Altered Hepatic Lipid Metabolism Contributes to Nonalcoholic Fatty Liver Disease in Leptin-Deficient Ob/Ob Mice by James W. Perfield, Laura C. Ortinau, R. Taylor Pickering, Meghan L. Ruebel, Grace M. Meers, R. Scott Rector

“…Ob/Ob mice also had greater liver weights, hepatic triglyceride (TG) content, and markers of de novo lipogenesis, including increased hepatic gene expression and protein content of acetyl-CoA carboxylase (ACC), fatty acid synthase (FAS), and stearoyl-CoA desaturase-1 (SCD-1), as well as elevated gene expression of PPARγ and SREBP-1c compared with WT mice. …”
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Methodical approaches in experimental modelling of non-alcoholic fatty liver disease by N. V. Bivalkevich, Yu. K. Denisenko, T. P. Novgorodtseva

“…In the first the liver of laboratory animals is the main pathogenic target, metabolic disorders develop insignificantly (lines of animals with of Acetyl-CoA oxidase gene deletion, knockoutmice for methionine-adenosyl transferases-1А gene and animals with deleted specific hepatic phosphatase and tensin homologue gene). …”
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miR-197 Participates in Lipopolysaccharide-Induced Cardiomyocyte Injury by Modulating SIRT1 by Miaomiao Liu, Ying Zhang, Xiantong Cao, Tao Shi, Yang Yan

“…LPS restrained viability, the expressions of B-cell lymphoma-2 (Bcl-2) and SIRT1, but promoted apoptosis, LDH release, and levels of interleukin-6 (IL-6), interleukin-1β (IL-1β), acetyl (AC)-p53, BCL2-associated X (Bax), and cleaved caspase-3 in H9c2 cells. miR-197 inhibition reversed the effects of LPS on H9c2 cells. …”
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Inhibition of BRD4 attenuated IFNγ-induced apoptosis in colorectal cancer organoids by Akimi Yonezawa, Kana Shimomura, Koji Okamoto, Haruna Takeda

“…Brd4 is a transcriptional regulator that recognizes acetylated histones and is known to be involved in inflammatory responses. …”
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Formulation of new drug delivery systems for insulin from natural bioactive biocompatible polymers by Howida A. Fetouh, Engy E. A. Aleem, Najiyah H. Mohammed, Jihad M. Abd-Almajeed Aldesouky, Amel M. Ismail

“…No release observed at pH 1.2, 6.8 due strong bonding to acetyl group of chitin. Insulin@chitin-GG system showed sustained targeting insulin-release at pH: 6.8 > 7.4 > 1.2. …”
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RETROSPECTIVE STUDY OF THE EFFICACY OF LONG-TERM TREATMENT OF FELINE IDIOPATHIC CYSTITIS by Anca Bărbos, Vlad Luca, Alexandra Biriș, Radu Lăcătuș

“…Felines in group A receive food supplements (hydrolysed milk proteins, corn silk, D-mannose, Cosequin®, N-acetyl glucosamine) in 53.57% of cases compared to 42.86% of cases in group B. …”
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Hydrolase-Treated Royal Jelly Attenuates H2O2- and Glutamate-Induced SH-SY5Y Cell Damage and Promotes Cognitive Enhancement in a Rat Model of Vascular Dementia by Nualpun Sirinupong, Worrapanitch Chansuwan, Pratchaya Kaewkaen

“…Importantly, RJH significantly improved memory performance in Morris water maze test and radial arm maze and decreased the level of acetyl cholinesterase activity. In conclusion, RJH is the potential neuroprotective agent and cognitive enhancer for VaD.…”
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Astaxanthin Inhibits Interleukin-6 Expression in Cerulein/Resistin-Stimulated Pancreatic Acinar Cells by Min Seung Kwak, Joo Weon Lim, Hyeyoung Kim

“…The calcium chelator BAPTA-AM inhibited cerulein/resistin-induced NADPH oxidase activation and ROS production. Antioxidant N-acetyl cysteine (NAC) and ML171, a specific NADPH oxidase 1 inhibitor, suppressed cerulein/resistin-induced ROS production, NF-κB activation, and IL-6 expression. …”
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Synthesis, Crystal Structural Characterization and Biological Properties of Thiosemicarbazones of Schiff Bases Derived from 4-Acyl-2-pyrazoline-5-one by Arjunsinh Rana, Nayan Parekh, Harish Dabhi, Dipak Bhoi, Niraj Kumari

“…The crystal structure was determined by single x-ray diffraction. 4-Acetyl thiosemicarbazone-3-methyl-1-(4`-methylphenyl)-2-pyrazolin-5-one(AcPTMP-ths) crystallizes in the monoclinic system, space group P21/n with a=6.0828(7)Å, b=29.547(4)Å, c=7.9101(15)Å, α=90°, γ=95.602(15)°, γ=90°, V=1414.9(4) Å3, Z=4, Dc=1.429 mg/m3 and 4-Propionylthiosemicarbazone-3-methyl-1-(4`-methylphenyl)-2-pyrazolin-5-one (PropPTMP-ths) crystallizes in the monoclinic system, space group P21/c with a=13.5622(10)Å, b=13.3671(12)Å, c=22.151(2)Å, α=90°, β=93.13(7)°, γ=90°, V=4010.1(6) Å3, Z=8, Dc=1.310 mg/m3. …”
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Carboxymethyl Hyaluronan-Stabilized Nanoparticles for Anticancer Drug Delivery by Jessica L. Woodman, Min Sung Suh, Jianxing Zhang, Yuvabharath Kondaveeti, Diane J. Burgess, Bruce A. White, Glenn D. Prestwich, Liisa T. Kuhn

“…Carboxymethyl hyaluronic acid (CMHA) is a semisynthetic derivative of HA that is recognized by HA binding proteins but contains an additional carboxylic acid on some of the 6-hydroxyl groups of the N-acetyl glucosamine sugar units. These studies tested the ability of CMHA to stabilize the formation of calcium phosphate nanoparticles and evaluated their potential to target therapy resistant, CD44+/CD24−/low human breast cancer cells (BT-474EMT). …”
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Relationship between Blood Lipid Profiles and Risk of Lupus Nephritis in Children by Jiajia Liu, Wenqi Song, Dawei Cui

“…The blood lipid levels were positively correlated with 24-hour urine protein quantification, urea, creatinine, uric acid, urinary IgG, urinary microalbumin, urinary transferrin, urinary α1 microglobulin, and urinary N-acetyl glucosidase, respectively. Receiver-operating characteristic curves showed that combined detection of TC, TG, LDL-C, and VLDL-C had higher discrimination capacity than that in individual measures. …”
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Hepatic Stellate Cell-Derived Microvesicles Prevent Hepatocytes from Injury Induced by APAP/H2O2 by Renwei Huang, Qunwen Pan, Xiaotang Ma, Yan Wang, Yaolong Liang, Bingyan Dai, Xiaorong Liao, Mingyi Li, Huilai Miao

“…Rat and human hepatocytes, BRL-3A and HL-7702, were used to build hepatocytes injury models by n-acetyl-p-aminophenol n-(APAP) or H2O2 treatment. MVs were prepared from human and rat HSCs, LX-2, and HST-T6 and, respectively, added to injured BRL-3A and HL-7702 hepatocytes. …”
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In Vivo Evaluation of the Combined Anticancer Effects of Cisplatin and SAHA in Nonsmall Cell Lung Carcinoma Using [18F]FAHA and [18F]FDG PET/CT Imaging by Skye Hsin-Hsien Yeh, Ming Hsien Lin, I. I. Leo Garcia Flores, Uday Mukhopadhyay, Danial Young, Kazuma Ogawa, Jeong-Hwan Jeong, William Tong, Juri G. Gelovani, Nobuyoshi Fukumitsu

“…Immunochemical staining for acetyl-histone H3 confirmed the PET/CT imaging findings. …”
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Bicarbonates for the Prevention of Postoperative Renal Failure in Endovascular Aortic Aneurysm Repair: A Randomized Pilot Trial by Véronique Brulotte, François A. Leblond, Stéphane Elkouri, Éric Thérasse, Vincent Pichette, Pierre Beaulieu

“…Biomarkers of renal injury from urine (interleukin-18 (IL-18), neutrophil gelatinase-associated lipocalin (NGAL), N-acetyl-β-D-glucosaminidase (NAG), and kidney injury molecule 1 (KIM-1)) and blood (NGAL, cystatin C) were measured at baseline and 3, 24, and 48 h postoperatively. …”
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Dexmedetomidine alleviates acute kidney injury in a rat model of veno‐arterial extracorporeal membrane oxygenation by Min Yu, Shilin Wei, Xueyang Shen, Junjie Ying, Dezhi Mu, Xiangyang Wu, Yongnan Li

“…The levels of Kidney Injury Molecule-1 (KIM-1) and N-acetyl-β-D-glucosaminidase (NAG) were also significantly reduced. …”
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Natural Deep Eutectic Solvents as Green Alternatives for Extracting Bioactive Compounds from <i>Sideritis</i> Taxa with Potential Cosmetic Applications by Lamprini Zissi, Virginia D. Dimaki, Vassiliki S. Birba, Vassiliki C. Galani, Vassiliki Magafa, Sophia Hatziantoniou, Fotini N. Lamari

“…The BGG4 extracts of both <i>Sideritis</i> taxa had a rich phenolic profile, with the major ingredients being chlorogenic acid, verbascoside, and non-, mono- and di-acetylated allosyl hypolaetin glycosides. Although distinct quantitative differences in their composition compared to the respective 70% ethanol extracts, and between them were noted, overall, the content of secondary metabolites in both <i>S. raeseri</i> extracts was lower than that of the <i>S. clandestina</i> extracts. …”
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Straw return was more beneficial to improving saline soil quality and crop productivity than biochar in the short term by Ping Cong, Ping Cong, Jiashen Song, Jianxin Dong, Wenyan Su, Wenyan Su, Wenhao Feng, Hongyuan Zhang

“…Furthermore, CS increased soil EMF than CK by 71% and CB by 39%, which was caused by the increased activities of 1,4-β-glucosidase, β-1,4-N-acetyl-glucosaminidase, and leucine aminopeptidase. …”
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Survey and Identification of Fusarium Head Blight Pathogens of Wheat in the Western Cape Region of South Africa by Ali Al-Hashimi, Augustine Innalegwu Daniel, Omolola Aina, Morné Du Plessis, Marshall Keyster, Ashwil Klein

“…Mycotoxin profiling revealed that <i>F. culmorum</i> and <i>F. pseudograminearum</i> produced zearalenone, <i>F. culmorum</i> and <i>F. tricinctum</i> produced 15-acetyl-deoxynivalenol (15-ADON), while <i>F. pseudograminearum</i> produced nivalenol (NIV). …”
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Decarboxylase mediated oxalic acid metabolism is important to antioxidation and detoxification rather than pathogenicity in Magnaporthe oryzae by Chang Liu, Yi Wei, Yuejia Dang, Wajjiha Batool, Xiaoning Fan, Yan Hu, Zhengquan He, Shihong Zhang

“…Simultaneously, as feedback to the tricarboxylic acid (TCA) cycle, the decrease of formic acid in ΔMooxdc leads to the reduction of acetyl-CoA content, and two genes involved in the β-oxidation of fatty acids were also upregulated, which enhanced the fatty acid metabolism of the ΔMooxdc. …”
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A soy glycinin derived octapeptide protects against MCD diet induced non-alcoholic fatty liver disease in mice by Peng Ma, Rongrong Huang, Yu Ou

“…Through activation of SIRT1/AMPK pathway, SGP8 downregulated the expression of sterol regulatory element binding protein 1c (SREBP-1c) and its target genes ACC and FAS expression levels, and increased the phosphorylation level of acetyl CoA carboxylase (ACC). Furthermore, SGP8 also upregulated the expression of transcription factor peroxisome proliferator activated receptor α (PPARα), which was regulated by SIRT1/AMPK pathway, and its target gene CPT1 level. …”
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