Investigation of Herb-Drug Interactions between Xylopia aethiopica, Its Principal Constituent Xylopic Acid, and Antidepressants by Christian C. Ndu, Wonder K. M. Abotsi, Priscilla K. Mante

“…XAE and XA in mice showed significant antidepressant-like activity in the tail suspension test. With interaction indices less than one, synergism of antidepressant effect was observed in the Xylopia aethiopica extract/fluoxetine (γXAE/FL = 0.502), Xylopia aethiopica extract/imipramine (γXAE/IP = 0.322), Xylopia aethiopica extract/venlafaxine (γXAE/VL = 0.601), xylopic acid/imipramine (γXA/IP = 0.556), xylopic acid/venlafaxine (γXA/VL = 0.451), and xylopic acid/fluoxetine (γXA/FL = 0.298) combinations, which may be potentially due to elevation of serotonergic neurotransmission via varying mechanisms. …”
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Anaerobic Soccer Training Model: Enhancing Soccer Players’ Performance through a Combination of Repeated Sprints and 4 vs 4 Games by I Dewa Made Aryananda Wijaya Kusuma, Nining Widyah Kusnanik, Bayu Agung Pramono, Adi Pranoto, Yanyong Phanpheng, Indra Himawan Susanto, Dewa Ayu Praba Amustikarani, Waristra Tyo Nirwansyah, Muhammad Bagus Firzam Bharlaman

“…Eighty-two soccer players from the UNESA male student activity unit were involved in this study, with 20 samples taken using random sampling techniques. …”
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Kidney Disease-Specific Quality of Life among Patients on Hemodialysis by Issa Al Salmi, Pramod Kamble, Eilean Rathinasamy Lazarus, Melba Sheila D’Souza, Yaqoob Al Maimani, Suad Hannawi

“…People on low incomes experienced social difficulties, while the maximum burden was found in physical activities and minimum social function. Conclusion. …”
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Impact of ZnO nanopriming on physiological and biochemical traits of wheat (Triticum aestivum L.) seedling by Priyanka Pandya, Sushil Kumar, Ghanshyam Patil, Monil Mankad, Zarna Shah

“…Additionally, the presence of ZnO NPs led to increased activity of antioxidant enzymes like superoxide dismutase (SOD) and catalase in a dose-dependent mananer. …”
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Forming a national community of practice of food system planning initiatives aligned with the United Nations Sustainable Development Goals by Konstantinos Zougris, Albie F. Miles, Rose Benjamin, Ella Geismar

“…The findings further indicate that in the process of developing a national community of practice, the principles and functions of shared governance, mutual trust and collective fundraising are essential to supporting credible and coordinated activities that promote equity, reinforce capacity building, promote research on food system measurements, and strengthen advocacy for systemic transformation aligned with the UN Sustainable Development Goals. …”
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Dynamics and Half-Life of Cell-Free DNA After Exercise: Insights from a Fragment Size-Specific Measurement Approach by Ryutaro Yamamoto, Hiroshi Asano, Ryo Tamaki, Yoshihiro Saito, Ami Hosokawa, Hidemichi Watari, Takeshi Umazume

“…<b>Results</b>: The results showed a cfDNA half-life of 24.2 min, with a transient increase in 100–250 base pair cfDNA fragments post-exercise, likely due to nuclease activity. These levels rapidly reverted to the baseline within an hour. …”
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Unveiling vegetation recovery dynamics in Andean grasslands along a trans-Andean natural gas pipeline by Fiorella Eduardo-Palomino, Héctor Chuquillanqui, Reynaldo Linares-Palomino

“…Ultimately, the new index presents itself as a valuable tool for assessing and monitoring the effectiveness of restoration activities in areas of Andean grasslands affected by development projects.…”
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The effect of the implementation of the health transformation plan on the health indicators of pregnant mothers in East Azerbaijan province, Iran: a longitudinal study from 2007 to... by Hossein Jabbari Beirami, Parisa Yoshari, Davood Gharekhani, Elahe Ghorbani, Rahim Khodayari-Zarnaq

“…The research population consisted of people living in villages in East Azerbaijan province - Tabriz district, Iran; with active health centers from 2007 to 2016, including a sample size of 200 mothers per year. …”
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Understanding the work-related challenges of organ and tissue donation coordinators during the COVID-19 pandemic: a mixed-method study by Sonny Dhanani, Ken Lotherington, Vanessa Silva e Silva, Amina Silva, Alessandra Minervini, Kendra-Lee Dupuis

“…Objectives This study aimed to explore the perceptions of donation coordinators in Canada and understand how the COVID-19 pandemic impacted their work activities.Design A sequential mixed-method design incorporating a cross-sectional survey investigating demographic data, substance use and abuse and perceived stress related to the pandemic and semistructured qualitative interviews to further investigate those.Setting Organ donation organisations across Canada.Participants Canadian organ and tissue donation coordinators working within deceased donation programmes. …”
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A post-marketing pharmacovigilance study of triazole antifungals: adverse event data mining and analysis based on the FDA adverse event reporting system database by Yalan Tian, Min Jin, Hong Ning

“…Filter out ADE signals detected by both the ROR and PRR methods, and categorize these ADE signals by System Organ Class (SOC) according to the Medical Dictionary for Regulatory Activities (MedDRA 26.0).ResultsA total of 8,898 ADE reports with voriconazole as the primary suspect drug were retrieved, 1,948 for posaconazole, and 944 for isavuconazole. …”
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The impact of comorbid depression in chronic rhinosinusitis on post-operative sino-nasal quality of life and pain following endoscopic sinus surgery by Javier Ospina, Guiping Liu, Trafford Crump, Jason M. Sutherland, Arif Janjua

“…The PROs included the Sinonasal Outcome Test-22 (SNOT-22), the Patient Health Questionnaire (PHQ-9) measuring symptoms of depression and an assessment of chronic pain using the pain intensity (P), interference with enjoyment of life (E) and general (G) activity instrument, the PEG instrument. Results The study had 142 participants complete their pre-operative and post-operative surveys. …”
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Systematic review of innate immune responses against Mycobacterium tuberculosis complex infection in animal models by Luisa Maria Nieto Ramirez, Carolina Mehaffy, Karen Marie Dobos

“…NHPs provided insights into age-dependent immunity and markers for active tuberculosis (ATB). Key innate immune factors/pathways identified included TNF-α, neutrophil recruitment, ROS/RNS responses, autophagy, inflammasomes, and antimicrobial peptides, with homologous proteins identified in insects. …”
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Naturally occurring variation in a cytochrome P450 modifies thiabendazole responses independently of beta-tubulin. by J B Collins, Clayton M Dilks, Steffen R Hahnel, Briana Rodriguez, Bennett W Fox, Elizabeth Redman, Jingfang Yu, Brittany Cooke, Kateryna Sihuta, Mostafa Zamanian, Peter J Roy, Frank C Schroeder, John S Gilleard, Erik C Andersen

“…Moreover, yeast expression assays showed that the lysine version of CYP-35D1 had twice the enzymatic activity of the glutamate allele. To connect our results to parasitic nematodes, we analyzed four Haemonchus contortus cytochrome P450 orthologs but did not find variation at the 267 position in fenbendazole-resistant populations. …”
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Daclatasvir and Sofosbuvir Therapy Enhance Monocyte Phenotypic Changes in Naive Chronic Hepatitis C Patients: A Prospective Cohort Study by Hanan M. Fayed, Ali A. Ghweil, Mona M. AbdelMeguid

“…SOF/DCV therapy efficiently decreases viral load, reduces fibrosis potentials, attenuates monocyte activation, normalizes monocytes phenotypic abnormalities, and modulates monocyte subsets recruitment and differentiation later in the liver.…”
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Hippocampal Anti-inflammatory Effect of Electroacupuncture at Baihui and Shenting on Cognitive Dysfunction Induced by Systemic Inflammation by CHEN Xiaomei, PANG Lina, WANG Zhifu

“…After the behavioral experiment, immunofluorescence and ELISA were used to detect the changes of hippocampal Iba-1, TNF-α and serum TNF-α.Results1) Compared with the control group, the learning and memory time related to "what-where-when" in the model group was decreased (<italic>P</italic>&lt;0.01), and serum TNF-α (3 h after LPS) and hippocampal TNF-α (24 h) were significantly increased (<italic>P</italic>&lt;0.01); immunofluorescence and ELISA detection showed that hippocampal Iba-1 was significantly increased (<italic>P</italic>&lt;0.01) in the model group. 2) Compared with the model group, "what" and "when" learning time in the EA group increased (<italic>P</italic>&lt;0.01); the serum and hippocampal TNF-α were obviously decreased (<italic>P</italic>&lt;0.01 and <italic>P</italic>&lt;0.05); hippocampal Iba-1 in the EA group was decreased (<italic>P</italic>&lt;0.05).ConclusionElectroacupuncture at Baihui and Shenting may improve the cognitive dysfunction caused by systemic inflammation via inhibiting the activation of hippocampal microglia and reducing the release of inflammatory factor TNF-α in the peripheral blood and hippocampal regions.…”
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Motor modules are largely unaffected by pathological walking biomechanics: a simulation study by Mohammad Rahimi Goloujeh, Jessica L. Allen

“…We extracted motor modules using nonnegative matrix factorization from the muscle activations from each simulation. We then examined how alterations in walking biomechanics influenced the number and structure of extracted motor modules and compared the findings to previous experimental studies. …”
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Comprehensive Analysis of the Immune Response to SARS-CoV-2 Epitopes: Unveiling Potential Targets for Vaccine Development by Huixiong Deng, Yanlei Li, Gefei Wang, Rui Li

“…The results highlighted regions within each SARS-CoV-2 protein where the immunological activity of antibodies, CD4⁺, and CD8⁺ T cell responses was predominantly concentrated. …”
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Sternoclavicular Joint Reconstruction Using the Sternal Docking Technique by Yazdan Raji MD, Galvin J. Loughran MD, George Bugarinovic MD, Michael T. Freehill MD

“…Results: The sternal docking technique was successfully implemented for the reconstruction of a chronic anterior SCJ dislocation and allowed the patient to return to full pain-free activity by 16 weeks. Discussion: Chronic anterior SCJ dislocations may fail to respond to conservative treatment measures necessitating operative reconstruction. …”
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Overview of Radar-Based Gait Parameter Estimation Techniques for Fall Risk Assessment by Sevgi Z. Gurbuz, Mohammad Mahbubur Rahman, Zahra Bassiri, Dario Martelli

“…Radar placed in a home or assisted living facility can acquire continuous ambulatory recordings over extended durations of a subject&#x0027;s natural gait and activity. Thus, radar-based QGA has the potential to capture day-to-day variations in gait, is time efficient and removes the burden for the subject to come to a clinic, providing a more realistic picture of older adults&#x2019; mobility. …”
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INTERPRETING A POEM OF BEN JONSON, “SONG: TO CELIA” by Nanik Mariana Effendie

“…How the language-users interpret what other language-users intend to convey and how they make sense of what they read in texts, understand what speakers mean despite what they say, recognize connected as opposed to jumbled or incoherent discourse, and successfully take part in that complex activity called conversation.   A poem can be interpreted through discourse analysis approach (Brown and Yule, 1983). …”
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