Experimental Study on Temperature Field Evolution Mechanism of Artificially Frozen Gravel Formation under Groundwater Seepage Flow by Tian-liang Wang, Fei Zhang, Yang Wang, Zhen Wu, Ya-meng He, Zu-run Yue

“…The “scouring effect” and “water barrier effect” simultaneously act on the merging process of the frozen wall. The total thickness of the frozen wall decreases by more than 30% when the flow rate increases from 0 to 5.0 m/d. …”
Get full text

Co-Supplementation of Flos Sophorae Extract with Tremella fuciformis Polysaccharides Improves Physicochemical, Textural, Rheological, and Antioxidant Properties of Low-Fat Yogurts by Renyong Tang, Yurong Lu, Caiyun Hou, Jiaxuan Peng, Wei Wang, Xiulan Guo

“…Flos Sophorae extract (FSE) with abundant rutin and Tremella fuciformis polysaccharides (TP) could act as novel natural improvers of low-fat yogurt due to their health benefits and properties of interacting with proteins. …”
Get full text

Exploring RNA modifications in infectious non-coding circular RNAs by Pavel Vopalensky, Anton Škríba, Michela Chiumenti, Lucia Ďuričeková, Anna Šimonová, Ondřej Lukšan, Francesco di Serio, Beatriz Navarro, Hana Cahova

“…Viroids, small circular non-coding RNAs, act as infectious pathogens in higher plants, demonstrating high stability despite consisting solely of naked RNA. …”
Get full text

A checklist of isopods (Crustacea: Isopoda) in Slovenia by Miloš Vittori, Borut Mavrič, Anja Pekolj, Marijan Govedič, Maja Zagmajster

“…Many synonyms and invalid taxa according to recent taxonomy point out the need for revision the national red list of Malacostraca as well as other nature protection acts. …”
Get full text

Positive feedback loop involving AMPK and CLYBL acetylation links metabolic rewiring and inflammatory responses by Wenke Wang, Boquan Wu, Mingjun Hao, Sichong Chen, Ruiting Cong, Wenjie Wu, Pengbo Wang, Qiaoyi Zhang, Pengyu Jia, Yuequn Song, Bo Liu, Siyao Qu, Jian-Fei Pei, Da Li, Naijin Zhang

“…The deacetylase enzyme SIRT2 acted as the bridge between AMPK phosphorylation and CLYBL acetylation, thereby regulating macrophage polarization and the release of pro-inflammatory cytokines. …”
Get full text

A truncated variant of the ribosome-associated trigger factor specifically contributes to plant chloroplast ribosome biogenesis by Fabian Ries, Jasmin Gorlt, Sabrina Kaiser, Vanessa Scherer, Charlotte Seydel, Sandra Nguyen, Andreas Klingl, Julia Legen, Christian Schmitz-Linneweber, Hinrik Plaggenborg, Jediael Z. Y. Ng, Dennis Wiens, Georg K. A. Hochberg, Markus Räschle, Torsten Möhlmann, David Scheuring, Felix Willmund

“…Abstract Molecular chaperones are essential throughout a protein’s life and act already during protein synthesis. Bacteria and chloroplasts of plant cells share the ribosome-associated chaperone trigger factor (Tig1 in plastids), facilitating maturation of emerging nascent polypeptides. …”
Get full text

AT2 Receptor-Interacting Proteins ATIPs in the Brain by Sylvie Rodrigues-Ferreira, Erwann le Rouzic, Traci Pawlowski, Anand Srivastava, Florence Margottin-Goguet, Clara Nahmias

“…Angiotensin II, the major biologically active peptide of the RAS, acts via binding to two main receptor subtypes designated AT1 and AT2. …”
Get full text

Investigation of the Load-Sharing Theory of the RC Pipes Rehabilitated with Slip Liners by Bai-jian Li, Liang-sheng Zhu, Xin-sha Fu

“…The RCP rehabilitated with the steel pipe, HDPE pipe, and steel bracket exhibited an increase in the load-carrying capacity (1.23, 1.50, and 1.31 times greater than the RCP, respectively), and the stiffness of these three pipes was not markedly changed. The slip-lined pipe acts as a “pipe within a pipe” system. A “load-sharing” theory was proposed in this study and provides estimates of the load-carrying capacity of the slip-lined pipes.…”
Get full text

GRHL3 Promotes Tumor Growth and Metastasis via the MEK Pathway in Colorectal Cancer by Lin Tan, Weiming Qu, Dajun Wu, Minji Liu, Qian Wang, Qiongjia Ai, Hongsai Hu, Min Chen, Weishun Chen, Hongbing Zhou

“…Our results suggested that GRHL3 may act as an oncogene to promote tumor growth and metastasis via the MEK pathway in colorectal cancer.…”
Get full text

Environmental Factors Promoting Neural Plasticity: Insights from Animal and Human Studies by Laura Mandolesi, Francesca Gelfo, Laura Serra, Simone Montuori, Arianna Polverino, Giuseppe Curcio, Giuseppe Sorrentino

“…We are made in a certain manner and what we do acts on our brain. In fact, our genetic basis can be modulated, modified, and changed by our experiences such as education and life events; daily, by sleep schedules and habits; or also by dietary elements. …”
Get full text

The 40S ribosomal subunit recycling complex modulates mitochondrial dynamics and endoplasmic reticulum - mitochondria tethering at mitochondrial fission/fusion hotspots by Foozhan Tahmasebinia, Yinglu Tang, Rushi Tang, Yi Zhang, Will Bonderer, Maisa de Oliveira, Bretton Laboret, Songjie Chen, Ruiqi Jian, Lihua Jiang, Michael Snyder, Chun-Hong Chen, Yawei Shen, Qing Liu, Boxiang Liu, Zhihao Wu

“…Our study illustrates that the USP10-G3BP1 complex acts as a hub that interacts with various pathways to adapt to environmental stimuli promptly. …”
Get full text

Levetiracetam Ameliorates L-DOPA-Induced Dyskinesia in Hemiparkinsonian Rats Inducing Critical Molecular Changes in the Striatum by Huan Du, Shuke Nie, Guiqin Chen, Kai Ma, Yan Xu, Zhentao Zhang, Stella M. Papa, Xuebing Cao

“…These data support that levetiracetam acts at multiple sites in the pathogenetic cascade of LID, and that further understanding of these actions of antiepileptics may contribute to developing new LID therapies.…”
Get full text

Integrating molecular photoswitch memory with nanoscale optoelectronics for neuromorphic computing by David Alcer, Nelia Zaiats, Thomas K. Jensen, Abbey M. Philip, Evripidis Gkanias, Nils Ceberg, Abhijit Das, Vidar Flodgren, Stanley Heinze, Magnus T. Borgström, Barbara Webb, Bo W. Laursen, Anders Mikkelsen

“…Here, we show that donor-acceptor Stenhouse adduct dyes integrated with III-V semiconductor nano-optoelectronics have combined excellent functionality for bio-inspired neural networks. The dye acts as synaptic weights in the optical interconnects, while the nano-optoelectronics provide neuron reception, interpretation and emission of light signals. …”
Get full text

MftG is crucial for ethanol metabolism of mycobacteria by linking mycofactocin oxidation to respiration by Ana Patrícia Graça, Vadim Nikitushkin, Mark Ellerhorst, Cláudia Vilhena, Tilman E Klassert, Andreas Starick, Malte Siemers, Walid K Al-Jammal, Ivan Vilotijevic, Hortense Slevogt, Kai Papenfort, Gerald Lackner

“…Cell-free enzyme assays and respirometry using isolated cell membranes indicated that MftG acts as a mycofactocin dehydrogenase shuttling electrons toward the respiratory chain. …”
Get full text

The Etiopathogenic Mosaic of Suicidal Behaviour by Doinița Temelie-Olinici, Anton Knieling, Dan Vâță, Laura Gheucă-Solovăstru, Monica Neamțu, Mădălina Mocanu, Adriana-Ionela Pătrașcu, Vasile-Bogdan Grecu, Daniela-Anicuța Leca

“…The micro-environment favouring the clinical evolution of self-harm/self-destructive thoughts and attempts to the terminal, final act integrates individual medical-biological and psychological factors into the overall social reality. …”
Get full text

Liminality Rituals of Interfaith Families: Symbolic Interactionism and MaqÄshid Sharia Perspectives by Muhammad Chairul Huda, Ilyya Muhsin

“…The cognition construction of interfaith family actors paid attention to the dimensions of society that demand the legality of a marriage. In the ritual act of liminality in the life cycle, interfaith families in Salatiga City had a fairly large tolerance. …”
Get full text

Discovery of ianthelliformisamines D–G from the sponge Suberea ianthelliformis and the total synthesis of ianthelliformisamine D by Sasha Hayes, Yaoying Lu, Bernd H. A. Rehm, Rohan A. Davis

“…The marine sponge Suberea ianthelliformis was investigated for new chemistry after the recent discovery that polyamines ianthelliformisamines A–C (1–3) – originally sourced from this Australian sponge – act as Pseudomonas aeruginosa biofilm inhibitors and antibiotic enhancers. …”
Get full text

Guanosine enhances the bactericidal effect of ceftiofur sodium on Streptococcus suis by activating bacterial metabolism by Yue Dong, Xiaona Liu, Shanshan Xiong, Mingyu Cao, Haojie Wu, Long Chen, Mengmeng Zhao, Yadan Zheng, Zhiyun Zhang, Yanyan Liu, Yanhua Li, Qianwei Qu, Chunliu Dong

“…However, the mechanism by which metabolites act as antibiotic adjuvant remains unclear. Here, we found that guanosine metabolism was repressed in multidrug-resistant S. suis. …”
Get full text

Synthesis and Properties of Bionanocomposites of Polyhydroxybutyrate-Polylactic Acid Doped with Copper and Silver Nanoparticles by Galo Cárdenas-Triviño, Nelson Linares-Bermúdez, Mario Núñez-Decap

“…Regarding tensile tests, PLA/PHB/nanoparticle (NP) blends showed higher Young modulus value action improving exponentially some properties and they can act as a powerful complementary component even in small amounts. …”
Get full text

Adoptive cell transfer of piezo-activated macrophage rescues immunosuppressed rodents from life-threating bacterial infections by Xiaoyi Liu, Wenxiu Xu, Junkun Feng, Ying Wang, Kai Li, Yi Chen, Wenjun Wang, Weiwei Zhao, Shaohua Ge, Jianhua Li

“…Moreover, we test the use of these piezo-activated macrophages (piezoMϕ) as adoptive cell therapy (ACT) for treating various immunosuppressive bacterial infections, including sepsis, pneumonia and peritonitis. …”
Get full text