Association between metabolic score for insulin resistance and stroke: a nationally representative cross-sectional study from NHANES 2007–2018 by Lingtian Weng, Yuqiu Lu, Hanning Song, Jiayi Xu, Xuhong Jiang, Xuhong Jiang

“…Interaction tests indicated no significant effects of gender, smoking status, alcohol consumption, hypertension, diabetes, physical activity, or serum cholesterol levels on this relationship. …”
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Hydrothermally synthesised porous NiAl-LDH as an efficient pseudocapacitive material in asymmetric supercapacitors by Raman Duddi, Shivani, Shobhna Dhiman, Arun Kumar Singh, Navpreet Kamboj, Sanjeev Kumar

“…When the as-prepared electrode is integrated with a commercial activated carbon (AC) to form a hybrid asymmetric supercapacitor (ASC) operating in 1 M KOH electrolyte, it delivers specific capacitance of 923 F g−1. …”
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Effect of High-Fat Diet on Spatial Learning and Memory and Regulatory Role of N-Methyl-D-Aspartate Receptors in the Dentate Gyrus by LIU Huaying, DONG Wei, ZHANG Zihan, LI Yingshun, JIN Qinghua

“…Moreover, blocking of NMDA receptors in the DG rescues spatial learning and memory impairments in DIO rats by activating the CaMKII-CREB signaling pathway and decreasing neuroinflammatory responses. …”
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Three Years of High Time-resolution Air Pollution Monitoring in the Complex Multi-source Harbor of New York and New Jersey by Gayle Hagler, Dan Birkett, Ronald C. Henry, Richard E. Peltier

“…Over the same period, indicators of shipping and cargo activity at the port remained relatively constant; therefore, a shift in emission factors is likely the cause of the change. …”
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Interventions that prevent or reduce perinatal loneliness and its proximal determinants: a restricted scoping review by Ruth Naughton-Doe, Rebecca Nowland, Stephanie Tierney, Martin Webber, Anja Wittkowski

“…Five mechanisms were identified within included papers: 1) opportunities for social connection to similar others, 2) positive relationships with a professional or volunteer, 3) normalisation and acceptance of difficulties, 4) meaningful activities and 5) support to overcome barriers (including cultural and financial) to connection. …”
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Modern possibilities of tear film stability restoration by V.V. Brzheskiy, G.G. Кim, V.А. Bobryshev

“…They differ from other lacrimal substitutes by their high hygroscopicity, thixotropy, mucomimeticity and other metabolic properties (biocompatibility, biodegradability, nonimmunogenicity, anti-inflammatory and regenerative activity, etc.). One of the ways to increase the viscosity, ocular surface stability and humectant duration is the cross-linking of hyaluronic acid using so-called "cross-linking agents" (carbodiimide hydrochloride, urea, divinyl sulfone, thiol-ene reaction, etc.). …”
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Genomic identification, evolutionary analysis, and transcript profiling of protein phosphatase 2C in Solanum lycopersicum by Miah Mohammad Sakib, Md. Sifatul Islam, Asifur Rob Bhuya, Md. Rihan Kabir Shuvo, Mohammad Abdullah-Al-Shoeb, Muhammad Abul Kalam Azad, Ajit Ghosh

“…An increase in total PP2C enzyme activity was also observed which indicates their significance in drought stress. …”
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Genetic mechanisms of the influence of light and phototransduction on Drosophila melanogaster lifespan by I. A. Solovev, M. V. Shaposhnikov, A. A. Moskalev

“…On the other hand, the stimulating nature of the effect of continuous illumination on reproductive function was noted, in particular, the effects of increasing the fecundity of females of various species are known. Increase in motor activity and, as a result, in metabolic rate and thermogenesis during permanent exposure to light also reduces the body's energy reserves and lifespan. …”
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Understanding neurocognitive recovery in older adults after total hip arthroplasty—neurocognitive assessment, blood biomarkers and patient experiences: a mixed-methods study by Ulrica Nilsson, Karin Liander, Lina Bergman, Anahita Amirpour, Jeanette Eckerblad, Gabriela Markovic

“…Future research should incorporate longitudinal follow-ups with performance-based measurements, fatigue assessment, evaluations of instrumental activities of daily living and subjective reporting, supported by a multidisciplinary team approach.Trial registration number NCT05361460.…”
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Enhanced Disc Herniation Classification Using Grey Wolf Optimization Based on Hybrid Feature Extraction and Deep Learning Methods by Yasemin Sarı, Nesrin Aydın Atasoy

“…The use of various activation functions (e.g., ReLU, identity, logistic, and tanh) in MLP and various kernel functions (e.g., linear, rbf, sigmoid, and polynomial) in SVM allows for a thorough evaluation of the classifiers’ performance. …”
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The battle of question formats: a comparative study of retrieval practice using very short answer questions and multiple choice questions by Elise V. van Wijk, Mario de Jonge, Floris M. van Blankenstein, Roemer J. Janse, Alexandra M.J. Langers

“…Abstract Background Retrieval practice is a highly effective learning strategy that enhances long-term retention by encouraging the active recall of information. However, the optimal question format for maximizing knowledge retention remains uncertain. …”
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The Intracellular Growth of M. tuberculosis Is More Associated with High Glucose Levels Than with Impaired Responses of Monocytes from T2D Patients by Martha Torres, María Teresa Herrera, Guadalupe Fabián-San-Miguel, Yolanda Gonzalez

“…Diabetes mellitus, a metabolic disease characterized by hyperglycemia and poor glucose control, is a risk factor for Mycobacterium tuberculosis (M. tuberculosis) infection and the development of active tuberculosis. To evaluate whether M. tuberculosis infection susceptibility is associated with an intrinsic factor in monocytes from type 2 diabetes (T2D) patients or it is associated with hyperglycemia per se, we analyzed TLR-2 and TLR-4 expression by flow cytometry and the cytokines IL-1β, IL-6, IL-8, IL-10, and TNF-α by cytometric bead array assays, either stimulated with TLR-2 and TLR-4 ligands or infected with M. tuberculosis in the whole blood from T2D patients (n=43) and healthy subjects (n=26) or in CD14+ monocytes from healthy subjects cultured in high glucose (HG) (30 mM). …”
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Unveiling molecular insights: in silico exploration of TLR4 antagonist for management of dry eye syndrome by Kothandan Sudhakar, Neeru Dugar, Srikanth Jupudi, Ravichandran Ashwin, Kuppusamy Gowthamarajan

“…Celastrol, lumacaftor and nilotinib were selected for further molecular dynamics studies for a deeper understanding of molecular systems consisting of protein and ligands by using the Desmond module of the Schrodinger Suite.Results The docking results revealed that the compounds are having binding affinity in the range of −5.1 to −8.78 based on the binding affinity and three-dimensional interactions celastrol, lumacaftor and nilotinib were further studied for their activity by molecular dynamics. Among the three compounds, celastrol was the most stable based on molecular dynamics trajectory analysis from 100 ns in the catalytic pockets of 2Z63.pdb.pdb. …”
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M2 Macrophages as a Potential Target for Antiatherosclerosis Treatment by Ying Bi, Jixiang Chen, Feng Hu, Jing Liu, Man Li, Lei Zhao

“…In addition, researchers have reported several potential approaches to modulate M2 polarization. Inhibiting or activating some kinds of enzymes, affecting transcription factors, or acting on several membrane receptors could regulate the polarization of the M2 phenotype. …”
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3-Acetyldeoxynivalenol induces pyroptosis in leydig cells via METTL3-mediated N6-methyladenosine modification of NLRP3 by Yangyun Wang, Chaoliang Shi, Wei Jiao, Xiaoxiang Wan

“…Mechanistic investigations further revealed that 3-ADON exposure triggers pyroptosis in TM3 cells, as evidenced by upregulation of NLRP3, activation of caspase-1, ASC, and GSDMD. Moreover, 3-ADON treatment resulted in a significant upregulation of METTL3 expression and increased global mRNA m6A modification levels. m6A sequencing and functional assays established that METTL3-mediated m6A modification of NLRP3 mRNA enhances its stability and expression. …”
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Chinese Scholars on the Progress and Outcomes of the Military Reforms in Russia (from the 1990s till Present) by Shiying Han

“…The author notes that there was a spike of research activity on that matter in 2009 soon after the start of radical reforms of the Russian Armed Forces. …”
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Comparative assessment of the climatic comfort of Ukrainian regions for the development of recreation and tourism by N. V. Maksymenko, O. S. Protasova

“…The study has identified periods with comfortable weather for different regions of Ukraine, which can be used for tourism needs: planning excursion routes; creating strategies for the development of recreational activities in the region; creating newsletters and providing information on the "best" time for recreation; organizing seasonal tours to the regions of Ukraine.…”
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The impact of the ursodeoxycholic acid as monotherapy and in the combination with the lactulose on the biochemical blood tests values of the nonalcoholic steatohepatitis patients by I. V. Mayev, Yu. A. Kucheryavyy, S. V. Morozov, M. G. Saidullayeva, M. L. Akhtayeva, N. Yu. Stukova, E. A. Krasnyakova

“…The credible dynamic of the biochemical tests values of the cytolysis as compared with the baseline (the reducing of the activity of the alanine transaminase and the aspartate transaminase) and of the cholestasis (gamma-glutamyl transpeptidase) was observed; the positive changes in the lipid profile (the increase in the concentration of the high density lipoproteins and the reduction in the total cholesterol, the low density lipoproteins, the very low density lipoproteins and triglycerides ) were seen during the treatmet in both groups. …”
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Therapeutic Effects of the Combination of Alpha-Lipoic Acid (ALA) and Coenzyme Q10 (CoQ10) on Cisplatin-Induced Nephrotoxicity by Eman Aly Khalifa, Ahmed Nabil Ahmed, Khalid Shaaban Hashem, Ahmad Gad Allah

“…Renal functions, tissue antioxidant activity, and inflammatory markers (tumor necrosis factor, TNF) were estimated along with histopathological study. …”
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Pharmacovigilance imbalance analysis of VEGFR-TKI-related taste and smell disorders by Zhong-hua Fu, Chenglong Zhao, Yaqin Wang, Lei Zhang, Lei Wang

“…The Standardized Medical Dictionary for Regulatory Activities (MedDRA) Queries (SMQs) were used to analyze the AEs of TSDs. …”
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