Oral 5-Aminosalicyclic Acid Versus 6-Methylprednisolone in Active Crohn's Disease by Jürgen Schölmerich, Harro Jenss, Franz Hartmann, Hanne Döpfer, The German 5-ASA Study Group

“…The response to 5-aminosalicylic acid (5-ASA) in active Crohn's disease was studied in comparison to methylprednisolone in a 24 week randomized double-blind multicentre study. …”
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Open Trial of Cyclosporine in Patients with Severe Active Crohn's Disease Refractory to Conventional Therapy by Kevork M. Peltekian, C. Noel Williams, Allan S. MacDonald, Peter D. Roy, Elizabeth Czolpinska

“…Cyclosporine appears to be a safe and effective therapy in patients with severe active Crohn's disease refractory to conventional therapy.…”
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Combination Ciprofloxacin and Metronidazole for Active Crohn’s Disease by Susan L Greenbloom, A Hillary Steinhart, Gordon R Greenberg

“…This open study examined the efficacy and safety of combination ciprofloxacin and metronidazole for patients with active Crohn's disease of the ileum and/or colon. Seventy-two patients with active Crohn's disease of the ileum (n=27), ileocolon (n=22) or colon (n=23) were treated with ciprofloxacin 500 mg bid and metronidazole 250 mg tid for a mean of 10 weeks. …”
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Fluticasone Propionate in Inflammatory Bowel Disease by Marta Carpani de Kaski, Humphery JF Hodgson

“…In particular, fluitcasone propionate is a fluorinated glucocorticoid, in which systemic side effects are absent or minimal due to its relatively low absorption and rapid first pass metabolism In an open trial in 12 patients with mild and moderately active Crohn's disease, administration of 20 mg fluitcasone propionate orally was associated with a significant fall in the Crohn's disease activity index and improvement in other parameters of inflammation, without change in either plasma cortisol levels or responsiveness to adrenocorticotropic hormone, suggesting that this drug is a promising therapy for Crohn's disease meriting evaluation against conventional corticosteroids.…”
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Budesonide in the Management of Patients with Crohn’s Disease by ABR Thomson, Daniel Sadowski, Robert Jenkins, Gary Wild

“…The evidence presented here is that budesonide (Entocort, Astra Pharma) 9 mg/day is superior to placebo and equivalent to systemically active glucocorticosteroids in achieving disease remission in patients with active Crohn's disease, and in prolonging the recurrence time of symptomatic disease. …”
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The use of oral topically acting glucocorticosteroids in the treatment of inflammatory bowel disease by P. Rutgeerts

“…Glucocorticosteroids are the mainstay of treatment of active Crohn's disease and ulcerative colitis. These drugs however carry important cosmetic short-term side effects and when used long-term they induce severe irreversible complications. …”
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Treatment of Inflammatory Bowel Disease in Children by D Grant Gall

“…Prednisone remains the drug of choice in severe ulcerative colitis and active Crohn's disease. The role of immunosuppressive drugs in pediatric patients is unclear. …”
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Nutrition and Crohn's Disease: An Overview by C Ó'Moráin

“…Patients with active Crohn's disease have increased intestinal permeability; treatment with an elemental diet improves the permeability defect.…”
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Role of Cyclosporine in Crohn's Disease by CN Williams

“…All patients in this study had active Crohn's disease (Crohn's disease activity index greater than 150). …”
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