Modulatory Effect of 1,25-Dihydroxyvitamin D3 on IL1β-Induced RANKL, OPG, TNFα, and IL-6 Expression in Human Rheumatoid Synoviocyte MH7A by Xiaoke Feng, Chengyin Lv, Fang Wang, Ke Gan, Miaojia Zhang, Wenfeng Tan

“…Receptor activator of nuclear factor κB ligand (RANKL) plays a crucial role in the bone erosion of rheumatoid arthritis (RA) by prompting osteoclastogenesis. …”
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Acanthopanax versus 3-Methyladenine Ameliorates Sodium Taurocholate-Induced Severe Acute Pancreatitis by Inhibiting the Autophagic Pathway in Rats by Xiaohong Wang, Guoxiong Zhou, Chun Liu, Ronglong Wei, Shunxing Zhu, Yuefen Xu, Mengjie Wu, Qing Miao

“…The mechanism may be through inhibiting abnormal autophagy activation of pancreatic acinar cells.…”
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Factors influencing therapeutic efficacy of denosumab against osteoporosis in systemic lupus erythematosus by Sung-Hwan Park, Seung-Ki Kwok, Wan-Uk Kim, Ji Hyeon Ju, Jiwon Yang, Youngjae Park, Jennifer Jooha Lee

“…Correlation analysis was performed between the degree of BMD improvement and covariates including SLE-specific factors such as SLE duration, SLE Disease Activity Index 2000 (SLEDAI-2K) score, glucocorticoid dose and hydroxychloroquine use. …”
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Identification of the AHP family reveals their critical response to cytokinin regulation during adventitious root formation in apple rootstock by Ke Li, Ke Li, Ke Li, Huan Li, Wei Ling Liang, Jing Ju Liu, Hui Yue Tian, Li Hu Wang, Li Hu Wang, Yan Hong Wei, Yan Hong Wei

“…GUS staining indicated that the activity of the MdAHP3 promoter was also significantly enhanced by CTK treatment. …”
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A Nitrogen-Rich Covalent Triazine Framework as a Photocatalyst for Hydrogen Production by Ruizhi Gong, Liuliu Yang, Shuo Qiu, Wan-Ting Chen, Qing Wang, Jiazhuo Xie, Geoffrey I. N. Waterhouse, Jing Xu

“….% Pt/CTF-CN was found to be a promising photocatalyst for hydrogen production, affording a rate of 487.6 μmol g-1 h-1 in a H2O/TEOA/CH3OH solution under visible light. The photocatalytic activity of CTF-CN was benchmarked against g-C3N4 for meaningful assessment of performance. …”
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Repeated Autologous Bone Marrow Transfusion through Portal Vein for Treating Decompensated Liver Cirrhosis after Splenectomy by Weiwei Zhang, Mujian Teng, Baochi Liu, Qiling Liu, Xin Liu, Yanhui Si, Lei Li

“…Liver function tests, including serum albumin (ALB), alanine aminotransferase (ALT), total bilirubin (TB), prothrombin activity (PTA), cholinesterase (CHE), α-fetoprotein (AFP), and liver stiffness measurement (LSM), were conducted before surgery and 1, 3, and 6 months after surgery. …”
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Impacts of IOD and ENSO on the phytoplankton’s vertical variability in the Northern Indian Ocean by Qiwei Hu, Xiaoyan Chen, Xianqiang He, Yan Bai, Tingchen Jiang, Yu Huan, Zhanlin Liang

“…Different from IOD, the ENSO-related wind reversal impedes subsurface upwelling in the STI and EEIO, thereby constraining vertical biological activity. These findings could shed light on how phytoplankton will respond to changing ocean dynamics under global warming.…”
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A Novel Mutation in the CYP11B1 Gene Causes Steroid 11β-Hydroxylase Deficient Congenital Adrenal Hyperplasia with Reversible Cardiomyopathy by Mohammad A. Alqahtani, Ayed A. Shati, Minjing Zou, Ali M. Alsuheel, Abdullah A. Alhayani, Saleh M. Al-Qahtani, Hessa M. Gilban, Brain F. Meyer, Yufei Shi

“…The mutation created a premature stop codon at amino acid 260 (p.W260∗), resulting in a truncated protein devoid of 11β-hydroxylase activity. Interestingly, a somatic mutation at the same codon (c.779 G>A, p.W260∗) was reported in a patient with papillary thyroid cancer (COSMIC database). …”
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Heterogeneous graph convolutional neural network for protein-ligand scoring by Kevin Crampon, Alexis Giorkallos, Xavier Vigouroux, Stephanie Baud, Luiz Angelo Steffenel

“…Aim: Drug discovery is a long process, often taking decades of research endeavors. It is still an active area of research in both academic and industrial sectors with efforts on reducing time and cost. …”
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Transcription factor FOXD1 and miRNA-204-5p play a major role in B4GALNT2 downregulation in colon cancer by Martina Duca, Nadia Malagolini, Michela Pucci, Virginie Cogez, Anne Harduin-Lepers, Fabio Dall’Olio

“…Their transient transfection in the cell line GP2d, whose B4GALNT2 is closer to that of a normal mucosa, confirmed their inhibitory activity with a crucial role for FOXD1. The latter inhibited B4GALNT2 also in the middle B4GALNT2 expresser cell line Caco2. …”
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Implementation of a Smart Home Intruder Detection System using a Vibrometer and ESP 32 CAM by Samuel Owoeye, Folasade Durodola, Adekunle Oyelami, Racheal Oladejo, Samuel Obasuyi, Ademola Qasim, Joshua Ogundairo

“…The ATMega328P contributes to the system's intelligence by supporting motion detection algorithms, which, in turn, trigger automated alerts and activate lighting or alarm systems in response to detected movement. …”
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State of the Art Compendium: Canadian Thoracic Society Recommendations for Management of Chronic Obstructive Pulmonary Disease by Denis E O’Donnell, Shawn Aaron, Jean Bourbeau, Paul Hernandez, Darcy Marciniuk, Meyer Balter, Gordon Ford, Andre Gervais, Roger Goldstein, Rick Hodder, Francois Maltais, Jeremy Road

“…Management strategies, consisting of combined modern pharmacotherapy and nonpharmacotherapeutic interventions (eg, pulmonary rehabilitation and exercise training) can effectively improve symptoms, activity levels and quality of life, even in patients with severe COPD.…”
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Titanium dioxide -mediated regulation of enzymatic and non-enzymatic antioxidants, pigments, and diosgenin content promotes cold stress tolerance in Trigonella foenum-graecum L. by Mohamad Javad Babaei, Amin Ebrahimi, Parviz Heidari, Elham Azadvari, Shahrokh Gharanjik, Zeinab Chaghakaboodi

“…Our findings revealed that the utilization of 2 and 5 ppm of TiO2 NPs, positively influenced pigments biosynthesis and enzymatic and non-enzymatic antioxidant activities. It also effectively reduced electrolyte leakage and malondialdehyde content, mitigating the adverse effects of cold stress. …”
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Effects of Tert-Butylhydroquinone on Intestinal Inflammatory Response and Apoptosis following Traumatic Brain Injury in Mice by Wei Jin, Hongbin Ni, Yuxiang Dai, Handong Wang, Tianyu Lu, Jun Wu, Jian Jiang, Weibang Liang

“…As a result, we found that oral treatment with 1% tBHQ prior to TBI for one week markedly decreased NF-κB activation, inflammatory cytokines production, and ICAM-1 expression in the gut. …”
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Biosynthesis of Lysosomally Escaped Apoptotic Bodies Inhibits Inflammasome Synthesis in Macrophages by Jiayi Mao, Wenzheng Xia, Yanglin Wu, Minxiong Li, Yun Zhao, Peisong Zhai, Yuguang Zhang, Tao Zan, Wenguo Cui, Xiaoming Sun

“…Hyperglycemia and bacterial colonization in diabetic wounds aberrantly activate Nod-like receptor protein 3 (NLRP3) in macrophages, resulting in extensive inflammatory infiltration and impaired wound healing. …”
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Characterization and genomic insights into bacteriophages Kpph1 and Kpph9 against hypervirulent carbapenem-resistant Klebsiella pneumoniae by Ye Huang, Yuan Huang, Zhiping Wu, Ziyue Fan, Fanglin Zheng, Yang Liu, Xinping Xu

“…Interestingly, both phages have been found to contain two tail fiber proteins that may exhibit potential depolymerase activities. However, the exact role of depolymerase in the interaction between phages and their hosts warrants further investigation. …”
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Sigma-1 Receptor Modulates CFA-Induced Inflammatory Pain via Sodium Channels in Small DRG Neurons by Yuanlong Song, Zifen Xu, Liangpin Zhang, Linlin Gao

“…Our results revealed several key findings: (1) The expression of Sig-1R was found to be upregulated during the progression of inflammatory pain, with a notable translocation from the cytoplasm to the membrane; (2) Inhibition of peripheral Sig-1R using S1RA resulted in a reduction of CFA-induced allodynia; (3) Activation of Sig-1R through PRE-084 led to a decrease in the fast sodium current in isolated DRG neurons from CFA-treated rats, which was associated with a diminished action potential (AP) peak and maximum depolarizing rate (MDR), as well as an increased rheobase; (4) Furthermore, PRE-084 was observed to enhance the slow component of the sodium current, resulting in hyperpolarization of the threshold potential and an increase in AP firing frequency, alongside an elevation in the mRNA expression of the slow sodium channel Nav1.9 in CFA-treated rats. …”
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Giant and flexible toroidal circular dichroism from planar chiral metasurface by Shijie Kang, Haitao Li, Jiayu Fan, Jiusi Yu, Boyang Qu, Peng Chen, Xiaoxiao Wu

“…Chirality, a fundamental concept describing an object cannot superpose with its mirror image, is crucial in optics and photonics and leads to various exotic phenomena, such as circular dichroism and optical activity. Recent findings reveal that besides electric and magnetic dipoles, toroidal dipoles, an elusive part of dynamic multipoles, can also significantly contribute to chirality. …”
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Microbial community differentiation in vent chimneys of the Lost City Hydrothermal Field reflects habitat heterogeneity by Osama M. Alian, William J. Brazelton, Karmina A. Aquino, Katrina I. Twing, H. Lizethe Pendleton, Gretchen Früh-Green, Susan Q. Lang, Matthew O. Schrenk, Matthew O. Schrenk

“…The Lost City Hydrothermal Field (LCHF) near the Mid-Atlantic Ridge is one such environment, and its large chimneys are unique in hosting actively venting hydrothermal fluids that are primarily controlled by serpentinization reactions in the subseafloor. …”
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Development and characterization of orthotopic patient-derived xenograft models of peritoneal metastatic mucinous appendiceal adenocarcinoma by I. Ito, V.K. Pattalachinti, A.M.G. Yousef, S. Chowdhury, M.M. Fanaeian, E. Haque, B.B. Gunes, M. Yousef, E.R. Salle, M.A. Zeineddine, S. Ji, R. Li, W. Wang, B.A. Helmink, M.W. Taggart, M.G. White, K.F. Fournier, N.W. Fowlkes, J.P. Shen

“…Transcriptomic comparison of patient and PDX tumors identified increased Myc and E2F signaling, suggesting that activation of Myc may be a driver of the dedifferentiation of AAs. …”
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