Ex vivo delivery of recombinant IL-10 to human donor lungs by Jonathan C. Yeung, Terumoto Koike, Dirk Wagnetz, Tiago N. Machuca, Riccardo Bonato, Mingyao Liu, Stephen Juvet, Marcelo Cypel, Shaf Keshavjee

“…Conclusions: Gene therapy remains superior as it allows for continued production of IL-10 within the alveoli where it has the potential to continuously act on alveolar macrophages and epithelial cells in a paracrine fashion.…”
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Current attitudes to testicular prosthesis insertion during radical orchidectomy—An international perspective by Anthony Emmanuel, Abi Kanthabalan, Cameron Alexander, Nikita Bhatt, Vinson Chan, Odunayo Kalejaiye, Krishna Narahari, Veeru Kasivisvanathan, Majed Shabbir

“…Increased clinician awareness of the low risk of complications and high patient satisfaction may act to reduce the perceived barriers in offering testicular prosthesis implantation.…”
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Aggregation of ice-nucleating macromolecules from <i>Betula pendula</i> pollen determines ice nucleation efficiency by F. Wieland, F. Wieland, N. Bothen, R. Schwidetzky, T. M. Seifried, T. M. Seifried, P. Bieber, P. Bieber, U. Pöschl, K. Meister, K. Meister, M. Bonn, J. Fröhlich-Nowoisky, H. Grothe

“…<p>Various aerosols, including mineral dust, soot, and biological particles, can act as ice nuclei, initiating the freezing of supercooled cloud droplets. …”
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Ultrasound May Suppress Tumor Growth, Inhibit Inflammation, and Establish Tolerogenesis by Remodeling Innatome via Pathways of ROS, Immune Checkpoints, Cytokines, and Trained Immun... by Qian Yang, Ruijing Zhang, Peng Tang, Yu Sun, Candice Johnson, Jason Saredy, Susu Wu, Jiwei Wang, Yifan Lu, Fatma Saaoud, Ying Shao, Charles Drummer, Keman Xu, Daohai Yu, Rongshan Li, Shuping Ge, Xiaohua Jiang, Hong Wang, Xiaofeng Yang

“…We made the following findings: (1) LIUS upregulates proinflammatory IGs and downregulates metastasis genes in cancer cells, and LIUS upregulates adaptive immunity pathways but inhibits danger-sensing and inflammation pathways and promote tolerogenic differentiation in bone marrow (BM) cells. (2) LIUS upregulates IGs encoded for proteins localized in the cytoplasm, extracellular space, and others, but downregulates IG proteins localized in nuclear and plasma membranes, and LIUS downregulates phosphatases. (3) LIUS-modulated IGs act partially via several important pathways of reactive oxygen species (ROS), reverse signaling of immune checkpoint receptors B7-H4 and BTNL2, inflammatory cytokines, and static or oscillatory shear stress and heat generation, among which ROS is a dominant mechanism. (4) LIUS upregulates trained immunity enzymes in lymphoma cells and downregulates trained immunity enzymes and presumably establishes trained tolerance in BM cells. (5) LIUS modulates chromatin long-range interactions to differentially regulate IGs expression in cancer cells and noncancer cells. …”
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High expression of SULF1 is associated with adverse prognosis in breast cancer brain metastasis by Yitong Li, Tingting Feng, Qinghong Wang, Yue Wu, Jue Wang, Wenlong Zhang, Qi Kong

“…Currently, docetaxel and vinorelbine can act as treatment options if the expression of SULF1 is high. …”
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Adjuvanted subunit intranasal vaccine reduces SARS-CoV-2 onward transmission in hamsters by Yongjun Sui, Swagata Kar, Bhavna Chawla, Tanya Hoang, YuanKai Yu, Shannon M. Wallace, Hanne Andersen, Jay A. Berzofsky

“…Notably, in this head-to-head comparison of COVID-19 booster vaccines on SARS-CoV-2 onward transmission, we found that statistically significant viral reduction in the lung tissues and oral swabs was observed only in the intranasal S1 nanoparticle vaccine-boosted group, but not in the systemic mRNA vaccine-boosted group, suggesting the superior protection of this intranasal vaccine, which could act as an attractive vaccine booster candidate to complement the current licensed systemic vaccines.DiscussionOverall, our study strongly supports the use of the intranasal vaccine as a boost to protect not only the vaccinated person, but also people exposed to the vaccinated person, a key public health goal.…”
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Anti-inflammatory effect of Angiotensin 1-7 in white adipose tissue by Nozomi Nishida, Satoru Sugimoto, Satoshi Miyagaki, Chiharu Cho, Madoka Konishi, Takeshi Goda, Mihoko Yamaguchi, Yasuhiro Kawabe, Hidechika Morimoto, Joji Kusuyama, Takuro Okamura, Masahide Hamaguchi, Jun Mori, Hisakazu Nakajima, Michiaki Fukui, Tomoko Iehara

“…Our results suggest that Ang 1–7 directly acts on WAT to mitigate obesity-induced inflammation. …”
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Associations of Sociodemographic Characteristics with Food Choice Motives’ Importance Among Mexican Adults: A Cross-Sectional Analysis by Miguel Amaury Salas-García, María Fernanda Bernal-Orozco, Andrés Díaz-López, Alejandra Betancourt-Núñez, Pablo Alejandro Nava-Amante, Barbara Vizmanos

“…Our findings highlight the influence of sociodemographic factors on FCMs that might act as barriers or drivers for adopting healthy diets.…”
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NMDA Reduces Tau Phosphorylation in Rat Hippocampal Slices by Targeting NR2A Receptors, GSK3β, and PKC Activities by Audrée De Montigny, Ismaël Elhiri, Julie Allyson, Michel Cyr, Guy Massicotte

“…Taken together, these data indicate that NR2A receptor activation may be important in limiting Tau phosphorylation by a PKC/GSK3β pathway and strengthen the idea that these receptors might act as an important molecular device counteracting neuronal cell death mechanisms in various pathological conditions.…”
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Leptin Receptor Deficiency Protects Mice against Chronic Cerebral Hypoperfusion-Induced Neuroinflammation and White Matter Lesions by Yu Du, Yufei Song, Xiaojie Zhang, Yan Luo, Wenying Zou, Jiawei Zhang, Jianliang Fu

“…Chronic cerebral hypoperfusion (CCH) induces inflammation in the central nervous system (CNS), which acts as one of the main reasons for CCH-induced white matter lesions (WMLs). …”
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Omics-Based Interaction Analysis Reveals Interplay of Chemical Pollutant (Ozone) and Photoradiation (UVSSR) Stressors in Skin Damage by Hong Zhang, Yiying Dong, Xue Xiao, Xiao Cui, Xuelan Gu

“…The skin acts as the first line of defense against various environmental stressors, such as solar ultraviolet radiation, visible light, pollution particles and ozone. …”
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Evaluation of Antimicrobial Activity of Four Organic Acids Used in Chicks Feed to Control Salmonella typhimurium: Suggestion of Amendment in the Search Standard by Aicha El Baaboua, Mohamed El Maadoudi, Abdelhakim Bouyahya, Omar Belmehdi, Ayoub Kounnoun, Rajae Zahli, Jamal Abrini

“…The MIC results demonstrated that tartaric acid, citric acid, and acetic acid inhibited Salmonella typhimurium at concentrations of 0.312%, 0.625%, and 0.512% for the three levels of strain: 10, 100, and 103 CFU/ml, respectively, while lactic acid and depending on the amount of the strain introduced acts differently: 0.078% for 10 CFU/ml and 0.156% for 100 and 103 CFU/ml. …”
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Extensional forearc structures at the transition from Alaska to Aleutian Subduction Zone: slip partitioning, terranes and large earthquakes by Kahrizi, Amin, Delescluse, Matthias, Chamot-Rooke, Nicolas, Pubellier, Manuel, Bécel, Anne, Shillington, Donna, Nedimović, Mladen, Bulois, Cédric

“…Both trench oblique and trench parallel faults have been cited as reactivated terrane sutures, the presence of which may act as upper-plate weaknesses needed to allow slip partitioning in a context of low convergence obliquity. …”
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Tofacitinib downregulates JAK1 and JAK3 on human intestinal monocytes and macrophages without affecting dendritic cells phenotype or function by Elisa Arribas-Rodríguez, Ángel De Prado, Beatriz de Andrés, Benito Velayos, Jesús Barrio, Alejandro Romero, Francisco Javier García-Alonso, Álvaro Martín-Muñoz, José A. Garrote, Eduardo Arranz, Luis Fernández-Salazar, David Bernardo

“…Given the central role that conventional dendritic cells (cDC) elicit in gut homeostasis, we hypothesised that Tofacitinib acts modulating cDC function in UC. Methods: Human biopsies were obtained from colon of controls, and patients with UC (active and quiescent). …”
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METTL3-dependent DLG2 inhibits the malignant progression of cervical cancer by inactivating the Hippo/YAP signaling by Mei Pu, Xia Xiao, Shasha Lv, Daqing Ran, Qian Huang, Mingming Zhou, Qirong Lei, Lingshuang Kong, Qing Zhang

“…Moreover, lowering DLG2 expression mitigated the effects of METTL3 silencing on cervical cancer cell malignancy. Conclusion DLG2 acted as a tumor suppressor in cervical cancer by inhibiting the Hippo/YAP signaling pathway. …”
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Preparation, Characterization, and Application of Metakaolin-Based Geopolymer for Removal of Methylene Blue from Aqueous Solution by Marouane El Alouani, Saliha Alehyen, Mohammed El Achouri, M’hamed Taibi

“…Our aim in this paper is to study the ability of geopolymer powder produced from metakaolin and alkaline activators to act as an adsorbent to remove methylene blue (MB). …”
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Vitamin B12 and diabetic neuropathies by V.A. Serhiyenko, M.-Y. Markevych, V.B. Sehin, A.A. Serhiyenko

“…Thus, cobalamin, regardless of its classical function as a cofactor, can act as an intracellular, in particular intramitochondrial, antioxidant. …”
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Furanocoumarin compounds isolated from Dorstenia foetida potentiate irinotecan anticancer activity against colorectal cancer cells by Pengnam Supusson, Jitkaroon Watcharapa, Srisuphan Roongtiwa, Wongprayoon Pawaris, Rayanil Kanok-On, Charoensuksai Purin

“…In conclusion, our results identified compound 2 as a plant-derived compound exhibiting anticancer properties that can act synergistically with Iri and warranted further research to assess the potential of this synergism for colorectal cancer treatment.…”
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Impact of water stress on <i>Phaeomoniella chlamydospora</i> abundance and Petri disease symptom development in young grapevines by Jared Hrycan, Pat Bowen, Thomas Forge, Miranda Hart, Jose Ramon Úrbez-Torres

“…Phaeomoniella chlamydospora has been shown to be prevalent in asymptomatic grapevine nursery material, leading to the hypothesis that it may act as a latent pathogen, transitioning from an endophytic to a pathogenic phase under grapevine stress. …”
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The mediating role of psychological capital in health behaviors among elderly nursing home residents by Liping Liao, Yunhua Li, Feng Tian, Ju Wu, Jing Zhong, Tingting He, Jinxiu Li

“…The indirect effect, mediated by positive psychological capital, was 0.321 (95% CI: 0.233, 0.409), contributing to 40.13% of the total effect.ConclusionPositive psychological capital acts as a mediating variable between social capital and health-promoting behaviors. …”
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