Are neurasthenia and depression the same disease entity? An electroencephalography study by Ge Dang, Lin Zhu, Chongyuan Lian, Silin Zeng, Xue Shi, Zian Pei, Xiaoyong Lan, Jian Qing Shi, Nan Yan, Yi Guo, Xiaolin Su

“…Conclusion Neurasthenia and MDD are different not only in symptoms but also in brain activities.…”
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Anaerobic metabolism promotes breast cancer survival via Histone-3 Lysine-18 lactylation mediating PPARD axis by Ying Xu, Weiwei Meng, Yingqi Dai, Lin Xu, Ning Ding, Jinqing Zhang, Xuewei Zhuang

“…During the proteomics analysis, AKT-phosphorylation in the aerobic respiration inhibitor group exhibited an apparent disparity and activity. Our study demonstrated that changes in H3K18la in BC and its downstream transcription factor PPARD support cell survival under anaerobic glycolysis conditions. …”
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Portable UV-C device to treat high flow of infectious aerosols generated during clinical respiratory care by Richard Vincent, David Rapoport, Priti Balchandani, Joseph Borrello, Michael Schotsaert, Robert Karlicek, Gabriel Laghlali, Prajakta Warang, Seokchan Park, Gagandeep Singh, Isabella Morgan, James Paredes, Raveen Rathnasinghe, Jacob Wolf, Adolfo García-Sastre

“…Viability experiments at low, medium and high (100 l/min) flows of contaminated gas were conducted with 6, 4, 2 and 1 lamp activated (single-pass and recirculation were tested). …”
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Single cell RNA sequencing reveals human tooth type identity and guides in vitro hiPSC derived odontoblast differentiation (iOB) by Sesha Hanson-Drury, Sesha Hanson-Drury, Sesha Hanson-Drury, Anjali P. Patni, Anjali P. Patni, Anjali P. Patni, Anjali P. Patni, Deborah L. Lee, Deborah L. Lee, Deborah L. Lee, Ammar Alghadeer, Ammar Alghadeer, Ammar Alghadeer, Ammar Alghadeer, Yan Ting Zhao, Yan Ting Zhao, Yan Ting Zhao, Devon Duron Ehnes, Devon Duron Ehnes, Devon Duron Ehnes, Vivian N. Vo, Vivian N. Vo, Vivian N. Vo, Sydney Y. Kim, Sydney Y. Kim, Druthi Jithendra, Druthi Jithendra, Ashish Phal, Ashish Phal, Ashish Phal, Natasha I. Edman, Natasha I. Edman, Natasha I. Edman, Natasha I. Edman, Thomas Schlichthaerle, Thomas Schlichthaerle, David Baker, David Baker, David Baker, Jessica E. Young, Jessica E. Young, Julie Mathieu, Julie Mathieu, Hannele Ruohola-Baker, Hannele Ruohola-Baker, Hannele Ruohola-Baker, Hannele Ruohola-Baker, Hannele Ruohola-Baker

“…During human odontoblast development, computational analysis predicts that early FGF and BMP activation followed by later HH signaling is crucial. …”
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Stochastic demethylation and redundant epigenetic suppressive mechanisms generate highly heterogeneous responses to pharmacological DNA methyltransferase inhibition by Mie K. Jakobsen, Sofie Traynor, Aaraby Y. Nielsen, Christina Dahl, Mette Staehr, Simon T. Jakobsen, Maria S. Madsen, Rasmus Siersbaek, Mikkel G. Terp, Josefine B. Jensen, Christina B. Pedersen, Anup Shrestha, Jonathan R. Brewer, Pascal H. G. Duijf, Odd L. Gammelgaard, Henrik J. Ditzel, Alexei F. Kirkin, Per Guldberg, Morten F. Gjerstorff

“…Methods In this study, we used cancer/testis antigen genes as a model for methylation-dependent gene expression to examine the activity of DNA methyltransferase inhibitors and their potential synergistic effect with histone deacetylase inhibitors at the single-cancer cell level. …”
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Deficit Irrigation Response and Climate Resilience of Mediterranean Tomato Landraces by Yüksel Tüzel, Hüseyin Biyke, Omar S. Harouna, Tunç Durdu, Mahmut Tepecik, Gölgen B. Oztekin, Ulaş Tunalı, Nazim S. Gruda

“…Among the tested tomato landraces, ‘Valldemossa’, ‘Chondrokats’, and ‘TR62367’ exhibited strong yield performance, with up to 4 kg m⁻² under water-limited conditions, whereas ‘Cherry-INRAE 1’, ‘Cherry-INRAE 3’, and ‘Cherry-INRAE 4’ excelled in fruit quality attributes, reaching up to 9.3% Brix, 14.07 mg 100 g⁻¹ vitamin C, 7.77 mg GAE 100 g⁻¹ total phenols, and 75.74 µmol TE g⁻¹ antioxidant activity. The amount of water could be reduced by 35% without compromising yield or quality in the most drought-tolerant landraces.…”
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Sporothrix brasiliensis Gp70 is a cell wall protein required for adhesion, proper interaction with innate immune cells, and virulence by Leonardo Padró-Villegas, Manuela Gómez-Gaviria, Iván Martínez-Duncker, Luz A. López-Ramírez, José A. Martínez-Álvarez, Gustavo A. Niño-Vega, Héctor M. Mora-Montes

“…Mutant strains with high GP70-silencing levels showed minimal levels of 3-carboxy-cis,cis-muconate cyclase activity, this glycoprotein's predicted enzyme function, and decreased ability to bind laminin and fibronectin. …”
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Robot-assisted upper limb therapy for personalized rehabilitation in children with cerebral palsy: a systematic review by Daniela Cardone, David Perpetuini, Marta Di Nicola, Arcangelo Merla, Giovanni Morone, Giovanni Morone, Irene Ciancarelli, Antimo Moretti, Antimo Moretti, Francesca Gimigliano, Francesca Gimigliano, Alice Cichelli, Francesco De Flaviis, Alex Martino Cinnera, Teresa Paolucci

“…IntroductionCerebral palsy (CP) is a group of permanent disorders of movement development that may cause activity limitations. In this context, robot-assisted therapy might play a key role in clinical management. …”
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The photo-electrocatalytic property of hollow mesoporous graphene oxide/tungsten trioxide/titanium dioxide membrane photo-anode by Yuan Li, Xinying Sun, Jiajia Chen, Shuping Luo, Guohua Li

“…Titania (TiO2) is one of promising photo catalysts for its high ability to resistant photo corrosion and environmental friendliness, but its photocatalytic activity is too low to be used in industry. To find an approach to solve this problem, graphene oxide (GO), tungsten trioxide (WO3) and TiO2 composite with hollow mesoporous structure was prepared by a two-step spray drying method. …”
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Learning and Teaching Geological Field Skills in a Virtual World: Insights From an Undergraduate Virtual Fieldtrip in Kinlochleven, Scotland by Matthew J. Genge, Valentin Laurent, Philippa J. Mason, Alan R. T. Spencer, Mark D. Sutton, Alex C. Whittaker

“…Student behavioural indicators, furthermore, suggest that the immersive strategy successfully produced a high degree of engagement with the activity. A major limitation of the virtual fieldtrip was in the development of skills requiring spatial visualisation, in particular, the spatial association of features across multiple scales. …”
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The Analysis of Estrogen-Degrading and Functional Metabolism Genes in Rhodococcus equi DSSKP-R-001 by Kejian Tian, Fanxing Meng, Qi Meng, Yan Gao, Lili Zhang, Le Wang, Yuqing Wang, Xue Li, Hongliang Huo

“…Environmental estrogens are mainly derived from human and vertebrate excretion, drugs, and agricultural activities. The use of microorganisms is currently the most economical and effective method for biodegradation of environmental estrogens. …”
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Data on compositional diversity of textural varieties of lake superior-type Banded Iron Formation (BIF) of the Njweng prospect, Mbalam iron ore district, southern CameroonMendeley... by Dieudonne Charles Isidore Ilouga, Cheo Emmanuel Suh, Akumbom Vishiti, Elisha Muntum Shemang

“…The BIF show a characteristic banding and no association with volcanic activity. Chemical analysis was accomplished using a combination of the Inductively Coupled Plasma Emission Spectrometry (ICP-ES) and Inductively Coupled Plasma Mass Spectrometry (ICP-MS) on the major and trace elements respectively. …”
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Lerociclib plus fulvestrant in patients with HR+/HER2− locally advanced or metastatic breast cancer who have progressed on prior endocrine therapy: LEONARDA-1 a phase III randomize... by Binghe Xu, Qingyuan Zhang, Yang Luo, Zhongsheng Tong, Tao Sun, Changping Shan, Xinlan Liu, Yumin Yao, Bing Zhao, Shusen Wang, Xiaohua Zeng, Changlu Hu, Xi Yan, Xiaojia Wang, Hongyan Jia, Zhendong Chen, Fuming Qiu, Xinhong Wu, Deyong Zhang, Tong Li

“…Abstract Lerociclib (GB491), a highly selective oral CDK4/6 inhibitor, has displayed anti-tumor activity and differentiated safety and tolerability profile in previous ph1/2 clinical trials. …”
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Characterizing a complex buildup in the Pearl River Mouth Basin of the northern South China Sea: an interplay of carbonates and igneous rocks by Beichen Chen, Leyi Xu, Baojun Liu, Lili Zhang, Dong Xiao, Ya Gao, Ya Gao, Feng Wu, Xueqi Yang, Yaming Zou, Yongkun Ma, Yinglin Zhang

“…We propose that volcanic rocks can be distinguished from carbonates by the temporal and spatial coupling of typical features: (a) surface volcanic rocks and subsurface intrusive bodies are inseparable, with igneous rocks identifiable through faults and volcanic conduits; (b) carbonates typically display symmetrical structures on both sides of the highland and exhibit better stratification away from igneous activity; (c) carbonates generally show a convex clinoform and steep slope at the platform margin, while volcanic mounds exhibit concave gentle slopes. …”
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Inhibitory Effect of PRMT5/MTA Inhibitor on MTAP‐Deficient Glioma May Be Influenced by Surrounding Normal Cells by Yunjie Wang, Xiaohui Sun, Runchen Ma, Xiaofan Zhang, Shengmin Ji, Zhaofeng Liu, Gangqiang Yang, Hongbo Wang, Peng Zhang, Jianzhao Zhang, Jingwei Tian

“…ABSTRACT Background Methylthioadenosine phosphorylase (MTAP) and protein arginine methyltransferase 5 (PRMT5) are considered to be a synthetic lethal pair of targets, due to the fact that deletion of MTAP leads to massive production of methylthioadenosine (MTA) decreasing the activity of PRMT5. In vitro and in vivo experiments have demonstrated that MRTX1719, a small molecule that selectively binds PRMT5/MTA complex, significantly inhibits the proliferation of MTAP‐deficient tumors and has a weak toxic effect on normal cells. …”
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AIEgen-self-assembled nanoparticles with anti-PD-L1 antibody functionalization realize enhanced synergistic photodynamic therapy and immunotherapy against malignant melanoma by Lu Li, Qing Xu, Xiuzhen Zhang, Yuan Jiang, La Zhang, Jiao Guo, Haichuan Liu, Bin Jiang, Shenglong Li, Qiling Peng, Ning Jiang, Jianwei Wang

“…The TBP@aPD-L1-mediated PDT induces more powerful effects of direct tumor cell-killing and further elicits effective immunogenic cell death (ICD), which exerts anti-tumor immunity by activating T cells for ICI treatment and reshapes the tumor immune microenvironment (TIME), thereby enhancing the efficacy of PD-L1 blockade of anti-PD-L1. …”
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MYH9 promotes malignant progression of glioma cells through regulating β-catenin stability via epithelial-mesenchymal transition signaling pathway by Zigui Chen, Chao Liu, Wei Zheng, Zhilong Li, Yuanhui Tang, Jun Peng, Changfeng Miao, Dandan Zheng, Ying Xia

“…Abstract Epithelial‒mesenchymal transition (EMT) is a process in which polar epithelial cells transform into active mesenchymal cells and acquire invasion and migration capabilities (Cano CE, Motoo Y, Iovanna JL in Sci World J 10, 2010). …”
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Immunotherapy in Recurrent Ovarian Cancer by Keyao Chen, Jingjing Wang, Meng Yang, Shaoqiong Deng, Li Sun

“…This review discusses various immunotherapy modalities, including active and passive immune strategies, for recurrent ovarian cancer. …”
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Proteomic profiling of bronchoalveolar lavage fluid uncovers protein clusters linked to survival in idiopathic forms of interstitial lung disease by Linh T. Ngo, Michaella J. Rekowski, Devin C. Koestler, Takafumi Yorozuya, Atsushi Saito, Imaan Azeem, Alexis Harrison, M. Kristen Demoruelle, Jonathan Boomer, Bryant R. England, Paul Wolters, Philip L. Molyneaux, Mario Castro, Joyce S. Lee, Joshua J. Solomon, Koji Koronuma, Michael P. Washburn, Scott M. Matson

“…The cluster with the worst prognosis featured decreased inflammatory signalling and complement activation, with pathway analysis highlighting altered immune response pathways related to immunoglobulin production and B-cell-mediated immunity. …”
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Actinidia deliciosa as a complemental therapy against nephropathy and oxidative stress in diabetic rats by Ali Y. Naoom, Wenyi Kang, Nora F. Ghanem, Mohamed M. Abdel-Daim, Fatma M. El-Demerdash

“…While, enzymatic and non-enzymatic antioxidants, protein content, and alkaline phosphatase (ALP) activity declined. Furthermore, histological, immunohistochemical alpha-smooth muscle actin immunoreactivity (α-SMA-ir) and histochemical (collagen, total protein, DNA, and RNA) alterations were observed in rat kidneys. …”
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