Deep reinforcement learning for active flow control in a turbulent separation bubble by Bernat Font, Francisco Alcántara-Ávila, Jean Rabault, Ricardo Vinuesa, Oriol Lehmkuhl

“…It is shown that the DRL agent acts on a wide range of frequencies to sustain these vortices in time. …”
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How does the mode of evolutionary divergence affect reproductive isolation? by De Sanctis, Bianca, Schneemann, Hilde, Welch, John J.

“…Results show that the strength and form of postzygotic reproductive isolation (RI) depend on just two properties of the evolutionary changes, which we call the "total amount" and "net effect" of change, and whose difference quantifies the similarity of the changes at different loci, or their tendency to act in the same phenotypic direction. It follows from our results that identical patterns of RI can arise in different ways, since different evolutionary histories can lead to the same total amount and net effect of change. …”
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Attainment of the Right Theory; A Window to the Justifiability of judges' Supervision on Ordinary Laws by Amirhossein Alizadeh, Ghasem Alizadeh

“…The problem is that the judge, in the position of hearing the case and invoking the rule of law, which may have a dual source in the constitution and the ordinary, can act as the basic supervisor of the ordinary law and set it aside? …”
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A nanocarrier containing carboxylic and histamine groups with dual action: acetylcholine hydrolysis and antidote atropine delivery by Elina E. Mansurova, Andrey A. Maslennikov, Anna P. Lyubina, Alexandra D. Voloshina, Irek R. Nizameev, Marsil K. Kadirov, Anzhela A. Mikhailova, Polina V. Mikshina, Albina Y. Ziganshina, Igor S. Antipin

“…The nanocarrier breaks down acetylcholine into choline and acetic acid. The latter acts on the boronate bonds, dissociating them. This leads to the destruction of the nanocarrier and the release of the antidote. …”
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Milk Products Containing Bioactive Tripeptides Have an Antihypertensive Effect in Double Transgenic Rats (dTGR) Harbouring Human Renin and Human Angiotensinogen Genes by Tiina Jauhiainen, Taru Pilvi, Zhong Jian Cheng, Hannu Kautiainen, Dominik N. Müller, Heikki Vapaatalo, Riitta Korpela, Eero Mervaala

“…Tripeptides isoleucyl-prolyl-proline (IPP) and valyl-prolyl-proline (VPP) act as ACE inhibitors in vitro. Double transgenic rats (dTGR) harbouring human renin and human angiotensinogen genes develop malignant hypertension due to increased angiotensin II formation. …”
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Design and Numerical Simulation of Pyramidal Prefolded Patterned Thin-Walled Tubes by Junxian Zhou, Chuang Dong, Bingzhi Chen, Xu Niu

“…This delicately designed pattern modularizes the tube to control the folding process and act as an inducer to trigger deformation modes with outstanding crushing performance. …”
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Determination and Pharmacokinetics of Okanin in Rat Plasma by UltraHigh Performance Liquid Chromatography Coupled with Triple-Quadrupole Tandem Mass Spectrometry by Yurui Shi, Rongda Chen, Jing Xie, Li Li, Guiming Liu, Meizhu Zheng, Ning Zhang

“…An ultrahigh performance liquid chromatography triple-quadrupole tandem mass spectrometry (UPLC-MS) was successfully used to determine okanin in rat plasma after oral administration of okanin. Bavachalcone acted as an internal standard (IS). By gradient elution, IS and analyte were separated on a C18 column for 7 min at a flow rate of 0.25 mL/min with acetonitrile-0.1% acetic acid mobile phase. …”
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Paracrine role of endothelial IGF-1 receptor in depot-specific adipose tissue adaptation in male mice by Cheukyau Luk, Katherine I. Bridge, Nele Warmke, Katie J. Simmons, Michael Drozd, Amy Moran, Amanda D. V. MacCannell, Chew W. Cheng, Sam Straw, Jason L. Scragg, Jessica Smith, Claire H. Ozber, Chloe G. Wilkinson, Anna Skromna, Natallia Makava, Hiran A. Prag, T. Simon Futers, Oliver I. Brown, Alexander-Francisco Bruns, Andrew MN Walker, Nicole T. Watt, Romana Mughal, Kathryn J. Griffin, Nadira Y. Yuldasheva, Sunti Limumpornpetch, Hema Viswambharan, Piruthivi Sukumar, David J. Beech, Antonio Vidal-Puig, Klaus K. Witte, Michael P. Murphy, Richard C. Hartley, Stephen B. Wheatcroft, Richard M. Cubbon, Lee D. Roberts, Mark T. Kearney, Natalie J. Haywood

“…The endothelium has been suggested to act as a paracrine organ. We explore the role of endothelial insulin-like growth factor-1 receptor (IGF-1R), as a paracrine modulator of white adipose phenotype. …”
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Frequency of orthostatic hypotension in the Pooled Resource Open-Access ALS Clinical Trials database by C. Quarracino, F. Capani, F. Capani, M. Otero-Losada, G. E. Rodríguez, S. Pérez-Lloret, S. Pérez-Lloret

“…PurposeTo explore the frequency of orthostatic hypotension (OH) in a large sample of amyotrophic lateral sclerosis patients (ALS).MethodsFrom the PRO-ACT database, data of 1,240 ALS patients were analyzed, focusing on blood pressure and heart rate before and after standing. …”
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Hypocholesterolemic Activity of Monascus Fermented Product in the Absence of Monacolins with Partial Purification for Functional Food Applications by Zahra Ajdari, Maaruf Abd Ghani, Mohd Khan Ayob, Saadi Bayat, Mazlin Mokhtar, Sahar Abbasiliasi, Anahita Khoramnia, Heshu Sulaiman Rahman, Parvaneh Mehrbod, Daniel Ajdari, Arbakariya B. Ariff

“…The GC-MS results of the active fraction revealed two main compounds, isosorbide and erythritol, which act as coronary vasodilator compounds.…”
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The impact of emotional intelligence of military leaders on the crisis management in wartime by Yevhenii Ishchenko, Iryna Yevchenko, Andrii Masliuk, Serhii Myronets, Yevhen Potapchuk

“…Leaders with high emotional intelligence are able to act more effectively in crisis situations.…”
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Experiences and academic alternatives of the University of Medical Sciences of Cienfuegos during COVID-19 by María Aurelia San Juan Bosch, Rubén Darío García Núñez, Norma Mur Villar, Arelys Falcón Hernández, Alexis Díaz Brito

“…<br /><strong>Results:</strong> developed experiences and alternatives of teaching rearrangement have had the purpose of guiding appropriately to act safely and proactively in complex circumstances and for which there was no history; they constitute a stimulus for incorporating alternative scenarios, using remote technology, digital resources and a reinforcement of medical education social mission. …”
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The potential of Mitragyna speciosa leaves as a natural source of antioxidants for disease prevention by Arief Ihsanul, Sunnardianto Gagus Ketut, Khairi Syahrul, Saputri Wahyu Dita

“…The virtual screening results showed that three compounds acted as inhibitors for each protein: (-)-epicatechin, sitogluside, and corynoxeine. …”
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Viral RNA polymerase as a SUMOylation decoy inhibits RNA quality control to promote potyvirus infection by Linhao Ge, Mingxuan Jia, Hongying Shan, Weifang Gao, Lu Jiang, Hongguang Cui, Xiaofei Cheng, Marilyne Uzest, Xueping Zhou, Aiming Wang, Fangfang Li

“…Here we demonstrate that the viral RNA-dependent RNA polymerase, NIb, acts as a SUMOylation decoy to effectively reduce Pelota SUMOylation by competing with SCE1 to inhibit Pelota-mediated RQC. …”
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Structural insights into human topoisomerase 3β DNA and RNA catalysis and nucleic acid gate dynamics by Xi Yang, Xuemin Chen, Wei Yang, Yves Pommier

“…Our studies reveal how TOP3B catalyzes both DNA and RNA relaxation, while TOP3A acts only on DNA.…”
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Gemcitabine combined with baicalein exerts antiviral activity against PEDV by inhibiting the entry and replication phases by Yingge Zheng, Yanfei Zhang, Fangying Xiong, Dehua Luo, Yuxiang Wang, Yijia Zhang, Dengguo Wei

“…The natural product baicalein acts by targeting the early entry stage and directly inactivates the virus, with an EC50 of 5.02 μM. …”
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Terrorist Group Behavior Prediction by Wavelet Transform-Based Pattern Recognition by Ze Li, Duoyong Sun, Bo Li, Zhanfeng Li, Aobo Li

“…Effective prediction of the behavior not only facilitates the understanding of the dynamics of organizational behaviors but also supports homeland security’s missions in prevention, preparedness, and response to terrorist acts. There are certain dynamic characteristics of terrorist groups, such as periodic features and correlations between the behavior and the network. …”
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The Effect of Group Cognitive Behavior Therapy on Behavior Changes on Adolescents Risked at Drug Abuse based on Age Characteristics in Kabupaten Dharmasraya by Wisdia Lola Erwinda, Susmiati Susmiati, Heppi Sasmita

“…Dharmasraya, which is very vulnerable to drug trafficking cases, a prevention act to drug abuse behavior among adolescents is required. …”
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Mechanism of action of 5-arninosalicylic acid by N. A. Punchard, S. M. Greenfield, R. P. H. Thompson

“…Reactive oxygen species (ROS) are involved in the metabolism of prostaglandins and leukotrienes and can act as second messengers, and so the scavenging of ROS may be the single mechanism of action of 5-ASA that gives rise to its antiinflammatory effects in both inflammatory bowel disease and rheumatoid arthritis.…”
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DETERMINING THE BLOOD ALCOHOL LEVEL OR THE PRESENCE OF PSYCHOACTIVE SUBSTANCES AMONG RAILWAY STAFF by Georgian RĂDĂȘANU

“…Following the examination of the Order of the Minister of Transport and Telecommunications no. 855/1986, we will be able to observe the causes for which, in order to prove the concentration of alcohol or the presence of psychoactive substances among railway personnel with duties regarding the safety of railway traffic, the judicial bodies end up applying, by extension, the provisions of a normative act aimed at judicial probation in the case of persons involved in events or circumstances related to road traffic. …”
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