EFFECT OF BIDARA LEAF EXTRACT (Ziziphus Mauritiana L.) ON THE FUNCTION OF THE PANCREAS OF MALE WISTAR STRAIN RATS IN REDUCING BLOOD SUGAR LEVELS by Musdayani Nasution, Ali Napiah Nasution, Maya Sari Mutia

“…The flavonoid content in bidara leaves is thought to play a significant role in increasing antioxidant activity and being able to regenerate damaged pancreatic ? …”
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In silico methods for immunogenicity risk assessment and human homology screening for therapeutic antibodies by Aimee E. Mattei, Andres H. Gutierrez, Soorya Seshadri, Jacob Tivin, Matt Ardito, Amy S. Rosenberg, William D. Martin, Anne S. De Groot

“…Even if the source of a given biologic is ‘fully human’, T cell epitopes that are contained in the sequences of the biologic may activate the immune system, enabling the development of anti-drug antibodies that can reduce drug efficacy and may contribute to adverse events. …”
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Dissecting macrophage heterogeneity and kaempferol in lung adenocarcinoma: a single-cell transcriptomic approach and network pharmacology by Laiyi Wan, Wentao Hao, Leilei Li, Lin Wang, Yanzheng Song

“…Network pharmacology highlighted active TCM ingredients, including quercetin, isorhamnetin, and kaempferol, targeting genes related to macrophage function. …”
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The effect of β-carotene supplementation above requirement on the production and reproduction performance of female sheep and goats - A mini review by Osman Ahmed, Abubeker Hassen, Khoboso Lehloenya

“…The high rate of metabolic activity during breeding, pregnancy, parturition and lactation may lead to oxidative stress in sheep and goats. …”
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Unraveling ankylosing spondylitis: Exploring the genetic and immunological factors and latest treatment innovations by Nilasree Hazra, Sudeshna Sengupta, Dipannita Burman, Jyoti Sekhar Banerjee, Malavika Bhattacharya

“…To develop more effective treatments, research is ongoing to identify specific signaling pathways and genetic markers associated with AS.Gender prevalence of AS is now more evenly distributed, with women experiencing longer diagnostic delays and increased disease activity. Treatment regimens and responses to medication may vary between genders. …”
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Is preoperative imaging of sentinel lymph node in breast cancer necessary? A retrospective case control study by Michael J. Reinhardt, Björn Ohmstede, Luz Angela Torres-de la Roche, Rudy Leon De Wilde

“…A reduction of applied activity from a median of 18 MBq in group 1 to a median of 12 MBq in group 2 had no negative effect on the SLN identification. …”
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A Spontaneous Complexation–Exfoliation Strategy for a Flexible Anode Towards Superior Durable and Ultrafast Lithium-Ion Batteries by Heying Chu, Jingchuan Zhang, Pengsen Zhao, Yong Li, Zhaoxia Liu, Hongzhou Zhang

“…The combination of large-area few-layer reduced graphene oxide (rGO) films and ultrafine MnO nanocrystals (MnO NCs) provides a high density of electrochemical active sites. Notably, the layer-by-layer embedded structure not only enables the MnO NCs@rGO electrodes to withstand various mechanical deformations but also produces a strong synergistic effect of enhanced reaction kinetics by providing an enlarged electrode/electrolyte contact area and reduced electron/ion transport resistance. …”
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Mining hypertension predictors using decision tree: Baseline data of Kharameh cohort study by abbas Rezaianzadeh, Samane Nematolahi, maryam jalali, Shayan Rezaeianzadeh, Masoumeh Ghoddusi Johari, Seyed Vahid Hosseini

“…In the first model (model I), 15 variables including age, gender, body mass index, years of education, Occupation status, marital status, family history of hypertension, physical activity, total energy, number of meals, salt, oil type, drug use, alcohol use and smoke entered in to the model. in the second model (model II) 16 variables including age, gender, BMI and Blood factors as HCT, MCHC, PLT, FBS, BUN, CERAT, TG, CHOL, ALP, HDL, GGT, LDL and SG were considered. a receiver operating characteristic (ROC) curve was applied to assess the validation of the models. …”
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Intranasal Immunization with DNA Vaccine HA-CCL19/Polyethylenimine/Chitosan Composite Provides Immune Protection Against H7N9 Infection by Yuqing Xiang, Hongbo Zhang, Youcai An, Ze Chen

“…Additionally, our results indicated that the composite formed by the HA-CCL19 DNA in combination with PEI and CS effectively activates local mucosal immunity as well as systemic humoral and cellular immunity, offering 100% protection against lethal doses of homologous virus challenges. …”
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How do users of a ‘digital-only’ contraceptive service provide biometric measurements and what does this teach us about safe and effective online care? A qualitative interview stud... by Paula Baraitser, Caroline Free, Hannah Mcculloch, Alessandra Morelli

“…Our purposive sampling strategy ensured that we included participants from a wide range of ages and those who were and were not prescribed the COC.Intervention A ‘digital-only’ contraceptive service that prescribes the COCafter an online medical history and self-reported height, weight and blood pressure (BP) with pills prescribed by a GMC registered doctor, dispensed by an online pharmacy and posted to the user.Design Semistructured interviews with a purposive sample of 20 participants who were already enrolled in a larger study of this service.Analysis Inductive, thematic analysis of the interviews assisted by NVivo qualitative analysis software.Results Users valued the convenience of ‘digital-only care’ but experienced measuring BP but not height or weight as a significant barrier to service use. They actively engaged in work to understand and measure BP through a combination of recent/past measurements, borrowed machines, health service visits and online research. …”
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Exogenous Application of Lanthanum Chloride to Rice at Booting Stage Can Increase Chlorophyll Content, Modulate Chlorophyll Fluorescence and Promote Grain Yield Under Deficit Irrig... by Peng Liu, Xilin Fang, Yue Wang, Xin Yang, Qiang Li

“…The application of 100 mg·L⁻¹ lanthanum chloride reduced the initial fluorescence (F0) and the non-photochemical quenching coefficient (qN); promoted the activity of leaf photosynthetic system II (PSII); and maximized the photochemical quantum yield (Fv/Fm), photochemical quenching coefficient (qP), and PSII relative electron transfer efficiency (ETR). …”
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Epidemiology of Pediatric Tuberculosis and Factors Associated with Unsuccessful Treatment Outcomes in the Centre Region of Cameroon: A Three-Year Retrospective Cohort Study by Thomas Achombwom Vukugah, Derick Akompab Akoku, Micheline Mekemnang Tchoupa, Edward Lambert

“…TB/HIV collaborative activities should be strengthened by implementing TB preventive interventions among HIV-infected children.…”
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An Efficient Herbal Approach for Treating Fungal Infection in Cervical Cancer Patients by Developing and Optimizing a Vaginal Suppository by Mohammed Ghazwani, Umme Hani, Riyaz Ali M. Osmani, Mohamed Rahamathulla, M. Yasmin Begum, Shadma Wahab, D. V. Gowda, Akhila Akkihebbal Ravikumar, Honnavalli Yogish kumar, Hissana Ather, Afrasim Moin

“…In addition, the formulation was also evaluated for visual examination, weight variation, pH determination, drug content, hardness test, disintegration time, melting zone, deformation time, in vitro drug release, antifungal activity, and stability tests. Results. Suppositories were devoid of holes and cracks, with a characteristic odor and a dark yellowish-orange color. …”
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The Mutual Inhibition of FoxO1 and SREBP-1c Regulated the Progression of Hepatoblastoma by Regulating Fatty Acid Metabolism by Yu Hu, Hongyan Zai, Wei Jiang, Zhenglin Ou, Yuanbing Yao, Qin Zhu

“…In Huh-6 cells and mouse tumor tissues, FoxO1 knockdown resulted in increased cell proliferation, migration, and invasion and active fatty acid metabolism. On the contrary, after the knockdown of SREBP-1c, cell proliferation, migration, and invasion were weakened, and fatty acid metabolism was significantly reduced. …”
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Application of efgartigimod in Chinese patients with myasthenia gravis: a single-center real-world prospective study by Geke Zhu, Han Zhou, Wanying Wang, Yongbo Ma, Xiangtao Nie, Wenjing Qi, Lei Hao, Xiuming Guo

“…Design: This single-center prospective study enrolled Chinese MG patients aged 18 and older who were treated with efgartigimod, classified as Myasthenia Gravis Foundation of America I–IV, with a baseline Myasthenia Gravis Activities of Daily Living (MG-ADL) score of at least 4. …”
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Linking altered neuronal and synaptic properties to nicotinic receptor Alpha5 subunit gene dysfunction: a translational investigation in rat mPFC and human cortical layer 6 by Danqing Yang, Guanxiao Qi, Daniel Delev, Uwe Maskos, Dirk Feldmeyer

“…L6 RS neurons in mPFC of α5SNP and α5KO rats differed from WT rats in dendritic morphology, spine density and spontaneous synaptic activity. Galantamine was applied to identified L6 neuron populations to specifically boost the nicotinic responses mediated by α5*nAChRs. …”
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Relationship Between Single-Leg Vertical Jump and Drop Jump Performance, and Return to Sports After Primary Anterior Cruciate Ligament Reconstruction Using Hamstring Graft by Shunsuke Ohji, Junya Aizawa, Kenji Hirohata, Takehiro Ohmi, Tomoko Kawasaki, Hideyuki Koga, Kazuyoshi Yagishita

“…Knee condition was assessed, including joint laxity, range of motion, muscle strength, and knee pain intensity during sports activities. Performance variables were also assessed, including SL hop distance, jump height in SL vertical jump, and reactive strength index (RSI; jump height/contact time) in SL drop jump. …”
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Indoor Air Exposure to Multiple Agricultural Pesticides Potentially Posing the Highest Risk to Young Children by Sithembiso Sifiso Msibi, Chung-Yu Chen, Cheng-Ping Chang, Chiou-Jong Chen, Su-Yin Chiang, Kuen-Yuh Wu

“…Abstract Pesticides are extensively used to improve crop yield and quality in many African countries where agricultural production is a critical economic activity, including Eswatini (formerly Swaziland) in southern Africa. …”
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Isoproterenol mechanisms in inducing myocardial fibrosis and its application as an experimental model for the evaluation of therapeutic potential of phytochemicals and pharmaceutic... by Lujain Bader Eddin, Mohamed Fizur Nagoor Meeran, Niraj Kumar Jha, Samer N. Goyal, Shreesh Ojha

“…The overstimulated and sustained activation of β‐adrenergic receptors has been reported to induce biochemical and physiological alterations and ultimately result in cardiac remodeling. …”
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Leveraging Social Media Data for Forest Fires Sentiment Classification: A Data-Driven Method by Warih Maharani, Hanita Daud, Noryanti Muhammad, Evizal Abdul Kadir

“…Background: The rise in forest fires over the last two years, which is due to rise in dry weather conditions and human activities, have greatly impacted an area of 1.6 million hectares, leading to significant ecological, economic, and health issues, hence the need to improve disaster response strategies. …”
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