Pulling a Ligase out of a “HAT”: pCAF Mediates Ubiquitination of the Class II Transactivator by Julie E. Morgan, Susanna F. Greer

“…Additionally, pCAF mediated ubiquitination is independent of pCAF’s HAT domain, and acetylation deficient CIITA is K48 polyubiquitinated and degraded in the presence of pCAF. …”
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Neurological impact of HIV/AIDS and substance use alters brain function and structure by James Haorah, Samikkannu Malaroviyam, Hemavathi Iyappan, Thangavel Samikkannu

“…The epigenetic modification of N-terminal acetylation is currently understudied, which is discussed in brief to demonstrate the important role of this epigenetic modification in infected microglia within specific brain regions. …”
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The RNA-dependent association of phosphatidylinositol 4,5-bisphosphate with intrinsically disordered proteins contribute to nuclear compartmentalization. by Martin Sztacho, Jakub Červenka, Barbora Šalovská, Ludovica Antiga, Peter Hoboth, Pavel Hozák

“…Moreover, these IDRs of RDPA proteins exhibit enrichment for phosphorylation, acetylation, and ubiquitination sites. Our results show for the first time that the RDPA protein Bromodomain-containing protein 4 (BRD4) associates with PIP2 in the RNA-dependent manner via electrostatic interactions, and that altered PIP2 levels affect the number of nuclear foci of BRD4 protein. …”
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Epigenetics and Breast Cancers by An T. Vo, Richard M. Millis

“…Enzymes that are involved in DNA methylation and histone modifications have been shown to be altered in several types of breast and other cancers resulting in abnormal patterns of methylation and/or acetylation. Hypermethylation at the CpG islands found in estrogen response element (ERE) promoters occurs in conjunction with ligand-bonded alpha subunit estrogen receptor (Erα) dimers wherein the ligand ERα dimer complex acts as a transcription factor and binds to the ERE promoter. …”
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The role of epigenetics in plant pathogens interactions under the changing environments: A systematic review by Wenhao Wu, Guoqiang Fan

“…DNA methylation influences plant immunity by modulating gene expression and chromatin accessibility, while histone modifications, such as acetylation and methylation, enable plants to establish robust defenses by fine-tuning stress-responsive genes. …”
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Mechanistic insight of curcumin: a potential pharmacological candidate for epilepsy by Saima Khatoon, Nida Kalam

“…Further, curcumin can persuade epigenetic alterations, including histone modifications (acetylation/deacetylation), which are the changes responsible for the altered expression of genes facilitating the process of epileptogenesis. …”
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Collagen Modulates the Biological Characteristics of WJ-MSCs in Basal and Osteoinduced Conditions by Vun Vun Hiew, Peik Lin Teoh

“…This molecular event was also accompanied by hypomethylation at the OCT4 promoter and increase of H3K9 acetylation. In conclusion, COL provides a conducive cellular environment in priming WJ-MSCs that undergo a lineage specification upon receiving an appropriate signal from extrinsic factor. …”
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FXR Mediates Adenylyl Cyclase 8 Expression in Pancreatic β-Cells by Xiangchen Kong, Bingfeng Li, Yushen Deng, Xiaosong Ma

“…Mechanistically, FXR directly binds to Adcy8 promoter and recruits the histone acetyltransferase Steroid Receptor Coactivator 1 (SRC1), thereby resulting in the increased acetylation of histone H3 in Adcy8 locus, promoting Adcy8 gene transcription in β-cells. …”
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Sodium butyrate restored TRESK current controlling neuronal hyperexcitability in a mouse model of oxaliplatin-induced peripheral neuropathic pain by Idy H.T. Ho, Yidan Zou, Kele Luo, Fenfen Qin, Yanjun Jiang, Qian Li, Tingting Jin, Xinyi Zhang, Huarong Chen, Likai Tan, Lin Zhang, Tony Gin, William K.K. Wu, Matthew T.V. Chan, Changyu Jiang, Xiaodong Liu

“…Immunofluorescence assays of histone acetylation at H3K9/14 were performed in primary DRG cultures treated with sodium butyrate. …”
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Sevoflurane Ameliorates Myocardial Cell Injury by Inducing Autophagy via the Deacetylation of LC3 by SIRT1 by Lihua Fan, Deyuan Chen, Jianping Wang, Yini Wu, Dongli Li, Xiaoyan Yu

“…Present results demonstrated a novel molecular mechanism by which sevoflurane induced autophagy by increasing the level of SIRT1 and reducing the acetylation of LC3.…”
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Differential Effects of Calorie Restriction and Exercise on the Adipose Transcriptome in Diet-Induced Obese Mice by Karrie E. Wheatley, Leticia M. Nogueira, Susan N. Perkins, Stephen D. Hursting

“…Chromatin immunoprecipitation assays of the Glut4 promoter revealed that, relative to the DIO controls, CR significantly increased histone 4 acetylation, suggesting epigenetic regulation may underlie some of the differential effects of CR versus EX on the adipose transcriptome.…”
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The role of myocardial energy metabolism perturbations in diabetic cardiomyopathy: from the perspective of novel protein post-translational modifications by Dongze Li, Li Zhang, Qiming Gong, Huilan Deng, Changfang Luo, Tingting Zhou, Wei Huang, Yong Xu

“…In recent years, novel protein post-translational modifications (PTMs) such as lactylation, β-hydroxybutyrylation, and succinylation have been demonstrated to be intimately associated with the myocardial energy metabolism process, and in conjunction with acetylation, they participate in the regulation of protein activity and gene expression activity in cardiomyocytes. …”
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The Pivotal Immunomodulatory and Anti-Inflammatory Effect of Histone-Lysine N-Methyltransferase in the Glioma Microenvironment: Its Biomarker and Therapy Potentials by Seidu A. Richard, Kuugbee D. Eugene

“…The amino acid succession of EZH2 protein makes it appropriate for covalent modifications, like phosphorylation, acetylation, O-GlcNAcylation, methylation, ubiquitination, and sumoylation. …”
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Detection and Characterization of the Metabolites of Ciwujianoside B in Rats Based on UPLC-Fusion Lumos Orbitrap Mass Spectrometry by Wan-Ru Dong, Xue Gao, Chen-Xue Li, Yan Song, Jun-Hong Chai, Jun Liang

“…Finally, ciwujianoside B metabolism and hederasaponin B metabolism were compared, reaching the following conclusions: (i) more than 40 metabolites were identified in both, with the majority of metabolites identified in feces; (ii) the corresponding metabolic pathways in vivo were basically similar, including deglycosylation, acetylation, hydroxylation, glucuronidation, oxidation, and glycosylation; and (iii) deglycosylation was considered the main metabolic reaction, and its metabolites accounted for approximately 50% of all metabolites. …”
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Trichostatin A Promotes the Generation and Suppressive Functions of Regulatory T Cells by Cristian Doñas, Macarena Fritz, Valeria Manríquez, Gabriela Tejón, María Rosa Bono, Alejandra Loyola, Mario Rosemblatt

“…We also show that the histone deacetylase inhibitor TSA stimulated the in vitro differentiation of naïve CD4+ T cells into Tregs and that this induction was accompanied by a global increase in histone H3 acetylation. Importantly, we also demonstrated that Tregs generated in the presence of TSA have phenotypical and functional differences from the Tregs generated in the absence of TSA. …”
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Concise Synthesis of Naphthalene-Based 14-Aza-12-Oxasteroids by Smriti Srivastava, Jun Luo, Daniel Whalen, Katherine N. Robertson, Amitabh Jha

“…After conversion of 2-naphthols to 2-naphthylamines by the Bucherer reaction, subsequent selective C-acetylation was achieved via the Sugasawa reaction and reduction of the acetyl group using borohydride, which resulted into the corresponding amino-alcohols. …”
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Therapeutic potential of SOX family transcription factors in osteoarthritis by Yue Huang, Zhuo Wang

“…While SOX9 has been utilized as a biomarker to indicate the occurrence and prognosis of osteoarthritis, investigations into other members of the SOX family and the development of targeted treatments around SOX9 are still required.Purpose This article considers the impact of the SOX protein on the development and inhibition of osteoarthritis and highlights the need for therapeutic approaches targeting SOX9, as supported by existing research.Results SOX9 can contribute to the process of osteoarthritis through acetylation and ubiquitination modifications. The regulation of the WNT signalling pathway, Nrf2/ARE signalling pathway, NF-κB signalling pathway and SOX9 is implicated in the emergence of osteoarthritis. …”
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Role of Epigenetics in Modulating Phenotypic Plasticity against Abiotic Stresses in Plants by Fayaz Ahmad Dar, Naveed Ul Mushtaq, Seerat Saleem, Reiaz Ul Rehman, Tanvir Ul Hassan Dar, Khalid Rehman Hakeem

“…Epigenomics refers to the large-scale study of epigenetic marks on the genome, which include covalent modifications of histone tails (acetylation, methylation, phosphorylation, ubiquitination, and the small RNA machinery). …”
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Comparative acetylome analysis reveals the potential mechanism of high fat diet function in allergic disease by Yanan Sun, Ning Liu, Huihui Wang, Taiqi Qu, Fazheng Ren, Yixuan Li

“…Among these, eight acetylated proteins were upregulated in the HFD group. …”
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ENL mutation and AML: a new model that reveals oncogenic condensate's function in leukemogenesis by Zhong Fan, Yanan Jiang, Xiaotian Zhang

“…Furthermore, they show that small‐molecule inhibition of the acetyl‐binding activity displaces ENL mutant condensates from oncogenic target loci, and this inhibitor significantly impairs the onset and progression of AML driven by mutant ENL in vivo.…”
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