The Effects of Hyperacute Serum on the Elements of the Human Subchondral Bone Marrow Niche by Melinda Simon, Bálint Major, Gabriella Vácz, Olga Kuten, István Hornyák, Adél Hinsenkamp, Dorottya Kardos, Marcell Bagó, Domonkos Cseh, Adrienn Sárközi, Denes Horvathy, Stefan Nehrer, Zsombor Lacza

“…Monolayer MSCs showed significantly higher metabolic activity following 5 days’ incubation in HAS, and osteoblast-specific mRNA expression was markedly increased, while cells also retained their MSC-specific cell surface markers. …”
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Gene Therapy with HSV1-sr39TK/GCV Exhibits a Stronger Therapeutic Efficacy Than HSV1-TK/GCV in Rat C6 Glioma Cells by Lei-qing Li, Fang Shen, Xiao-yan Xu, Hong Zhang, Xiao-feng Yang, Wei-guo Liu

“…Therefore, In order to reduce the GCV dose required, we aim to compare the therapeutic efficacy of HSV1-sr39TK, an HSV1-TK mutant with increased GCV prodrug catalytic activity, with wildtype TK in C6 glioma cells. Accordingly, rat C6 glioma cells were first transfected with pCDNA-TK and pCDNA-sr39TK, respectively, and the gene transfection efficacy was verified by immunocytochemistry and western blot analysis. …”
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Dichotomitin promotes osteoblast differentiation and improves osteoporosis by inhibiting oxidative stress by Meichun Han, Weibin Du, Lei Zhang, Zhenwei Wang, Shengqiang Fang, Yang Zheng, Renfu Quan

“…In vitro studies showed that DH enhanced ALP activity and elevated expression of RUNX2, OPN, OCN, SOD1, and SOD2. …”
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One Earth-One Health (OE-OH): Antibacterial Effects of Plant Flavonoids in Combination with Clinical Antibiotics with Various Mechanisms by Ganjun Yuan, Fengxian Lian, Yu Yan, Yu Wang, Li Zhang, Jianping Zhu, Aiman Fatima, Yuxing Qian

“…<b>Methods</b>: The antibacterial activities of thirty-seven plant flavonoids and nine clinical antibiotics with various antimicrobial mechanisms were determined using the microbroth dilution method. …”
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Molecular mechanisms of cis-oxygen bridge neonicotinoids to Apis mellifera Linnaeus chemosensory protein: Surface plasmon resonance, multiple spectroscopy techniques, and molecular... by Xiangshuai Li, Shiyu Li, Yang Liu, Li Cui, Daibin Yang, Shuning Chen, Xusheng Shao, Huizhu Yuan, Xiaojing Yan

“…Molecular docking and dynamics simulations further illustrated the stability of these interactions within the active site of the protein. Of particular interest, cis-structured neonicotinoids demonstrated distinct binding characteristics compared to their trans-structured counterparts, including an inverse relationship between the binding constant and temperature. …”
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Detecting Ground Level Enhancements Using Soil Moisture Sensor Networks by A. D. P. Hands, F. Baird, K. A. Ryden, C. S. Dyer, F. Lei, J. G. Evans, J. R. Wallbank, M. Szczykulska, D. Rylett, R. Rosolem, S. Fowler, D. Power, E. M. Henley

“…However, there are only a few dozen active stations worldwide, and there has not been a UK‐based station for several decades. …”
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Organic iron at ultralow doses catalyzes hydrogen peroxide to eliminate cyanobacterial blooms: a study on algicidal effects and mechanisms under natural conditions by Yongdong Lin, Ziru Niu, Juan Li, Sijin Li, Hai Li, Lei Li

“…Our findings indicate that inorganic iron (FeSO4) shows minimal catalytic activity on H2O2 under varying light conditions. In contrast, organic iron, specifically the combination of H2O2, EDTANaFe, and light irradiation, demonstrates significant algicidal effects. …”
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Enhanced wheat yield and flag leaf physiology in saline-alkali soils using modified straw water-retaining agent by Min Yang, Cexun Ji, Kui Chao, Pengfei Zhu, Xiaoqing Yuan, Zenghui Hao, Xiulin Wang, Yan Shi

“…The results showed that the application of water-retaining agent could increase the chlorophyll content and improve the photosynthetic characteristics of wheat flag leaves, and the application of water-retaining agent was beneficial to increase the activities of Superoxide Dismutase (SOD), Peroxidase (POD) and Ascorbate Peroxidase (APX) and reduce the content of Malondialdehyde (MDA) in wheat flag leaves. …”
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Advanced statistical analysis of air quality and its health impacts in India: Quantifying significance by detangling weather-driven effects by Akshansha Chauhan, Guggilla Pavan Sai, Chin-Yu Hsu

“…The COVID-19 lockdown offered a unique opportunity to examine air pollutant reductions under restricted human activities. This study conducted a long-term analysis of air quality in five major Indian cities—Delhi, Kolkata, Bengaluru, Hyderabad, and Visakhapatnam—by analysing variations in PM2.5, PM10, NOx, NH3, SO2, CO, and O3, incorporating a de-weathering strategy to isolate meteorological influences. …”
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Anti-Inflammatory Effects of Concentrated Ethanol Extracts of Edelweiss (Leontopodium alpinum Cass.) Callus Cultures towards Human Keratinocytes and Endothelial Cells by Lulli Daniela, Potapovich Alla, Riccardo Maurelli, Dellambra Elena, Pressi Giovanna, Kostyuk Vladimir, Dal Toso Roberto, De Luca Chiara, Pastore Saveria, Korkina Liudmila

“…Comparison of the dose-dependent inhibition of chemokine (IL-8, IP-10, MCP-1) and growth factor (GM-CSF) release from PHK activated by TNFα + IFNγ showed that leontopodic acid was mainly responsible for the inhibitory effects of ECC55. …”
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Preamble Arbitration Rule and Interference Suppression-Based Polling Medium Access Control for In-Vehicle Ultra-Wideband Networks by Makoto Okuhara, Nobuyuki Kurioka, Shigeki Mitoh, Patrick Finnerty, Chikara Ohta

“…First, it prioritizes the timing of signal reception over radio signal power, enhancing interference suppression by activating the receiver at the optimal moment before the desired frame arrives, thereby minimizing data loss. …”
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Characterization of the C5H11ORF96 gene in chickens: cloning, tissue distribution and investigation of its potential function in stress response regulation by Yiping Wan, Jiannan Zhang, Xiao Zhang, Jiliang He, Ningkun Shi, Yuanyou Li, Juan Li, Yajun Wang

“…To be in response to the varied stimulus, the hypothalamic-pituitary-adrenal (HPA) axis is activated through the controlling of the synthesis and secretion of glucocorticoids (GCs). …”
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CYP2C19 Genotype‐Guided Antiplatelet Therapy and Clinical Outcomes in Patients Undergoing a Neurointerventional Procedure by Kayla R. Tunehag, Ashton F. Pearce, Layna P. Fox, George A. Stouffer, Sten Solander, Craig R. Lee

“…However, patients carrying CYP2C19 no‐function alleles have diminished capacity for inhibition of platelet reactivity due to reduced formation of clopidogrel's active metabolite. In patients with cardiovascular disease undergoing a percutaneous coronary intervention, CYP2C19 no‐function allele carriers treated with clopidogrel experience a higher risk of major adverse cardiovascular outcomes, and multiple large prospective outcomes studies have shown an improvement in clinical outcomes when antiplatelet therapy selection was guided by CYP2C19 genotype. …”
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The Treatment Effect of Plantago Major on Lung Cancer Based on the Computed Tomography and Pathological Findings: A Case Report Study by Saade Abdalkareem Jasim, Bashar Mudhaffar Abdullah, Patricio Yánez-Moretta, Wesam R. Kadhum, Yasser Fakri Mustafa, Enas R. Alwaily, Munther Abosoda, Ali Alsalamy, Sada Ghalib Al-Musawi, Alaa A. Omran

“… Purpose: Plantago Major (PM) is widely used for the treatment of different diseases due to several active compounds. Previous studies demonstrated the treatment effect of this plant on lung cancer cell lines. …”
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The Clinical Significance of HLA Compatibility Scores in Lung Transplantation by Liesbeth Daniëls, Liesbeth Daniëls, Hanne Beeckmans, Andrea Zajacova, Pieterjan Kerckhof, Saskia Bos, Maarten Naesens, Bart Vanaudenaerde, Frans Claas, Frans Claas, Robin Vos, Robin Vos

“…Since HLA disparity between donor and recipient plays a major role in rejection, we performed a single center, retrospective observational cohort analysis in our lung transplant cohort (n = 128) in which we calculated HLA compatibility scores for B-cell epitopes (HLAMatchmaker, HLA-EMMA), T-cell epitopes (PIRCHE-II) and missing self-induced NK cell activation (KIR Ligand Calculator). Adjusted Cox proportional hazards model was used to investigate the association between mismatched scores and time to development of donor-specific antibodies (DSA) post-transplant, time to first biopsy-proven acute rejection episode, freedom from CLAD, graft survival and overall survival. …”
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Predicting waste generation using Bayesian model averaging by M.G. Hoang, T. Fujiwara, S.T. Pham Phu, K.T. Nguyen Thi

“…The model obtained from this study indicated that household location, household size, house area per person, and family economic activity are important determinants of the waste generation rate. …”
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An ecosystem approach to the evaluation and impact analysis of heterogeneous preventive and/or early interventions projects for veterans and first responders in seven countries by S. Lukersmith, L. Salvador-Carulla, C. Woods, T. Niyonsenga, M.R. Gutierrez-Colosia, I. Mohanty, C.R. Garcia-Alonso, D. Diaz-Milanes, J.A. Salinas-Perez, R. Davey, A. Aryani

“…Embedded in the evaluation design are methods, knowledge sharing and organisational learning activities for all stakeholders. Data is collected by the Projects and evaluation team on input, throughputs, and output indicators. …”
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An Improved One-Pot Procedure for Preparation Of N,N -Diethyl-m-Toluamide from m-Toluic Acid by Thinh Pham Duc, Thu Nguyen Van, Phuong Bui Thu, Chau Phan Dinh, Duc Viet Le, Duong Vu Binh

“…Method: The input materials: m-toluic acid has been activated with thionyl chloride to create the intermediate product, m-toluoyl chloride. …”
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Diospyros mespilifoemis hochst Modulates the Hippocampus and Prefrontal Cortex of Wistar Rat following Lithium chloride pilocarpine-induced Epilepsy by Sunday Yinka Olatunji, Oluwafemi Ezekiel Kale, Oluseyi Abimbola Ogunsola, John Afees Olanrewaju, Ijeoma Esiaba, Taiye Adelodun, Olubunmi Philip Ogunnaike

“…In the open field test, DM reversed the altered activities in the epileptic rats.  DM ameliorates neuronal vacuolation, disorientation and increased reactive gliosis. …”
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Genomic insights and comparative analysis of Colletotrichum species associated with anthracnose fruit rot and crown rot of strawberry in North Carolina by Tika B. Adhikari, Norman Muzhinji, Ashley N. Philbrick, Frank J. Louws, Frank J. Louws

“…The predicted gene models included effectors (339 to 480), secondary metabolic gene clusters (67 to 90), and carbohydrate-active enzymes (800 to 1,060), with C. siamense isolates exhibiting the highest numbers in these categories. …”
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