Promising Therapeutic Functions of Bone Marrow Mesenchymal Stem Cells Derived-Exosome in Asthma by Jia-Ying Yuan, Xiang-Yun Wang, Zhi-Ying Tong, Yu-Chao Dong, Jia-Yi Zhao, Yi Zhang, Yan Shang

“…At present, inhaled corticosteroid (ICS) and long-acting β-agonists (LABAs) are standard treatments for regular management. …”
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Implementation of the state policy for innovative development of the heat supply sector by Yu. O. Bakrunov, V. V. Glazkova

“…The normative basis of the study was the legislative acts of the Russian Federation regulating the heat supply activities and determining the directions of state policy in the sphere under consideration. …”
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The effect of plasma nitriding duration on the tribological performance of Ni-B-Gr self-lubricant composite coatings on AISI 4140 steel by Vahid Niksefat, Farzad Mahboubi

“…The Ni-B-Gr composites were applied to AISI 4140 steel using an electroless method, with the Ni-B matrix providing structural rigidity and graphite flakes (<20 μm, 0.275 g/L) acting as a self-lubricating agent. Plasma nitriding (PN) treatment was performed at 400 °C for 30–240 min, using a gas combination of 25% nitrogen and 75% hydrogen. …”
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Projecting the Potential Budget Impact Analysis of Paliperidone Palmitate in Egyptian Adult Patients with Schizophrenia by Gihan Elsisi, Mohamed Ezzat, Mohamed Ramadan

“…**Objective:** We evaluated the economic impact of long-acting injections of paliperidone palmitate (PP) vs daily oral antipsychotics to treat chronic schizophrenia from a societal perspective over a 2-year period. …”
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Effectiveness of carbon dioxide cryotherapy for the treatment of cutaneous leishmaniasis: Systematic review and meta-analysis. by Feleke Tilahun Zewdu, Bisrat Misganaw Geremew, Endalamaw Gadisa Belachew, Kassahun Alemu Gelay

“…The search, screening, data extraction, and critical evaluation were carried out by two authors, with a third acting as a tiebreaker. To locate papers, we used Medical Subject Headings (MeSH) phrases and keywords. …”
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Sexual dimorphism and ancestral variation in the pectoral and pelvic girdles of modern humans by Daphne R. Hudson, John H. Langdon

“…These results suggest that sexual dimorphism in the pectoral region is not a product of scaling and that differences in this region reflect adaptive forces acting in unique ways on each sex, consistent with the assumptions of earlier evolutionary explanations.…”
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Enhancement of BDNF Concentration and Restoration of the Hypothalamic-Pituitary-Adrenal Axis Accompany Reduced Depressive-Like Behaviour in Stressed Ovariectomised Rats Treated wit... by Badriya Al-Rahbi, Rahimah Zakaria, Zahiruddin Othman, Asma’ Hassan, Asma Hayati Ahmad

“…In conclusion, both Tualang honey and E2 mediate antidepressive-like effects in stressed OVX rats, possibly acting via restoration of hypothalamic-pituitary-adrenal axis and enhancement of the BDNF concentration.…”
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Conjugation of Triterpenic Acids with 3-Aminoquinuclidine Moiety: An Approach to Acetylcholinesterase Mixed or Uncompetitive Type Inhibitors by Anastasiya V. Petrova, Ha T. T. Nguyen, Irina V. Zueva, Konstantin A. Petrov, Alexander N. Lobov, Oxana B. Kazakova

“…The best activity for ursolic acid derivatives was observed for the 3-oxoamide <b>8</b>, with an IC₅₀ value of 0.43 µM, acting as a mixed-type inhibitor. In turn, for the oleanane type, the amide with an indole unit in the A ring <b>11</b> exhibited the best activity with an IC₅₀ value of 0.47 µM (while the ursane-type analog was weakly active) and led to an uncompetitive type of inhibition. …”
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The History of the Brazilian Sardine (<i>Sardinella brasiliensis</i>) Between Two Fishery Collapses: An Ecosystem Modeling Approach to Study Its Life Cycle by Rafael Schroeder, Angélica Petermann, Alberto Teodorico Correia

“…This pattern was coincidental with the increasing mean temperature of the catches, which was probably acting as a limiting factor for the primary production, resulting in a higher natural mortality and flow to detritus. …”
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A Case Study of Using Numerical Analysis to Assess the Slope Stability of National Freeways in Northern Taiwan by Hao-Wei Chiu, Yi-Hao Tsai, Chao-Wei Tang, Chih-Yu Chu, Shong-Loong Chen

“…By comparison, under seismic conditions, the force acting on the slope extended to the whole slope. Furthermore, the slope safety factor of Site 1 was greater than the design specification value in three different scenarios. …”
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Etiopathogenic theories of nervous system diseases in Vilnius in the early 19th century: “insanity and epilepsy exacerbate when the moonlight shines” by E. Sakalauskaitė-Juodeikienė

“…The authors also described the theory of “poison, specifically acting on the NS” that was transmitted by a rabid animal to a bitten patient. …”
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Ameliorative Potential of Tamarindus indica on High Fat Diet Induced Nonalcoholic Fatty Liver Disease in Rats by Suja Rani Sasidharan, Joshua Allan Joseph, Senthilkumar Anandakumar, Vijayabalaji Venkatesan, Chandrasekharan Nair Ariyattu Madhavan, Amit Agarwal

“…The study findings, therefore suggested the therapeutic potential of ETS against NAFLD, acting in part through antiobesity, insulin sensitizing, and antioxidant mechanisms.…”
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Repurposing Drugs for Synergistic Combination Therapies to Counteract Monkeypox Virus Tecovirimat Resistance by Haydar Witwit, Beatrice Cubitt, Roaa Khafaji, Esteban M. Castro, Miguel Goicoechea, Maria M. Lorenzo, Rafael Blasco, Luis Martinez-Sobrido, Juan C. de la Torre

“…Our findings support combination therapy of direct-acting (TPOXX) and host-targeted (MMF and IMP-1088) antivirals as a promising approach to treat mpox and prevent the emergence and spread of TPOXX-resistant MPXV variants.…”
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The Angiotensin-Melatonin Axis by Luciana A. Campos, Jose Cipolla-Neto, Fernanda G. Amaral, Lisete C. Michelini, Michael Bader, Ovidiu C. Baltatu

“…Angiotensin production in the central nervous system may not only influence hypertension but also appears to affect the circadian rhythm of blood pressure. Drugs acting on RAS have been proven effective in the treatment of cardiovascular and metabolic disorders including hypertension and diabetes mellitus (DM). …”
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Molecular complexity of quantitative immunity in plants: from QTL mapping to functional and systems biology by Chauveau, Carine, Roby, Dominique

“…First, from genetic analyses by QTL (Quantitative Trait Locus) mapping and GWAs (Genome Wide Association studies), the identification, cloning and functional analysis of this gene have been used as a starting point for the exploration of the multiple and coordinated pathways acting together to mount the QDR response dependent on RKS1. …”
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Propellant Slosh Force and Mass Measurement by Andrew Hunt, Richard Foster-Turner, Ross Drury

“…Because of the limitations of operating in earth-bound gravity, it has not been possible to check the exact numerical accuracy of the slosh force acting on the vessel. We are therefore in the process of undertaking a further project to (i) build a prototype integrated “Smart Tank for Space”, (ii) undertake slosh tests in zero or microgravity, (iii) develop the system for commercial ground testing, and (iv) qualify ECT for use in space.…”
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Transcriptional Profiling Reveals Kidney Neutrophil Heterogeneity in Both Healthy People and ccRCC Patients by Yiliang Meng, Kai Cai, Jingjie Zhao, Keyu Huang, Xiumei Ma, Jian Song, Yunguang Liu

“…In a healthy kidney, neutrophils exhibit two subpopulations: one is more associated with renal autoimmunity, probably acting as therapeutic target; the other is suggested to resist infectious microorganisms. …”
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Formulation of Ebastine Fast-Disintegrating Tablet Using Coprocessed Superdisintegrants and Evaluation of Quality Control Parameters by Bhawana Dhakal, Jaybir Kumar Thakur, Reema Kumari Mahato, Ishwori Rawat, D. C. Rabin, Rahul Rana Chhetri, Kedar Prasad Shah, Atul Adhikari, Jitendra Pandey

“…Ebastine is a long-acting, nonsedating, second-generation antihistaminic drug that prevents histamine action, mainly in immediate hypersensitivity. …”
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Cost–consequence analysis of COPD treatment according to NICE and GOLD recommendations compared with current clinical practice in the UK by Jennifer K Quint, Helene Vioix, Toby Capstick, Sue Langham, Jennifer Cook, Antony Wright, Shamika de Silva

“…Objectives The objective of this study was to model the clinical and economic impact of adapting current clinical practice in the management of patients with chronic obstructive pulmonary disease (COPD) to treatment according to national and international guideline recommendations.Design Treatment mapping was undertaken to hypothetically redistribute patients from current clinical practice, representing actual prescribing patterns in the UK, to an alternative recommendation-based treatment scenario, representing prescribing in accordance with either National Institute for Health and Care Excellence (NICE) guidance [NG115] or Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2020 strategy.Setting Primary care practices in the UK (1-year time horizon).Participants Adults with COPD undergoing long-acting inhaler maintenance therapy in the UK (N=1 067,531).Interventions Inhaler maintenance therapy.Outcome measures Costs and clinical outcomes (type of treatment, rates of moderate and/or severe exacerbations, and mild-to-moderate and/or severe pneumonia events) were modelled for the two alternative pathways.Results Compared with current clinical practice, treating patients according to NICE guidance resulted in an estimated annual reduction in expenditure of £46.9 million, and an estimated annual reduction in expenditure of over £43.7 million when patients were treated according to GOLD 2020 strategy. …”
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Mortality among Alaska Native Adults with Confirmed Hepatitis C Virus Infection Compared with the General Population in Alaska, 1995–2016 by Sara S. Bressler, Dana Bruden, Leisha D. Nolen, Michael G. Bruce, Lisa Towshend-Bulson, Philip Spradling, Brian J. McMahon

“…Hepatitis C virus (HCV) infection incidence rates in the United States have increased since 2010 as a byproduct of the opioid crisis despite the introduction of direct-acting antiviral agents in 2013. HCV infection is associated with higher rates of liver-related and nonhepatic causes of death. …”
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