Treatment of Hepatitis C Post-Liver Transplantation Could Mitigate Discard Rates of Hepatitis C-Positive Deceased Donor Livers and Expand the Donor Pool by Jennifer Keller, Gary Marklin, Obi Okoye, Roshani Desai, Tej Sura, Ajay Jain, Chintalapati Varma, Mustafa Nazzal

“…However, the subsequent introduction of direct acting antiviral medications (DAA) against hepatitis C led to improvements in morbidity and better medication tolerance. …”
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Nonlinear Stress‐Induced Transformations in Collagen Fibrillar Organization, Disorder and Strain Mechanisms in the Bone‐Cartilage Unit by Waqas Badar, Sheetal R. Inamdar, Peter Fratzl, Tim Snow, Nicholas J. Terrill, Martin M. Knight, Himadri S. Gupta

“…With the calcified plate acting as an anchor for surrounding tissue, a qualitative switch occurs in fibrillar deformation between the articular cartilage and calcified regions. …”
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A deep dive into cation-modified structural, mechanical, magneto‑electronic, and thermophysical properties of MAlO3 (M = Ca, Sr, Ba, and Ra): First-principles investigation by Asif Hosen, Md. Rafiqul Islam, Ahmad A. Mousa, Mohammed S. Abu-Jafar

“…In contrast, SrAlO3, BaAlO3, and RaAlO3 have half-metallic characteristics displaying a metallic nature in the down-spin channel while acting as insulators in the up-spin channel. However, half-metallic properties are preserved within -6 % to +8 % of the applied strain for the compounds SrAlO3, BaAlO3, and RaAlO3. …”
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Ionospheric Disturbances Over the Indian Sector During 8 September 2017 Geomagnetic Storm: Plasma Structuring and Propagation by L. Alfonsi, C. Cesaroni, L. Spogli, M. Regi, A. Paul, S. Ray, S. Lepidi, D. Di Mauro, H. Haralambous, C. Oikonomou, P. R. Shreedevi, A. K. Sinha

“…The EPB (or EPBs) occurring in the south of India is/are freshly generated just above the magnetic equator, and is/are likely triggered by the sudden increase of EEJ just before the local sunset, acting as a pre‐reversal enhancement. The EPB appearing in the North‐East Indian region is associated with a migrating structure, resulting in a northward movement with a velocity of about 650 m/s, possibly testifying the passage of a large‐scale traveling ionospheric disturbance. …”
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Resilience in the time of crisis: A review of the maternal, perinatal and reproductive health effects of COVID-19 in South Africa by S Fawcus, S Gebhardt, R Niit, R Pattinson

“…The use of oral and injectable contraceptives and termination of pregnancy services decreased markedly in 2020 and 2021, with a sustained shift to long‐acting reversible contraceptives. The increase in maternal deaths was predominantly due to COVID‐19 respiratory complications, but also an increase in obstetric haemorrhage. …”
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Genome-wide identification, characterization and expression pattern analysis of HAK/KUP/KT potassium transporter gene family in potato by Kun Liu, Yonglin Qin, Lan Wu, Rong Yi, Xiaohua Shi, Jing Yu, Xiaohong Shi, Wenzhuo Dong, Liguo Jia, Mingshou Fan

“…All StHAK protein sequences contained the conserved motifs and domains. Promoter cis-acting elements analysis revealed that most StHAK gene family members in potatoes were associated with responses to light and hormones such as abscisic acid or methyl jasmonate, however, many motifs responsive to hormones and stress conditions have not been clearly studied or reported in plants. …”
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Eliminating Postoperative Nausea and Vomiting in Outpatient Surgery with Multimodal Strategies including Low Doses of Nonsedating, Off-Patent Antiemetics: Is “Zero Tolerance“ Achie... by Susan J. Skledar, Brian A. Williams, Manuel C. Vallejo, Patricia L. Dalby, Jonathan H. Waters, Ronald Glick, Michael L. Kentor

“…Rescue therapy consists of avoiding unnecessary repeat doses of drugs acting by the same mechanism: haloperidol 2 mg i.v. …”
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A Transcriptomic Analysis Reveals Diverse Regulatory Networks That Respond to Cold Stress in Strawberry (Fragaria×ananassa) by Yong Zhang, Yunting Zhang, Yuanxiu Lin, Ya Luo, Xiaorong Wang, Qing Chen, Bo Sun, Yan Wang, Mengyao Li, Haoru Tang

“…The cold signaling initiated expression of downstream cold-responsive (COR) genes with cis-acting element ABRE or CRT/DRE in the ABA-independent or ABA-dependent pathway to impel plant defense against the stress. …”
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The biogenesis, regulation and functions of transitive siRNA in plants by Tan Huijun, Liu Yuelin, Guo Hongwei

“…In Arabidopsis thaliana, two RDRs participate in the generation of transitive siRNAs, acting cooperatively with various siRNA generation-related factors, such as the RNA-induced silencing complex (RISC) and aberrant RNAs. …”
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Characterization of <i>PHT</i> Genes in ‘duli’ (<i>Pyrus betulifolia Bunge</i>) and Expression Analysis of <i>PbPHTs</i> in Response to Plant Growth Regulators, P, and Salt Stress... by Shuai Yuan, Weilong Zhang, Yuxing Zhang

“…The promoter analysis showed that there were a large number of cis-acting elements related to phytohormones, growth, development, stress, and light response in <i>PbPHTs</i>. qRT-PCR analysis revealed that most <i>PHT</i> genes in ‘duli’ were highly expressed in the fruits, flowers, leaves, stems, and roots, and 15 <i>PbPHT</i> genes were responsive to 5 μM, 0.5 mM, 5 mM H₂PO₄, NaCl, GR24 (synthetic SL analog), GA3 (gibberellin 3), ABA (abscisic acid), and IAA (indole-3-acetic acid). …”
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Unlocking soybean meal pectin recalcitrance using a multi-enzyme cocktail approach by Lauriane Plouhinec, Liang Zhang, Alexandre Pillon, Mireille Haon, Sacha Grisel, David Navarro, Ian Black, Virginie Neugnot, Parastoo Azadi, Breeanna Urbanowicz, Jean-Guy Berrin, Mickael Lafond

“…In this study, we produced 15 recombinant fungal carbohydrate-active enzymes (CAZymes) identified from fungal secretomes acting on pectin. After observing that these enzymes were not active on soybean meal pectin when used alone, we developed a semi-miniaturized method to evaluate their effect as multi-activity cocktails. …”
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Illuminating the impact of CD38-induced adenosine formation in B-cell lymphoma by Shams ElDoha Galal ElDin Zaiema, Heba Mohamed Saber Hafez, Diaa El-Din Moussa Sherif Abou El-Ela, Rawda Ahmed Alaaeldin Ahmed Mohamed Saad

“…Abstract The expression of CD38 by cancer cells may mediate an immune-suppressive effect by producing Extracellular Adenosine (ADO) acting through G-protein-coupled cell surface receptors on cellular components and tumor cells. …”
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Hypnotics' association with mortality or cancer: a matched cohort study by Daniel F Kripke, Lawrence E Kline, Robert D Langer

“…This association held in separate analyses for several commonly used hypnotics and for newer shorter-acting drugs. Control of selective prescription of hypnotics for patients in poor health did not explain the observed excess mortality.…”
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Shaping Administrative Activity (Legal Forms): A Legislative Approach by Sára Hrubešová

“…In the Czech legal order, the Parliament acts as the rule-maker of statutory foundations for public administration, making it crucial to focus on the legislative approach to enacting legal forms. …”
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Improved Antibacterial Activity of Water-Soluble Nanoformulated Kaempferol and Combretastatin Polyphenolic Compounds by Y. Santhosh Kumar, Langeswaran Kulanthaivel, G. S. Hikku, R. Saravanan, Thangavelu Lakshmi, C. Kirubhanand, Murugesan Karthikeyan, P. Vijayalakshmi, Gowtham Kumar Subbaraj

“…This complicates the determination of the exact mechanisms acting against bacterial growth when using nanoformulation drugs. …”
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Chromogranin A: From Laboratory to Clinical Aspects of Patients with Neuroendocrine Tumors by Paola Di Giacinto, Francesca Rota, Laura Rizza, Davide Campana, Andrea Isidori, Andrea Lania, Andrea Lenzi, Paolo Zuppi, Roberto Baldelli

“…An open-label, phase II trial assesses the clinical activity of long-acting repeatable pasireotide in treatment-naive patients with metastatic grade 1 or 2 NETs. …”
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Photoswitch dissociation from a G protein-coupled receptor resolved by time-resolved serial crystallography by Hannah Glover, Torben Saßmannshausen, Quentin Bertrand, Matilde Trabuco, Chavdar Slavov, Arianna Bacchin, Fabio Andres, Yasushi Kondo, Robin Stipp, Maximilian Wranik, Georgii Khusainov, Melissa Carrillo, Demet Kekilli, Jie Nan, Ana Gonzalez, Robert Cheng, Werner Neidhart, Tobias Weinert, Filip Leonarski, Florian Dworkowski, Michal Kepa, Josef Wachtveitl, Michael Hennig, Joerg Standfuss

“…Depending on the chemical nature of the ligand, interactions between extracellular loops 2 and 3, acting as a lid on the binding pocket, are disrupted and rearrangement of the orthosteric binding pocket is invoked upon ligand dissociation. …”
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Androgen Receptor-Target Genes in African American Prostate Cancer Disparities by Bi-Dar Wang, Qi Yang, Kristin Ceniccola, Fernando Bianco, Ramez Andrawis, Thomas Jarrett, Harold Frazier, Steven R. Patierno, Norman H. Lee

“…Gene promoter analysis revealed that 382 out of 1,188 genes contained cis-acting AR-binding sequences. Chromatin immunoprecipitation confirmed STAT1, RHOA, ITGB5, MAPKAPK2, CSNK2A,1 and PIK3CB genes as novel AR targets in PCa disparities. …”
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Generalising axion-like particle as the curvaton: sourcing primordial density perturbation and non-Gaussianities by Anish Ghoshal, Abhishek Naskar

“…Subsequently the ALP decays converting the isocurvature perturbations to adiabatic perturbations thereby acting as the origin of the primordial density perturbations. …”
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Cytoskeletal Vimentin Directs Cell‐Cell Transmission of Hepatitis C Virus by Yifan Xing, Zeyu Wen, Jie Mei, Xinyi Huang, Shuangshuang Zhao, Jin Zhong, Yaming Jiu

“…Abstract Hepatitis C virus (HCV) is a major human pathogen causing liver diseases. Although direct‐acting antiviral agents effectively inhibit HCV infection, cell–cell transmission remains a critical venue for HCV persistence in vivo. …”
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