Use of an observer tool to enhance learning of anaesthesia resident’s non-technical skills during high-fidelity simulation: a randomised controlled trial by Caroline Havard, Viridiana Jouffroy, Agnès Le Gouez, Marie Bruyère, Samy Figueiredo, Philippe Roulleau, Dan Benhamou, Aurore Margat, Antonia Blanié

“…Both groups observed a high-fidelity simulation of crisis management (with or without OT), then were asked to perform actively another simulation. The primary outcome was NTS performance, assessed by an evaluator using the Anaesthesia Non-Technical Skills score (ANTS score out of 16) on video recording. …”
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AI in academia: How do social influence, self-efficacy, and integrity influence researchers' use of AI models? by Benicio Gonzalo Acosta-Enriquez, Marco Arbulu Ballesteros, César Robin Vilcapoma Pérez, Olger Huamaní Jordan, Joseph Anibal Martin Vergara, Rafael Martel Acosta, Carmen Graciela Arbulu Perez Vargas, Julie Catherine Arbulú Castillo

“…This investigation pursued two main objectives: first, to identify the variables that condition the implementation of AI models in research activities, and second, to analyze how perceived ethical considerations and academic integrity influence their adoption. …”
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Arctiin alleviates knee osteoarthritis by suppressing chondrocyte oxidative stress induced by accumulated iron via AKT/NRF2/HO-1 signaling pathway by Junzheng Yang, Delong Chen, Qi He, Baihao Chen, Zhaofeng Pan, Gangyu Zhang, Miao Li, Shaocong Li, Jiacong Xiao, Haibin Wang, Peng Chen, Zhantian An

“…Based on the results of scRNA-seq, we found that ARC can play a role by activating AKT/NRF2/HO-1 signaling pathway. In vivo, ARC can significantly improve the severity of KOA caused by IO. …”
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Review of the environmental and health risks of hydraulic fracturing fluids by Sara Makki, Elsa Maalouf, Alissar Yehya

“…In this paper, the composition of the HF fluid and related toxicity are described, along with insights about the environmental impact linked with HF fluid, synthesized spill data, main factors affecting the flow-back ratio, and induced seismicity related to HF activities. The environmental and health hazards posed by HF fluid are concerning due to the high concentration of toxic chemicals, the limited data on toxicity, the high probability of spills, and the reported cases of aquifer contamination. …”
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An EBSD study on microstructure and texture development in graphene-reinforced Al–Mg–Si nanocomposites via FSP by Hesam Pouraliakbar, Mohammad Reza Jandaghi, Hamed Jamshidi Aval, Sang Hun Shim, Johan Moverare, Yong-Sang Na, Gholamreza Khalaj, Vahid Fallah

“…Higher heat input and plastic strain lead to a reduction of the fraction of low-Σ boundaries, while increasing high-Σ boundaries suggest activation of other deformation mechanisms, i.e., from dislocation slip to twinning, respectively, as a function of dislocation generation and recovery kinetics. …”
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The role of 1-Deoxysphingolipids and Polyamines in the pathogenesis of placental syndrome by Filiz Yarsilikal Guleroglu, Ali Cetin, Goknil Pelin Coskun, Meltem Caliskan, Fulya Karaduman, Can Bilginer, Resat Misirlioglu, Sinem Tekin, Merve Nur Al, Tugce Caklili, Yusuf Tutar

“…Conclusion This study demonstrates significantly altered levels of 1-deoxySL and polyamines, with corresponding enzyme activity changes, in placental syndrome compared to healthy pregnancies. …”
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Optimizing lipopeptide bioactivity: The impact of non-ionic surfactant dressing by Ágnes Ábrahám, Gergő Gyulai, Judith Mihály, Andrea Horváth, Orsolya Dobay, Zoltán Varga, Éva Kiss, Kata Horváti

“…The pL1 lipopeptide, formulated with the selected poloxamers, exhibited enhanced antibacterial activity with significantly reduced haemolytic side effects. …”
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Relationship Between Frequency Domain Indicators of Heart Rate Variability and Both Age and Duration of Illness in Patients with Headache: A Cross-Sectional Study by Jong-Ho Kim, Jong-Hee Sohn, Sung-Mi Hwang, Jae-Jun Lee, Young-Suk Kwon

“…Heart rate variability (HRV) serves as an indicator of the autonomic nervous system’s activity and balance. In this study, we looked at the frequency domain of HRV in relation to age and headache duration in patients who had headaches. …”
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Low-budget equipment facilitating skid coefficient extraction for traffic accident analysis by Vinicius Lima, Umit Karabiyik, Felipe Kennedy, Igor Mello, Jorge Farias, Manoel Martins

“…Unlike traditional approaches, this solution accounts for skid marks and brake activation, offering a more comprehensive and accurate method for traffic accident reconstruction. …”
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The role of the C5a-C5aR pathway in iron metabolism and gastric cancer progression by Qinxue Ni, Hong Yang, Hang Rao, Liyong Zhang, Mengyuan Xiong, Xiao Han, Boshao Deng, Lulu Wang, Jian Chen, Yan Shi

“…Second, it increases the expression of LCN2, a high-affinity iron-binding protein critical for iron export from tumor-associated macrophages, by activating endoplasmic reticulum stress in these cells. …”
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A Transcriptomic Analysis Reveals Diverse Regulatory Networks That Respond to Cold Stress in Strawberry (Fragaria×ananassa) by Yong Zhang, Yunting Zhang, Yuanxiu Lin, Ya Luo, Xiaorong Wang, Qing Chen, Bo Sun, Yan Wang, Mengyao Li, Haoru Tang

“…Functional enrichment analysis showed that DEGs were significantly (adjusted P value < 0.05) overrepresented in six pathways including plant hormone signal transduction, flavonoid biosynthesis, mitogen-activated protein kinase (MAPK) signaling, starch and sucrose metabolism, circadian rhythm, and alpha-linolenic acid metabolism. …”
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Exposure to PM2.5 and its components leads to obesity: role of socioeconomic status by Yindi Peng, Yamin Zhao, Minzhen Wang, Yingqian He, Lulu Zhang, Yanan Zhao, Jing Liu, Shan Zheng

“…Public health campaigns could be launched to raise awareness among higher SES individuals about the obesity risk associated with air pollutants and encourage them to adopt preventive measures such as using air purifiers and increasing physical activity.…”
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Acute beneficial effects of a functional energy shot on cognitive performance and mood states during cognitively demanding task performance: a randomized, double-blind, placebo-con... by Olivia K. O’Shea, Olivia K. O’Shea, Nathan Lawley, Anna Azzopardi, Allison Gutkowski, Michelle Murphy Niedziela, Rachel Horn, David O. Kennedy, Jason Adamson

“…Working memory tasks showed faster performance post-consumption, and mood assessments revealed positive effects on vigor, fatigue and overall mood disturbance.DiscussionThese results indicate wide cognitive and mood effects of this functional energy shot, potentially attributable to synergistic combination of active ingredients.Clinical trial registrationclinicaltrials.gov, identifier NCT06384586.…”
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miR-34a Regulates Multidrug Resistance via Positively Modulating OAZ2 Signaling in Colon Cancer Cells by Yong Li, Ping Gong, Ji-xue Hou, Wei Huang, Xiao-ping Ma, Yu-li Wang, Jing Li, Xiao-bin Cui, Na Li

“…Consequently, suppression of the expression of miR-34a/OAZ2 signaling by chemotherapeutic agents significantly enhanced the activation of MDR-associated ATP-binding cassette (ABC) transporters and antiapoptosis pathways, thus leading to MDR development in CCa cells. …”
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Decreased nitric oxide production is a novel therapeutic target for salt-induced nocturnal polyuria in aging by Takahiro Imanaka, Kentaro Takezawa, Yuma Kujime, Hiroaki Kitakaze, Go Tsujimura, Sohei Kuribayashi, Yosuke Sekii, Norichika Ueda, Shinichiro Fukuhara, Hiroshi Kiuchi, Hiromitsu Negoro, Norio Nonomura

“…To validate, we assessed the impact of 4 weeks of moderate-intensity exercise on intrarenal renin-angiotensin system activity and salt-induced polyuria during inactive periods in 80-week-old mice. …”
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Supportive care needs of the family caregivers of urostomy patients: a qualitative study by Kaixia Gao, Shaoguo Zhang, Jie Liu, Fang Zhang, Na Liu, Jiyan Dong, Tingting Zhang, Junping Gao, Sufang Qin, Junhong An, Xiaojuan Han

“…Medical staff should comprehensively understand the needs of the family caregivers of urostomy patients and then actively provide targeted psychological/physical/information/social/spiritual support to these caregivers. …”
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Spatial-temporal evolution of habitat quality in tropical monsoon climate region based on “pattern–process–quality” – a case study of Cambodia by Kang Junmei, Yang Fengshuo, Wang Jun, Liu Yang, Fang Dengmao, Jiang Chengcheng

“…The results show that (1) during 2000–2022, forest in Cambodia covered a wide range, showing a landscape pattern mainly distributed in the east and west. (2) The degree of fragmentation of impervious landscape pattern increased gradually from 2000 to 2022, indicating that it was seriously affected by human activities and natural factors, and with the increase in elevation and slope, the area of various types converted to impervious decreased. (3) During 2000–2022, high habitat quality areas were concentrated in Tonle SAP Lake in the east, southwest, and central part of Cambodia, while low habitat quality areas were concentrated in the central part. (4) Natural factors, socio-economic factors, policies, and regulations all have an impact on the change in land use pattern and habitat quality in Cambodia.…”
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Protective role of 3-mercaptopyruvate sulfurtransferase (MPST) in the development of metabolic syndrome and vascular inflammation by Paraskevas Zampas, Zhen Li, Antonia Katsouda, Aimilia Varela, Stelios Psarras, Constantinos H. Davos, David J. Lefer, Andreas Papapetropoulos

“…Global deletion of Mpst (Mpst-/-) resulted in increased body weight and greater glucose intolerance in mice with MetS, without affecting their blood pressure, and caused an upregulation of genes involved in immune responses in the vasculature suggestive of T-cell infiltration and activation. Pharmacological restoration of H2S levels ameliorated the comorbidities of MetS; GYY4137 administration reduced body weight and blood pressure, attenuated cardiac fibrosis and improved glucose handling and endothelium-dependent relaxation. …”
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Microplastic exposure induces HSP90α secretion and aggravates asthmatic airway remodeling via PI3K-Akt-mTOR pathway by Mingming Xu, Jiyuan Chen, Lin Gao, Shaoxi Cai, Hangming Dong

“…Then, microplastics were proved to activate PI3K-Akt-mTOR pathway by prompting airway epithelial cells secrete HSP90α and proliferation of airway smooth muscle cells(ASMCs), leading to airway narrowing and hypersensitivity. 1G6-D7 is a monoclonal antibody to HSP90, which can reverse the pulmonary inflammation infiltration, mucus production, and airway hyperresponsiveness(AHR). …”
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Preliminary Results on Deformations of the Central North Anatolian Fault Zone by Kayhan Aladoğan, Mehmet Nurullah Alkan, İbrahim Tiryakioğlu, Hasan Hakan Yavaşoğlu, Halil İbrahim Solak, Cemil Gezgin, Ali Özkan, Eda Esma Eyübagil, Furkan Şahiner, Ece Bengünaz Çakanşimşek, Zafer Köse

“… The North Anatolian Fault Zone (NAFZ) in the north of Türkiye is considered one of the most active faults on earth and have caused many major earthquakes in the last century. …”
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