Proinflammatory Cytokine IL-6 and JAK-STAT Signaling Pathway in Myeloproliferative Neoplasms by Vladan P. Čokić, Olivera Mitrović-Ajtić, Bojana B. Beleslin-Čokić, Dragana Marković, Marijana Buač, Miloš Diklić, Nada Kraguljac-Kurtović, Svetozar Damjanović, Pavle Milenković, Mirjana Gotić, Puri K. Raj

“…Therefore, the JAK2V617F mutant allele burden participated in inflammation biomarkers induction and related signaling pathways activation in MPNs.…”
Get full text

In silico characterisation of the avocado WAK/WAKL gene family with a focus on genes involved in defence against Phytophthora cinnamomi by Aaron Harvey, Aaron Harvey, Noëlani van den Berg, Noëlani van den Berg, Velushka Swart, Velushka Swart

“…WAK and WAK-Like (WAKL) proteins are known to bind to fragmented pectin (oligogalacturonides) produced during pathogen penetration, thereby activating downstream defence-related pathways. To better understand the P. cinnamomi-avocado defence interaction, this gene family was assessed using in silico methods. …”
Get full text

Concept of producing of the Russian national system of functional food by Yu. V. Fotev, V. F. Pivovarov, A. M. Artemyeva, I. M. Kulikov, Y. K. Goncharova, А. I. Syso, N. P. Goncharov

“…The depletion of food products (FP) of vegetable and animal origin in vital mineral elements, vitamins and other physiologically active components represents a serious long-term threat to human health and the national security. …”
Get full text

Correlation between follicle diameter and pre-ovulatory metabolic profile in Bos grunniens by Jiuru Yan, Jiuru Yan, Jiuru Yan, Yuxin Fu, Yuxin Fu, Yuxin Fu, Lan Lan, Huizhu Zhang, Huizhu Zhang, Huizhu Zhang, Ling Huang, Ling Huang, Yaying Wang, Yaying Wang, Xianrong Xiong, Xianrong Xiong, Xianrong Xiong, Shi Yin, Shi Yin, Shi Yin, Jian Li, Jian Li, Jian Li, Honghong He, Honghong He, Honghong He

“…Differential metabolites enriched KEGG pathways to screen the pathways that might be related to follicle development.ResultsWe found that most of the metabolites were mainly enriched in amino acid metabolism pathways, energy metabolism pathways and other pathways of cofactor synthesis, and that during the development of the small follicle to the large follicle, 2-Lysophosphatidylcholine, PC (17:0/0:0), PC (16:0/0:0), and LysoPC (18:0/0:0) were down-regulated; Dioctyl succinate, P-Coumaraldehyde, ISOPRENE, L-Isoleucine, Dioctyl succinate up-regulated.ConclusionThese results suggest that amino acid metabolism, the production of steroid hormones and their metabolites, and the metabolic activity of granulosa cells play important roles in follicle development. …”
Get full text

Integrative pan-cancer analysis and experiment validation identified GLS as a biomarker in tumor progression, prognosis, immune microenvironment, and immunotherapy by Dongming Li, Donghui Cao, Yangyu Zhang, Xinyi Yu, Yanhua Wu, Zhifang Jia, Jing Jiang, Xueyuan Cao

“…Meanwhile, we noticed GLS expression was strongly related to the infiltration of various immune cells and stromal cells, the expression of immunomodulatory genes, the activity of some conventional antitumor agents, and the therapeutic response of immunotherapy. …”
Get full text

Twenty years’ experience of midgut malrotation and volvulus in a tertiary center in northern Taiwan: A retrospective study by Wen-Yu Tseng, Ming-Wei Lai, Jin-Yao Lai, Chien-Chang Chen, Hsun-Chin Chao, Jeng-Chang Chen, Shih-Yen Chen, Yung-Ching Ming, Hung-Yu Yeh, Hung-Hsiang Lai, Sze-Ya Ting, Pai-Jui Yeh

“…Initial presentations such as respiratory distress, poor activity, and shock status were notably more prevalent in the PO group. …”
Get full text

Protection Measures for Shield Tunneling Closely Under-passing Operating Metro Tunnels in Water-rich Soft Soil Area by MA Xifeng, JIN Hua, ZHOU You, CHEN Shaobo, WANG Yu, WU Yaojie

“…［Method］ Based on a project of Nanjing Metro Line 5 shield tunneling closely under-passing the existing section of Nanjing Metro Line 1, the MIDAS/GTS NX finite element software is used to simulate the construction of the shield tunneling. Then, active protection measures for the existing tunnel and control measures for the shield tunneling of the newly-built tunnel are put forward. …”
Get full text

A compressive damage model for a rock considering the microcrack mechanical behavior by Cui LIU, Zhong LI, Feiya XU, Mo ZHANG, Xiaowei CAO, Heng LEI

“…The contributions of the microcrack sliding and propagation to the rock total deformation, the mixed propagation criterion of the microcrack, and the influence of the rock damage degree on the number of the activated microcracks are not completely considered in the existing rock compressive damage model. …”
Get full text

Grade IV oral mucositis treatment with Brazilian green propolis mucoadherent gel by Diogo Alvarenga Silva, Patrícia Carlos Caldeira, Silvia Ferreira de Sousa, Vagner Rodrigues Santos

“…It has several chemical compounds that confer anti-inflammatory, antimicrobial, healing, and antioxidant biological activities. To report a series of clinical cases in the treatment of oral mucositis (OM) in patients with cancer undergoing radiotherapy in the head and neck region. …”
Get full text

Uranium Mineral Transport in the Peña Blanca Desert: Dissolution or Fragmentation? Simulation in Sediment Column Systems by Victoria Pérez-Reyes, Rocio M. Cabral-Lares, Jesús G. Canche-Tello, Marusia Rentería-Villalobos, Guillermo González-Sánchez, Blanca P. Carmona-Lara, Cristina Hernández-Herrera, Fabián Faudoa-Gómez, Yair Rodríguez-Guerra, Gregorio Vázquez-Olvera, Jorge Carrillo-Flores, Ignacio A. Reyes-Cortés, Daniel Hernández-Cruz, René Loredo-Portales, María E. Montero-Cabrera

“…Common uranium minerals in this area include uranophane, schoepite, and weeksite/boltwoodite, with several superficial occurrences. Mining activities in the 1980s left unprocessed uranium ore exposed to weathering, with potential transport towards Laguna del Cuervo. …”
Get full text

A SARS‐CoV‐2 EG.5 mRNA vaccine induces a broad‐spectrum immune response in mice by Hongyu Wang, Qinhua Peng, Xinxian Dai, Zhifang Ying, Xiaohong Wu, Xinyu Liu, Hongshan Xu, Jia Li, Leitai Shi, Jingjing Liu, Yunpeng Wang, Danhua Zhao, Yanqiu Huang, Lihong Yang, Ren Yang, Guangzhi Yue, Yue Suo, Qiang Ye, Shouchun Cao, Yuhua Li

“…Six‐week‐old female BALB/C mice were used to assess humoral and cellular immune responses and cross‐reactive neutralizing activity against various SARS‐CoV‐2 subvariants. Meanwhile different immunization strategies and doses were performed to detect the immunogenicity of this mRNA vaccine. …”
Get full text

Atmospheric corrosion of carbon and galvanized steel under high rainfall conditions by Ariel Arroyo Heredia, Hector David Agudelo Arias, Maycol F. Mena, Elcy Serna Copete, F.A. Vásquez, Nerly Liliana Mosquera, Edison Banguero Palacios, Reiner Palomino Lemus, J.A. Calderón, Samir Córdoba Machado

“…The formation of γ-FeOOH induces active corrosion on the iron substrate. The zincite phase (ZnO) was observed in the galvanized steel corrosion products. …”
Get full text

HMGB1 released from pyroptotic vascular endothelial cells promotes immune disorders in exertional heatstroke by Chaoping Yu, Yang Huang, Jiangang Xie, Chujun Duan, Shanshou Liu, Wei Zhao, Yutong Wang, Ran Zhuang, Junjie Li, Wen Yin

“…As high mobility group box 1 (HMGB1) is a prototypical alarmin that activates inflammatory and immune responses, this study aimed to investigate the effect and mechanism of HMGB1 in the pathogenesis of EHS.Methods Peripheral blood mononuclear cell (PBMC) transcriptome sequencing of healthy volunteers, classical heatstroke patients, and EHS patients was performed. …”
Get full text

Scientific basis for design low-speed synchronous permanent magnet generators for wind power plants by A. A. Tatevosyan

“…For example, in the Russian Federation, a promising direction is the creation of Autonomous WPP with low-speed medium- and low- power SGPMs that have the maximum range of applications by type of activity and climate zones throughout the territory. …”
Get full text

The Effects of Krill Oil on mTOR Signaling and Resistance Exercise: A Pilot Study by John Georges, Matthew H. Sharp, Ryan P. Lowery, Jacob M. Wilson, Martin Purpura, Troy A. Hornberger, Flint Harding, James H. Johnson, David M. Peele, Ralf Jäger

“…Conclusion. Krill oil activates mTOR signaling. Krill oil supplementation in athletes is safe, and its effect on resistance exercise deserves further research.…”
Get full text

Design of Bacterial Cultures in Fermented Functional Maize Product Formulation by Zuzana Matejčeková, Anna Mikulajová, Eva Vlková, Denisa Liptáková, Silvia Mošovská, Eva Hybenová, Ľubomír Valík

“…Fermentation process was observed to significantly increase (p<0.05) the total phenolics content (143.9-206.1%) and the antioxidant activities (53.7-107.4%) of the samples. Potentially probiotic Lactobacillus plantarum HM1, Bifidobacterium choerinum K1/1, Bifidobacterium pseudolongum K4/4, Bifidobacterium animalis ssp. …”
Get full text

Development of <i>Aspergillus oryzae</i> BCC7051 as a Robust Cell Factory Towards the Transcriptional Regulation of Protease-Encoding Genes for Industrial Applications by Sarocha Panchanawaporn, Chanikul Chutrakul, Sukanya Jeennor, Jutamas Anantayanon, Kobkul Laoteng

“…Our transcriptional analysis indicated that the regulation of several protease-encoding genes was AoPrtR-dependent, with AoPrtR acting as a potent activator for extracellular acid-protease-encoding genes and a likely repressor for intracellular non-acid-protease-encoding genes. …”
Get full text

Mitigating salinity stress on tomato growth, water regime, gas exchange, and yield with the application of QuitoMax by Leandris Argentel-Martínez, Ofelda Peñuelas-Rubio, Carlos Ávila Amador, Fábio Steiner, Jorge González Aguilera, Jae-Ho Shin, Alan Mario Zuffo, Rafael Felippe Ratke, Paulo Eduardo Teodoro, Ugur Azizoglu

“…QuitoMax caused an increase in the variables evaluated in both varieties (tolerant and susceptible) of tomato, with a lower contribution of QuitoMax to the variables related to water regime and the greatest contributions to chlorophyll content and photosynthetic activity. QuitoMax contributed positively to all variables and was superior to stress intensity for most of the variables evaluated in the tolerant variety (Amalia), except for stem thickness and the number of flowers per bunch. …”
Get full text

Knowledge, attitude, and practice toward vitiligo among vitiligo patients: a mediation analysis by Hua Feng, Xiulian Xu, Shuzhen Qi, Kun Chen, Mei Ju, Xiaofang Li, Shuxian Shang

“…Vitiligo patients exhibited significant gaps in knowledge and attitudes toward their condition despite active management practices. Given the chronic nature of vitiligo and its slow treatment response, tailored health education strategies focusing on improving knowledge and attitudes are essential for standardizing treatment and enhancing patient adherence.…”
Get full text

How do various strategies for returning residues change microbiota modulation: potential implications for soil health by Nan Jiang, Nan Jiang, Zhenhua Chen, Zhenhua Chen, Yi Ren, Shichang Xie, Zimeng Yao, Zimeng Yao, Dongqi Jiang, Yulan Zhang, Yulan Zhang, Lijun Chen, Lijun Chen

“…Finally, through analyzing the correlation network among indices that exhibited active responses to residue additions, potential indicators for functional changes in response to residue additions were identified. …”
Get full text