Editorial by Michael Rose, Jonathan M. Hoffmann

“…The next two opinion pieces are concerned with whether remote acts and effects are causally and/or morally relevant for the identity of future humans. …”
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Inhaled [D-Ala2]-Dynorphin 1-6 Prevents Hyperacetylation and Release of High Mobility Group Box 1 in a Mouse Model of Acute Lung Injury by Vladislav N. Karkischenko, Veronika I. Skvortsova, Melik T. Gasanov, Yuriy V. Fokin, Maxim S. Nesterov, Nataliya V. Petrova, Oxana V. Alimkina, Igor A. Pomytkin

“…The acetylation of HMGB1 is a prerequisite for its translocation from the nucleus to the cytoplasm and then to the extracellular milieu. When released, HMGB1 acts as a proinflammatory cytokine that binds primarily to toll-like receptor 4 (TLR4) and RAGE, thereby stimulating immune cells, endothelial cells, and airway epithelial cells to produce cytokines, chemokines, and other inflammatory mediators. …”
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Role of Cannabis in the Management of Chronic Non-Cancer Pain: A Narrative Review by Lou’i Al-Husinat, Shrouq Obeidat, Saif Azzam, Yara Al-Gwairy, Fatima Obeidat, Sarah Al Sharie, Deema Haddad, Fadi Haddad, Martina Rekatsina, Matteo Luigi Giuseppe Leoni, Giustino Varrassi

“…The inhalation of cannabis offers quick relief but poses respiratory risks, while its oral administrations are safer but act more slowly. Short-term cannabis use can impair cognition and motor skills, while long-term use may lead to dependency and cognitive decline, especially if used from an early age. …”
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Optimization of Rh blood group antigen precision transfusion strategy across multiple hospital campuses by PDCA circle by YING Qiming, CHEN Luyan, DONG Kedi, HE Yiwen, ZHAN Yating, YANG Yexiaoqing, ZHAO Feng, LYU Dingfeng

“…[Objective] To explore the effectiveness of applying the PDCA (Plan-Do-Check-Act) cycle to enhance the compatibility rate of five Rh blood group antigen phenotypes between donors and recipients across multiple hospital campuses. …”
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Interplay between fecundity, sexual and growth selection on the spring phenology of European beech (Fagus sylvatica L.). by Oddou-Muratorio, Sylvie, Bontemps, Aurore, Gauzere, Julie, Klein, Etienne K

“…Results: Overall, directional fecundity selection on female fitness favored trees with earlier TBB. Sexual selection acted only on male fitness through assortative mating favoring trees with mean TBB value (stabilizing selection). …”
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Contamination profile of heavy metals in marine fish and shellfish by M.A. Salam, S.C. Paul, S.N.B.M. Noor, S.A. Siddiqua, T.D. Aka, R. Wahab, E.R. Aweng

“…</em>Although the concentrations of all the heavy metals in all fish, prawn and crab species were lower as per Malaysian Food Act, but the concentrations showed remarkable differences among the species and organs. …”
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Importance of OsRac1 in Signalling of Pigm-1 Mediated Resistance to Rice Blast Disease by Dewei Yang, Niqing He, Fenghuang Huang, Jialin Chen, Minxiang Yu, Yidan Jin, Shaojun Lin, Shengping Li

“…Additionally, a transcriptional activator, RAI1, acts as an essential Pigm-1 interactor for blast resistance. …”
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A pan-cancer analysis of homeobox family: expression characteristics and latent significance in prognosis and immune microenvironment by Yuanhui Wang, Jie Gao, Ziyi Ren, Ziyi Shen, Wei Gu, Qinyi Miao, Xiaomeng Hu, Xiaomeng Hu, Yan Wu, Yan Wu, Wei Liu, Jia Jia, Jia Jia, Yi Cai, Chunpeng (Craig) Wan, Lei Sun, Tingdong Yan, Tingdong Yan

“…LUAD Cell migration and proliferation were inhibited when HOXB7 or HOXC6 was knocked down.ConclusionsMany HOX genes may act as both oncogenes and tumor suppressor genes, necessitating precision medicine based on specific cancers. …”
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‘I Feel Disempowered Because I Could Not Do Anything’: Clinical Facilitators' Perception of Violence Towards Nursing Students During Clinical Placement by Hila Ariela Dafny, Paul Cooper, Nasreena Waheed, Stephanie Champion, Christine Mccloud, Nicole Snaith, Leeanne Pront

“…Implications for the Nursing Profession This study highlights that by understanding the causation of WPV and recognising the lack of influence and scope of clinical facilitators to act to support RNS during WPV events, positive industry changes can be instigated to promote student placement experiences and healthcare provision. …”
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Large-Scale Compatible Roll-to-Roll Coating of Paper Electrodes and Their Compatibility as Lithium-Ion Battery Anodes by Nicklas Blomquist, Manisha Phadatare, Rohan Patil, Renyun Zhang, Noah Leuschen, Magnus Hummelgård

“…This concept highlights the potential of using paper as a separator and strengthens the outlook of a new design concept wherein paper can both act as a separator and a substrate for coating the anode material.…”
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Theranostic nanoemulsions suppress macrophage-mediated acute inflammation in rats by Riddhi Vichare, Yalcin Kulahci, Rebecca McCallin, Fatih Zor, Fatma Nurefsan Selek, Lu Liu, Caitlin Crelli, Anneliese Troidle, Michele Herneisey, James M. Nichols, Andrew J. Shepherd, Vijay S. Gorantla, Jelena M. Janjic

“…In a rodent model of Complete Freund’s adjuvant (CFA)-induced inflammation, we demonstrated that infiltrating macrophages sequestered curcumin-loaded nanoemulsion droplets and acted as cellular drug depots at the site of inflammation. …”
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Protocol for the enhanced management of multimorbid patients with COPD and severe asthma: role of indoor air quality by Emili Vela, Isaac Cano, Josep Roca, Antoni Sisó-Almirall, Carme Hernandez, Ebymar Arismendi, Ramon Farré, Alba Gómez-López, María Figols, Antonio Montilla-Ibarra, Núria Sánchez-Ruano, Benigno Sánchez, Marta Sorribes, Jordi Piera-Jiménez, Jaume Benavent, Jose Fermoso, Rubèn González-Colom

“…The service components will be articulated through four sequential 6-month plan-do-study-act cycles. Each cycle involves a targeted cocreation process following a mixed-methods approach with the active participation of patients, health professionals, managers and digital experts.Ethics and dissemination The Ethics Committee for Human Research at Hospital Clinic de Barcelona approved the protocol on 29 June 2023 (HCB/2023/0126). …”
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Dual Functions of Androgen Receptor Overexpression in Triple-Negative Breast Cancer: A Complex Prognostic Marker by Umay Kiraz, Emma Rewcastle, Silja K. Fykse, Ingrid Lundal, Einar G. Gudlaugsson, Ivar Skaland, Håvard Søiland, Jan P. A. Baak, Emiel A. M. Janssen

“…In high AR-DIA patients with unfavorable characteristics, ACT did not improve survival, and patients may benefit from AR-targeted therapy. …”
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Mapping Chilean clinical research: a protocol for a scoping review and multiple evidence gap maps by Sergio R Muñoz, Nicolás Meza, Eva Madrid, Juan Victor Ariel Franco, Gerard Urrútia, Camila Micaela Escobar Liquitay, Javier Bracchiglione

“…We will elaborate evidence matrices for the 20 conditions with the highest burden in Chile (according to the Global Burden of Disease 2019) selected from those defined under the General Regime of the Health Guarantees Act. To elaborate the evidence gap maps, we will consider prioritised interventions and core outcome sets. …”
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γ-Aminobutyric Acid (GABA) Metabolic Bypass Plays a Crucial Role in Stress Tolerance and Biofilm Formation in <i>C. sakazakii</i> ATCC 29544 by Jiangchao Wu, Yigang Yu, Fengsong Liu, Yifang Cao, Jiahao Ren, Yiting Fan, Xinglong Xiao

“…Gamma-aminobutyric acid (GABA) is a kind of non-protein amino acid that acts as an osmoprotectant. This study aimed to elucidate the effects of the <i>gabT</i> gene on the survival of <i>C. sakazakii</i>, GABA accumulation, and biofilm formation under desiccation, osmotic stress, and acid exposure. …”
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GWAS of CRP response to statins further supports the role of APOE in statin response: A GIST consortium study by Emma F. Magavern, Harshal Deshmukh, Geraldine Asselin, Elizabeth Theusch, Stella Trompet, Xiaohui Li, Raymond Noordam, Y.-D. Ida Chen, Teresa E. Seeman, Kent D. Taylor, Wendy S. Post, Jean-Claude Tardif, Dirk S. Paul, Emelia J. Benjamin, Nancy L. Heard-Costa, Ramachandran S. Vasan, Jerome I. Rotter, Ronald M. Krauss, J.Wouter Jukema, Paul M. Ridker, Patricia B. Munroe, Mark J. Caulfield, Daniel I. Chasman, Marie-Pierre Dubé, Graham A. Hitman, Helen R. Warren

“…Clinical studies show statins act independently of lipid-lowering mechanisms to decrease C-reactive protein (CRP), an inflammation marker. …”
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Green biosynthetic silver nanoparticles from Ageratum conyzoides as multifunctional hemostatic agents: Combining hemostasis, antibacterial, and anti-inflammatory properties for eff... by Yang Li, Yinfeng Tan, Huange Zhao, Shiting Chen, Azadeh Nilghaz, Rong Cao, Songlin Zhou

“…These findings indicate that AC-AgNPs act on multiple signaling pathways, including endogenous and exogenous coagulation pathways, complement system, platelet activation, and aggregation. …”
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Harnessing defects in Ag/CeO2 for enhanced photocatalytic degradation of antibiotic in water: Structural characteristics, in-depth insights on mechanism, degradation pathway by Ajit Kumar Dhanka, Emerson C. Kohlrausch, Raghabendra Samantray, Vinod Kumar, Balaram Pani, Nityananda Agasti

“…Oxygen vacancies in Ag/CeO2 act as trapping sites for photogenerated electrons and successfully restrain the recombination of photogenerated electron and hole pairs, thereby exhibiting improved catalytic activity of Ag/CeO2 nanocomposites. …”
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Symptom network analysis of insomnia-depression-anxiety-stigma in tuberculosis patients by Xiangmin Liu, Xue Qiu, Huizhen Lan, LiuYue Diao, Wei Huang, Yan Wen, Mei Feng, Mei Feng, Xiangdong Tang

“…In addition, sleep problems act as a bridge in the overall network. Stigma, particularly negative perceptions from family, may play a crucial mediating role in sustaining the entire symptom network. …”
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Bone Marrow Stromal Cells Generate a Pro-Healing Inflammasome When Cultured on Titanium–Aluminum–Vanadium Surfaces with Microscale/Nanoscale Structural Features by David J. Cohen, Christine M. Van Duyn, Jingyao Deng, Musaddiq K. Lodi, Michelle B. Gallagher, James T. Sugar, Jeremy J. Rawlinson, Preetam Ghosh, Barbara D. Boyan, Zvi Schwartz

“…These findings highlight the importance of Ti6Al4V surface properties in directing MSC differentiation and indicate that MN-modified surfaces act via signaling pathways that differ from OM culture methods, more accurately mimicking peri-implant osteogenesis in vivo.…”
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