Advances in Drug Targeting, Drug Delivery, and Nanotechnology Applications: Therapeutic Significance in Cancer Treatment by Fatih Ciftci, Ali Can Özarslan, İmran Cagri Kantarci, Aslihan Yelkenci, Ozlem Tavukcuoglu, Mansour Ghorbanpour

“…Drug targeting aims to ensure that the drug acts only in the pathological area; it is defined as the ability to accumulate selectively and quantitatively in the target tissue or organ, regardless of the chemical structure of the active drug substance and the method of administration. …”
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Regulatory Role of GSK-3β on NF-κB, Nitric Oxide, and TNF-α in Group A Streptococcal Infection by Yu-Tzu Chang, Chia-Ling Chen, Chiou-Feng Lin, Shiou-Ling Lu, Miao-Huei Cheng, Chih-Feng Kuo, Yee-Shin Lin

“…Furthermore, GSK-3β inhibitors reduced NF-κB activation and subsequent TNF-α production, which indicates that GSK-3β acts upstream of NF-κB in GAS-infected macrophages. …”
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Encapsulation of Lactiplantibacillus plantarum and Beetroot Extract with Alginate and Effect of Capsules on Rheological Properties and Stability of an Oil-in-Water Emulsion Model... by Minerva Bautista Villarreal, Sandra Loruhama Loruhama Castillo Hernández, Salvador López Uriarte, María Porfiria Barrón González

“…Furthermore, co-encapsulation with a vegetal material could act as a prebiotic and enhance the viability of the encapsulated probiotic. …”
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Cholecystokinin (CCK) Is a Mediator Between Nutritional Intake and Gonadal Development in Teleosts by Hangyu Li, Hongwei Liang, Xiaowen Gao, Xiangtong Zeng, Shuo Zheng, Linlin Wang, Faming Yuan, Shaohua Xu, Zhan Yin, Guangfu Hu

“…This indicates that hypothalamic CCK may act as a nutrient sensor involved in regulating gonadal development in teleosts.…”
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High-Performance MAPbI3-Based Perovskite Solar Cell: Design, Simulation, and Analysis of Optoelectronic Properties and Efficiency Metrics Using SILVACO TCAD by Rashique Hamjah Chowdhury, Hojaifa Daiyan Chowdhury, Muhammad Johirul Islam, Iqbal Bahar Chowdhury

“…A thinner layer of PEDOT: PSS based organic material acts as the hole transport layer to enhance the hole transport towards the ITO electrode and a thin layer of ZnO based inorganic material serves as the electron transport layer to assist electron transport to the aluminum electrode. …”
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HMGB1 Promotes Systemic Lupus Erythematosus by Enhancing Macrophage Inflammatory Response by Mudan Lu, Shanshan Yu, Wei Xu, Bo Gao, Sidong Xiong

“…Background/Purpose. HMGB1, which may act as a proinflammatory mediator, has been proposed to contribute to the pathogenesis of multiple chronic inflammatory and autoimmune diseases including systemic lupus erythematosus (SLE); however, the precise mechanism of HMGB1 in the pathogenic process of SLE remains obscure. …”
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Intestinal Mucosal Barrier Is Injured by BMP2/4 via Activation of NF-κB Signals after Ischemic Reperfusion by Kang Chen, Wei Xie, Binyu Luo, Weidong Xiao, Daniel H. Teitelbaum, Hua Yang, Kebin Zhang, Chaojun Zhang

“…On the basis of these data, we conclude that BMP2/4 may act as the pathogenic basis for intestinal mucosal barrier dysfunction when the intestines suffer an I/R injury. …”
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Artificial intelligence and assisted reproductive technology: A comprehensive systematic review by Yen-Chen Wu, Emily Chia-Yu Su, Jung-Hsiu Hou, Ching-Jung Lin, Krystal Baysan Lin, Chi-Huang Chen

“…This review underscores the potential of AI to act as a catalyst for innovative solutions in the optimization of ART.…”
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Possible Roles of IL-33 in the Innate-Adaptive Immune Crosstalk of Psoriasis Pathogenesis by Serafinella Patrizia Cannavò, Lucrezia Bertino, Eleonora Di Salvo, Valeria Papaianni, Elvira Ventura-Spagnolo, Sebastiano Gangemi

“…IL-33 belongs to the IL-1 family, playing a role in several biologic processes as well as in the pathogenesis of different diseases, including skin pathologies. It acts as an alarmin, released by damaged cells. Binding to a ST2 receptor, it stimulates many immune cells such as ILC2 and Th2 cells. …”
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CircRNA TUBA1C promotes proliferation and glucose metabolism, and blocks apoptosis of osteosarcoma cells through sponging miR-143-3p by Yi-Bing Liu, Wen-Hao Dai, Jun-Jie Chang, Kang Wei

“…Bioinformatics analysis, RNA pull-down assay, and luciferase assay demonstrated that circTUBA1C acted as a sponge for miR-143-3p, blocking its expression in OS cells. …”
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Paradox of Laws on Age of Consent for Children when Testing, or Participating in HIV/AIDS Research and Clinical Trials in South Africa by Paul T. Mtunuse, Tembela Mdunyelwa-Melane

“…The inconsistencies are that whereas other laws allow children of 12 years of age to consent to testing or participation in HIV/AIDS research, other rules do not permit such a minor to act on his or her behalf if his or her health is harmed in the process, until 18 years. …”
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Observance with the Principles of Fair Trial in Administrative and Disciplinary Violations; Iran and England with Emphasis on the Non Bis in Idem Principle by Hakime Farnam, Mohammad Mahdavisabet, , Mohammad Ashouri, Ali Saffary

“…The principle ne bis in idem, as one of the principles of fair proceedings, is rooted in the acceptance of the negative effect of foreign criminal sentences and is derived from the most important goals of international criminal law, i.e. preventing re-punishment of the accused for a single criminal act. This prohibition is a reminder of an important rule in the Criminal proceedings are called the validity of the judged criminal case in the criminal court. …”
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Intercellular communication is crucial in the regulation of healthy aging via exosomes by Huifang Sun, Tengyuan Xia, Shuting Ma, Tao Lv, Yuhong Li

“…In conclusion, exosomes act as intercellular messengers that influence the maintenance of a healthy aging process and link the hallmarks of aging with indicators of well-being.…”
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PPARγ and the Innate Immune System Mediate the Resolution of Inflammation by Amanda Croasdell, Parker F. Duffney, Nina Kim, Shannon H. Lacy, Patricia J. Sime, Richard P. Phipps

“…Finally, novel specialized proresolving mediators—eicosanoids with critical roles in resolution—may act through PPARγ modulation to promote resolution, providing another exciting area of therapeutic potential for this receptor.…”
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Plasmonic Polarization Sensing of Electrostatic Superlattice Potentials by Shuai Zhang, Jordan Fonseca, Daniel Bennett, Zhiyuan Sun, Junhe Zhang, Ran Jing, Suheng Xu, Leo He, S. L. Moore, S. E. Rossi, Dmitry Ovchinnikov, David Cobden, Pablo Jarillo-Herrero, M. M. Fogler, Philip Kim, Efthimios Kaxiras, Xiaodong Xu, D. N. Basov

“…Our nanoimages unambiguously reveal that t-BN with triangular domains acts like a ferrielectric rather than a ferroelectric as claimed by many previous studies.…”
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Tracking Boats on Amazon Rivers—A Case Study with the LoRa/LoRaWAN by Marlos Rodrigues, Alyson dos Santos, Hillermann Lima, Warley Nogueira, Vicente de Lucena Junior

“…The Amazon region has the largest hydrographic basin in the world. The rivers act as roads, and boats serve as vehicles for transporting passengers and cargo to large urban centers, municipalities, riverside communities, villages, and settlements. …”
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Trans-kingdom sRNA silencing in the prevention and control of crop Fusarium wilt disease by Xin-Ni Huang, Yue Wang, Yan-Ting Li, Ying Xiao, Shou-Qiang Ouyang

“…Subsequently, based on the mechanisms by which small RNA (sRNA) acts in gene silencing, especially in bidirectionally trans-kingdom sRNA silencing between F. oxysporum and their hosts in the development of disease, we summarize technological breakthroughs like Spray-Induced Gene Silencing (SIGS) technology in the developing and applying to protect crops from Fusarium wilt disease. …”
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Non-discrimination and equality in healthcare: guarantees of implementation in international law and Ukrainian legislation by Blashchuk T.

“…The study was conducted through a comprehensive analysis of international and national legal acts regulating non-discrimination in healthcare.The following were used methods of scientific cognition, such as terminological, logical and semantic, comparative and legal, systemic and structural, and analytical. …”
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Prediction of Emotional Divorce based on Family Communication Patterns with the Mediating Role of Marital Burnout in Married Female Teachers of Darab City by Zakiye Faraji, Zahra Ghavaminia, Jalal Kalantari

“…There was a direct and significant correlation between emotional divorce and conformity orientation, and an inverse and significant correlation between emotional divorce and communication orientation. Marital boredom also acted as a mediator in the interaction between emotional divorce and family communication styles (p<0.05).Conclusion: Thus, it can be anticipated that as the family's conformance orientation increases, the rate of marital discontent will rise as well, and that as this variable rises, so too will the emotional divorce rate.…”
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Content Determination of Active Component in Huangqi Yinyanghuo Group and Its Effects on hTERT and Bcl-2 Protein in Osteosarcoma by Ying Tan, Lei Tan, Shuai Huang, Junfan Lu, Longtan Yu

“…To screen the optimal extraction process and content determination of active component of Huangqi Yinyanghuo group (HYG) and to study the effects of HYG on human telomerase reverse transcriptase (hTERT) and Bcl-2 protein in osteosarcoma (HOS) cells, providing the theoretical basis for clinical application of HYG in treatment of osteosarcoma, orthogonal design table L9(43) was used to design the extraction process of HYG, and icariin was taken as the investigation index to optimize the extraction process of HYG. 0.125, 0.25, 0.5, 1, 2, 4, and 8 μmol/L HYG were taken to act separately on logarithmic growth phase osteosarcoma HOS cells, CCK-8 assay was used to determine cell viability, and immunohistochemical SP assay was used to determine the expression of hTERT and Bcl-2 protein. …”
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