METTL1 mediates PKM m7G modification to regulate CD155 expression and promote immune evasion in colorectal cancer by Fang Wang, Chen Yang, Fang Zheng, Yang Yan, Guifang Li, Yanyan Feng, Hejia Xu, Zilong He, Dongyan Cai, Hairong Sun, Xiaowei Qi, Yong Mao

“…Results We demonstrated that m7G RNA METTL1 enhances PKM2 expression by acting on PKM mRNA, leading to tumor progression and increased glycolysis. …”
Get full text

The effects of growth hormone on the outcomes of in vitro fertilization and embryo transfer in age-grouped patients with decreased ovarian reserve: a prospective cohort study by Jiexiu Chen, Xumei Kong, Zonghui Luan, Yu Qiu, Yu Qiu, Shiqi Chen, Jesse Li−Ling, Yan Gong

“…The ovarian stimulation protocol was gonadotrophin-releasing hormone antagonist (GnRH-A) or long-acting GnRH agonist protocol. The quality of oocytes and embryos and the outcome of pregnancy were compared.ResultsIn group B, the number (1.16 ± 0.12 vs. 0.74 ± 0.09) and rate (34.27% vs. 23.90%) of high-quality cleavage embryos, rate of implantation (32.37% vs. 22.35%), clinical pregnancy (48.98% vs. 33.67%), and live birth (44.90% vs. 29.59%) were significantly higher, whereas the canceled oocyte retrieval rate was significantly lower (1.49% vs. 6.58%) in the GH part than those of the control part (P < 0.05). …”
Get full text

Increased methane production associated with community shifts towards Methanocella in paddy soils with the presence of nanoplastics by Zhibin He, Yarong Hou, Ying Li, Qicheng Bei, Xin Li, Yong-Guan Zhu, Werner Liesack, Matthias C. Rillig, Jingjing Peng

“…Conclusions The specific enrichment of Syntrophomonas and Methanocella indicates that LDPE NPs stimulate the syntrophic oxidation of LCFAs and SCFAs, with Methanocella acting as the hydrogenotrophic methanogen partner. …”
Get full text

The accurate determination of Perfluorooctane sulfonic acid (PFOS) removal efficiency by integrated-sonochemical system by Debabrata Panda, Maxime Cochennec, Stéfan Colombano, Benjamin Laulier, Pascal Tierce, Alexandre Baudouard, Sebastian Bristeau, Anne Togola, Julie Lions, Nicolas Devau, Eric D. van Hullebusch

“…This work will be useful for both laboratory and industrial upscaling while acting as a benchmark reference to follow.…”
Get full text

An Areal Assessment of Subseafloor Carbon Cycling in Cold Seeps and Hydrate-Bearing Areas in the Northern South China Sea by Yanping Zhang, Min Luo, Yu Hu, Hongbin Wang, Duofu Chen

“…Gas hydrates, acting as a dynamic methane reservoir, store methane in the form of a solid phase under high-pressure and low-temperature conditions and release methane through the sediment column into seawater when they are decomposed. …”
Get full text

Based on bioinformatics, SESN2 negatively regulates ferroptosis induced by ischemia reperfusion via the System Xc−/GPX4 pathway by Jiejie Hu, Lijun Qin, Guoqiang Zhu, Jingjing Ren, Hongxia Wang, Jing Jin, Haixue Zheng, Dan Li, Zhaoming Ge

“…By integrating bioinformatics analysis with mechanistic exploration, this study revealed that ferroptosis plays a crucial role in IR-induced BMVECs injury, with SESN2 acting as a negative regulator via the System Xc−/GPX4 pathway.…”
Get full text

Tat-fimbriae (“tafi”): An unusual type of haloarchaeal surface structure depending on the twin-arginine translocation pathway by Anna V. Galeva, Dahe Zhao, Alexey S. Syutkin, Marina Yu Topilina, Sergei Yu Shchyogolev, Elena Yu Pavlova, Olga M. Selivanova, Igor I. Kireev, Alexey K. Surin, Gennady L. Burygin, Jingfang Liu, Hua Xiang, Mikhail G. Pyatibratov

“…Based on protein structure prediction (including AlphaFold 3), tafi exhibits a linear structure: TafC at the tip, TafE acting as an adapter, TafA forming the core filament, and they link the fourth subunit TafF, anchoring tafi to the cell wall. …”
Get full text

Seabed Acoustic Mapping Revealing an Uncharted Habitat of Circular Depressions Along the Southeast Brazilian Outer Shelf by Ana Carolina Lavagnino, Marcos Daniel Leite, Tarcila Franco, Pedro Smith Menandro, Fernanda Vedoato Vieira, Geandré Carlos Boni, Alex Cardoso Bastos

“…The circular depressions mapped at high resolution could be related to sea level processes acting during the last glacial period and shelf exposure, i.e., relict features. …”
Get full text

Estradiol-dependent and independent effects of FGF21 in obese female mice by T. V. Jakovleva, A. Yu. Kazantseva, A. D. Dubinina, N. Yu. Balybina, K. O. Baranov, E. N. Makarova, N. M. Bazhan

“…The f ibroblast growth factor 21 (FGF21) synthesized in the liver, acting as a hormone, increases insulin sensitivity and energy expenditure. …”
Get full text

Real World Experience of Chronic Hepatitis C Retreatment with Genotype Specific Regimens in Nonresponders to Previous Interferon-Free Therapy by Dorota Zarębska-Michaluk, Iwona Buczyńska, Krzysztof Simon, Magdalena Tudrujek-Zdunek, Ewa Janczewska, Dorota Dybowska, Marek Sitko, Beata Dobracka, Jerzy Jaroszewicz, Paweł Pabjan, Jakub Klapaczyński, Łukasz Laurans, Włodzimierz Mazur, Łukasz Socha, Olga Tronina, Miłosz Parczewski, Robert Flisiak

“…The aim of our study was to evaluate the efficacy of retreatment with genotype specific direct acting antivirals- (DAA-) based regimens in nonresponders to previous IFN-free therapy. …”
Get full text

NF-κB/AP-1-Targeted Inhibition of Macrophage-Mediated Inflammatory Responses by Depigmenting Compound AP736 Derived from Natural 1,3-Diphenylpropane Skeleton by Van Thai Ha, Heung Soo Beak, Eunji Kim, Kwang-Soo Baek, Muhammad Jahangir Hossen, Woo Seok Yang, Yong Kim, Jun Ho Kim, Sungjae Yang, Jeong-Hwan Kim, Yung Hyup Joo, Chang Seok Lee, Joonho Choi, Hong-Ju Shin, Sungyoul Hong, Song Seok Shin, Jae Youl Cho

“…AP736 was identified as an antimelanogenic drug that can be used for the prevention of melasma, freckles, and dark spots in skin by acting as a suppressor of melanin synthesis and tyrosinase expression. …”
Get full text

Nanomaterials–plants–microbes interaction: plant growth promotion and stress mitigation by Gurleen Kaur Sodhi, Tharuka Wijesekara, Kailash Chand Kumawat, Priyanka Adhikari, Kuldeep Joshi, Smriti Singh, Beatrice Farda, Rihab Djebaili, Enrico Sabbi, Fares Ramila, Fares Ramila, Fares Ramila, Devendra Sillu, Gustavo Santoyo, Sergio de los Santos-Villalobos, Ajay Kumar, Marika Pellegrini, Debasis Mitra

“…These materials also serve as carriers of nutrients, growth regulators, and pesticides, thus acting like “smart fertilizers. While nanotechnology offers great promise, addressing potential environmental and ecotoxicological risks associated with their use is necessary. …”
Get full text

Thioredoxin-interacting protein (TXNIP) inhibition promotes retinal ganglion cell survival and facilitates M1-like microglial transformation via the PI3K/Akt pathway in glaucoma by Junjue Chen, Huimin Zhong, Bingqiao Shen, Huan Yu, Yang Zhang, Ruiqi Han, Ping Huang, Shouyue Huang, Yisheng Zhong

“…Moreover, IL-17A was found to play a role in acting synergistically with TXNIP upon the regulation of microglia polarity transformation. …”
Get full text

IMPLEMENTASI MODUL IPA BERBASIS ETNOSAINS MASYARAKAT BENGKULU MATERI PENGUKURAN MELALUI DISCOVERY LEARNING UNTUK MENINGKATKAN KEMAMPUAN BERPIKIR KRITIS MAHASISWA by Indra Sakti, Aprina Defianti, Nirwana Nirwana

“…Each cycle consists of four research steps, namely planning, acting, observing, and reflecting. The learning tools consist of (1) RPP Discovery Learning model; (2) Science module based on Bengkulu Community ethnoscience measurement material; (3) LKPD; (4) assessment instruments for Critical Thinking Skills and Activities. …”
Get full text

Elucidation of the mechanism of berberine against gastric mucosa injury in a rat model with chronic atrophic gastritis based on a combined strategy of multi-omics and molecular bio... by Lisheng Chen, Lisheng Chen, Xin Wang, Xin Wang, Jianyu Li, Lijuan Zhang, Wenbin Wu, Shizhang Wei, Wenjun Zou, Yanling Zhao, Yanling Zhao

“…Integrating transcriptomics and metabolomics analyses indicated that BBR directly regulated Carnitine C3:0, LPC (0:0/20:3), L-Glutamic Acid and FFA (15:0) by acting on SLC25A20, PNLIPRP1, PLA2G4C, GSR, GFPT2, GCLM, CTPS1, ACSL1, ACOT4 and ACOT2. 16S rRNA sequencing revealed that BBR could restore the balance of gut microbiota dysbiosis by significantly regulating the relative abundance of unclassified_Muribaculaceae and Lactobacillus_johnsonii.ConclusionThis study demonstrated that BBR alleviates CAG through the regulation of the MAPK signaling pathway, metabolic disorders and gut microbiota dysbiosis, thereby revealing the complex mechanism of BBR in relation to alleviating CAG from multiple levels and perspectives.…”
Get full text

Temporal trends of the utilization patterns of sedative-hypnotic medications in children, adolescents and young adults: a 21-year population-based study with joinpoint regression a... by Carltin Chun Ting Kwok, Heidi Ka Ying Lo, Ching Yui Chan, Joe Kwun Nam Chan, Corine Sau Man Wong, Calvin Pak Wing Cheng, Chung Ho, Brian Man Ho Leung, Wilfred Shone Horn Wong, Zoe Hoi Shuen Yu, Edwin Ho Ming Lee, Wing Chung Chang

“…We calculated annual prescription prevalence (per 1,000 persons per year) for any BZRA, BZRA-subtypes (short- and long-acting benzodiazepines, Z-drugs) and individual BZRAs. …”
Get full text

Assessing the Comparative Efficacy and Safety of Warfarin and Rivaroxaban for Cancer Associated Thrombosis: Experience From a Resource Limited Setting by Abel Tenaw Tasamma, Tsegab Alemayehu Bukate, Abdulrahim Mehadi, Bereket Tagesse Handiso, Beniam Yohannes Kassa, Eman Omer Hassen, Zekarias Seifu Ayalew, Dawit Habtie Tegegne, Gebeyehu Tessema Azibte, Tigest Abebaw Zewdie, Tinsaye Zergaw Shihur, Yonas Degelo Geremamo, Yeabsira Dessalegne Mesfin, Rediet M. Alemayehu, Amanuel Kassu Asefa, Fozia Abdela, Addisu Melkie

“…ABSTRACT Background Thromboembolic events are a common cause of morbidity and mortality in patients with cancer. While direct‐acting oral anticoagulants (DOACs) have been established as the preferred agents of anticoagulation in most patients with cancer, data in resource‐limited settings is limited. …”
Get full text

Genome-Wide Comprehensive Identification and In Silico Characterization of Lectin Receptor-Like Kinase Gene Family in Barley (Hordeum vulgare L.) by Fee Faysal Ahmed, Farah Sumaiya Dola, Md Shohel Ul Islam, Fatema Tuz Zohra, Nasrin Akter, Shaikh Mizanur Rahman, Md. Abdur Rauf Sarkar

“…Most notably, eight TFFs were found to be linked to the promoter region of both L-type HvleckRLK64 and HvleckRLK86. The promoter cis-acting regulatory element (CARE) analysis of barley identified a total of 75 CARE motifs responsive to light responsiveness (LR), tissue-specific (TS), hormone responsiveness (HR), and stress responsiveness (SR). …”
Get full text

Unraveling the interconnectedness between physician burnout and symptoms of depression, anxiety, and stress: a network analysis among Chinese psychiatrists by Song Wang, Song Wang, Mengyue Gu, Mengyue Gu, Shujing Zhang, Jingyang Gu, Jingyang Gu, Yudong Shi, Yudong Shi, Yating Yang, Yating Yang, Ling Zhang, Ling Zhang, Mengdie Li, Mengdie Li, Lei Xia, Lei Xia, Feng Jiang, Feng Jiang, Feng Jiang, Feng Jiang, Huanzhong Liu, Huanzhong Liu, Huanzhong Liu, Yi-lang Tang, Yi-lang Tang

“…Network analysis was used to examine the interconnection between physician burnout and psychological symptoms, with further analysis conducted on multiple levels, including individual symptoms in central positions or acting as bridges between clusters, and identifying core symptom combinations with significant correlations.ResultsStress emerged as the highest Expected Influence (EI) index, with emotional exhaustion in the burnout cluster being the singular bridge symptom. …”
Get full text