and NPK fertilizers, insecticides, and herbicides, and intensifying extension activities and technical guidance on maize cultivation are alternative agricultural policies that the government can implement to support the efficiency and effectiveness of maize farming management.…”
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Evaluation of longan (Dimocarpus longan) peel powder as fruit by-product additive in Nile tilapia (Oreochromis niloticus) feed: Effects on growth, immunity, and immune-antioxidant... by Supreya Wannavijit, Piyatida Outama, Chinh Le Xuan, Camilla Maria Fontana, Marina Paolucci, Md Afsar Ahmed Sumon, Ehab El-Haroun, Hien Van Doan

“…Moreover, skin mucus and serum immune parameters (lysozyme and peroxidase activity) were significantly higher (P < 0.05) in fish fed with different LP concentrations at both 4 and 8 weeks. …”
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Milk fat globule membrane supplementation protects against β-lactoglobulin-induced food allergy in mice via upregulation of regulatory T cells and enhancement of intestinal barrier... by Han Gong, Tiange Li, Dong Liang, Jingxin Gao, Xiaohan Liu, Xueying Mao

“…In summary, MFGM alleviated CMA in a BLG-induced allergic mice model through enhancing intestinal barrier and promoting Tregs differentiation, which may be correlated with SCFAs-mediated activation of GPRs. These findings suggest that MFGM may be useful as a promising functional ingredient against CMA.…”
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A cross-tissue transcriptome-wide association study identifies new susceptibility genes for benign prostatic hyperplasia by Li Wang, Si-yu Chen, Jian-wei Yang, Kang-yu Wang, Kun-peng Li, Shun Wan, Xiao-ran Li, Li Yang

“…However, further functional studies are necessary to elucidate the potential biological activity of these significant signals.…”
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