S100P is a ferroptosis suppressor to facilitate hepatocellular carcinoma development by rewiring lipid metabolism by Min Yang, Weiwei Cui, Xiaoting Lv, Gaozhong Xiong, Caiyu Sun, Haocheng Xuan, Wei Ma, Xiuling Cui, Yeping Cheng, Lihui Han, Bo Chu

“…Mechanistically, S100P facilitates lysosomal degradation of acetyl-CoA carboxylase alpha (ACC1), which is indispensable for de novo biosynthesis of lipids. …”
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Akkermansia muciniphila-directed polyphenol chlorogenic acid intervention for obesity in mice by Xiaoxiang Gao, Chenbo Yue, Ruocen Tian, Leilei Yu, Fengwei Tian, Jianxin Zhao, Wei Chen, Qixiao Zhai

“…Microbiome and metabolomics revealed that the increased abundance of A. muciniphila resulted from the inhibition of CGA on Desulfovibrio and Alistipes and the influence of docosahexaenoic acid, β-hydroxybutyrate, and N-acetyl-lactosamine. Finally, to confirm the regulation of CGA on A. muciniphila under disease conditions, high-fat diet-fed mice were established. …”
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Methylglyoxal Impairs Insulin Secretion of Pancreatic β-Cells through Increased Production of ROS and Mitochondrial Dysfunction Mediated by Upregulation of UCP2 and MAPKs by Jinshuang Bo, Shiya Xie, Yi Guo, Chunli Zhang, Yanming Guan, Chunmei Li, Jianxin Lu, Qing H. Meng

“…These effects of MG were attenuated by MG scavenger N-acetyl cysteine. Collectively, these data indicate that MG impairs insulin secretion of pancreatic β-cells through increasing ROS production. …”
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XPS-Characterization of Heterometallic Coordination Compounds with Optically Active Ligands by Yenny Ávila-Torres, Lázaro Huerta, Noráh Barba-Behrens

“…The heterometallic optical complexes [Cu2Co(S,S(+)cpse)3(H2O)3]·4H2O (1) and [Cu2Ni(S,S(+)cpse)3(H2O)3]·10H2O (2) were obtained from the mononuclear copper(II) compound by the addition of nickel(II) or cobalt(II) chlorides, where (H2cpse) is the acetyl amino alcohol derivative N-[2-hydroxy-1(R)-methyl-2(R)-phenylethyl]-N-methylglycine. …”
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Tripterygium Glycosides Tablet Ameliorates Renal Tubulointerstitial Fibrosis via the Toll-Like Receptor 4/Nuclear Factor Kappa B Signaling Pathway in High-Fat Diet Fed and Streptoz... by Ze-jun Ma, Xiao-na Zhang, Li Li, Wei Yang, Shan-shan Wang, Xin Guo, Pei Sun, Li-ming Chen

“…The results showed that 24 h proteinuria and urinary N-acetyl-glucosaminidase (NAG) in diabetic rats were decreased by TGT treatment without affecting blood glucose. …”
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Broad-spectrum bioactivities of a sulfated heteropolysaccharide from Bacillus tequilensis MYG163: antioxidant, anti-Inflammatory, anticancer, antimicrobial, and antibiofilm propert... by Maha Abdullah Alwaili, Mohammed A. Alshehri, Thanaa R. Abdulrahman, Faisal Miqad K. Albaqami, Abdullah Alghamdi, Mona Othman I. Albureikan, Taghreed Shamrani, Abdullah Albelasi, Mohammad El-Nablaway, Samy Selim, Ahmed Ghareeb

“…The strain produced 6.33 g/l of EPS-R1, which was identified as a sulfated heteropolysaccharide containing uronic acid, N-acetyl glucose amine, and various monosaccharides. …”
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Advanced Efficient Feature Selection Integrating Augmented Extreme Learning Machine and Particle Swarm Optimization for Predicting Nitrogen Use Efficiency and Yield in Corn by Josselin Bontemps, Isa Ebtehaj, Gabriel Deslauriers, Alain N. Rousseau, Hossein Bonakdari, Jacynthe Dessureault-Rompré

“…The results highlight that integrating soil health indicators such as enzyme activities (β-glucosidase [BG] and N-acetyl-β-D-glucosaminidase [NAG]) and soil proteins into nitrogen management models improves prediction accuracy, leading to enhanced productivity and environmental sustainability. …”
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Tartary buckwheat (Fagopyrum tataricum (L.) Gaertn) protein-derived antioxidant peptides: mechanisms of action and structure-activity relationship in Caco-2 cell models by Yiming Zhou, Xuanming She, Zhidong Chen, Yun Wei, Ying Xiao, Xiaoli Zhou

“…The results showed that after CR-8 intervention, the content of metabolites such as L-acetyl carnitine has increased. This indicated that CR-8 can improve the antioxidant capacity of damaged cells by intervening in multiple metabolic pathways. …”
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Improved insulin sensitivity and reproductive profile in overweight/obese PCOS patients undergoing integrative treatment with carnitines, L-arginine, L-cysteine and myo-inositol by Alessandro D. Genazzani, Christian Battipaglia, Martina Foschi, Elisa Semprini, Claudia Aio, Eleonora Spelta, Anna Kostrzak, Maria Laura Rusce, Anna Szeliga, Blazej Meczekalski

“…The hormonal profile, routine exams and insulin and C-peptide response to oral glucose tolerance test (OGTT) were evaluated before and after 12 weeks of a daily oral complementary treatment with L-carnitine (500 mg), acetyl-L-carnitine (250 mg), L-arginine (500 mg), L-cysteine (100 mg) and myo-inositol (1 gr). …”
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Lipid metabolic reprogramming and associated ferroptosis in osteosarcoma: From molecular mechanisms to potential targets by Zhiyang Yin, Guanlu Shen, Minjie Fan, Pengfei Zheng

“…Key enzymes such as adenosine triphosphate-citrate lyase (ACLY), acetyl-CoA synthetase 2 (ACSS2), fatty acid synthase (FASN) and stearoyl-CoA desaturase-1 (SCD1) are overexpressed in OS and associated with poor prognosis.Based on specific changes in metabolic processes, this review highlights potential therapeutic targets in the lipid metabolism and ferroptosis pathways, and in particular the HMG-CoA reductase inhibitor simvastatin has shown potential in inducing apoptosis and inhibiting OS metastasis. …”
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Effect of platelet activating factor antagonist treatment on gentamicin nephrotoxicity by A. Rodriguez-Barbero, E. Bosque, L. Rivas-Cabaero, M. Arévalo, J. M. López-Novoa

“…GENTA group showed a progressive increase in plasma creatinine, a drop in creatinine clearance and an increase in urinary excretion of N-acetyl-β-D-glucosaminidase and alkaline phosphatase. …”
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Characterization of the Sodium Multi-Vitamin Transporter in the Mosquito <i>Anopheles stephensi</i> and Its Capacity to Mobilize Pantothenate and Biotin by Jun Isoe, Brendan F. Riske, Megan E. Dobson, Hannah L. Kaylor, Jessica C. Brady, Yared Debebe, Laura M. Saavedra, Shirley Luckhart, Michael A. Riehle

“…Pantothenate (Pan), or vitamin B5, is essential for the synthesis of co-enzyme A (CoA), acetyl-CoA, and numerous downstream physiological processes. …”
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Biosynthesis of the Essential Fatty Acid Oxidation Cofactor Carnitine Is Stimulated in Heart and Liver after a Single Bout of Exercise in Mice by Tom L. Broderick, Frank A. Cusimano, Chelsea Carlson, Jeganathan Ramesh Babu

“…Free carnitine (FC) in plasma was assayed using acetyltransferase and [14C]acetyl-CoA in Swiss Webster mice after 1 hour of moderate-intensity treadmill running or 4 hours and 8 hours into recovery. …”
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Hematopoietic Stem Cell Function in a Murine Model of Sickle Cell Disease by Elisabeth H. Javazon, Mohamed Radhi, Bagirath Gangadharan, Jennifer Perry, David R. Archer

“…We observed partial restoration of engraftment by n-acetyl cysteine (NAC) treatment of KSL cells prior to transplantation. …”
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Microwave Assisted Synthesis of N-Substituted-7-hydroxy-4-methyl-2-oxoquinolines as Anticonvulsant Agents by P. Y. Pawar, P. M. Gaikwad, P. H. Balani

“…The compound 1-{4ɴ-[(substituted benzylidene)-amino]-biphenyl-4-yl}-7-hydroxy-4-methyl-1H-quinolin-2-one (3a-j) on cyclization with chloro acetyl chloride in presence of triethylamine as catalyst under microwave irradiation furnished 1-{4ʹ-[3-chloro-2-(substituted phenyl)-4-oxo-azetidin-1-yl]-biphenyl-4-yl}-7-hydroxy-4-methyl-1H-quinolin-2-one (4a-j). …”
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Particle-size fractions-dependent extracellular enzyme activity in sediments and implications for resource allocation in a subtropical mangrove ecosystem by L. Luo, J.-D. Gu

“…Among these fractions, the highest activities of phenol oxidase (PHO), β-D glucosidase (GLU), and N-acetyl-glucosiminidase (NAG) were found in sand, and greater than bulk sediments of both intertidal zone (IZ) and mangrove forest (MG). …”
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Inferring transcriptomic dynamics implicated in odor fatty acid accumulation in adipose tissue of Hulun Buir sheep from birth to market by Yechan Zhao, Zhangyan Li, Huimin Ou, Zhiliang Tan, Jinzhen Jiao

“…Furthermore, DEGs involved in lipid metabolism and branch-chain amino acid degradation pathways exhibited surge in expression at mid-fattening vs. weaning, with acetyl-CoA and branched-chain-CoA as intermediates, and driven by regulation of PPAR and AMPK signaling pathways. …”
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A Cardiac‐Targeting and Anchoring Bimetallic Cluster Nanozyme Alleviates Chemotherapy‐Induced Cardiac Ferroptosis and PANoptosis by Junyue Xing, Xiaohan Ma, Yanan Yu, Yangfan Xiao, Lu Chen, Weining Yuan, Yingying Wang, Keyu Liu, Zhiping Guo, Hao Tang, Kelong Fan, Wei Jiang

“…This work introduces a novel antioxidant therapeutic approach, utilizing libraries of tannic acid and N‐acetyl‐L‐cysteine‐protected bimetallic cluster nanozymes. …”
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Normal tissue radioprotection by amifostine via Warburg-type effects by Michael I. Koukourakis, Alexandra Giatromanolaki, Christos E. Zois, Dimitra Kalamida, Stamatia Pouliliou, Ilias V. Karagounis, Tzu-Lan Yeh, Martine I. Abboud, Timothy D. W. Claridge, Christopher J. Schofield, Efthimios Sivridis, Costantinos Simopoulos, Savvas P. Tokmakidis, Adrian L. Harris

“…A sharp reduction of acetyl-CoA and ATP levels in NCTC cells indicated reduced mitochondrial usage of pyruvate. …”
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Increased Susceptibility to Ethylmercury-Induced Mitochondrial Dysfunction in a Subset of Autism Lymphoblastoid Cell Lines by Shannon Rose, Rebecca Wynne, Richard E. Frye, Stepan Melnyk, S. Jill James

“…We also tested whether pretreating the autism LCLs with N-acetyl cysteine (NAC) to increase glutathione concentrations conferred protection from ethylmercury. …”
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