Modulatory Effects of Eschscholzia californica Alkaloids on Recombinant GABAA Receptors by Milan Fedurco, Jana Gregorová, Kristýna Šebrlová, Jana Kantorová, Ondřej Peš, Roland Baur, Erwin Sigel, Eva Táborská

“…Alkaloids detected in E. californica could be hypothesized to act at GABAA receptors, which are widely expressed in the brain mainly at the inhibitory interneurons. …”
Get full text

Nicotinamide Adenine Dinucleotide Phosphate Oxidases and Metabolic Dysfunction-Associated Steatotic Liver Disease by Vittoria Cammisotto, Emanuele Valeriani, Pasquale Pignatelli, Francesco Violi

“…Growing evidence linked the activity of nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOX) to the increased liver production of reactive oxygen species up to liver damage and fibrosis. NOX acts both in hepatocytes and in non-parenchymal hepatic cells, contributing to hepatocyte lipotoxicity, impaired hepatic microcirculation, hepatic stellate, and mesenchymal stem cells activation and proliferation. …”
Get full text

Optimization of Seed-Receiving Mechanism in Belt-Driven Seed Guide Tube Based on High-Speed Videography Experiment by Chengcheng Ma, Zhihuan Zhao, Xiaomei Chen, Youyuan Tang, Ning Song, Yanfeng Xiao, Xu Yang

“…The findings of this study can act as a theoretical basis for the further optimization of the experimental belt-driven seed guide tube.…”
Get full text

Oral colon-targeted responsive chitosan/pectin-based nanoparticles propels the application of tofacitinib in colitis therapy by Chunfei Wu, Chuanlin Bi, Geun-soo Kim, Zizhen Yang, Shuao Li, Tong Dai, Xiaoyu Wu, Jiaojiao Tan, Ningning He, Shangyong Li

“…Additionally, the gut microbiota-secreted polysaccharide-degrading enzyme acts as the triggering agent for Pcn/Csn shell degradation. …”
Get full text

Aβ-Induced Repressor Element 1-Silencing Transcription Factor (REST) Gene Delivery Suppresses Activation of Microglia-Like BV-2 Cells by Tongya Yu, Hui Quan, Yuzhen Xu, Yunxiao Dou, Feihong Wang, Yingying Lin, Xue Qi, Yanxin Zhao, Xueyuan Liu

“…When REST was knocked down by a specific short hairpin RNA (sh-RNA), BV-2 cell proliferation, migration, and proinflammation cytokine expression and secretion induced by Aβ1-42 were increased, demonstrating that REST may act as a repressor of microglia-like BV-2 cell activation.…”
Get full text

An Extremely Pseudo‐Plastic, Organic Crystal‐Based Concentric‐Ring‐Resonator Coupled Optical Waveguide by Avulu Vinod Kumar, Deepak Manoharan, Ankur Khapre, Soumyajit Ghosh, Rajadurai Chandrasekar

“…This property enables the creation of compact CCGs with three interconnected turns utilizing an atomic force microscopy cantilever tip‐based mechanophotonics technique. This CCG acts as a concentric ring‐resonator (CRR) that splits and routes light in clockwise and anticlockwise directions along circular turns, providing optical interference. …”
Get full text

Mechanisms of multidrug resistance caused by an Ipi1 mutation in the fungal pathogen Candida glabrata by Taiga Miyazaki, Shintaro Shimamura, Yohsuke Nagayoshi, Hironobu Nakayama, Akihiro Morita, Yutaka Tanaka, Yasuhiko Matsumoto, Tatsuo Inamine, Hiroshi Nishikawa, Nana Nakada, Makoto Sumiyoshi, Tatsuro Hirayama, Shigeru Kohno, Hiroshi Mukae

“…The Ipi1-Ssb/Ssz1 complex inhibits Pdr1-mediated gene expression and multidrug resistance in C. glabrata, in contrast to Saccharomyces cerevisiae where Ssz1 acts as a positive regulator of Pdr1. Furthermore, micafungin exposure reduces metabolic activity and cell proliferation in the ipi1 R70H mutant, which may contribute to micafungin tolerance.…”
Get full text

Pheromone Production, Attraction, and Interspecific Inhibition among Four Species of Ips Bark Beetles in the Southeastern USA by Göran Birgersson, Mark J. Dalusky, Karl E. Espelie, C. Wayne Berisford

“…The subtractive assays showed that I. grandicollis and I. calligraphus share (–)-(4S)-cis-verbenol as one pheromone component, while their second, synergistic pheromone component, (–)-(S)-ipsenol in I. grandicollis and (±)-ipsdienol in I. calligraphus, acts as an interspecific inhibitor to the other species. …”
Get full text

HFE-Related Hemochromatosis: The Haptoglobin 2-2 Type Has a Significant but Limited Influence on Phenotypic Expression of the Predominant p.C282Y Homozygous Genotype by Gérald Le Gac, Chandran Ka, Isabelle Gourlaouen, Laurence Bryckaert, Anne-Yvonne Mercier, Brigitte Chanu, Virginie Scotet, Claude Férec

“…Whether the Hp2-2 genotype acts as a modifier in HFE-related hemochromatosis is unclear. …”
Get full text

Workplace Fear of Missing Out and Telepressure: How Digital Workplace Challenges Contribute to Employee Burnout? by Yücel Efe, İbrahim Yıkılmaz, İlkay Güleryüz

“…The study results reveal that the Workplace Telepressure (WPT) levels of academicians have a significant effect on Burnout and Workplace-Fear of Missing Out (WFOMO). Additionally, WFOMO acts as a mediator role in the relationship between WPT and Burnout. …”
Get full text

Uncertainty of Flood Forecasting Based on Radar Rainfall Data Assimilation by Xinchi Chen, Liping Zhang, Christopher James Gippel, Lijie Shan, Shaodan Chen, Wei Yang

“…Radar-based precipitation measurement offers advantages over ground-based measurement in the quantitative estimation of temporal and spatial aspects of precipitation, but errors inherent in this method will still act to reduce the performance. Using data from White Lotus River of Hubei Province, China, five methods were used to assimilate radar rainfall data transformed from the classified Z-R relationship, and the postassimilation data were compared with precipitation measured by rain gauges. …”
Get full text

Predicting snow structures relevant to reindeer husbandry by Emma T. D. Perkins, Amanda H. Lynch, Vera Solovyeva, David A. Bailey

“…At the same time, Norwegian coastal cities are competing to act as multi-model transportation hubs as sea-ice retreat creates expectations for increased marine accessibility. …”
Get full text

Chitosan/Silica Hybrid Nanogels by Inverse Nanoemulsion for Encapsulating Hydrophilic Substances by Asmaa M. Elzayat, Katharina Landfester, Rafael Muñoz‐Espí

“…Chitosan is used as a biopolymer matrix, while silica acts as a structuring additive. Hydrogel nanocapsules are obtained through the ionic interaction of the cationic groups of chitosan with the anionic groups of sodium triphosphate (STP), which is used as a physical cross‐linker. …”
Get full text

Toxicity of insecticide quinalphos-based Kinalux 25EC on fingerling climbing perch (Anabas testudineus): Brain cholinesterase and growth inhibitions by Nguyen Van Cong, Tran Hoang Kha, Bui Thi Bich Hang, Duong Tri Dung, Tran Sy Nam

“…Monitoring and controlling quinalphos levels in aquatic environments are important acts to mitigating its adverse impacts on aquatic organisms. …”
Get full text

Disease Stage-Associated Alterations in Learning and Memory through the Electroacupuncture Modulation of the Cortical Microglial M1/M2 Polarization in Mice with Alzheimer’s Disease... by Long Li, Le Li, Jiayong Zhang, Sheng Huang, Weilin Liu, Zhifu Wang, Shengxiang Liang, Jing Tao, Lidian Chen

“…Microglia are the primary cells that exert immune function in the central nervous system, and accumulating evidence suggests that microglia act as critical players in the initiation of neurodegenerative disorders, such as Alzheimer’s disease (AD). …”
Get full text

Current Problems of International Legal Copyright Protection by L. V. Shvarts, S. M. Burova

“…The analysis suggests that the establishment of common criteria for calculating the term of copyright protection in a single unified act is due to the need to combine private and public interests in using the results of intellectual activity and their exceptional importance for the globalization of the world economic and cultural space. …”
Get full text

An Analysis of QoS in ZigBee Network Based on Deviated Node Priority by Md. Jaminul Haque Biddut, Nazrul Islam, Md. Maksudul Karim, Mohammad Badrul Alam Miah

“…A large number of devices from different vendors can work seamlessly. These devices act as a network and send huge data traffic to the Coordinator. …”
Get full text

The role of host plants, land cover and bioclimate in predicting the invasiveness of Aromia bungii on a global scale by Enrico Ruzzier, Seunghyun Lee, Pietro Tirozzi, Valerio Orioli, Andrea Di Giulio, Olivia Dondina, Luciano Bani

“…The range of A. bungii was substantially limited by the bioclimate, while habitat conditions acted as limiting factors in the species’ distribution. …”
Get full text

Educational potential of subject training of the future teacher in the conditions of modern educational policy by Arthur M. Allagulov, Ravilya R. Khisamutdinova

“…The main methods used were: comparative analysis of pedagogical and methodological literature, normative legal acts and methodological documents regulating the educational process in educational organizations; generalization and synthesis of the results obtained; questioning and observation. …”
Get full text

Emodin Enhanced Microwave‐Responsive Heterojunction with Powerful Bactericidal Capacity and Immunoregulation for Curing Bacteria‐Infected Osteomyelitis by Tao Xu, Hao Cheng, Hailiang Pei, Jiameng Wang, Yiwei Shi, Xiangyu Zhang, Di Huang

“…As an enhanced microwave sensitizer, it shows supernormal microwave response ability. Specifically, Fe3O4 acts as a matrix to mediate magnetic loss. After CuS loading, the heterogeneous interface forms induce significant interfacial polarization, which increasing dielectric loss. …”
Get full text