A VersaTile Approach to Reprogram the Specificity of the R2-Type Tailocin Towards Different Serotypes of <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> by Dorien Dams, Célia Pas, Agnieszka Latka, Zuzanna Drulis-Kawa, Lars Fieseler, Yves Briers

“…<b>Results:</b> This platform achieved three key milestones: (I) engineering R2 tailocins specific to <i>Escherichia coli</i> serogroups O26, O103, O104, O111, O145, O146, and O157; (II) reprogramming R2 tailocins to target, for the first time, the capsule and a new species, specifically the capsular serotype K1 of <i>E. coli</i> and K11 and K63 of <i>Klebsiella pneumoniae</i>; (III) creating the first bivalent tailocin with a branched RBP and cross-species activity, effective against both <i>E. coli</i> K1 and <i>K. pneumoniae</i> K11. …”
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Hydrochemistry of a Tropical harbor: Influence of Industrial and Municipal inputs by Balogun Kayode James, Ladigbolu Ismail Adejare, Olaji Ebenezer Dayo

“…In recent times, pollution hazards of coastal waters have increased due to human activities including sand mining and dredging, industrial effluent discharges, indiscriminate dumping of sewage and domestic waste, use of detergents and heavy metals. …”
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Beneficial Effects of Ursodeoxycholic Acid on Metabolic Parameters and Oxidative Stress in Patients with Type 2 Diabetes Mellitus: A Randomized Double-Blind, Placebo-Controlled Cli... by Biljana Lakić, Ranko Škrbić, Snežana Uletilović, Nebojša Mandić-Kovačević, Milkica Grabež, Mirna Popović Šarić, Miloš P. Stojiljković, Ivan Soldatović, Zorica Janjetović, Anastasija Stokanović, Nataša Stojaković, Momir Mikov

“…After two months of the intervention period, a significant decrease in the activity of liver enzymes was noticed. Furthermore, a significant reduction in prooxidative parameters (TBARS, NO2-, H2O2) and significant elevation in antioxidative parameters such as SOD and GSH were found (p<0.001). …”
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Vascular Protective Effects of Morinda citrifolia Leaf Extract on Postmenopausal Rats Fed with Thermoxidized Palm Oil Diet: Evidence at Microscopic Level by C. L. G. Chong, Faizah Othman, Farida Hussan

“…In conclusion, we reported the mechanism of antiatherosclerotic property of MCLE through lipids elimination and anti-inflammatory activity. In addition, we do not recommend the use of statin in the absence of dyslipidemia as it causes PVAT deposition.…”
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Genome wide identification of MATE and ALMT gene family in lentil (Lens culinaris Medikus) and expression profiling under Al stress condition by Ankita Tripathi, Dharmendra Singh, Jyotika Bhati, Deepti Singh, Jyoti Taunk, Jawaher Alkahtani, Abdulrahman Al-Hashimi, Madan Pal Singh

“…Abstract Background The membrane transporters viz. multidrug and toxic compound extrusion (MATE) and aluminum-activated malate transporter (ALMT) are associated with aluminum (Al) tolerance by accelerating secretion of organic acids, which can influence nutrient availability and stress response. …”
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A comprehensive review and meta-analysis of the relationships between interleukin-7 levels and COVID-19 severity by Michal MATUSZEWSKI, Michal PRUC, Lukasz SZARPAK, Alla NAVOLOKINA, Katarzyna KIEZUN, Francesco CHIRICO, Gabriella NUCERA, Yuriy STEPANOVSKYY, Murat YILDIRIM, Anna HILFANOVA, Anastasia BONDARENKO

“…Its role in COVID-19 cytokine storms is thought to be related to its ability to stimulate the formation and activation of immune cells such as T cells and B cells. …”
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المکتبات الخضراء ودورها فى مواجهة تحدیات الاستدامة البیئیة : دراسة تحلیلیة مقارنة by د. مها لؤى حاتم

“…The least effective stepsfor sustainability can have a significant impact on the overall picture of libraries.With a small funding, the library gets significant returns as a result of marketing.Achieving environmental awareness does not necessarily require significant effortor substantial funds, but also effective activities in developing joint relationshipswith other institutions, library friend groups, school projects, suppliers and librarybeneficiaries.The problem of the study lies in, the spread of the phenomenon of greenlibraries at the level of many developed countries in the Western world, andactivates its components at the level of the Arab world, which calls forextrapolation of the elements of environmental sustainability and therequirements of their application to various categories of libraries. …”
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Clinical Outcome of Arthroscopic Management of Mucoid Degeneration of Anterior Cruciate Ligament by Madan Mohan Ballal, K. J. C. Chidanand, Vijendra Yadav, Akshay Dhanda, Chetan Nagaraja, Sachin K. Gowda

“…They respond well to a judicious arthroscopic debulking of the ACL with or without notchplasty, improving patient satisfaction and function without causing clinical instability in daily activities. However, young patients should be forewarned about the risk of instability, and the necessity of ACL reconstruction in the future.…”
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Inadequate toothbrushing practice and associated factors among in-school adolescents in Malaysia: Findings from Global School Health Survey (GSHS) 2017. by Mohamad Fuad Mohamad Anuar, Nurulasmak Mohamed, S Maria Awaluddin, Habibah Yacob

“…A validated self-administered bilingual, comprised of topics related to sociodemographic as well as adolescent health and risky lifestyles; substance use (alcohol, drug, smoking cigarettes), eating patterns, hygiene (inclusive of oral and hand hygiene), mental health status, lack of peer and parental/guardian support, truancy, physical activity, and body mass index (BMI). Analysis was performed using IBM SPSS for Windows version 26.0 involving complex sampling analysis and logistic regression.…”
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Evaluating the reflux suppression properties of Gaviscon Infant powder with different milk formulations using an in vitro model of the infant stomach by Fiona McLaughlin, Jeanine Fisher, Mark Atherton, Cathal Coyle

“…A previously evaluated artificial infant stomach model simulated an internal pressure-inducing reflux event (five reflux events performed at 5 min intervals). Suppression activity of Gaviscon Infant combined with eHF, pHF, and AAF was assessed by measuring the height that the refluxate event traveled up a tube mimicking the infant esophagus, alongside a benchmark unhydrolyzed formulation (uHF) with Gaviscon Infant and a negative control without Gaviscon Infant. …”
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Modified citrus pectin ameliorates methotrexate-induced hepatic and pulmonary toxicity: role of Nrf2, galectin-3/TLR-4/NF-κB/TNF-α and TGF-β signaling pathways by Randa Ismail, Heba A. Habib, Aliaa F. Anter, Amr Amin, Gehan H. Heeba

“…Moreover, MCP minimized oxidative stress elicited by MTX in lung and liver tissues, as indicated by reduced malondialdehyde levels, elevated levels of reduced glutathione, increased superoxide dismutase activity, and upregulated Nrf2 protein expression. …”
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Effect of Essential Microelements on Proteomic Profile of Lamb Muscle Tissue Protein by Tatiana M. Giro, Andrey V. Kulikovsky, Anna V. Giro

“…The research provided relevant data on the effect of innovative feed additives on the molecular mechanisms that occur in mutton muscle tissue and affect the proteomic profile of meat proteins and electrophoretic activity. The feed additives with organic microelements proved efficient. …”
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Interhemispheric Asymmetries in the Ground Magnetic Response to Interplanetary Shocks: The Role of Shock Impact Angle by Z. Xu, M. D. Hartinger, D. M. Oliveira, S. Coyle, C. R. Clauer, D. Weimer, T. R. Edwards

“…Recent work has shown that IP shock impact angle plays a significant role in controlling the subsequent geomagnetic activity and magnetic perturbations; for example, highly inclined shocks drive asymmetric MI responses due to interhemispherical asymmetric magnetospheric compressions, while almost head‐on shocks drive more symmetric MI responses. …”
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The Adducts Lipid Peroxidation Products with 2′-DeoxyNucleosides: A Theoretical Approach of Ionisation Potential by Boleslaw T. Karwowski

“…Unsaturated fatty acids are located on the external layer and, as a result, are particularly exposed to harmful factors, including xenobiotics and ionising radiation. During this activity, lipid peroxidation products are generated, e.g., 4-hydroxy-2-nonenal (HNA), 4-oxo-2(<i>E</i>)-nonenal (ONE), and malondialdehyde (MDA). …”
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Timosin alpha-1 immunomodulating properties by M. V. Mayevskaya

“…Timosin alpha-1 is successfully applied in clinical practice in treatment of chronic viral hepatites B and C, as antineoplastic immunomodulating drug and requires further active studies.…”
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Sour Cherry (Cerasus vulgaris Miller) Kernel Oil as the Novel Functional Edible Oil: Sensory Evaluation and Antioxidant and Physicochemical Properties by Maryam Kazempour-Samak, Ladan Rashidi, Mehrdad Ghavami, Anoosheh Sharifan, Fakhrisadat Hosseini

“…The most abundant sterol compounds were β-sitosterol (83.55%), ∆5-avenasterol (6.8%), sitostanol (4.8%), campesterol (3.5%), and stigmasterol (0.53%), respectively. Also, antioxidant activity, total phenol content (TPC), total anthocyanin content (TAC), total flavonoid content (TFC), total tannin content (TTC), and total tocopherol content were obtained as 73.22%, 33.44 mg GA/g dry matter, 177.84 mg/L, 46.37 mg/g dry matter, and 1.21 mg GA/g dry matter, 832.5 mg/kg oil, respectively. …”
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Clinical Outcomes and Patient Experience of Biosimilar to Biosimilar Infliximab Switching in Patients with Inflammatory Bowel Disease: A Prospective, Single-Centre, Phase IV Interv... by Clare Harris, Richard James Harris, David Young, Martin McDonnell, Bridget Clancy, Justin Harvey, Carlos Araujo, Ines Iria, Joao Goncalves, Susan Latter, J. R. Fraser Cummings

“…Demographics, disease history, validated disease activity scores, PROMs, and laboratory measurements were collected. …”
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Respiratory drive: a journey from health to disease by Dimitrios Georgopoulos, Maria Bolaki, Vaia Stamatopoulou, Evangelia Akoumianaki

“…Changes in respiratory drive can be explained by simultaneously considering the (1) ventilatory demands, as dictated by respiratory centers activity to CO2 (brain curve); (2) actual ventilatory response to CO2 (ventilation curve); and (3) metabolic hyperbola. …”
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Uncontrolled Hypertension and Behavioral Risk Factors among Adult Hypertensive Patients at Saint Paul’s Hospital, Millennium Medical College, Addis Ababa, Ethiopia by Yemisirach Sisay, Hana Abera, Tolesa Diriba Biratu, Tesfaye Girma Legesse

“…Hypertensive patients from urban areas, those who did not engage in physical activity, and those who were overweight had uncontrolled hypertension odds that were 0.55, 0.43, and 0.25 (AOR and 95% CI) times lower, respectively. …”
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GEOINFORMATION TECHNOLOGIES IN THE TRAINING OF FUTURE MINING ENGINEERS by Vladimir S. Morkun, Serhiy O. Semerikov, Svitlana M. Hryshchenko

“…In the professional activities of mining engineers, information technologies make it possible not only to consider the location of production units of a mining company, mineral warehouses and rock dumps of a mining company at any required level of detail, but also to help meet the basic environmental requirements in the field of mining.  …”
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