Circuitry and Synaptic Dysfunction in Alzheimer’s Disease: A New Tau Hypothesis by Siddhartha Mondragón-Rodríguez, Humberto Salgado-Burgos, Fernando Peña-Ortega

“…Confronting this leading hypothesis, a few years ago, we reported that the increase in phosphorylation levels of dendritic Tau, at its microtubule domain (MD), acts as a neuroprotective mechanism that prevents N-methyl-D-aspartate receptor (NMDAr) overexcitation, which allowed us to propose that Tau protein phosphorylated near MD sites is involved in neuroprotection, rather than in neurodegeneration. …”
Get full text

Evaluation of the role of unconventional prefoldin RPB5 interactor (URI1) in hepatitis B virus infection by Karolína Štaflová, Aleš Zábranský, Iva Pichová

“…Although previous reports have suggested that URI1 may act as an HBV restriction factor, our results showed that URI1 silencing or overexpression did not affect HBV replication in HepG2-NTCP cells. …”
Get full text

Intelligent Robust Control of Roadheader Based on Disturbance Observer by Shuo Wang, Dongjie Wang, Aixiang Ma, Xihao Yan, Sihai Zhao

Get full text

Green Monetary Policy Measures and Central Bank Mandates: A Comparative Political Economy Analysis by Susana Matos Rosa

“…Despite the seriousness of environmental issues and the seeming existence of monetary policy tools to address them, some economists and central bank officials argue that monetary authorities cannot, or should not, be responsible for making policies that act upon the source of those problems. Among other reasons, the adoption of green monetary policy measures can conflict with the primary monetary policy goals, compromise the political independence of central banks, and raise questions about the legitimacy and increased power of some of these banks. …”
Get full text

THE PROBLEMS OF COMPLIANCE WITH THE LEGAL REGIME OF AGRICULTURAL LANDS WHEN PLACING LINEAR FACILITIES ON THEM by IGNATYEVA Inna Anatolyevna

“…Purpose: to study land law regulation and legal acts in order to resolve the issue of correct realisation of legal institutions of public servitude and use without provision on agricultural lands. …”
Get full text

Exploring the Role of Human Resource Management in Advancing Change in the Public Sector by Akinseye Olowu

“…The underlying presumptions of this paradigm include the following: actors act in a way that maximizes benefits; there are conflicts of interest; actors’ rationality is limited; and there are information asymmetries between principals and agents. …”
Get full text

La traductologie canadienne : ancrage européen, tropisme anglo-américain by Annie Brisset

“…In 1969 when the Official Languages Act compels the Canadian government to communicate both in French and English to restore the rights of the francophone minority, translators are in short supply. …”
Get full text

Trifolirhizin: A Phytochemical with Multiple Pharmacological Properties by Varun Jaiswal, Hae-Jeung Lee

“…Mechanistic studies of trifolirhizin showed that it could act on important target genes and pathways such as the NF-κB-MAPK, EGFR-MAPK, AMPK/mTOR, and PI3K/Akt signaling pathways. …”
Get full text

South Africa after 30 years of democracy: Land claims and transitional justice in the spotlight by Pulane Adelaide Molomo, Bekithemba Dube

“…It traces the causes of conflicts surrounding land that have affected rural poverty by examining the roles played by transitional justice, land acts, and government policies over the past 30 years. …”
Get full text

International Experience of Legal Regulation of Social Vacations by V. O. Latysheva

“…The author of the article has studied international and legal acts that envisage the norms that provide social vacations for employees. …”
Get full text

Ethical and Legal Aspects of the Dispute Over the Legalization of Assisted Suicide in Italy in 2017-2022 by Andrzej Kobyliński

“…It differs from direct euthanasia in the fact that the final act of taking one’s own life, involving deliberate administration of the necessary substances is performed entirely by the patient themself without interference of any third parties. …”
Get full text

Study on the Influence of Scaling‐Up in the Transesterification Process for the Synthesis of Biodegradable Monoglycerides of Fatty Acids by Roland Nagy, Rebeka Bejczi

“…Monoglycerides, with their hydrophilic and hydrophobic properties, act as effective non‐ionic surfactants for oil‐in‐water emulsions. …”
Get full text

The Documentation Status Continuum and the Impact of Categories on Healthcare Stratification by Tiffany Denise Joseph

“…Using the 2006 Massachusetts Health Reform and national 2010 Affordable Care Act (ACA) Reform as policy examples and interviews conducted with 207 immigrants, healthcare professionals, and immigrant organization employees in Boston, this article demonstrates how healthcare access is stratified along the DSC between citizens and noncitizens. …”
Get full text

Anti-Diabetic Therapeutic Medicinal Plant Identification Using Deep Fused Discriminant Subspace Ensemble (D2SE) by N. Sasikaladevi, S. Pradeepa, A. Revathi, S. Vimal, Gaurav Dhiman

“…The natural medications with antidiabetic activity are widely formulated because they have better compatibility with human body, are easily available and have less side effects. They may act as an alternative source of antidiabetic agents. …”
Get full text

Effects of Gyroscope on Arm Swing and Gait in Healthy Volunteers by Meriç Selim Şipal, Elif Yalçın, Aynur Ayşe Karaduman

“…In the case of bradykinesia, the arms act as a generator to maintain lower extremity movement while walking. …”
Get full text

Mettre en situation et accompagner la construction de connaissances : un parti pris pour la formation à l’accompagnement de projets en agriculture by Lucie Gouttenoire, Marion Guillot

“…We consider that supporting students’ reflexivity is a good way to help them become responsible professionals who act in a relevant way in their working situations. …”
Get full text

A «necklace» of large clusters of strategic raw materials over a stagnant oceanic slab in East Asia by Natalia Boriskina

“…Decompression and advection, which are particularly active near the natural boundaries of the slab, act as triggers for the intense interaction of under and over subduction asthenospheric fluids with adjacent sections of the mantle and for the directed upwelling of powerful flows of matter and energy into the lithosphere. …”
Get full text

Efficacy of Lockdowns in Africa by Daglous Makumbe

“…Except for a few countries in Europe and Africa that did not act homogeneously, the rest of the world ceased to function. …”
Get full text

Coffee Consumption and Cardiovascular Diseases – Has the Time Come to Change Dietary Advice? A Mini Review by Wierzejska Regina

“…On the other hand coffee contains polyphenols which act as antioxidants, and these compounds are probably responsible for the suggested beneficial effect of coffee on health. …”
Get full text

Secukinumab-Induced Inflammatory Bowel Disease in a Patient Treated for Chronic Plaque Psoriasis and Psoriatic Arthritis: A Case Report and Review of the Role of Novel Biologic Age... by K. M. Darch, T. L. Holland, L. J. Spelman

“…Secukinumab (Cosentyx), a fully-human monoclonal antibody that acts by selectively binding to and neutralising the proinflammatory cytokine IL-17A, is used widely for the treatment of both chronic plaque psoriasis and psoriatic arthritis. …”
Get full text