Characterization of the Cannabis sativa glandular trichome epigenome by Lee J. Conneely, Bhavna Hurgobin, Sophia Ng, Muluneh Tamiru-Oli, Mathew G. Lewsey

“…To address this lack of epigenomic data, we mapped H3K4 trimethylation, H3K56 acetylation, H3K27 trimethylation post-translational modifications and the histone variant H2A.Z, using chromatin immunoprecipitation, in C. sativa glandular trichomes, leaf, and stem tissues. …”
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A gene expression atlas of Nicotiana tabacum across various tissues at transcript resolution by Shizhou Yu, Jufen Wan, Jufen Wan, Tenghang Xu, Tenghang Xu, Jie Zhang, Linggai Cao, Jie Liu, Hongfeng Liu, Xueliang Ren, Zhixiao Yang

“…Moreover, we identified 21,763 splicing quantitative trait locus (sQTLs), which were enriched in genes involved in biological processes such as histone acetylation. Furthermore, sQTLs involved genes related to plant hormone signal transduction, terpenoid backbone biosynthesis, and other resistance pathways. …”
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Enhanced Generation of Human Induced Pluripotent Stem Cells from Peripheral Blood and Using Their Mesoderm Differentiation Ability to Regenerate Infarcted Myocardium by Ju-Young Kim, Han-Mo Yang, Joo-Eun Lee, Mika Jeon, Sang-Bum Bang, Jihye You, Joonoh Kim, Jaewon Lee, Jin Hur, Hyo-Soo Kim

“…In contrast, histone H3 lysine 9 acetylation was downregulated during the differentiation process of the CiMS-iPSCs. …”
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Transcriptome Sequencing Reveals Regulatory Mechanisms of Taxol Synthesis in Taxus wallichiana var. Mairei by Tao Wang, Yiming Chen, Weibing Zhuang, Fengjiao Zhang, Xiaochun Shu, Zhong Wang, Qing Yang

“…Our results indicated that high expressions of the genes taxadienol acetyltransferase (TAT), taxadiene 5-alpha hydroxylase (T5H), 5-alpha-taxadienol-10-beta-hydroxylase (T10OH), and 2-debenzoyl-7,13-diacetylbaccatin III-2-O-benzoyl-transferase (DBBT), which catalyze a series of key acetylation and hydroxylation steps, are the main cause of high taxol content in JXS. …”
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Heat shock transcription factor 1 facilitates liver cancer progression by driving super‐enhancer‐mediated transcription of MYCN by Yizhe Liu, Qili Shi, Yue Su, Zhiao Chen, Xianghuo He

“…Additionally, we utilized CUT&Tag, H3K27 acetylation enrichment, and RNA sequencing (RNA‐seq) to investigate the super‐enhancer (SE) regulatory landscapes of HSF1 in liver cancer cell lines. …”
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Oxamflatin and ascorbic acid improves developmental competence and quality of buffalo (Bubalis bubalis) cloned embryos by Sonal Gupta, Gaurav Tripathi, Kartikey Patel, Ram Parsad, Tanya Gupta, Naresh L. Selokar, Manoj Kumar Singh

“…In conclusion, the combined treatment with oxamflatin and ascorbic acid improves the in vitro and in vivo developmental potential in buffalo-cloned embryos, which could probably be due to decreased methylation and increased acetylation of the embryos. …”
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Inhaled [D-Ala2]-Dynorphin 1-6 Prevents Hyperacetylation and Release of High Mobility Group Box 1 in a Mouse Model of Acute Lung Injury by Vladislav N. Karkischenko, Veronika I. Skvortsova, Melik T. Gasanov, Yuriy V. Fokin, Maxim S. Nesterov, Nataliya V. Petrova, Oxana V. Alimkina, Igor A. Pomytkin

“…HMGB1 is a ubiquitous nuclear DNA-binding protein whose biological function depends on posttranslational modifications, its redox state, and its cellular localization. The acetylation of HMGB1 is a prerequisite for its translocation from the nucleus to the cytoplasm and then to the extracellular milieu. …”
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Aspirin inhibits proteasomal degradation and promotes α-synuclein aggregate clearance through K63 ubiquitination by Jing Gao, Yang Liu, Chenfang Si, Rui Guo, Shouqiao Hou, Xiaosong Liu, Houfang Long, Di Liu, Daichao Xu, Zai-Rong Zhang, Cong Liu, Bing Shan, Christoph W. Turck, Kaiwen He, Yaoyang Zhang

“…Abstract Aspirin is a potent lysine acetylation inducer, but its impact on lysine ubiquitination and ubiquitination-directed protein degradation is unclear. …”
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EPIGENETICS TODAY AND TOMORROW by B. F. Vanyushin

“…The most known epigenetic mechanisms (signals) are enzymatic DNA methylation, the histone code (various enzymatic histone modifications including acetylation, methylation, phosphorylation, ubiquitination and others), and gene silencing mediated by small RNAs (miRNA, siRNA). …”
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HDC1 Promotes Primary Root Elongation by Regulating Auxin and K⁺ Homeostasis in Response to Low-K⁺ Stress by Xiaofang Kuang, Hao Chen, Jing Xiang, Juan Zeng, Qing Liu, Yi Su, Chao Huang, Ruozhong Wang, Wanhuang Lin, Zhigang Huang

“…Histone modifications, such as de-/acetylation, can function as epigenetic markers of stress-inducible genes. …”
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Suberoylanilide Hydroxamic Acid Attenuates Autoimmune Arthritis by Suppressing Th17 Cells through NR1D1 Inhibition by Da Som Kim, Hong-Ki Min, Eun Kyung Kim, Seung Cheon Yang, Hyun Sik Na, Seon-Yeong Lee, Jeong-Won Choi, Kyung-Ah Jung, Seung-Ki Kwok, Sung-Hwan Park, Mi-La Cho

“…One of the pathological mechanisms of RA is known to involve histone acetylation. Although the histone deacetylase (HDAC) inhibitor suberoylanilide hydroxamic acid (SAHA) can attenuate arthritis in animal models of RA, the mechanism underlying this effect is poorly understood. …”
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The role of lactylation in tumor growth and cancer progression by Khulood Al-Malsi, Khulood Al-Malsi, Khulood Al-Malsi, Sinan Xie, Sinan Xie, Sinan Xie, Yunshi Cai, Yunshi Cai, Yunshi Cai, Nader Mohammed, Kunlin Xie, Kunlin Xie, Kunlin Xie, Tian Lan, Tian Lan, Tian Lan, Hong Wu, Hong Wu, Hong Wu

“…The ability of lactate to dynamically alter gene expression is further supported by its function as a histone deacetylase(HDAC)inhibitor and its impact on histone acetylation. Its wide-ranging involvement in cellular metabolism and epigenetic control has been demonstrated by the discovery of particular lactylation sites on histones in various cell types, including cancer cells.…”
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Comparative Structural and Biophysical Investigation of <i>Lycosa erythrognatha</i> Toxin I (LyeTx I) and Its Analog LyeTx I-b by Amanda Neves de Souza, Gabriele de Azevedo Cardoso, Lúcio Otávio Nunes, Christopher Aisenbrey, Evgeniy Salnikov, Kelton Rodrigues de Souza, Ahmad Saad, Maria Elena de Lima, Jarbas Magalhães Resende, Burkhard Bechinger, Rodrigo Moreira Verly

“…<b>Background/Objectives:</b> This study investigates the structural and biophysical properties of the wild-type antimicrobial peptide LyeTx I, isolated from the venom of the spider <i>Lycosa erythrognatha</i>, and its analog LyeTx I-b, designed to enhance antibacterial activity, selectivity, and membrane interactions by the acetylation and increased amphipathicty. <b>Methods</b>: To understand the mechanisms behind these enhanced properties, comparative analyses of the structural, topological, biophysical, and thermodynamic aspects of the interactions between each peptide and phospholipid bilayers were evaluated. …”
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Degradation kinetics, pathways, transformation products, and toxicity assessment of fluorochloridone in agricultural soils by Dong Zhao, Hongyu Chen, Shuo Shen, Enyu Lu, Junlong Feng, Hui Zhi, Lei Wang, Wei Li

“…The primary transformation reactions of FLC in the environment include oxidative dechlorination, reductive dechlorination, reductive defluorination, acetylation, and hydrolysis. Predictive assessments via ECOSAR, alongside empirical laboratory experiments, revealed that most novel TPs exhibit significantly lower acute toxicity towards Danio rerio, Daphnia magna Straus, and Algae compared to FLC. …”
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Molecular Characterization of the Tumor Suppressor Candidate 5 Gene: Regulation by PPARγ and Identification of TUSC5 Coding Variants in Lean and Obese Humans by Trina A. Knotts, Hyun Woo Lee, Jae Bum Kim, Pieter J. Oort, Ruth McPherson, Robert Dent, Keisuke Tachibana, Takefumi Doi, Songtao Yu, Janardan K. Reddy, Kenji Uno, Hideki Katagiri, Magdalena Pasarica, Steven R. Smith, Dorothy D. Sears, Michel Grino, Sean H. Adams

“…Chromatin immunoprecipitation (ChIP) experiments confirmed that PPARγ protein binds a ∼−1.1 kb promotor sequence of murine TUSC5 transiently during 3T3-L1 adipogenesis, concurrent with histone H3 acetylation. No change in Tusc5 mRNA or protein levels was evident in type 2 diabetic patients treated with pioglitazone. …”
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Microwave Assisted Heterocyclization: A Rapid and Efficient Synthesis and Antibacterial Activity of Novel Thiazolidinones by B. D. Naik, K. R. Desai

“…As a target to synthesize various Thiazolidinone derivatives, 2-Amino-4-(coumarin-3-yl)-thiazole has been prepared by the reactions of 3-Bromo acetyl coumarin with thiourea. 3-Bromo acetyl coumarin was prepared from 3-Acetyl coumarin. …”
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Synthesis and Antimicrobial Studies of Some Bis-Glycosyl Isodithiobiurets by Prashant R. Mahalle, Shirish P. Deshmukh

“…Certain 2-S-tetra-O-benzoyl-D-glucopyranosyl-1-aryl-5-tetra-O-acetyl–β-D-galactopyranosyl-2, 4- isodithiobiurets have been synthesized by the interaction of tetra-O-acetyl-β-D-galactopyranosyl isothiocyante and various S- tetra-O-benzoyl-D- glucopyranosyl-1-aryl isothiocarbamides. …”
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A New Triterpenoid Saponin and Antimicrobial Activity of Ethanolic Extract from Sapindus mukorossi Gaertn. by Amita Sharma, Satish Chandra Sati, Om Prakash Sati, Maneesha Dobhal Sati, Sudhir Kumar Kothiyal, Deepak Kumar Semwal, Anil Mehta

“…A new acetylated triterpenoid saponin elucidated as hederagenin-3-O-β-D-xylopyranosyl (2→1)-[3-O-acetyl-α-L-arabinopyranosyl-28-O-α-L-rhamnopyranosylester has been isolated from pericarps of Sapindus mukorossi Gaertn. …”
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Synthesis, Structural, and Antimicrobial Studies of Some New Coordination Compounds of Palladium(II) with Azomethines Derived from Amino Acids by Monika Gupta, Sangeeta Sihag, A. K. Varshney, S. Varshney

“…Azomethines used in these studies have been prepared by the condensation of 2-acetyl fluorene and 4-acetyl biphenyl with glycine, alanine, valine, and leucine in methanol. …”
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The Synthesis of the Locating Substitution Derivatives of Chitosan by Click Reaction at the 6-Position of Chitin by Yu Chen, Yanchun Ye, Yanyan Jing, YuanYuan Gao, Yanwen Guo, Huimin Tan

“…Ultimately, CTS-6-CD was obtained by removing the acetyl group of chitin unit. The structures and properties of these products were characterized by FTIR, TG, and XRD, respectively. …”
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