Coupling Strategies for the Synthesis of Peptide-Oligonucleotide Conjugates for Patterned Synthetic Biomineralization by Joshua D. Carter, Thomas H. LaBean

“…The peptide, selected from a combinatorial library for its gold-binding behavior, was 12 amino acids long with an N-terminus acetyl cap. Formation of the conjugates was confirmed by gel electrophoresis and mass spectrometry while molecular recognition functionality of the peptide portion was verified using atomic force microscopy. …”
Get full text

Volatile Organic Compounds, Total Phenolic Content, Color, and Heating Uniformity of Lemon Peel as Affected by Rotational Speed of Turntable During Microwave Drying by Sevilay San, Işıl Barutçu Mazı

“…At 600W, formation of furan compounds (furfural, furfuryl alcohol, tetrahydrofurfuryl alcohol, 2-acetyl furan, 5-methyl furfural, and HMF) were identified. …”
Get full text

Target‐site mutations Ile1781Leu and Ile2041Asn in the ACCase2 gene confer resistance to fluazifop‐p‐butyl and pinoxaden herbicides in a johnsongrass accession from Arkansas, USA... by Fidel González‐Torralva, Jason K. Norsworthy

“…An accession with low susceptibility to the acetyl‐CoA carboxylase (ACCase)‐inhibiting herbicides fluazifop‐p‐butyl (fluazifop) and pinoxaden was collected in eastern Arkansas. …”
Get full text

Tripterygium Glycosides Tablet Ameliorates Renal Tubulointerstitial Fibrosis via the Toll-Like Receptor 4/Nuclear Factor Kappa B Signaling Pathway in High-Fat Diet Fed and Streptoz... by Ze-jun Ma, Xiao-na Zhang, Li Li, Wei Yang, Shan-shan Wang, Xin Guo, Pei Sun, Li-ming Chen

“…The results showed that 24 h proteinuria and urinary N-acetyl-glucosaminidase (NAG) in diabetic rats were decreased by TGT treatment without affecting blood glucose. …”
Get full text

Advanced Efficient Feature Selection Integrating Augmented Extreme Learning Machine and Particle Swarm Optimization for Predicting Nitrogen Use Efficiency and Yield in Corn by Josselin Bontemps, Isa Ebtehaj, Gabriel Deslauriers, Alain N. Rousseau, Hossein Bonakdari, Jacynthe Dessureault-Rompré

“…The results highlight that integrating soil health indicators such as enzyme activities (β-glucosidase [BG] and N-acetyl-β-D-glucosaminidase [NAG]) and soil proteins into nitrogen management models improves prediction accuracy, leading to enhanced productivity and environmental sustainability. …”
Get full text

Tartary buckwheat (Fagopyrum tataricum (L.) Gaertn) protein-derived antioxidant peptides: mechanisms of action and structure-activity relationship in Caco-2 cell models by Yiming Zhou, Xuanming She, Zhidong Chen, Yun Wei, Ying Xiao, Xiaoli Zhou

“…The results showed that after CR-8 intervention, the content of metabolites such as L-acetyl carnitine has increased. This indicated that CR-8 can improve the antioxidant capacity of damaged cells by intervening in multiple metabolic pathways. …”
Get full text

Improved insulin sensitivity and reproductive profile in overweight/obese PCOS patients undergoing integrative treatment with carnitines, L-arginine, L-cysteine and myo-inositol by Alessandro D. Genazzani, Christian Battipaglia, Martina Foschi, Elisa Semprini, Claudia Aio, Eleonora Spelta, Anna Kostrzak, Maria Laura Rusce, Anna Szeliga, Blazej Meczekalski

“…The hormonal profile, routine exams and insulin and C-peptide response to oral glucose tolerance test (OGTT) were evaluated before and after 12 weeks of a daily oral complementary treatment with L-carnitine (500 mg), acetyl-L-carnitine (250 mg), L-arginine (500 mg), L-cysteine (100 mg) and myo-inositol (1 gr). …”
Get full text

Lipid metabolic reprogramming and associated ferroptosis in osteosarcoma: From molecular mechanisms to potential targets by Zhiyang Yin, Guanlu Shen, Minjie Fan, Pengfei Zheng

“…Key enzymes such as adenosine triphosphate-citrate lyase (ACLY), acetyl-CoA synthetase 2 (ACSS2), fatty acid synthase (FASN) and stearoyl-CoA desaturase-1 (SCD1) are overexpressed in OS and associated with poor prognosis.Based on specific changes in metabolic processes, this review highlights potential therapeutic targets in the lipid metabolism and ferroptosis pathways, and in particular the HMG-CoA reductase inhibitor simvastatin has shown potential in inducing apoptosis and inhibiting OS metastasis. …”
Get full text

Effect of platelet activating factor antagonist treatment on gentamicin nephrotoxicity by A. Rodriguez-Barbero, E. Bosque, L. Rivas-Cabaero, M. Arévalo, J. M. López-Novoa

“…GENTA group showed a progressive increase in plasma creatinine, a drop in creatinine clearance and an increase in urinary excretion of N-acetyl-β-D-glucosaminidase and alkaline phosphatase. …”
Get full text

Characterization of the Sodium Multi-Vitamin Transporter in the Mosquito <i>Anopheles stephensi</i> and Its Capacity to Mobilize Pantothenate and Biotin by Jun Isoe, Brendan F. Riske, Megan E. Dobson, Hannah L. Kaylor, Jessica C. Brady, Yared Debebe, Laura M. Saavedra, Shirley Luckhart, Michael A. Riehle

“…Pantothenate (Pan), or vitamin B5, is essential for the synthesis of co-enzyme A (CoA), acetyl-CoA, and numerous downstream physiological processes. …”
Get full text

Biosynthesis of the Essential Fatty Acid Oxidation Cofactor Carnitine Is Stimulated in Heart and Liver after a Single Bout of Exercise in Mice by Tom L. Broderick, Frank A. Cusimano, Chelsea Carlson, Jeganathan Ramesh Babu

“…Free carnitine (FC) in plasma was assayed using acetyltransferase and [14C]acetyl-CoA in Swiss Webster mice after 1 hour of moderate-intensity treadmill running or 4 hours and 8 hours into recovery. …”
Get full text

Hematopoietic Stem Cell Function in a Murine Model of Sickle Cell Disease by Elisabeth H. Javazon, Mohamed Radhi, Bagirath Gangadharan, Jennifer Perry, David R. Archer

“…We observed partial restoration of engraftment by n-acetyl cysteine (NAC) treatment of KSL cells prior to transplantation. …”
Get full text

Particle-size fractions-dependent extracellular enzyme activity in sediments and implications for resource allocation in a subtropical mangrove ecosystem by L. Luo, J.-D. Gu

“…Among these fractions, the highest activities of phenol oxidase (PHO), β-D glucosidase (GLU), and N-acetyl-glucosiminidase (NAG) were found in sand, and greater than bulk sediments of both intertidal zone (IZ) and mangrove forest (MG). …”
Get full text

Normal tissue radioprotection by amifostine via Warburg-type effects by Michael I. Koukourakis, Alexandra Giatromanolaki, Christos E. Zois, Dimitra Kalamida, Stamatia Pouliliou, Ilias V. Karagounis, Tzu-Lan Yeh, Martine I. Abboud, Timothy D. W. Claridge, Christopher J. Schofield, Efthimios Sivridis, Costantinos Simopoulos, Savvas P. Tokmakidis, Adrian L. Harris

“…A sharp reduction of acetyl-CoA and ATP levels in NCTC cells indicated reduced mitochondrial usage of pyruvate. …”
Get full text

Increased Susceptibility to Ethylmercury-Induced Mitochondrial Dysfunction in a Subset of Autism Lymphoblastoid Cell Lines by Shannon Rose, Rebecca Wynne, Richard E. Frye, Stepan Melnyk, S. Jill James

“…We also tested whether pretreating the autism LCLs with N-acetyl cysteine (NAC) to increase glutathione concentrations conferred protection from ethylmercury. …”
Get full text

Endocrine and Metabolic Signaling in Retroperitoneal White Adipose Tissue Remodeling during Cold Acclimation by Aleksandra Jankovic, Aleksandra Korac, Biljana Buzadzic, Vesna Otasevic, Ana Stancic, Milica Vucetic, Milica Markelic, Ksenija Velickovic, Igor Golic, Bato Korac

“…What is more, after an initial decrease on day 1, a sequential increase in pyruvate dehydrogenase, acyl-CoA dehydrogenase, cytochrome c oxidase, and ATP synthase and a decrease in acetyl-CoA carboxylase (from day 3) were observed. …”
Get full text

New Insights into Behçet’s Syndrome Metabolic Reprogramming: Citrate Pathway Dysregulation by Anna Santarsiero, Pietro Leccese, Paolo Convertini, Angela Padula, Paolo Abriola, Salvatore D’Angelo, Faustino Bisaccia, Vittoria Infantino

“…Citrate is an intermediary metabolite synthesized in mitochondria, and when transported into the cytosol by the mitochondrial citrate carrier—SLC25A1-encoded protein—it is cleaved into acetyl-CoA and oxaloacetate by ATP citrate lyase (ACLY). …”
Get full text

Whole-Body Physiologically Based Pharmacokinetic Modeling of GalNAc-Conjugated siRNAs by Emilie Langeskov Salim, Kim Kristensen, Erik Sjögren

“…<b>Background/Objectives</b>: N-acetyl-galactosamine small interfering RNAs (GalNAc-siRNA) are an emerging class of drugs due to their durable knockdown of disease-related proteins. …”
Get full text

Polyamine Content of Enteral Nutrition Formulas: Effect of Daily Intake on the Feeding Tolerance of Patients During the First Week in the Intensive Care Unit by Manuel Sánchez, Eva Rodríguez-Hernández, Lorena Suárez, Begoña Cantabrana, María González-García

“…Differences existed among the analysed EN formulas. The <i>N</i>-acetyl putrescine content was higher than that of the remaining amines. …”
Get full text

Olfactory transport efficiency of the manganese oxide nanoparticles (II) after their single or multiple intranasal administrations by A. V. Romashchenko, M. B. Sharapova, D. V. Petrovskii, M. P. Moshkin

“…In addition, the decrease in the efficiency of olfactory transport observed after repeated administration of MnO-NPs was partially restored by intranasal application of mucolytic (0.01 M N-acetyl-L-cysteine). In this case, the concentration of particles in the olfactory bulb was proportional to the volume of the structure, which in particular depends on the number of synaptic contacts between the mitral cell of the olfactory bulb (OB) and olfactory epithelium (OE). …”
Get full text