Anti-IL-22 Antibody Attenuates Acute Graft-versus-Host Disease via Increasing Foxp3+ T Cell through Modulation of CD11b+ Cell Function by Jianbo Wu, Jian Gu, Shun Zhou, Hao Lu, Yunjie Lu, Ling Lu, Xuehao Wang

“…To investigate the association between IL-22 and aGVHD, an anti-mouse IL-22 antibody (IL-22Ab) was used to ablate IL-22 activity in a mouse aGVHD model. Administration of IL-22Ab significantly reduced the progression of aGVHD in B6D2F1 recipients of B6 grafts. …”
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Occurrence and management of thrombosis recurrence and bleeding in low-molecular-weight heparin-treated patients with cancer-associated thrombosis: a French nationwide cohort study by Isabelle Mahé, Gaelle Gusto, Nadia Quignot, Artak Khachatryan, Jose Chaves, Audrey Moniot, Lucas Andre, Sylvain Van Roy, Ruth Mokgokong, Laurent Bertoletti

“…Methods: An observational study was conducted using nationwide French data for adults with active cancer who were hospitalized with VTE in 2013-2018 and were reimbursed for LMWH ≤ 30 days after hospital discharge. …”
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Comprehensive bioinformatic profiling of matrix metalloproteinases and their inhibitors: Expression and interaction patterns in head and neck cancer toward predictive biomarkers an... by Rishaba Byju, Sredha Sunil, Sabari Sadhasivan, Rajesh Parsanathan

“…TIMP1 was significantly upregulated in HNSCC, while TIMP3 downregulation correlated with increased MMP activity and tumour progression. According to Kaplan-Meier survival analyses, higher TIMP expression was associated with poor overall survival in HNSCC patients. …”
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Gnidia glauca- and Plumbago zeylanica-Mediated Synthesis of Novel Copper Nanoparticles as Promising Antidiabetic Agents by Dhiraj A. Jamdade, Dishantsingh Rajpali, Komal A. Joshi, Rohini Kitture, Anuja S. Kulkarni, Vaishali S. Shinde, Jayesh Bellare, Kaushik R. Babiya, Sougata Ghosh

“…Further, the CuNPs were checked for antidiabetic activity using porcine pancreatic α-amylase and α-glucosidase inhibition followed by evaluation of mechanism using circular dichroism spectroscopy. …”
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Accuracy of the combined method (auscultation and pH measurement) and ultrasonography for confirmation of gastric tube placement: a study protocol for a prospective study by Fernanda Raphael Escobar Gimenes, Rosana Aparecida Pereira, Mayara Carvalho Godinho Rigobello, Jorge Elias Junior, Carlos Alberto Grespan Bonacim, Renata Cristina de Campos Pereira Silveira, Fernanda Caroline Bonardi, Roosevelt Santos Nunes

“…The findings will be reported through academic journals, seminars and conference presentations, social media, print media, the internet and community/stakeholder engagement activities.…”
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Efficacy of Wii-Fit on Static and Dynamic Balance in Community Dwelling Older Veterans: A Randomized Controlled Pilot Trial by Kalpana P. Padala, Prasad R. Padala, Shelly Y. Lensing, Richard A. Dennis, Melinda M. Bopp, Christopher M. Parkes, Mark K. Garrison, Patricia M. Dubbert, Paula K. Roberson, Dennis H. Sullivan

“…The primary (Berg Balance Scale (BBS)) and secondary outcomes (fear of falling, physical activity enjoyment, and quality of life) were measured at baseline, 4 weeks, and 8 weeks. …”
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Rational engineering of Escherichia coli strain for stable and enhanced biosynthesis of pinene by Muhammad Hammad Hussain, Lu Han, Yanlong Wei, Muhammad Javid, Kamran Ashraf, Maria Martuscelli, Waleed Aldahmash, Meijin Guo, Ali Mohsin, Zhanxia Li

“…It demonstrates multiple biological activities and has a wide range of applications. However, the limited supply of pinene extracted from plants poses a challenge in meeting the needs of the aviation industry and other sectors. …”
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Enhanced Expression of NR2B Subunits of NMDA Receptors in the Inherited Glaucomatous DBA/2J Mouse Retina by Ling-Dan Dong, Jie Chen, Fang Li, Feng Gao, Jihong Wu, Yanying Miao, Zhongfeng Wang

“…Moreover, expression of Cdk5, p35 and ratio of p-NR2AS1232/NR2A progressively increased with time in both strains, suggestive of activated Cdk5/p35 signaling pathway. However, the changes in these proteins were in the same levels in both strain mice, except a significant increase of p35 proteins at 6 months in DBA/2J mice. …”
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The study protocol of a double-blind randomized controlled trial of EMDR and multifocal transcranial current stimulation (MtCS) as augmentation strategy in patients with fibromyalg... by I. Gardoki-Souto, O. Martín de la Torre, B. Hogg, D Redolar-Ripoll, L. Martínez Sadurní, M. Fontana-McNally, J. M. Blanch, W. Lupo, V. Pérez, J. Radua, B. L. Amann, A. Valiente-Gómez, A. Moreno-Alcázar

“…Methods Ninety-six patients with FM and a history of traumatic events will be randomly allocated to the treatment as usual (TAU) condition, EMDR + active-MtCS condition, or EMDR + sham-MtCS condition. …”
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Quantitative Proteomics Analysis Reveals XDH Related with Ovarian Oxidative Stress Involved in Broodiness of Geese by Ning Zhou, Yaoyao Zhang, Youluan Jiang, Wang Gu, Shuai Zhao, Wanwipa Vongsangnak, Yang Zhang, Qi Xu, Yu Zhang

“…The results of this study showed that during the broody period, geese exhibited degraded ovarian tissues, disrupted follicular development, a thinner granulosa cell layer, and lower levels of ovarian hormones E2, P4, and AMH. Antioxidant activity (GSH, CAT, SOD, T-AOC, and the content of H₂O₂) and the mRNA expression levels of antioxidant genes (GPX, SOD-1, SOD-2, CAT, COX-2, and Hsp70) were significantly higher in pre-broody geese compared to laying geese, while the expression of apoptosis-related genes (p53, Caspase-3, and Caspase-9) increased and the anti-apoptotic gene Bcl-2 decreased. …”
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Dual-immunomodulatory effects on RAW264.7 macrophages and structural elucidation of a polysaccharide isolated from fermentation broth of Paecilomyces hepiali by Baoming Tian, Renjian Liu, Qi Li, Hanshan Xu, Ming Cai, Rongfa Guan, Peilong Sun, Kai Yang

“…The nitric oxide (NO) production, phagocytosis activity, and cytokine secretion were significantly increased (P < 0.05) after PHP40-2 treatment; however, PHP40-2 could inhibit NO production and cytokine secretion in LPS-induced RAW264.7 macrophages (P < 0.05). …”
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IVF cycle safety when a positive passive air sampling occurs under laminar flow hood in absence of a detectable contamination in the embryo culture by Claudia Omes, Roberto Bassani, Patrizia Cambieri, Fausto Baldanti, Fausto Baldanti, Rossella Elena Nappi, Rossella Elena Nappi

“…In this study, we investigated the IVF outcome of procedures carried out during 5 years of laboratory activity when a positive passive air sampling occurs under laminar flow hood in the absence of clear contamination in the embryo culture. …”
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Study on hot deformation behavior and microstructure evolution of ultrafine W-0.5 wt%La2O3 alloy wire during processing by Yuan Yao, Jianwei Guo, Shizhong Wei, Jinghong Yang, Zhou Li, Hongan Geng, Liujie Xu

“…Lanthanum oxide gradually aggregates to the grain boundary during the hot deformation process, which improves the thermal deformation activation energy of tungsten. The Q value is about 410.018 kJ/mol, which improves the high temperature strength of tungsten alloy. …”
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Experimental Study on the Durability of Fly Ash-Based Filling Paste in Environments with Different Concentrations of Sulfates by Boqiang Cui, Yin Liu, Hao Guo, Zhanxin Liu, Yao Lu

“…A sodium sulfate solution with a concentration of 5% had an activator effect on the fly ash-based filling paste and enhanced the strength of the filling paste. …”
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Legionella pneumophila subverts the antioxidant defenses of its amoeba host Acanthamoeba castellanii by Alban Hay, Willy Aucher, Romain Pigeault, Joanne Bertaux, Alexandre Crépin, Quentin Blancart Remaury, Yann Héchard, Ascel Samba-Louaka, Romain Villéger

“…It is known that L. pneumophila WT can block the activation of NADPH oxidase as soon as it enters the macrophage and suppress ROS production compared to ΔdotA mutant strain. …”
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Knockdown of hexokinase 2 results in a decreased expression level of the glycolytic enzymes PFKP, BPGM, and GPI in RKO cell line by M. S. Fedorova, I. Y. Karpova, A. V. Lipatova, E. A. Pudova, Z. G. Guvatova, D. V. Kochetkov, A. V. Chaika, B. Y. Alekseev, M. V. Kiseleva, A. D. Kaprin, A. V. Kudryavtseva, A. V.  Snezhkina

“…In many types of tumors, one of the key changes in metabolism is the  activation of glycolysis, which is associated with alterations in the expression of the main glycolytic enzymes and regulatory molecules. …”
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YOLO-UP: A High-Throughput Pest Detection Model for Dense Cotton Crops Utilizing UAV-Captured Visible Light Imagery by Chenglei Sun, Afizan Bin Azman, Zaiyun Wang, Xiaoxiao Gao, Kai Ding

“…YOLO-PEST incorporates a custom-designed SC3 module to enhance low-level feature extraction and employs the GeLU activation function to address the vanishing gradient issue. …”
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Integration of ATAC-seq and RNA-seq reveals signal regulation during post-molt and inter-molt stages in muscle of Eriocheir sinensis by Bin Wang, Bin Wang, Jingjing Li, Mingzhi Zhang, Mingzhi Zhang, Anqi Li, Zhentao Song, Zhentao Song, Zhen He, Zhen He, Ruiqi Zhang, Ruiqi Zhang, Tong Hao, Tong Hao, Jinsheng Sun, Jinsheng Sun

“…Further protein structure analysis and RT-qPCR validation confirmed five GPCR genes related to molting process, in which four genes (GRM7, FMRFaR, mth2, gpr161) are active during the post-molt stage and one gene (moody) functions during the inter-molt stage.DiscussionThese findings highlight the key regulatory proteins and pathways involved in E. sinensis muscle during molting and also offer foundational data for studying the mechanisms of molting and discontinuous growth in crustaceans.…”
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Effect of Prolonged-Release Pirfenidone on Renal Function in Septic Acute Kidney Injury Patients: A Double-Blind Placebo-Controlled Clinical Trial by Jonathan S. Chávez-Iñiguez, Jorge L. Poo, Miguel Ibarra-Estrada, Leonel García-Benavides, Guillermo Navarro-Blackaller, Cynthia Cervantes-Sánchez, Eduardo Nungaray-Pacheco, Ramón Medina-González, Juan Armendariz-Borunda, Guillermo García-García

“…The anti-inflammatory activity of prolonged-release pirfenidone (PR-PFD) could be beneficial in this clinical setting. …”
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Thermal Characteristics and Kinetics of the Thermal Degradation of Sugar Beet Waste Leaves and Pulp in Relation to Chemical Composition by Sanja Ostojić, Darko Micić, Josipa Dukić, Iva Sabljak, Ayça Akyüz, Seda Ersus, Anet Režek Jambrak

“…The kinetic parameters of the degradation, obtained by Ortega and Friedman non-isothermal isoconversional methods did not significantly differ between models: Ea-activation energy at a conversion degree 0.1–0.9 ranged 50–200 kJ/mol; lnA- the natural logarithm of the pre-exponential factor 8–48; kp₁-thermal degradation rate constant at a conversion extent of 0.5 ranged of 0.19–2.55 min⁻¹. …”
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