Tunable structuring of nanocellulose-based sustainable lubricants by an external electric field by Samuel D. Fernández-Silva, Miguel A. Delgado, María García-Pérez, Claudia Roman, Moisés García-Morales

“…Commercial fibrillated (CNF) and crystalline (CNC) nanocelluloses were dispersed in castor oil, at two selected concentrations of 1 and 4 wt%, to obtain fully sustainable electro-active lubricants. Small amplitude oscillatory shear (SAOS) tests were performed within the linear viscoelastic (LVE) range to investigate the rheological behavior induced by the combined effect of pre-shear and voltage. …”
Get full text

Ichthyoarchaeological perspectives on roles of fish and red meat during Indus Civilization in Gujarat, India by G. S. Abhayan, Pramod P. Joglekar, Pramod P. Joglekar, P. Ajithprasad, S. V. Rajesh, Pankaj Goyal, Brad Chase, Jeevan Kharakwal, Prabodh Shirvalkar

“…Evidence of anthropogenic activities such as cut marks, charring, and chewing on the bones suggests various aspects of fish consumption. …”
Get full text

Molecular Detection of <i>Rickettsia</i> spp. and Other Tick-Borne Pathogens in Ticks from a Nature Reserve: Implications for Zoonotic Transmission by Santina Di Bella, Valeria Blanda, Silvia Scibetta, Ilenia Giacchino, Antonino Gentile, Giuseppina Chiarenza, Vincenza Cannella, Giovanni Provinzano, Francesca Grippi, Annalisa Guercio

“…This study focused on ticks found in a nature reserve in southern Italy, highly frequented for recreational activities and inhabited by wild boars. Using molecular techniques, 214 ticks, including questing ticks and those removed from wild boars, were examined for tick-borne pathogens (TBPs), with a focus on zoonotic pathogens. …”
Get full text

Effect of salt stress on plants of wild-type <i>Nicotiana tabacum</i> L. and transformants with a choline oxidase (<i>cod</i>A) gene by I. G. Shirokikh, S. Yu. Ogorodnikova, Ya. I. Nazarova, O. N. Shupletsova

“…The sensitivity of plants to salt stress was analyzed using biochemical tests that reflected the intensity of peroxidation processes and the activity of antioxidant enzymes (superoxide dismutase, and peroxidase).Results. …”
Get full text

The contribution of leaders' and managers' attributes, values, principles, and behaviours to the sustainable implementation of Lean in healthcare: A realist review protocol [versio... by Seán Paul Teeling, Anne Marie Keown, Martin McNamara

“…Lean, derived from the Toyota Production System, focuses on eliminating non-value-adding activity and enhancing efficiency, making it a prominent quality improvement approach in healthcare. …”
Get full text

Connectome-based disentangling of epilepsy networks from insular stereoelectroencephalographic leads by Kathrin Machetanz, Eliane Weinbrenner, Thomas Volkmar Wuttke, Silke Ethofer, Randolph Helfrich, Josua Kegele, Stephan Lauxmann, Michael Alber, Sabine Rona, Marcos Tatagiba, Holger Lerche, Jürgen Honegger, Georgios Naros

“…The propagation of local epileptic activity from the seizure onset zone (SOZ) along neuronal networks determines the semiology of seizures. …”
Get full text

The immune-related gene CD5 is a prognostic biomarker associated with the tumor microenvironment of breast cancer by Yi Zhao, Hengheng Zhang, Wenwen Wang, Guoshuang Shen, Miaozhou Wang, Zhen Liu, Jiuda Zhao, Jinming Li

“…TIC analysis showed that CD5 expression was positively correlated with the infiltration of CD8+ T cells, activated memory CD4+ T cells, gamma delta T cells, and M1 macrophages and negatively correlated with the infiltration of M2 macrophages. …”
Get full text

IUPHAR review: Targeted therapies of signaling pathways based on the gut microbiome in autism spectrum disorders: Mechanistic and therapeutic applications by Abdullah Al Mamun, Peiwu Geng, Shuanghu Wang, Chuxiao Shao, Jian Xiao

“…Autism spectrum disorders (ASD) are complex neurodevelopmental disorders characterized by impairments in social interaction, communication and repetitive activities. Gut microbiota significantly influences behavior and neurodevelopment by regulating the gut-brain axis. …”
Get full text

Carbon Dioxide Micro-Nano Bubbles Aeration Improves Carbon Fixation Efficiency for Succinic Acid Synthesis by <i>Escherichia coli</i> by Ying Chen, Hao Wu, Qianqian Huang, Jingwen Liao, Liuqing Wang, Yue Pan, Anming Xu, Wenming Zhang, Min Jiang

“…The CO₂ requirement for SA synthesis decreased by 83.4%, and the fugitive emission of CO₂ was successfully controlled. The activities of key enzymes within the SA synthesis pathway were also maintained or enhanced in the fermentation process with MNB aeration. …”
Get full text

Using ICT Tools for Exploring the Impact of Urban Blue-Green Spaces on Human Health and Well-Being by Sanja IVANKOVIC, Dragana JOVANOVIC, Predrag SAVIC, Vesna KARADŽIĆ, Milena VASIĆ

“…HEART study is using ICT tools as instruments in studying how blue-green spaces (BGS) impact public health and well-being in urban areas. 800 volunteers are equipped with smart-bands during their active time at demo sites in the cities of Belgrade, Athens and Aarhus. …”
Get full text

Prognostic value of miR-223 for pregnancy outcomes in patients with in vitro fertilisation and intracytoplasmic sperm injection by Qi Song, Jiajia Liu, Chen Li, Rongrong Liu, Nan Zhang, Hongzhi Shi

“…In addition, bioinformatics analysis indicated that the target genes of miR-223 were predominantly located in the endocytic vesicle membrane and were primarily enriched in adenosine monophosphate-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathways.Conclusion In this study, levels of miR-223 in the embryo culture medium predicted pregnancy outcomes in subjects undergoing IVF/ICSI. …”
Get full text

The Resuscitation, Equilibrium and De-escalation (RED) strategy: a phased, personalized hemodynamic support in children with sepsis by Jaime Fernández-Sarmiento, Sushitra Ranjit, L. Nelson Sanchez-Pinto, Vinay M. Nadkarni, Roberto Jabornisky, Niranjan Kissoon

“…After the resuscitation phase, active fluid removal through diuresis or dialysis is increasingly being used in patients who receive fluid therapy, but it has not yet been standardized, and the safest and most effective strategies in children are still not known. …”
Get full text

Forskolin Inhibits Lipopolysaccharide-Induced Modulation of MCP-1 and GPR120 in 3T3-L1 Adipocytes through an Inhibition of NFκB by Jeanne Durendale Chiadak, Tatjana Arsenijevic, Kevin Verstrepen, Françoise Gregoire, Nargis Bolaky, Valérie Delforge, Véronique Flamand, Jason Perret, Christine Delporte

“…Furthermore, TLR-4-induced activation of NFκB may be involved in the LPS-induced regulation of these genes.…”
Get full text

Incidence and pathological features of IgA nephropathy before and during the COVID-19 pandemic by Wen Liu, Ricong Xu, Di Wu, Zhihang Su, Yuan Cheng, Haofei Hu, Xinzhou Zhang, Qijun Wan

“…Although clinical manifestations and laboratory indicators of disease activity in IgAN patients remained consistent over both periods, observable changes occurred in pathological features. …”
Get full text

Efficacy of cartilage-targeted IGF-1 in a mouse model of growth hormone insensitivity by Krishma Tailor, Krishma Tailor, Janine van Ree, Timothy Stowe, Brit Ventura, Connor Sisk, Joanna Courtis, Anna Camp, Fatima Elzamzami, Jan van Deursen, Robert O’Brien, Jeffrey Baron, Julian C. Lui

“…Lastly, to gain mechanistic insights into the role of matrilin-3 targeting, we assessed the ability of CV1574-1 to activate AKT signaling in vitro and found that CV1574-1 caused a prolonged increase in AKT signaling compared to IGF-1 and that this effect was dependent on matrilin-3. …”
Get full text

Inventory and Conservation of Triassic Vertebrate Tracks in the Monts d’Ardèche UNESCO Global Geopark, France by Emmanuel Fara, Jean-David Moreau, Leo Szewczyk, Nicolas Klee, Georges Gand, Emmanuelle Vennin

“…The strategy is to make a detailed and sedimentologically contextualized inventory of vertebrate tracks in the Geopark and its surroundings, establish conservation and protection priorities, set up geosites for the public and involve local people in all these activities. To date, 15 tracksites and nearly a thousand individual tracks have been inventoried. …”
Get full text

Evidence of Rehabilitative Impact of Progressive Resistance Training (PRT) Programs in Parkinson Disease: An Umbrella Review by T. Paolucci, S. Sbardella, C. La Russa, F. Agostini, M. Mangone, L. Tramontana, A. Bernetti, M. Paoloni, L. Pezzi, R. G. Bellomo, V. Santilli, R. Saggini

“…Overall, this review suggests that PRT should be included in rehabilitation programs for PD patients, in combination with balance training for postural control and other types of exercise, in order to preserve cardiorespiratory fitness and improve endurance in daily life activities.…”
Get full text

Adjuvanted subunit intranasal vaccine reduces SARS-CoV-2 onward transmission in hamsters by Yongjun Sui, Swagata Kar, Bhavna Chawla, Tanya Hoang, YuanKai Yu, Shannon M. Wallace, Hanne Andersen, Jay A. Berzofsky

“…As a subunit intranasal COVID-19 vaccine reduced nasopharyngeal virus more than did an intramuscular (IM) vaccine, we hypothesized that this vaccine might reduce onward transmission to others.MethodsWe vaccinated hamsters with either the IM-administrated licensed mRNA vaccine twice or one dose of mRNA IM followed by adjuvanted subunit intranasal vaccine. 24 hours after SARS-CoV-2 challenge, these animals were housed with naïve recipients in a contactless chamber that allows airborne transmission.ResultsOnward airborne transmission was profoundly blocked: the donor and recipients of the intranasal vaccine-boosted group had lower oral and lung viral loads (VL), which correlated with mucosal ACE2 inhibition activity. Notably, in this head-to-head comparison of COVID-19 booster vaccines on SARS-CoV-2 onward transmission, we found that statistically significant viral reduction in the lung tissues and oral swabs was observed only in the intranasal S1 nanoparticle vaccine-boosted group, but not in the systemic mRNA vaccine-boosted group, suggesting the superior protection of this intranasal vaccine, which could act as an attractive vaccine booster candidate to complement the current licensed systemic vaccines.DiscussionOverall, our study strongly supports the use of the intranasal vaccine as a boost to protect not only the vaccinated person, but also people exposed to the vaccinated person, a key public health goal.…”
Get full text

Switch of phosphorylation to O-GlcNAcylation of AhR contributes to vascular oxidative stress induced by benzo[a]pyrene by Rong Wang, Yun Huang, Xiaoruo Gan, Chenghao Fu, Yuemin Li, Ning Chen, Hao Xi, Huishan Guo, Wei Zhang, Yuhong Lü, Yan Zhang, Pin Lü

“…However, from the posttranslational modification level, the mechanism by which B[a]P activates and regulates the nuclear translocation of AhR is unclear. …”
Get full text

Long-Covid in Children and Adolescents: Clinical Challenges and Treatment Perspectives by Kornelia Karamus, Rafał Rejamak, Jan Biłogras, Martyna Borowska-Łygan, Konrad Strużek, Wojciech Urban, Jakub Tomaszewski

“…Most available studies focus on adults, with limited reports suggesting the efficacy of lactoferrin in managing gastrointestinal symptoms of LC in children. Physical activity is also suggested as an effective rehabilitation method for addressing reduced physical capacity and chronic fatigue. …”
Get full text