Multi-omic and machine learning analysis of mitochondrial RNA modification genes in lung adenocarcinoma for prognostic and therapeutic implications by Xiao Zhang, Jiatao Liu, Yaolin Cao, Wei Wang, Haoran Lin, Yue Yu

“…Single-cell analysis further reveals MRM-driven cell-cell interactions and pathway activation, particularly in cycling and epithelial cells. …”
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Tryptophan metabolism-related gene CYP1B1 serves as a shared biomarker for both Parkinson’s disease and insomnia by Xin-Yu Li, Wen-Kai Yu, Jing-Hao Wu, Wen-Jun He, Yu-Nan Cheng, Kai Gao, Yi-Han Wei, Yu-Sheng Li

“…Subsequently, we employed CIBERSORT and single-sample gene set enrichment analysis (ssGSEA) to further investigate the association between hub genes and peripheral immune activation and inflammatory response. Additionally, gene interaction, Drug-mRNA, Transcription Factor (TF)-mRNA, and competing endogenous RNA (ceRNA) networks centered on these hub genes were constructed to explore regulatory mechanisms and potential drug interactions. …”
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Hole-selective-molecule doping improves the layer thickness tolerance of PEDOT:PSS for efficient organic solar cells by Bin Zhao, Xiaozhen Huang, Sein Chung, Min Zhang, Yufei Zhong, Anhai Liang, Zhenmin Zhao, Chaofeng Zhu, Jingjing Zhao, Seunghyun Kim, Jimin Kim, Ming Wang, Shilin Chen, Kilwon Cho, Yang Wang, Zhipeng Kan

“…When used in organic solar cells, poly (3,4-ethylenedioxythiophene)-poly (styrenesulfonate) (PEDOT:PSS) aligns interfacial energy levels, promotes hole extraction, blocks electrons, and optimizes the active layer’s morphology. However, with an optimal thickness of approximately 30–40 ​nm, PEDOT:PSS has insufficient layer thickness tolerance, owing to its low conductivity and hole extraction property. …”
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TraxVBF: A hybrid transformer-xLSTM framework for EMG signal processing and assistive technology development in rehabilitation by Seyyed Ali Zendehbad, Athena Sharifi Razavi, Marzieh Allami Sanjani, Zahra Sedaghat, Saleh Lashkari

“…The fact that people with mobility impairments often have great difficulties in performing essential Activities of Daily Living (ADL) shows the importance of developing effective rehabilitation strategies. …”
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Association between vascular endothelial growth factor and atrial fibrillation: a systematic review by Nikhil Sharma, Mahalaqua Nazli Khatib, R. Roopashree, Mandeep Kaur, Manish Srivastava, Amit Barwal, G. V. Siva Prasad, Pranchal Rajput, Rukshar Syed, Kamal Kundra, Vinamra Mittal, Muhammed Shabil, Amit Kumar, Pancham Cajla, Ganesh Bushi, Rachana Mehta, Zaid Khan, Prakasini Satapathy, Shilpa Gaidhane, Afukonyo Shidoiku Daniel, Renu Sah

“…Conclusion VEGF is potentially a significant contributor to AF pathophysiology, with its levels reflecting disease activity. The variability observed across studies suggests a need for standardized measurement approaches and further investigation into VEGF subtypes. …”
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Si-Wu-Tang improves liver fibrosis by restoring liver sinusoidal endothelial cell functionality and reducing communication with hepatic stellate cells by Le Wang, Jiaorong Qu, Jianan Li, Xiaoyong Xue, Lingling Qin, Yufei Li, Yuanfeng Dou, Xiaohong Mu, Xiaojiaoyang Li

“…Conclusion SWT collectively ameliorated liver fibrosis by inhibiting the COL8A1/IL-1β/OLR1 pathways associated with LSEC angiogenesis, adhesion and defenestration, as well as suppressing LSEC secretion of IL-1β to reduce HSC activation.…”
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GTPase GPN3 facilitates cell proliferation and migration in non-small cell lung cancer by impeding clathrin-mediated endocytosis of EGFR by Linlin Xu, Jiankun Guo, Xinsheng Xie, Hailong Wang, Alan Jiang, Changhua Huang, Hua Yang, Shiwen Luo, Limin Chen

“…As a result, this leads to a decrease in endocytic levels of EGFR and an increase in the accumulation of EGFR on the cell membrane surface, thereby prolonging activation of EGFR signaling. The functional effects exerted by GPN3 are dependent on cellular levels of GTP abundance. …”
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Physics-driven Explosions of Stripped High-mass Stars: Synthetic Light Curves and Spectra of Stripped-envelope Supernovae with Broad Light Curves by Jing Lu, Brandon L. Barker, Jared Goldberg, Wolfgang E. Kerzendorf, Maryam Modjaz, Sean M. Couch, Joshua V. Shields, Andrew G. Fullard

“…The origins and explosion mechanisms of SESNe remain a topic of active investigation. In this work, we employ radiative-transfer simulations to model the light curves and spectra of a set of explosions of single, solar-metallicity, massive Wolf–Rayet stars with ejecta masses ranging from 4 to 11 M _⊙ , which were computed from a turbulence-aided and neutrino-driven explosion mechanism. …”
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The temporal evolution of HCHO and changes in atmospheric composition in the southeast of the United Kingdom by Balendra V.S. Chauhan, Kirsty L. Smallbone, Maureen Berg, Kevin P. Wyche

“…This surge is attributed to heightened photochemical activity driven by increased solar radiation and temperatures. …”
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The Feasibility and Acceptability of a Community Science Approach to Explore Infant Formula Preparation Safety in the Home by Sara Jones, Jonie Cooper, Abbie Dolling, Tara McNamara, Susan Dvorak, Vicky Sibson, Amy Brown, Emma Yhnell, Phyll Buchanan, Sharon Breward, Rebecca Ellis, Aimee Grant

“…Parents often seek out information about health and parenting topics, but despite this, there have been few attempts to actively engage them in the research process. We aimed to assess the feasibility and acceptability of using community science (CS) in a pilot study to explore infant formula preparation safety in the home in the United Kingdom. …”
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Inner-heliospheric Signatures of Steadily Declining Solar Magnetic Fields and Their Possible Implications by Harsha Avinash Tanti, Susanta Kumar Bisoi, Abhirup Datta, K. Fujiki

“…We discuss the implications of the long declining trend and other anomalies in solar cycle activity.…”
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Detection of inversion with breakpoints in ARSB causing MPS VI by whole-genome sequencing: lessons learned and best practices by Yufeng Huang, Wenyue Deng, Hui Huang, Xiankai Zhang, Xiaohong Chen, Jian Ye, Sukun Luo, Ting Yu, Hui Yao, Hao Du, Xuelian He

“…Lysosomal enzymatic assays for leucocytes were used to assess the activity of arylsulfatase B of the boy’s leucocytes. …”
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Air pollution exposures in early life and brain development in children (ABC): protocol for a pregnancy cohort study by John Kinuthia, R Scott McClelland, Barbra A Richardson, Elizabeth Maleche-Obimbo, Brent R Collett, Sarah Benki-Nugent, Faridah H Were, Anne M Riederer, Michael Gatari, CJ Karr, Edmund YW Seto, Beatrice C Mutai, Susan Wamithi, Priscilla Wanini Edemba, Timothy V Larson, Julian D Marshall

“…At entry, mothers (n=400) are administered surveys to characterise air pollution exposures reflecting household features and occupational activities and provide blood (for lead analysis) and urine specimens (for polycyclic aromatic hydrocarbon (PAH) metabolites). …”
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Integrated omics revealed the altered colonic microenvironment after inhibition of peripheral serotonin synthesis by LP533401 by Yidan Ling, Ziyu Liu, Shuibing Han, Haiqin Wu, Chunlong Mu, Weiyun Zhu

“…Consistent with increased crypt depth, marker genes related to cell proliferation were excessively activated. Metabolomics analysis indicated lower ascorbate level and higher succinic acid level, correlating with 5‐HT concentrations and increased crypt depth. …”
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Observations of Loki Patera by Juno during Close Flybys by Alessandro Mura, Rosaly M. C. Lopes, Federico Tosi, Francesca Zambon, Roberto Sordini, Peter J. Mouginis-Mark, Julie Rathbun, Scott Bolton, Jani Radebaugh, Alberto Adriani, Andrea Cicchetti, Davide Grassi, Melissa Mirino, Raffaella Noschese, Giuseppe Piccioni, Christina Plainaki, Giuseppe Sindoni

“…Loki shows a thermal structure unlike other active lava lakes previously reported, with some brightening near the lake’s perimeter but lacking the continuous “hot ring” seen at other paterae. …”
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Simulation of β-induced Alfvén eigenmode instabilities and mode transition for HL-3 hybrid scenario by Yunpeng Zou, Vincent S Chan, Yasushi Todo, Ruirui Ma, Miao Xue, Xiaoran Zhang, Yiren Zhu, Wei Chen

“…Focusing on the n = 2 mode, sensitivity analysis indicates that mode activity and transition depend on the EP pressure, injected energy, and q -profile. …”
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Telomere length sensitive regulation of interleukin receptor 1 type 1 (IL1R1) by the shelterin protein TRF2 modulates immune signalling in the tumour microenvironment by Ananda Kishore Mukherjee, Subhajit Dutta, Ankita Singh, Shalu Sharma, Shuvra Shekhar Roy, Antara Sengupta, Megha Chatterjee, Soujanya Vinayagamurthy, Sulochana Bagri, Divya Khanna, Meenakshi Verma, Dristhi Soni, Anshul Budharaja, Sagar Kailasrao Bhisade, Vivek Anand, Ahmad Perwez, Nija George, Mohammed Faruq, Ishaan Gupta, Radhakrishnan Sabarinathan, Shantanu Chowdhury

“…Enhanced TRF2 binding at the IL1R1 promoter in cells with short telomeres directly recruited the histone-acetyl-transferase (HAT) p300, and consequent H3K27 acetylation activated IL1R1. This altered NF-kappa B signalling and affected downstream cytokines like IL6, IL8, and TNF. …”
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Heavy metal and metalloid pollution: A systematic review of health implications for pregnant women, children, and geriatrics in the East African region by Godswill J. Udom, Brian Turyahabwe, Ayodeji Aturamu, Omoirri M. Aziakpono, Richard D. Agbana, Omole G. Joseph, Nita-wills G. Udom, Nuru Mugide, Omali P. Odey, Haron Olot, Orish E. Orisakwe

“…Despite increasing industrialisation and mining activities in the region, there is a lack of comprehensive analysis addressing the exposure pathways and associated health implications of these toxicants. …”
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Stage-dependent changes in culture medium osmolality promote porcine oocyte maturation in vitro by Lixiang Liu, Lixiang Liu, Yu Tang, Yu Tang, Jing Shao, Jing Shao, Bingfeng Fan, Bingfeng Fan, Yifeng Yang, Yifeng Yang, Ying Zhang, Ying Zhang, Xiangyuan Zhao, Xiangyuan Zhao, Hailong Xue, Hailong Xue, Huimin Sun, Huimin Sun, Xulin Zhang, Xulin Zhang, Yushi Zhang, Yushi Zhang, Baozeng Xu, Baozeng Xu

“…In the presence of 1 mM glycine, we adjusted the osmolality of the culture medium from low to high (290 mOsM for the first 22 h and 320 mOsM thereafter) by adding raffinose, which cannot be used by animal cells, in a culture stage-dependent manner.ResultsStage-dependent adjustment of simplified medium PZM-3 osmolarity (290 mOsM for the first 22 h and 320 mOsM thereafter) in the presence of 1 mM glycine significantly improved the quality of porcine oocyte maturation in vitro, manifested by the oocyte maturation rate, functional mitochondrial distribution and activity, the transcript levels of glycolysis genes in granulosa cells, and subsequent embryonic developmental ability and ROS levels.ConclusionOur study demonstrates that optimizing cell volume regulation can further enhance the developmental potential of oocytes cultured in vitro.…”
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A zebrafish model of Ifih1-driven Aicardi–Goutières syndrome reproduces the interferon signature and the exacerbated inflammation of patients by Beatriz Bernal-Bermúdez, Beatriz Bernal-Bermúdez, Beatriz Bernal-Bermúdez, Alicia Martínez-López, Alicia Martínez-López, Francisco J. Martínez-Morcillo, Francisco J. Martínez-Morcillo, Francisco J. Martínez-Morcillo, Sylwia D. Tyrkalska, Sylwia D. Tyrkalska, Sylwia D. Tyrkalska, Teresa Martínez-Menchón, Teresa Martínez-Menchón, Teresa Martínez-Menchón, Pablo Mesa-del-Castillo, Pablo Mesa-del-Castillo, Pablo Mesa-del-Castillo, María L. Cayuela, María L. Cayuela, María L. Cayuela, Victoriano Mulero, Victoriano Mulero, Victoriano Mulero, Diana García-Moreno, Diana García-Moreno

“…Using the unique advantages of the zebrafish model for gene editing, we have generated Tg(ifih1_mut) knocked down for mavs and ikbke, which completely abrogated the Poly I:C induction and activation of the GFP of the reporters. Finally, we used an FDA-approved drug, Baricitinib (Jak1/Jak2 inhibitor), which was able to reduce the inflammation and the ISG expression. …”
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