Cx43 Inhibition Attenuates Sepsis-Induced Intestinal Injury via Downregulating ROS Transfer and the Activation of the JNK1/Sirt1/FoxO3a Signaling Pathway by Zhaowei Zou, Bin Liu, Lisi Zeng, Xianzi Yang, Renli Huang, Cheng Wu, Huijuan Zhu, Yi Gao, Dongdong Yuan, Jinlong Yu

“…Firstly, different methods, such as Cx43 inhibitors (18-α-GA and oleamide) or siRNA targeting Cx43 and N-acetyl cysteine (NAC) (a kind of ROS scavenger), were used to observe the effects of Cx43 channels mediating ROS transfer on intestinal injury. …”
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Effects of Different Microplastics on Methane Production and Microbial Community Structure in Anaerobic Digestion of Cattle Manure by Mengjiao Zhang, Congxu Zhao, Tian Yuan, Qing Wang, Qiuxian Zhang, Shuangdui Yan, Xiaohong Guo, Yanzhuan Cao, Hongyan Cheng

“…Based on changes observed in key enzyme functional gene abundances, PHA MPs reduced acetyl-CoA carboxylase functional gene abundance, negatively affecting the acetone cleavage methanogenesis pathway. …”
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Herbicide resistance in Leptochloa chinensis (L.) Nees populations from different regions of Jiangsu Province, China: sensitivity differences and underlying mechanisms by Peng Xu, Ke Wang, Yawen Ju, Yousheng Fu, Axiu Zhu, Kaige Cao, Hongchun Wang

“…The proportion of populations resistant to acetyl-CoA carboxylase (ACCase)-inhibiting herbicides increased progressively from the south to the north of Jiangsu. …”
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Assessment of diversity of Indian aromatic rice germplasm collections for morphological, agronomical, quality traits and molecular characters to identify a core set for crop improv... by G. S. V. Prasad, G. Padmavathi, K. Suneetha, M. S. Madhav, K. Muralidharan

“…With PowerCore, 46 genotypes (22%) were identified as a core set of ARG that represent all the alleles detected in the entire set investigated. 2-Acetyl-1-pyrroline is considered to impart aroma; it was not detected by GC–MS tests in many ARG. …”
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Multi-omics analysis reveals the interplay between intratumoral bacteria and glioma by Ting Li, Zhanyi Zhao, Meichang Peng, Lu Zhang, Cheng Wang, Feiyang Luo, Meiqin Zeng, Kaijian Sun, Zhencheng Fang, Yunhao Luo, Yugu Xie, Cui Lv, Jiaxuan Wang, Jian-Dong Huang, Hongwei Zhou, Haitao Sun

“…Integrated microbiomics, transcriptomics, and metabolomics revealed that genes associated with intratumoral microbes were enriched in multiple synapse-associated pathways and that metabolites associated with intratumoral microbes were (R)-N-methylsalsolinol, N-acetylaspartylglutamic acid, and N-acetyl-l-aspartic acid. Further mediation analysis suggested that the intratumoral microbiome may affect the expression of neuron-related genes through bacteria-associated metabolites. …”
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Computer-guided identification of novel inhibitors of apoptosis-signaling kinase 1 from Spondia mombim bioactive compounds against colorectal cancer by Olusola Olalekan Elekofehinti, Hannah Oluwaseun Popoola, Adedotun Olayemi Oluwatuyi, Opeyemi Iwaloye, Moses Orimoloye Akinjiyan, Oluwamodupe Cecilia, Frank Abimbola Ogundolie, Olalekan Isaac Olatunde, Oussama Abchir, Samir Chtita, Joao Batista Texeira Rocha

“…Results Molecular docking studies identified 10 promising candidates which include uvaretin, rutin, isoquercitrin, ellagic acid, quercetin, linalool, acetyl eugenol, tangeretin (-)-catechin, and d-sorbitol based on their favorable binding affinity, with uvaretin having the best score (− 11.328 kcal/mol). …”
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Accumulation of advanced oxidation protein products aggravates bone-fat imbalance during skeletal aging by Yu-Sheng Huang, Jia-Wen Gao, Rui-Feng Ao, Xin-Yu Liu, Di-Zheng Wu, Jun-Long Huang, Chen Tu, Jing-Shen Zhuang, Si-Yuan Zhu, Zhao-Ming Zhong

“…Aged mice were also gavaged by non-selective antioxidant N‐acetyl‐L‐cysteine (NAC), followed by close monitoring of the changes in AOPPs levels and bone-fat metabolism. …”
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Effect of Tea Polyphenols, α-Lipoic Acid and Their Joint Use on the Antioxidant and Lipid Metabolism Performance of Hybrid Grouper (♀Epinephelus fuscoguttatus × ♂E. lanceolatu) Fed... by Xiangxiang Suo, Xiaobo Yan, Beiping Tan, Simiao Pan, Tao Li, Hao Liu, Weibin Huang, Shuang Zhang, Yuanzhi Yang, Xiaohui Dong

“…In contrast, the TL group had the highest fatty acid synthetase (FAS) activity (P<0.05). (5) The oil-red aspects of liver tissue displayed lipid particles in other groups were reduced to different degrees compared with FL group, and the OL group showed the best lipid-lowering effect. (6) Compared with the FL group, the relative expressions of FAS, acetyl-CoA carboxylase (acc), and apolipoprotein b-100 (apoB100) genes in the liver were decreased. …”
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Nouveaux triterpènes à activité antiplasmodiale isolés des feuilles de Neoboutonia macrocalyx L., une plante consommée par les chimpanzés du parc national de Kibale (Ouganda) by Jane Namukobe, Bernard T Kiremire, Robert Byamukama, John M Kasenene, Vincent Dumontet, Françoise Guéritte, Sabrina Krief, Isabelle Florent, John D Kabasa

“…L’investigation phytochimique de cet extrait guidé par l’activité biologique a conduit à l’isolement de 9 cycloartane triterpéniques nouveaux (1-9), un phénanthrène nouveau, le 7-methoxy-2,8 dimethyl-9,10-dihydrophenantherene-3,6 diol (10), ainsi que 3 composés connus, la 22-dé-O-acétyl-26-désoxynéoboutomellerone (11), la mellerine B (12) et le 6-hydroxystigmast-4-èn-3-one (13). …”
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High Concentration of Glucose Increases Reactive Oxygen Species Generation and Apoptosis Induced by Endoplasmic Reticulum Stress Pathway in Rabbit Corneal Epithelial Cells by Jiajun Lu, Minjie Sheng, Panpan Yao, Chaochao Ran, Hao Liu, Li Chen, Rui Liu, Bing Li

“…Meanwhile, the effects of N-acetyl-L-cysteine (NAC), an active oxygen inhibitor, on the experimental results were observed. …”
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Ursodeoxycholic acid protects against sepsis-induced acute kidney injury by activating Nrf2/HO-1 and inhibiting NF-κB pathway by Yunpeng Lou, Hongguang Shi, Ning Sha, Feifei Li, Xiaofeng Gu, Huiyan Lin

“…Kidney injury was evaluated by HE staining and biochemical markers, including serum creatinine (Cr), blood urea nitrogen (BUN), urinary protein, neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), N-acetyl-β-D-glucosaminidase (NAG), and retinol binding protein (RBP). …”
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FBR2 modulates ferroptosis via the SIRT3/p53 pathway to ameliorate pulmonary fibrosis by Yu Cheng, Yang Jiao, Wan Wei, Mengjia Kou, Yaodong Cai, Yang Li, Hao Li, Tonghua Liu

“…Furthermore, FBR2 increased SIRT3 levels and suppressed p53 and its acetylated forms, promoting the translocation of p53 from the nucleus to the cytoplasm where it co-localized with SIRT3. …”
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Breaking the biofilm barrier: Juglone derivatives as dual-action inhibitors and anti-quorum sensing agents by Muhammad Abdullah Bhatti, Atif Ali Khan Khalil, Sayed Muhammad Ata Ullah Shah Bukhari, Faisal Hanif, Mi-Jeong Ahn, Sumra Wajid Abbasi, Nazir Ahmed Lone, Wen-Jun Li, Wasim Sajjad

“…Among these compounds, 2-ethoxy-6-acetyl-7-methyljuglone displayed potent inhibitory activity with zones of inhibition of 15 ± 0.03 and 17 ± 0.03 against MRSA respectively. …”
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Comparison of sialic acid content in bovine and buffalo milk and meat by Michela Contò, Simona Rinaldi, Sebastiana Failla

“…Two significant SIAs in mammals are N-acetyl-neuraminic acid (Neu5Ac) and N- glycolylneuraminic acid (Neu-5Gc). …”
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Slowly digestible starch impairs growth performance of broiler chickens offered low-protein diet supplemental higher amino acid densities by inhibiting the utilization of intestina... by Caiwei Luo, Yao Yu, Gang Meng, Jianmin Yuan

“…Targeted metabolomics analysis revealed that the SDS diet significantly increased acetyl-CoA and α-ketoglutaric acid levels in the tricarboxylic acid (TCA) cycle (P < 0.05) but decreased the ileal digestibility of Lys, Tyr, Leu, Asp, Ser, Gly, Pro, Arg, Ile, and Val compared to the corn starch group (P < 0.05). …”
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Plasma Levels of Propionylcarnitine Improved Prediction of Heart Failure and All-Cause Mortality in Patients with Stable Coronary Artery Disease by Jairo Lumpuy-Castillo, Francisco J. Rupérez, Brenda Lee Simas Porto, Carmen Cristóbal, Nieves Tarín, Ana Isabel Huelmos, Joaquín Alonso, Jesús Egido, Ignacio Mahíllo-Fernández, Lorenzo López-Bescós, José Tuñón, Óscar Lorenzo

“…These patients showed increased plasma levels of NT-proBNP (1300 vs. 250 pg/mL; <i>p</i> < 0.001), pro-inflammatory/fibrotic MCP-1 (1.7 vs. 1.4 × 10² pg/mL; <i>p</i> = 0.043), Gal-3 (12.7 vs. 7.9 ng/mL; <i>p</i> < 0.001), and NGAL (2.7 vs. 1.6 × 10² ng/mL; <i>p</i> < 0.001), and lower acetyl- and propionylcarnitines (0.59 vs. 0.99 µM, <i>p</i> = 0.007, and 3.22 vs. 6.49 × 10⁻² µM, <i>p</i> < 0.001, respectively). …”
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FAM134B-mediated endoplasmic reticulum autophagy protects against cisplatin-induced spiral ganglion neuron damage by Fan Wang, Yue Xu, Yajie Wang, Qian Liu, Yanan Li, Weiwei Zhang, Huiming Nong, Junhong Zhang, Hao Zhao, Huaqian Yang, Lingchuan Guo, Jianfeng Li, Jianfeng Li, Hong Li, Qianqian Yang

“…Additionally, co-treatment with the N-Acetyl-L-Cysteine (NAC), ROS scavenger, alleviated Cis-induced ER stress, ER-phagy, and apoptosis. …”
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A murine model of acute and prolonged abdominal sepsis, supported by intensive care, reveals time-dependent metabolic alterations in the heart by Bart Jacobs, Inge Derese, Sarah Derde, Sarah Vander Perre, Lies Pauwels, Greet Van den Berghe, Jan Gunst, Lies Langouche

“…Intermediate glycolytic metabolites (hexose-phosphates, GADP, DHAP) were elevated (p ≤ 0.05), but gene expression of several enzymes for glycolysis and mitochondrial oxidation of pyruvate, fatty-acyl-CoA and ketone bodies to acetyl-CoA were suppressed in prolonged sepsis (p ≤ 0.05). …”
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Beta 3 adrenoreceptors protect from hypertrophic remodelling through AMP‐activated protein kinase and autophagy by Emilie Dubois‐Deruy, Roselle Gelinas, Christophe Beauloye, Hrag Esfahani, Lauriane Y.M. Michel, Chantal Dessy, Luc Bertrand, Jean‐Luc Balligand

“…Treatment of NRVM with PE induced hypertrophy and a decrease in phosphorylation of Thr172‐AMPK (/2, P = 0.0487) and phosphorylation of Ser79‐acetyl‐CoA carboxylase (ACC) (/2.6, P = 0.0317), inducing an increase in phosphorylated Ser235/236 S6 protein (×2.5, P = 0.0367) known to be involved in protein synthesis. …”
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EGFR inhibition augments the therapeutic efficacy of the NAT10 inhibitor Remodelin in Colorectal cancer by Yongbin Zheng, Dan Song, Ming Guo, Chenhong Wang, Mingzhen Ma, Gongcai Tao, Licui Liu, Xiaobo He, Fengyu Cao, Dan Luo, Qingchuan Zhao, Zhongyuan Xia, Yanxin An

“…The potential mechanisms of NAT10 in CRC were investigated using RNA sequencing, RNA immunoprecipitation sequencing, and acetylated RNA immunoprecipitation sequencing. Additional in vivo and in vitro experiments, including CCK-8 assays, colony formation and mouse xenograft models, were conducted to explore the biological role of NAT10-mediated ac4C modifications. …”
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