Early Neurological Deterioration following acute stroke: association with reperfusion therapies and National Institutes Of Health Stroke Scale score by Tony Bing Yu, Cameron Lee, Mohammed Mallah, Mohammed Mallah, Caroline Domingos Belo, Maria Lucia Uribe Mz Recaman, Yassine Noui, Yassine Noui, Samantha Bayhonan, Beatrix Sari, Yee-Haur Mah, Yee-Haur Mah

“…NIHSS alone appears insufficient in its sensitivity to END to act as a risk-stratification tool, as significant END risk remains in those with stable or improving NIHSS.…”
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Predicting dupilumab effectiveness with Type-2 biomarkers: A real-world study of severe asthma by Kenji Mizumura, Yasuhiro Gon, Norihiro Harada, Shiho Yamada, Asami Fukuda, Ryosuke Ozoe, Shuichiro Maruoka, Sumiko Abe, Kazuhisa Takahashi, Akihiko Tanaka, Hironori Sagara, Taisuke Akamatsu, Toshihiro Shirai, Katsunori Masaki, Koichi Fukunaga, Konomi Kobayashi, Hiroyuki Nagase, Nobuaki Miyahara, Arihiko Kanehiro, Noboru Kitamura, Naruhiko Sugihara, Fumio Kumasawa, Junko Terada-Hirashima, Masayuki Hojo, Kazuyuki Chibana, Etsuko Tagaya

“…Conclusions: Type-2 biomarkers may act as indicators of improvement in FEV1 and sputum outcomes among patients with severe asthma undergoing dupilumab treatment in real-world settings.…”
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Frequent mutation of K-RAS in addition to BRAF V600E in Ameloblastoma – An immunohistochemical study by Aishwariya Mohanty, Abikshyeet Panda, Pallavi Mishra, Lipsa Bhuyan, Harish Kumar

“…Results: K-RAS and BRAF V600E immunoexpression was evaluated and there is a significantly higher expression of K-RAS (mean score 6.20 ± 1.883) when compared with BRAF V600E (mean score 4.50 ± 2.271). BRAF V600E and K-RAS act independently in the pathogenesis of Ameloblastoma as the pattern of variation of BRAF V600E score was uneven when compared to K-RAS values. …”
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Multimessenger Probes of Supermassive Black Hole Spin Evolution by Angelo Ricarte, Priyamvada Natarajan, Ramesh Narayan, Daniel C. M. Palumbo

“…We show that the observed spin distribution is in agreement with a model that includes jet-driven spin-down, a key mechanism that acts to modulate spins across cosmic time at both high and very low specific accretion rates. …”
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In Vivo Evaluation of the Combined Anticancer Effects of Cisplatin and SAHA in Nonsmall Cell Lung Carcinoma Using [18F]FAHA and [18F]FDG PET/CT Imaging by Skye Hsin-Hsien Yeh, Ming Hsien Lin, I. I. Leo Garcia Flores, Uday Mukhopadhyay, Danial Young, Kazuma Ogawa, Jeong-Hwan Jeong, William Tong, Juri G. Gelovani, Nobuyoshi Fukumitsu

“…The ability of well-tolerated doses of HDACIs that act as chemosensitizers for platinum-based chemotherapeutics has recently been proven in many types and stages of cancer in vitro and in vivo. …”
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Alpha Lipoic Acid Modulated High Glucose-Induced Rat Mesangial Cell Dysfunction via mTOR/p70S6K/4E-BP1 Pathway by Chuan Lv, Can Wu, Yue-hong Zhou, Ying Shao, Guan Wang, Qiu-yue Wang

“…LA at a relatively low concentration (0.25 mmol/L) acted as a growth factor in rat mesangial cells, promoted entry of cell cycle into S phase, extracellular matrix formation, and phosphorylated AKT, mTOR, p70S6K, and 4E-BP1. …”
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Patient education and follow-up units in Iran: A quality improvement project by Elham Almassi Ghaleh, Susan Jamshidi Farsani, Parastoo Ariamloo, Nasrin Mehrnoosh, Maryam Rassouli, Abbas Ebadi

“…Methods & Materials: This perspective article presents a quality improvement project utilizing the Plan-Do-Study-Act cycle model. Initially, the problem of non-compliance among discharged patients and the resulting adverse consequences were identified. …”
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The OXT rs6133010 variant modulates susceptibility to psychiatric symptoms during withdrawal in patients with alcohol dependence by Guanghui Shen, Wei Wang, Yuyu Wu, Xinguang Luo, Kexin Wang, Yu-Hsin Chen, Yimin Kang, Yanlong Liu, Fan Wang, Li Chen

“…Additionally, OXT may not directly act as an anxiolytic but instead regulates anxiety by modulating hostility.…”
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Addressing vaccine hesitancy in the training of healthcare professionals: Insights from the VAX-TRUST project by Fábio Rafael Augusto, Cátia Sá Guerreiro, Rita Morais, Joana Mendonça, André Beja, Tiago Correia, Ana Patrícia Hilário

“…Evidence was gathered on ways to reflect and act to develop this capacity, namely, by increasing the ability to communicate empathetically, responding to patients' concerns with evidence-based information, and to building stronger and more collaborative relationships with them.…”
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Medication Adherence Mediates the Association between Type D Personality and High HbA1c Level in Chinese Patients with Type 2 Diabetes Mellitus: A Six-Month Follow-Up Study by Xuemei Li, Min Gao, Shengfa Zhang, Huiwen Xu, Huixuan Zhou, Xiaohua Wang, Zhiyong Qu, Jing Guo, Weijun Zhang, Donghua Tian

“…Type D personality was associated with HbA1c in direct and indirect ways, and medication adherence acted as a mediator role.…”
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Small Extracellular Vesicles from Inflamed Adipose Derived Stromal Cells Enhance the NF-κB-Dependent Inflammatory/Catabolic Environment of Osteoarthritis by Carola Cavallo, Giulia Merli, Nicoletta Zini, Stefania D’Adamo, Luca Cattini, Michele Guescini, Brunella Grigolo, Alessandro Di Martino, Spartaco Santi, Rosa Maria Borzì, Giuseppe Filardo

“…In the perspective of developing a cell-free advanced therapy medicinal product, a focus has been recently addressed to the ADSC secretome that lends itself to an allogeneic use and can be further dissected for the selective purification of small extracellular vesicles (sEVs). sEVs can act as “biological drug carriers” to transfer information that mirror the pathophysiology of the providing cells. …”
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Downregulation of MerTK in circulating T cells of patients with non-proliferative diabetic retinopathy by Shimiao Bu, Shimiao Bu, Jiang-Yue Ling, Jiang-Yue Ling, Xiaojun Wu, Xiaojun Wu, Liting Zhang, Liting Zhang, Xiangyu Shi, Lang Huang, Zheng Zhao, Ying Yang, Zongqin Xiang, Yong U. Liu, Yong U. Liu, Yufeng Liu, Yuehong Zhang, Yuehong Zhang

“…ConclusionsThe study indicates that MerTK expression in T cells within PBMCs could act as a viable blood biomarker for NPDR risk in patients with DM. …”
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Research Progress on Sugar Signaling during Fruit Development and Ripening by Libin WANG, Junpeng NIU, Guodong WANG, Yuhua XIE, Chen ZHANG, Zhifang YU, Bing XIE, Qiuqin ZHANG, Heyun ZHENG, Ruihong YUAN, Xinli GENG, Shaoling ZHANG

“…Sugar is not only the carbon source and energy source of plants, but also acts as the signal molecule involved in the regulation of embryo formation, seed germination, fruit vegetative growth and reproductive growth during fruit growth. …”
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GTPase GPN3 facilitates cell proliferation and migration in non-small cell lung cancer by impeding clathrin-mediated endocytosis of EGFR by Linlin Xu, Jiankun Guo, Xinsheng Xie, Hailong Wang, Alan Jiang, Changhua Huang, Hua Yang, Shiwen Luo, Limin Chen

“…Collectively, these findings reveal that GPN3 acts as an oncogene promoting cell proliferation and migration in NSCLC through regulation of clathrin-dependent EGFR endocytosis. …”
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Arctiin alleviates knee osteoarthritis by suppressing chondrocyte oxidative stress induced by accumulated iron via AKT/NRF2/HO-1 signaling pathway by Junzheng Yang, Delong Chen, Qi He, Baihao Chen, Zhaofeng Pan, Gangyu Zhang, Miao Li, Shaocong Li, Jiacong Xiao, Haibin Wang, Peng Chen, Zhantian An

“…ARC increased cell viability and inhibited chondrocyte apoptosis. Further, ARC acts as an anti-ferroptosis effect by reducing the intracellular iron, ROS, and lipid-ROS content and restoring mitochondrial damage. …”
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Spatial behavior of mesocarnivores living in seasonal ecosystems: A case study in arid landscapes in northern-central Chile by Darío Moreira-Arce, Pablo M. Vergara, Alex Oporto, Alberto J. Alaniz, Claudia Hidalgo-Corrotea, Alfredo H. Zúñiga, Alejo Gutiérrez, Sebastián Moreno, Daniela Araya, Simone Ciuti

“…Extreme microclimate conditions can directly shape the habitat use patterns but also indirectly through seasonally modifying plant productivity, while terrain morphology (topography and elevation) acts as a regulator of extreme climate. We also noted that road network influences the behavioral response of foxes and its expansion is expected to exert pressure on the conservation of fox populations.…”
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The ENaC taste receptor’s perceived mechanism of mushroom salty peptides revealed by molecular interaction analysis by Wen Li, Wanchao Chen, Di Wu, Zhong Zhang, Peng Liu, Zhengpeng Li, Yan Yang

“…Abstract The ENaC receptor acts as a taste receptor to recognize and perceive salty substances. …”
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Convergent origin and accelerated evolution of vesicle-associated RhoGAP proteins in two unrelated parasitoid wasps by Colinet, Dominique, Cavigliasso, Fanny, Leobold, Matthieu, Pichon, Apolline, Urbach, Serge, Cazes, Dominique, Poullet, Marine, Belghazi, Maya, Volkoff, Anne-Nathalie, Drezen, Jean-Michel, Gatti, Jean-Luc, Poirié, Marylène

“…In both species, these RhoGAPs are associated with vesicles that act as transport systems to deliver virulence factors, but are produced in different tissues: the venom gland in Leptopilina sp. and the ovarian calyx in V. canescens. …”
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Investigation of pesticidal ability of humic acid derived from palm oil Empty Fruit Bunch (EFB) vermicompost by Alvyana Khiew Ai May, Rashid Shamsuddin, Lew Jin Hau, Aqsha Aqsha, Nurlidia Mansor, Nur Izzati Mustapa, Murugesu Narasimha

“…It performs better when it is coupled with GE as HA acts as a diluent to promote GE absorption into soil thus enhancing the pesticidal effect. …”
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The Great Vasyugan Mire of western Siberia: Hydrochemistry and greenhouse gas dynamics of peatland pools of the world’s largest mire by Sergey N. Vorobyev, Yuri Kolesnichenko, Ivan V. Krickov, Alexander E. Berezin, Sergey N. Kirpotin, Oleg S. Pokrovsky

“…Siberian peatlands act as the primary regulator for carbon (C) exchange between land and atmosphere; however, the aquatic component of this ecosystem, peatland pools, remains virtually unknown with respect to biogeochemical parameters and C fluxes. …”
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