New Steroid–Alkaloid Bioconjugates as Potential Bioactive Compounds: Synthesis, Spectroscopic and In Silico Study by Hanna Koenig, Karolina Babijczuk, Kamil Ostrowski, Damian Nowak, Tomasz Pospieszny, Beata Jasiewicz

“…In silico methods demonstrated that most obtained compounds, especially caffeine derivatives, exhibited potential biological activity. These compounds act as cholesterol antagonists, analeptics, antihypercholesterolemic, and respiratory analeptic compounds. …”
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Health Care Fraud and Abuse: Lessons From One of the Largest Scandals of the 21st Century in the Field of Spine Surgery by Thomas Szewczyk, BS, Michael S. Sinha, MD, JD, MPH, Jack Gerling, BS, Justin K. Zhang, MD, MSCI, Philippe Mercier, MD, PhD, Tobias A. Mattei, MD, FACS

“…This study investigates a specific instance of health care fraud in spine surgery, in which a medical device company ended up paying $75 million to settle violations of the False Claims Act. We review the surgical background regarding the kyphoplasty procedure, as well as its billing and reimbursement details. …”
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Current Overview of Allergens of Plant Pathogenesis Related Protein Families by Mau Sinha, Rashmi Prabha Singh, Gajraj Singh Kushwaha, Naseer Iqbal, Avinash Singh, Sanket Kaushik, Punit Kaur, Sujata Sharma, Tej P. Singh

“…Many of these plant pathogenesis related proteins are found to act as food allergens, latex allergens, and pollen allergens. …”
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DNA targeting by compact Cas9d and its resurrected ancestor by Rodrigo Fregoso Ocampo, Jack P. K. Bravo, Tyler L. Dangerfield, Isabel Nocedal, Samatar A. Jirde, Lisa M. Alexander, Nicole C. Thomas, Anjali Das, Sarah Nielson, Kenneth A. Johnson, Christopher T. Brown, Cristina N. Butterfield, Daniela S. A. Goltsman, David W. Taylor

“…Our structures provide insights into the intricately folded guide RNA which acts as a structural scaffold to anchor small, flexible protein domains for DNA recognition. …”
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Biomolecules of the Horseshoe Crab’s Hemolymph: Components of an Ancient Defensive Mechanism and Its Impact on the Pharmaceutical and Biomedical Industry by Md. Ashrafuzzaman, Mamudul Hasan Razu, Nazmir-Nur Showva, Tohmina Afroze Bondhon, Md. Moniruzzaman, Sad Al Rezwan Rahman, Md. Raisul Islam Rabby, Fatema Akter, Mala Khan

“…These proteins in granules and hemolymph act synergistically to fight infections. These biomolecules are antimicrobial and antibacterial, enabling them to be drug resistant. …”
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Progress in the Relationship between Vitamin D Deficiency and the Incidence of Type 1 Diabetes Mellitus in Children by Lian-Ping He, Yu-Xin Song, Ting Zhu, Wei Gu, Chang-Wei Liu

“…Vitamin D is a fat-soluble sterol derivative that not only participates in calcium and phosphorus metabolism but also acts as an immunomodulatory role by binding to nuclear vitamin D receptors to regulate the expression of transcription factors. …”
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First Case of Respiratory Infection in Rabbits Caused by <i>Alcaligenes faecalis</i> in Romania by Vlad Iorgoni, Ionica Iancu, Ionela Popa, Alexandru Gligor, Gabriel Orghici, Bogdan Sicoe, Corina Badea, Cristian Dreghiciu, Călin Pop, Timea Bochiș, Janos Degi, Luminita Costinar, Corina Pascu, Viorel Herman

“…This bacterium has the potential to act as an opportunistic pathogen, capable of causing severe infections in both humans and animals, which can sometimes result in fatal outcomes. …”
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IFI44L as a Forward Regulator Enhancing Host Antituberculosis Responses by Haiqin Jiang, Lemuel Tsang, Hongsheng Wang, Changhong Liu

“…This study showed that IFI44L acts as an antimicrobial target and positive modulator in human macrophages. …”
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Selected elements of crisis communication by Grzegorz Wojciech Pietrek, Marcel Kuhlmey

“…Material and methods In order to solve the research problem and realise the research objective, research methods such as analysis of literature and legal acts, comparison, analysis, synthesis, inductive and deductive reasoning and abstraction, among others, were used. …”
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Preferential mortgage: discrimination or differentiation by A. V. Romanova, S. Yu. Shchukin, S. V. Chelokidi, N. E. Spirina, L. R. Khakimova, L. A. Koptev

“…The research used domestic and foreign scientists’ scientific works in the field of preferential mortgage lending, regulatory legal acts and program and strategic documents for the development of the mortgage bank lending market, as well as data generated by the authors on the basis of official statistical materials. …”
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Initial teacher education for inclusion, equity, and equality: An analysis of practicum reports by Maria Alfredo Moreira, Manuel António Silva, Ana Sofia Afonso

“…However, the persistence of the invariants of educational action, like textbooks, teacher isolation, the compartmentalization of the subjects, the emphasis on academic literacy development, or summative assessment, acts as structural obstacles to sustainable impact and to inclusive, equal, and equitable educational practice.…”
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Phospho-relay feedback loops control egress vs. intracellular development in Toxoplasma gondii by Ja E. Claywell, Yong Fu, L. David Sibley

“…Perturbation of cyclic GMP (cGMP) vs. calcium demonstrates that PKAc1 acts on targets between guanylate cyclase and calcium release. …”
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Intelligent Pyroptosis Inducer for Precise and Augmented Tumor Therapy Through Specific Activation Pyroptosis in Tumor by Linlin Huo, Shiqi Zhu, Muyao Li, Mingya Tan, Mengke Fan, Jiayi Zhao, Jie Zeng, Meiling Liu, Kunyan Liu, Chao Tong, Zhenghuan Zhao

“…Here, an intelligent inducer is reported that acts as a reactive oxygen species (ROS) scavenger in normal cells to keep pyroptosis silence, while serving as ROS generator to induce obvious pyroptotic tumor cells death dependent on high hydrogen peroxide levels and near‐infrared laser irradiation. …”
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Using Bioinformatics Approach to Explore the Pharmacological Mechanisms of Multiple Ingredients in Shuang-Huang-Lian by Bai-xia Zhang, Jian Li, Hao Gu, Qiang Li, Qi Zhang, Tian-jiao Zhang, Yun Wang, Cheng-ke Cai

“…We also extracted the subnetwork to explicitly display the pathway where one effective component acts on the pneumonia related targets. In conclusions, a bioinformatics approach was established for exploring the drug targets, pharmacological activity distribution, effective components of SHL, and its mechanism of antipneumonia. …”
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TGF‐β regulates the release of breast cancer cell‐derived extracellular vesicles and the sorting of their protein cargo by downregulating RAB27B expression by Chao Li, Agustin Enciso‐Martinez, Roman I. Koning, Mona Shahsavari, Peter ten Dijke

“…The cytokine transforming growth factor‐β (TGF‐β) facilitates cancer progression via EVs secreted by cancer cells, which act on recipient cells in the tumour microenvironment. …”
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Embedded-Based Quadratic Boost Converter With Sliding-Mode Controller for the Integration of Solar Photo-Voltaic Source With Microgrid by S. Chitra Selvi, Ramya Govindaraj, Subrata Chowdhury, Saumya Singh, Baseem Khan

“…Further, the capability of the QBC, along with an SMC, for the regulation of voltage across the terminals of the load, when the QBC acts as an interface between a load and the bus bar of the microgrid is also investigated. …”
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On Bringing the Controlling Debtor to Subsidiary Liability (Clause in the Ruling of the Constitutional Court of the Russian Federation in the Case of Checking the Constitutionality... by T. A. Tereshchenko

“…In particular, the Constitutional Court indicated that the conclusion made in the Resolution of the Constitutional Court of the Russian Federation related to the subject matter of this case cannot in itself be considered as excluding the application of the same approach to the distribution of the burden of proof in cases where another subject acts as a creditor, rather than an individual, the obligation of the company to which arose not in connection with the implementation of entrepreneurial activities by the creditor.Illustrating the grounds for ambiguous interpretation laid down in such a phrase, the author concludes that a narrowapproach is still preferable, when the clause is interpreted in favor of only such a creditor who is “another subject, theobligation of the entity to which arose not in connection with carrying out entrepreneurial activity”.According to the author, such a conclusion is not only consistent with the idea of fairness in the distribution of theburden of proof in terms of the status of creditors, but is generally consistent with the general prohibition on takingadvantage of unfair behavior.…”
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Poly(Acrylic Acid)/TiO₂ Nanocomposite Hydrogels for Paper Artwork Cleaning and Protection by Sabina Botti, Francesca Bonfigli, Rosaria D’Amato, Jasmine Rodesi, Maria Gabriella Santonicola

“…Furthermore, this innovative material can act as a protective coating against UV-induced aging, preserving both color and stability of the paper. …”
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Divalent Metal- and High Mobility Group N Protein-Dependent Nucleosome Stability and Conformation by Michelle S. Ong, Dileep Vasudevan, Curt A. Davey

“…High mobility group N proteins (HMGNs) bind specifically to the nucleosome core and act as chromatin unfolding and activating factors. …”
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Distribution, Composition, and Vertical Fluxes of Particulate Matter in Bays of Novaya Zemlya Archipelago, Vaigach Island at the End of Summer by N. V. Politova, V. P. Shevchenko, V. V. Zernova

“…Results of our investigation indicate that the western bays of the Novaya Zemlya act as traps for SPM derived from glaciers and coastal abrasion.…”
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