Microbial metabolites and immune modulation by Hassan Ghasemi

“…For instance, butyrate epigenetically alters regulatory T cells (Tregs) by promoting histone acetylation, significantly enhancing their suppressive capacity and maintaining immune tolerance. …”
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Microwave Assisted Heterocyclization: A Rapid and Efficient Synthesis and Antibacterial Activity of Novel Thiazolidinones by B. D. Naik, K. R. Desai

“…As a target to synthesize various Thiazolidinone derivatives, 2-Amino-4-(coumarin-3-yl)-thiazole has been prepared by the reactions of 3-Bromo acetyl coumarin with thiourea. 3-Bromo acetyl coumarin was prepared from 3-Acetyl coumarin. …”
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Pantothenate kinase 4 controls skeletal muscle substrate metabolism by Adriana Miranda-Cervantes, Andreas M. Fritzen, Steffen H. Raun, Ondřej Hodek, Lisbeth L. V. Møller, Kornelia Johann, Luisa Deisen, Paul Gregorevic, Anders Gudiksen, Anna Artati, Jerzy Adamski, Nicoline R. Andersen, Casper M. Sigvardsen, Christian S. Carl, Christian T. Voldstedlund, Rasmus Kjøbsted, Stefanie M. Hauck, Peter Schjerling, Thomas E. Jensen, Alberto Cebrian-Serrano, Markus Jähnert, Pascal Gottmann, Ingo Burtscher, Heiko Lickert, Henriette Pilegaard, Annette Schürmann, Matthias H. Tschöp, Thomas Moritz, Timo D. Müller, Lykke Sylow, Bente Kiens, Erik A. Richter, Maximilian Kleinert

“…Conversely, increasing PanK4 levels in glycolytic muscle lowers acetyl-CoA and enhances glucose uptake. Our findings highlight PanK4 as an important regulator of acetyl-CoA levels, playing a key role in both muscle lipid and glucose metabolism.…”
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Synthesis and Antimicrobial Studies of Some Bis-Glycosyl Isodithiobiurets by Prashant R. Mahalle, Shirish P. Deshmukh

“…Certain 2-S-tetra-O-benzoyl-D-glucopyranosyl-1-aryl-5-tetra-O-acetyl–β-D-galactopyranosyl-2, 4- isodithiobiurets have been synthesized by the interaction of tetra-O-acetyl-β-D-galactopyranosyl isothiocyante and various S- tetra-O-benzoyl-D- glucopyranosyl-1-aryl isothiocarbamides. …”
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A New Triterpenoid Saponin and Antimicrobial Activity of Ethanolic Extract from Sapindus mukorossi Gaertn. by Amita Sharma, Satish Chandra Sati, Om Prakash Sati, Maneesha Dobhal Sati, Sudhir Kumar Kothiyal, Deepak Kumar Semwal, Anil Mehta

“…A new acetylated triterpenoid saponin elucidated as hederagenin-3-O-β-D-xylopyranosyl (2→1)-[3-O-acetyl-α-L-arabinopyranosyl-28-O-α-L-rhamnopyranosylester has been isolated from pericarps of Sapindus mukorossi Gaertn. …”
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Synthesis, Structural, and Antimicrobial Studies of Some New Coordination Compounds of Palladium(II) with Azomethines Derived from Amino Acids by Monika Gupta, Sangeeta Sihag, A. K. Varshney, S. Varshney

“…Azomethines used in these studies have been prepared by the condensation of 2-acetyl fluorene and 4-acetyl biphenyl with glycine, alanine, valine, and leucine in methanol. …”
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Study on Starch-Based Thickeners in Chyme for Dysphagia Use by Youdong Li, Lingying Li, Guoyan Liu, Li Liang, Xiaofang Liu, Jixian Zhang, Chaoting Wen, Xin Xu

“…In this study, we investigated the rheological properties (viscosity, thixotropy, and viscoelasticity), textural properties, and swallowing behaviour of commercially available natural, pregelatinised, acetylated, and phosphorylated maize starch and tapioca starch. …”
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The Synthesis of the Locating Substitution Derivatives of Chitosan by Click Reaction at the 6-Position of Chitin by Yu Chen, Yanchun Ye, Yanyan Jing, YuanYuan Gao, Yanwen Guo, Huimin Tan

“…Ultimately, CTS-6-CD was obtained by removing the acetyl group of chitin unit. The structures and properties of these products were characterized by FTIR, TG, and XRD, respectively. …”
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Diosgenin and solasodine-based saponins and sapogenines—Effects of structural modifications on Panagrellus redivivus, Spodoptera littoralis and Trichoderma reesei by Christina Rodler, Johann Schinnerl, Miriam Schalamun, Wolfgang Hinterdobler, Lothar Brecker

“…The same reaction was applied to (22R,25R)-spirost-5-en-3β-yl α-d-3′,4′,6′-tri-O-acetyl-glucopyranoside and (22R,25R)-spirost-5-en-3β-yl β-d-2′,3′,6′-tri-O-acetyl-glucopyranosyl-(1 → 4)-β-d-8′,9′,10′,12′-tetra-O-acetyl-glucopyranoside, leading to new compounds. …”
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The role of isoniazid dosage and NAT2 gene polymorphism in the treatment of tuberculous meningitis by Yi Jian, Yuhang Bao, Fashuang Yang, Mei Zhu

“…The NAT2 genotypes were distributed as follows: 34 (28.6%) fast acetylators (FA), 73 (61.3%) intermediate acetylators (IA), and 12 (10.1%) slow acetylators (SA). …”
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Fast Hadamard-Encoded 7T Spectroscopic Imaging of Human Brain by Chan Hong Moon, Frank S. Lieberman, Hoby P. Hetherington, Jullie W. Pan

“…Linear regressions of creatine/N-acetyl aspartate and glutamate/N-acetyl aspartate with tissue gray matter content are consistent with literature values. …”
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A Novel Synthesis of 1,2,3-Benzotriazinones from 2-(o-Aminophenyl)oxazolines by Fernando Rocha-Alonzo, Daniel Chávez, Adrián Ochoa-Terán, David Morales-Morales, Enrique F. Velázquez-Contreras, Miguel Parra-Hake

“…The crystal structure of the acetyl derivative of one of the 1,2,3-benzotriazinones provided additional support for the spectroscopic structural characterization of the title compounds.…”
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Cyanuric Chloride as an Efficient Catalyst for the Synthesis of 2,3-Unsaturated O-Glycosides by Ferrier Rearrangement by Xiaojuan Yang, Na Li

“…Cyanuric chloride has been found to be an efficient catalyst for the synthesis of 2,3-unsaturated O-glycosides from the reaction of 3,4,6-tri-O-acetyl-D-glucal and a wide range of alcohols in dichloromethane at room temperature. …”
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E4F1 coordinates pyruvate metabolism and the activity of the elongator complex to ensure translation fidelity during brain development by Michela Di Michele, Aurore Attina, Pierre-François Roux, Imène Tabet, Sophie Laguesse, Javier Florido, Morane Houdeville, Armelle Choquet, Betty Encislai, Giuseppe Arena, Carlo De Blasio, Olivia Wendling, François-Xavier Frenois, Laura Papon, Lucille Stuani, Maryse Fuentes, Céline Jahannault Talignani, Mélanie Rousseau, Justine Guégan, Yoan Buscail, Pierrick Dupré, Henri-Alexandre Michaud, Geneviève Rodier, Floriant Bellvert, Hanna Kulyk, Carole Ferraro Peyret, Hugo Mathieu, Pierre Close, Francesca Rapino, Cédric Chaveroux, Nelly Pirot, Lucie Rubio, Adeline Torro, Tania Sorg, Fabrice Ango, Christophe Hirtz, Vincent Compan, Elise Lebigot, Andrea Legati, Daniele Ghezzi, Laurent Nguyen, Alexandre David, Claude Sardet, Matthieu Lacroix, Laurent Le Cam

“…Using genetically engineered mouse model and primary neuronal cells, we identify the transcription factor E4F1 as a key coordinator of AcetylCoenzyme A (AcCoA) production by the pyruvate dehydrogenase complex (PDC) and its utilization as an essential co-factor by the Elongator complex to acetylate tRNAs at the wobble position uridine 34 (U34). …”
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Novel 2,3-unsaturated O-glycosides containing an alkynyl function in their aglycones by Adriana C.N. de Melo, Natália M. Bezerra, Rajendra M. Srivastava, Carlos Alberto de Simone

“…Two compounds, namely, (R)-(+)-3-butyn-2-yl 4,6-di-O-acetyl-2,3-dideoxy-α-D-erythro-hex-2-enopyranoside, 3d, and (R)-(+)-3-butyn-2-yl 4,6-di-O-acetyl-2,3-dideoxy-α-D-threo-hex-2-enopyranoside, 4d, were subjected to X-ray diffraction analyses and their experimental values compared with the calculated values obtained by molecular orbital calculations. …”
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Modulation of cytokine production by carnitine by Nicola M. Kouttab, Claudio De Simone

“…The results showed that at 50 μg/ml of acetyl L-carnitine the most significant response was obtained for TNFα. …”
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A Multidisciplinary Investigation to Determine the Structure and Source of Dimeric Impurities in AMG 517 Drug Substance by Maria Victoria Silva Elipe, Zhixin Jessica Tan, Michael Ronk, Tracy Bostick

“…Further investigation revealed that these two dimeric impurities originated from existing impurities in the AMG 517 starting material, N-acetyl benzothiazole. The characterization of these two dimeric impurities allowed for better quality control of new batches of the N-acetyl benzothiazole starting material. …”
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Semisynthesis of Derivatives of Oleanolic Acid from Syzygium aromaticum and Their Antinociceptive and Anti-Inflammatory Properties by Sibusiso Rali, Opeoluwa O. Oyedeji, Olukayode O. Aremu, Adebola O. Oyedeji, Benedicta N. Nkeh-Chungag

“…In the formalin-induced pain test, the derivatives showed better analgesic effects compared to their precursor, whereas, in the tale flick test, oleanolic acid proved to be superior in analgesic effects compared to all its derivatives with the exception of the acetyl derivative. Acute inflammatory tests showed that acetyl derivatives possessed better anti-inflammatory activity compared to the other compounds. …”
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Interrelationship between altered metabolites and the gut microbiota in people living with HIV with different immune responses to antiretroviral therapy by Xuebin Tian, Zhongyao Gao, Yiwen Xie, Xiangyun Lu, Yulong Zhao, Peng Yao, Mingqing Dong, Lifeng Yu, Nanping Wu

“…Moreover, mRNA expression analysis showed that Indole-3-acetyl-beta-1-D-glucoside treatment led to a suppression of pro-inflammatory cytokines. …”
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Determination of Polar Pesticides Based on a Modified QuPPe with Liquid Chromatography Coupled to Tandem Mass Spectrometry by Gözde Türköz Bakirci

“…Maleic hydrazide, glyphosate, glufosinate N-acetyl, glufosinate ammonium, fosetyl Al, ethephon, chlormequat chloride, aminomethyl phosphonic acid N-acetyl, aminomethyl phosphonic acid, cyanuric acid, ethylene thiourea, phosphonic acid, propylene thiourea, and acidified methanol solution were used to extract tomato, wheat, olive, sunflower, and herbal tea samples. …”
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