Heterogeneity of cancer-associated fibroblast subpopulations in prostate cancer: Implications for prognosis and immunotherapy by Chen Ding, Jiange Wang, Jie Wang, Jiqiang Niu, Zhikai Xiahou, Zhou Sun, Zhenzhen Zhao, Dongyang Zeng

“…Results: C1 ABCA8+ fibroblasts demonstrated heightened proliferative activity, underscoring their pivotal role in fostering tumor growth and metastasis via intricate signaling pathways. …”
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Effects of pyrazosulfuron-ethyl on caudal fin regeneration in zebrafish larvae by Chenkai Ge, Zhijun Ye, Weitao Hu, Jingrong Tang, Huimin Li, Fasheng Liu, Xinjun Liao, Jianjun Chen, Shouhua Zhang, Zigang Cao

“…Pyrazosulfuron-ethyl exposure resulted in the decreased number of neutrophils and macrophages, and the downregulation of immune related gene expression levels during caudal fin. Using LPS to activate inflammation can effectively rescue the fin regeneration defects induced by pyrazosulfuron-ethyl. …”
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The Feasibility of Telephone-delivered Self-management Intervention in Multiple Sclerosis by Mozaffar Hosseininezhad, Sajjad Saadat, Fatemeh Younesi Rostami, Roghaye Zare, Ali Bonyad, Masoumeh Qanbary Joopish, Alia saberi, Fateme Shafaee

“…Background: Self-management plays a significant role in people’s active participation in treating multiple sclerosis (MS), improving quality of life, suppressing symptoms, and reducing treatment costs. …”
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Vegetation greening and climate change respectively regulates the long-term trend and interannual variability in evapotranspiration over the Loess Plateau since the 21st century by Qiaoyin Tan, Ting Hua, Ting Hua, Haichen Zhao, Peiye Zhou, Peiye Zhou

“…In this study, we employed a logical attribution method, which attributes vegetation changes predominantly to anthropogenic activities (e.g., reforestation or land-use changes), while directly linking changes in climatic factors (e.g., temperature and precipitation) to climate change. …”
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A Significant Association of Upper Limb Muscle Strength with Thyroid Function in Overweight and Obese Population: A Study of the Sixth Korea National Health and Nutrition Examinati... by Jeongmin Lee, Kwanhoon Jo, Jeonghoon Ha, Dong-Jun Lim, Jung Min Lee, Sang-Ah Chang, Moo Il Kang, Min-Hee Kim

“…After exclusion of subjects with FT4 level out of normal range, a history of thyroid disease or cerebral disease, restricted activity, and incomplete data, a total of 3503 were recruited (age range 19–80 years, 51% male). …”
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Scalable Manufacturing Method for Model Protein-Loaded PLGA Nanoparticles: Biocompatibility, Trafficking and Release Properties by Selin Akpinar Adscheid, Marta Rojas-Rodríguez, Salma M. Abdel-Hafez, Francesco S. Pavone, Marc Schneider, Akif E. Türeli, Martino Calamai, Nazende Günday-Türeli

“…Furthermore, encapsulated WGA-488 protein retained its functional activity after release, validating the integrity of the encapsulation and release processes. …”
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How and why a multifaceted intervention to improve adherence post-MI worked for some (and could work better for others): an outcome-driven qualitative process evaluation by Holly O Witteman, Laura Desveaux, Justin Presseau, Noah Michael Ivers, Marianne Saragosa, Kirstie Russell, Nicola McCleary, J-D Schwalm

“…Participants who were engaged with positive adherence outcomes attributed their success to the intervention’s ability to activate determinants including behavioural regulation and knowledge, which encouraged an increase in self-monitoring behaviour and awareness of available supports, as well as reinforcement and social influences. …”
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Enhanced multistress tolerance of Saccharomyces cerevisiae with the sugar transporter-like protein Stl1F427L mutation in the presence of glycerol by Zixiong Liu, Lingling Shangguan, Linglong Xu, Huiyan Zhang, Wenxin Wang, Qiao Yang, Xiaoling Zhang, Lan Yao, Shihui Yang, Xiong Chen, Jun Dai

“…Additionally, under multistress conditions, pyruvate and ergosterol levels and catalase (CAT) and superoxide dismutase (SOD) activities were significantly increased in the mutant strain STL compared with the control strain 5D. …”
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PET Study of Sphingosine-1-Phosphate Receptor 1 Expression in Response to Vascular Inflammation in a Rat Model of Carotid Injury by Hui Liu PhD, MD, Hongjun Jin PhD, Xuyi Yue PhD, Junbin Han PhD, Pamela Baum SRS, Dana R. Abendschein PhD, Zhude Tu PhD

“…Sphingosine-1-phosphate receptor (S1PR) activation plays a key role in vascular inflammatory response. …”
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Surveillance on the coverage of herpes zoster vaccine and post-marketing adverse events in Jiangsu province, China by Xiang Sun, Lei Zhang, Tingting Zhang, Jinning Sun, Yan Xu, Li Liu, Yuan Bao Liu, Ran Hu, YaLi Fu, Zhiguo Wang, Hui Sun

“…To enhance the comprehensiveness of post-marketing safety data, it is imperative to conduct further active surveillance studies.…”
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The role of polymorphic variants of arginase genes (<i>ARG1, ARG2</i>) involved in beta-2-agonist metabolism in the development and course of asthma by O. N. Savelieva, A. S. Karunas, Yu. Yu. Fedorova, R. R. Murzina, A. N. Savelieva, R. F. Gatiyatullin, E. I. Etkina, E. K. Khusnutdinova

“…According to published data, allelic variants of the arginase ARG1 and ARG2 genes are associated with a risk of asthma development, spirometry measures and efficacy of bronchodilator therapy. High arginase activity results in a low level of plasma L-arginine and in a decrease in nitric oxide, and, as a result, in an increase in airway inflammation and remodeling. …”
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Effects of helium irradiation damage on deuterium plasma-driven permeation through tungsten coated RAFM steel by Yue Xu, Xiao-Ping Tian, Hong-Yan Tan, Hai-Ying Fu, Jun-Jie Ni, Lai-Ma Luo, Yu-Cheng Wu

“…In this work, the effects of He plasma irradiation on D permeation through tungsten (W) coated reduced activation ferritic/martensitic (RAFM) steel were systematically investigated by performing plasma-driven permeation (PDP) measurements in the temperature range of 523–833 K. …”
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Radiochemistry and Preclinical PET Imaging of Ga-Desferrioxamine Radiotracers Targeting Prostate-Specific Membrane Antigen by Eleni Gourni PhD, Luigi Del Pozzo BSc, Mark Bartholomä PhD, Yvonne Kiefer BSc, Philipp T. Meyer MD, PhD, Helmut R. Maecke PhD, Jason P. Holland D.Phil

“…Radiosynthesis proceeded quantitatively at room temperature with high radiochemical yields, chemical/radiochemical purities, and specific activities. Pharmacokinetic profiles of 68 Ga-4 and 68 Ga-7 were assessed using positron-emission tomography (PET) in mice bearing subcutaneous LNCaP tumors. …”
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A New Prognostic Risk Model Based on PPAR Pathway-Related Genes in Kidney Renal Clear Cell Carcinoma by Yingkun Xu, Xiunan Li, Yuqing Han, Zilong Wang, Chenglin Han, Ningke Ruan, Jianyi Li, Xiao Yu, Qinghua Xia, Guangzhen Wu

“…This study is aimed at using genes related to the peroxisome proliferator-activated receptor (PPAR) pathway to establish a prognostic risk model in kidney renal clear cell carcinoma (KIRC). …”
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Effects of lipid levels on growth performance and glucose and lipid metabolism of adult Nile tilapia (Oreochromis niloticus) fed with high carbohydrate diets by Ningning Xie, Jianmin Zhang, Ming Jiang, Xiaolin Meng, Lixue Dong, Xing Lu, Hua Wen, Juan Tian

“…Tilapia also showed an adaption to D1 and D2 diets with increased digestive enzyme activities and enhanced mRNA expression levels of glucose carriers. …”
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Wenxin Granules Influence the TGFβ-P38/JNK MAPK Signaling Pathway and Attenuate the Collagen Deposition in the Left Ventricle of Myocardial Infarction Rats by Ya Huang, Aiming Wu, Lixia Lou, Dongmei Zhang, Bo Nie, Yizhou Zhao, Keke Liu, Mingjing Zhao, Hongcai Shang

“…A large number of proinflammatory/anti-inflammatory cytokines are produced in the extracellular matrix (ECM) after myocardial infarction (MI), and the inflammatory pathways activated by these inflammatory stimuli are involved in the regulation of lesions with excessive accumulation of ECM. …”
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Do you have depression? A summative content analysis of mental health-related content on TikTok by Roxanne Turuba, Marco Zenone, Raman Srivastava, Jonathan Stea, Yuri Quintana, Nikki Ow, Kirsten Marchand, Amanda Kwan, Anna-Joy Ong, Xiaoxu Ding, Cassia Warren, Alessandro R Marcon, Jo Henderson, Steve Mathias, Skye Barbic

“…Background TikTok is a global social media platform with over 1 billion active users. Presently, there are few data on how TikTok users navigate the platform for mental health purposes and the content they view. …”
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Groundwater for drinking and sustainable agriculture and public health hazards of nitrate: Developmental and sustainability implications for an arid aquifer system by Boualem Bouselsal, Adel Satouh, Johnbosco C. Egbueri, Mofreh A. Hashim, Ahmed A. Arafat, Prabhu Paramasivam, Ali Alzaed, Enas E. Hussein

“…The integration of the water quality index, health risk assessments, hydrogeochemical modeling, and GIS mapping provides a comprehensive framework for analyzing groundwater in arid regions under pressure from climate change and human activities. These findings highlight the need for integrated strategies for sustainable groundwater management worldwide.…”
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Acidity, sugar, and alcohol contents during the fermentation of Osmanthus-flavored sweet rice wine and microbial community dynamics by Ping Tian, Jiaqiong Wan, Tuo Yin, Li Liu, Hongbing Ren, Hanbing Cai, Xiaozhen Liu, Hanyao Zhang

“…Metabolic pathway analysis revealed that energy production and conversion, carbohydrate transport, amino acid transport, and metabolic pathways were the most active metabolic pathways in the fermenter. These results provide a reference basis for changes in the microbial community during the fermentation of cinnamon-flavored sweet rice wine.…”
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Cross-education: motor unit adaptations mediate the strength increase in non-trained muscles following 8 weeks of unilateral resistance training by Edoardo Lecce, Alessandra Conti, Alessandro Del Vecchio, Francesco Felici, Alessandro Scotto di Palumbo, Massimo Sacchetti, Ilenia Bazzucchi

“…To address this gap, we recorded myoelectrical activity from the biceps brachii using high-density electromyography.MethodsNine participants performed 8-week unilateral resistance training and were compared to nine control individuals who did no intervention. …”
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