Quantifying Joystick Interactions and Movement Patterns of Toddlers With Disabilities Using Powered Mobility With an Instrumented Explorer Mini by Kimberly A. Ingraham, Nicole L. Zaino, Claire Feddema, Mia E. Hoffman, Liesbeth Gijbels, Alexis Sinclair, Andrew N. Meltzoff, Patricia K. Kuhl, Heather A. Feldner, Katherine M. Steele

“…Over 12 visits, participants significantly increased their distance traveled and the time spent with the joystick active. Surprisingly, we found that only 48% of joystick interactions resulted in device movement, which has important implications for learning. …”
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In relation to NO-System, Stable Pentadecapeptide BPC 157 Counteracts Lidocaine-Induced Adverse Effects in Rats and Depolarisation In Vitro by Marin Lozic, Vasilije Stambolija, Ivan Krezic, Aleksandra Dugandzic, Gordana Zivanovic-Posilovic, Slaven Gojkovic, Josip Kovacevic, Luka Vrdoljak, Ivan Mirkovic, Antonio Kokot, Andreja Petrovic, Katarina Horvat Pavlov, Domagoj Drmic, Jelena Suran, Alenka Boban Blagaic, Sven Seiwerth, Predrag Sikiric

“…Thus, BPC 157 has antidote activity in its own right against lidocaine and local anesthetics.…”
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Convergent origin and accelerated evolution of vesicle-associated RhoGAP proteins in two unrelated parasitoid wasps by Colinet, Dominique, Cavigliasso, Fanny, Leobold, Matthieu, Pichon, Apolline, Urbach, Serge, Cazes, Dominique, Poullet, Marine, Belghazi, Maya, Volkoff, Anne-Nathalie, Drezen, Jean-Michel, Gatti, Jean-Luc, Poirié, Marylène

“…We also show that both RhoGAP families have undergone evolution under positive selection and that almost all of these RhoGAPs lost their GAP activity and GTPase binding ability due to substitutions in key amino acids. …”
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Tumour heterogeneity and personalized treatment screening based on single-cell transcriptomics by Xinying Zhang, Jiajie Xie, Zixin Yang, Carisa Kwok Wai Yu, Yaohua Hu, Jing Qin

“…Interestingly, although tumour cell subpopulations exhibit dramatic differences within the same cancer type and between different cancers at both the genomic and transcriptomic levels, some demonstrate similar oncogenic pathway activities and phenotypes. Tumour cell subpopulations from the five cancers listed above were classified into three major groups corresponding to different treatment strategies. …”
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Kinetics of Sphalerite Leaching by MnO₂-KI Oxidation System in Sulfuric Acid by Mladen Bugarčić, Aleksandar Jovanović, Dimitrije Anđić, Ivana Jelić, Milica Miletić, Branislav Marković, Miroslav Sokić

“…The results demonstrated that for the MnO₂-KI system, a zinc leaching degree of 89.78% was achieved after 3 h of leaching at 80 °C, and kinetic studies indicated that the leaching process is diffusion-controlled (through the thin film), with an activation energy of 27.65 kJ mol⁻¹. Moreover, this system offers an improved method for separating iodine from the leachate upon completion, enhancing the overall process efficiency. …”
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p38/JNK Is Required for the Proliferation and Phenotype Changes of Vascular Smooth Muscle Cells Induced by L3MBTL4 in Essential Hypertension by Chaowei Hu, Kun Zuo, Kuibao Li, Yuanfeng Gao, Mulei Chen, Roumu Hu, Ye Liu, Hongjie Chi, Hongjiang Wang, Yanwen Qin, Xiaoyan Liu, Jiuchang Zhong, Jun Cai, Xinchun Yang, Jing Li

“…Our previous work has identified L3MBTL4 as a novel susceptibility gene for the development of essential hypertension, accompanied with activation of p38/JNK. Yet, little evidence has been reported whether p38/JNK contributed directly to L3MBTL4-induced vascular remodeling and exploring the potential mechanism of L3MBTL4 in vascular smooth muscle cells (VSMCs). …”
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MAT2A inhibitor AG-270/S095033 in patients with advanced malignancies: a phase I trial by Mrinal Gounder, Melissa Johnson, Rebecca S. Heist, Geoffrey I. Shapiro, Sophie Postel-Vinay, Frederick H. Wilson, Elena Garralda, Gerburg Wulf, Caroline Almon, Salah Nabhan, Elia Aguado-Fraile, Peng He, Mathilde Romagnoli, Mohammad Hossain, Rohini Narayanaswamy, Amel Sadou-Dubourgnoux, Michael Cooper, Vasileios Askoxylakis, Howard A. Burris, Josep Tabernero

“…Our data provide preliminary evidence of clinical activity and proof-of-mechanism for MAT2A inhibition.…”
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Molecular detection and genomic characterization of Samak Micromys paramyxovirus-1 and -2 in Micromys minutus, Republic of Korea by Augustine Natasha, Sarah E. Pye, Seung Hye Cho, Haryo Seno Pangestu, Jieun Park, Kyungmin Park, Sara P. Prayitno, Bohyeon Kim, Jong Sun Lee, Jongwoo Kim, Shailesh Budhathoki, Yeonsu Oh, Jin-Won Song, Carolina B. López, Jun Gyo Suh, Won-Keun Kim

“…The overlap in habitats between rodents and humans increases the risk of zoonotic events, underscoring the importance of active surveillance. Rodent species, such as Apodemus agrarius, are natural hosts for Paramyxoviridae in the Republic of Korea (ROK). …”
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Facile synthesis of size-tunable L-carnosine-capped silver nanoparticles and their role in metal ion sensing and catalytic degradation of p-nitrophenol by Akash Kumar, Ridhima Chadha, Abhishek Das, Nandita Maiti, Rayavarapu Raja Gopal

“…Additionally, these nanoparticles demonstrated catalytic activity regarding the degradation of p-nitrophenol (P-NP), achieving complete degradation of 0.25 and 1 mM solutions within 5 and 10 min, respectively. …”
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Characterization of LY3324954 a long-acting glucagon-receptor agonist by William Roell, Tamer Coskun, Teayoun Kim, Libbey O’Farrell, Jennifer A. Martin, Shelly Nason, Jasmin Hernandez-Alamillo, Saidharshana Dhantu, Daniel J. Drucker, Kyle W. Sloop, James P. Steele, Jorge Alsina-Fernandez, Kirk M. Habegger

“…Thus, modulation of glucagon receptor (GCGR) activity in the context of single-molecule multi-receptor co-agonists has become an emerging therapeutic target against obesity and obesity-associated metabolic dysfunction. …”
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Impact of eggshell membrane on metabolism and cell adhesion in oxidatively stressed canine chondrocytes by Juraj Vozar, Nikola Hudakova, Natalia Nosalova, Mykhailo Huniadi, Dana Marcincakova, Slavomir Hornak, Lubica Hornakova, Petra Majerova, Dasa Cizkova, Dasa Cizkova

“…This significant therapeutic potential was validated through XTT assays, which measured cell metabolic activity at 24 h, and Real-time Cell Analysis (RTCA), providing continuous monitoring over 98 h. …”
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A 3D Empirical Model of Electron Density Based on CSES Radio Occultation Measurements by He Huang, Jian Lin, Song Xu, Huijun Le, Feng Guo, Zhima Zeren, Libo Liu, Xuhui Shen

“…The three models describe that NmF2, hmF2, and Hm vary with solar activity, season, longitude, and latitude. Through the comparison with CSES observations, the NmF2, hmF2, and Hm models could reproduce the physical characteristics rather well. …”
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The new information about the seizure of church valuables from the Peter and Paul Court Cathedral in Peterhof in 1917. Items search perspective by Zelenyanskaya, Yulia V.

“…On the basis of previously unpublished administrative documents of the Office of Peterhof Palaces-Museums for the first time the chronology and specificity of church valuables’ confiscation from the “palace town” Peterhof, which was associated to the Provisional Government’s resolutions, the activity of the Commission of Acceptance and Protection of Property and the Artistic-Historical Commission founded in the palaces-museums, was traced. …”
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Rational design of nitrogen and fluorine co-doped metal-free porous carbons electrocatalysts for highly efficient oxygen reduction and zinc-air batteries by Linqiang Li, Na Qin, Huayun Ma, Jing Liu, Zhiqiang Zhu, Yaxiong Huo, Lipeng Zhai, Liwei Mi

“…TF-1000 had a high initial potential (0.90 V) and half-wave potential (0.83 V) in an alkaline medium, indicating good catalytic activity. In addition, the ORR stability of TF-1000 was better than that of commercial Pt/C (20%). …”
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Mesenchymal Stem Cell-Derived Extracellular Vesicles for Regenerative Applications and Radiotherapy by Ning Wang, Feifei Ma, Huijuan Song, Ningning He, Huanteng Zhang, Jianguo Li, Qiang Liu, Chang Xu

“…Tissue repair involves the regeneration, proliferation, differentiation, and migration of tissue cells; imbalance of local tissue homeostasis, progressive chronic inflammation; decreased cell activity and stem cell function; and wound healing. …”
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Comparative analysis of bulk ceramics and thick film coatings for optimized energy storage technologies by Imran Hussain Khan, Muhammad Salman Habib, Adnan Maqbool, Muhammad Asif Rafiq, Amjad Ali, Khushnuda Nur, Aqil Inam, Nasimullah, Vojtech Blazek, Stanislav Misak

“…Impedance spectroscopy explained the electrically active regions and hopping conduction mechanism which witnessed NTCR behavior. …”
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Rap1 and mTOR signaling pathways drive opposing immunotoxic effects of structurally similar aryl-OPFRs, TPHP and TOCP by Bilin Zhao, Shuang Zheng, Gaoxiang Yang, Zhijun He, Jiewei Deng, Lijuan Luo, Xinyan Li, Tiangang Luan

“…TPHP reduced GTP levels necessary for Rap1 activation, thereby inhibiting phagocytosis and adhesion of THP-1 macrophages. …”
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Roles for Prlhr/GPR10 and Npffr2/GPR74 in feeding responses to PrRP by Yi Wang, Weiwei Qiu, Stace Kernodle, Carly Parker, Marc-Antonio Padilla, Jiaao Su, Abigail J. Tomlinson, Stephanie Oldham, Joss Field, Elise Bernard, David Hornigold, Christopher J. Rhodes, David P. Olson, Randy J. Seeley, Martin G. Myers, Jr

“…Not only does the artificial activation of NTSPrlh cells decrease feeding, but also the expression of Prlh (which encodes the neuropeptide PrRP) and neurotransmission by NTSPrlh neurons contributes to the restraint of food intake and body weight, especially in animals fed a high fat diet (HFD). …”
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Development and characterization of a chicory extract fermented by Akkermansia muciniphila: An in vitro study on its potential to modulate obesity-related inflammation by A. Chervet, R. Nehme, C. Defois-Fraysse, C. Decombat, C. Blavignac, C. Auxenfans, B. Evrard, S. Michel, E. Filaire, J.-Y. Berthon, A. Dreux-Zigha, L. Delort, F. Caldefie-Chézet

“…The anti-inflammatory and anti-obesity activities of C-Akm extract were studied by testing the extract (50 μg/mL) on the polarization of THP-1 into macrophages, the secretion of pro-inflammatory cytokines in LPS-stimulated PBMCs, and the secretion of leptin and adiponectin in adipospheroids derived from human adipose stem cells. …”
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Community of trauma care partnering with stakeholders to improve injury outcomes: focus group analysis by Deborah M Stein, Elliott R Haut, Michelle A Price, Pam J Bixby, Anna Newcomb, Rosemary Kozar, Rochelle Dicker, Princess Fortin, Rachel D Appelbaum, Katherine Joseph, Morgan Hennessy, Sue Prentiss, Alexandra McConnell-Hill, Rochelle Flayter

“…The project’s next phases are distribution of a vignette-based survey to establish broad stakeholder consensus; education and dissemination activities to share strategies that increase research engagement and relevance for patients; and the formation of a panel of patients to support future research endeavors.Level of evidence Level IV.…”
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