TARGET Protein: the effect of augmented administration of enteral protein to critically ill adults on clinical outcomes—statistical analysis plan for a cluster randomized, cross-se... by Sophie Zaloumis, Matthew J. Summers, Jeffrey J. Presneill, Rinaldo Bellomo, Lee-anne S. Chapple, Marianne J. Chapman, Adam M. Deane, Suzie Ferrie, Craig French, Sally Hurford, Nima Kakho, Matthew J. Maiden, Stephanie N. O’Connor, Sandra L. Peake, Emma J. Ridley, An Tran-Duy, Patricia J. Williams, Paul J. Young, Amalia Karahalios, on behalf of the TARGET Protein Investigators, the Australian, New Zealand Intensive Care Society Clinical Trials Group

“…All statistical models will account for the cluster-randomized cross-over design to ensure correct estimation of the 95% confidence intervals. …”
Get full text

Formation of the Figge Maar Seafloor Crater During the 1964 B1 Blowout in the German North Sea by Jens Karstens, Jens Schneider von Deimling, Christian Berndt, Christoph Böttner, Michel Kühn, Benedict T. I. Reinardy, Axel Ehrhardt, Jonas Gros, Bettina Schramm, Dirk Klaeschen, Judith Elger, Matthias Haeckel, Mark Schmidt, Sven Heinrich, Philipp Müller, Frithjof Bense

“…The focused discharge of gas at the seafloor removed up to 4.8 Mt of sediments in the following weeks of vigorous venting. Eyewitness accounts document that the initial phase of crater formation was characterized by the eruptive expulsion of fluids and sediments cutting deep into the substrate. …”
Get full text

Odor symptom management in patients with malignant wounds in Mali: the use of a cinnamon dressing by Charlotte Ngô, Fatoumata M Sidibe, Sophie Goossens, Dianeko Zenabou Tapa, Irène Kriegel, Abdramane A Kone, Moussa Bathily, Hamidou D Doumbia, Claire Rieux, Isabelle Fromantin

“…The cinnamon dressing had no effect on appetite, but most of the patients were undergoing palliative chemotherapy, which may account for this result. Conclusion The use of innovative dressings is feasible, even in very deprived contexts, and might decrease the discomfort linked with unpleasant odors in tumoral wounds. …”
Get full text

Conception of a mobile health application targeting early postoperative physiotherapeutic care after total knee replacement, a qualitative study by Hassan Tarek Hakam, Hassan Tarek Hakam, Hassan Tarek Hakam, Nikolai Ramadanov, Nikolai Ramadanov, Awda Garzuzi, Mikhail Salzmann, Mikhail Salzmann, Hannes Hofmann, Hannes Hofmann, Felix Muehlensiepen, Felix Muehlensiepen, Roland Becker, Roland Becker, Robert Prill, Robert Prill, Robert Prill

“…Final changes were then undertaken to account for the expert's opinions.ResultsSeveral reviews with recommendations for the design of applications targeting patients after total joint replacement were identified. …”
Get full text

Donor Small-Droplet Macrovesicular Steatosis Affects Liver Transplant Outcome in HCV-Negative Recipients by Flaminia Ferri, Quirino Lai, Antonio Molinaro, Edoardo Poli, Lucia Parlati, Barbara Lattanzi, Gianluca Mennini, Fabio Melandro, Francesco Pugliese, Federica Maldarelli, Alessandro Corsi, Mara Riminucci, Manuela Merli, Massimo Rossi, Stefano Ginanni Corradini

“…No data are available on liver transplantation (LT) outcome and donor liver steatosis, classified as large droplet macrovesicular (Ld-MaS), small-droplet macrovesicular (Sd-MaS), and true microvesicular (MiS), taking into account the recipient Hepatitis C virus (HCV) status. …”
Get full text

Mineralogy and geochemistry of shale from Shanxi Formation, Southern North China Basin: Implication for organic matter accumulation by Qian Chen, Pei Li, Xiaoliang Wei, Changsheng Chen, Wei Dang, Haikuan Nie, Jinchuan Zhang

“…The Shanxi Shale is primarily composed of clay minerals (34.24 %–75.20 %) and quartz (23.80%–46.39 %), with a notably low carbonate content (<5 %). (2) Illite in the lower sections of the Shanxi Shale is likely sourced from detrital input rather than chemical conversion, while the dissolution of potassium feldspar may account for the elevated kaolinite content. This is further supported by the oxygen level variations between the lower and upper shale intervals. …”
Get full text

Phylogenetic and pangenomic analyses of members of the family <i>Micrococcaceae</i> related to a plant-growth-promoting rhizobacterium isolated from the rhizosphere of potato (<i>S... by S. Yu. Shchyogolev, G. L. Burygin, L. A. Dykman, L. Yu. Matora

“…However, these strains were isolated from strongly contrasting ecological and geographical habitats, which could not but affect their genotypes and phenotypes and which should be taken into account in evaluation of their systematic position. …”
Get full text

Incidence and predictors of respiratory tract infections among birth cohorts in Ethiopia, 2023 by Fekade Demeke Bayou, Mastewal Arefaynie, Anissa Mohammed, Abiyu Abadi Tareke, Awoke Keleb, Natnael Kebede, Yawkal Tsega, Bayu Hailemariam Mersha, Abel Endawkie, Shimels Derso Kebede, Kaleab Mesfin Abera, Eyob Tilahun Abeje, Ermias Bekele Enyew, Chala Daba, Lakew Asmare

“…It is one of the major causes of under-five mortality in Ethiopia, accountable for 18% of total deaths. Nationwide studies on the incidence of respiratory infections and maternal risk factors are limited. …”
Get full text

Renal Dysfunction among Ghanaians Living with Clinically Diagnosed Hypertension in the Asutifi-South District: A Cross-Sectional Descriptive Study at the St. Elizabeth Hospital, Hw... by Sylvester Yao Lokpo, James Osei-Yeboah, William K. B. A. Owiredu, Francis Abeku Ussher, Verner Ndudiri Orish, Felix Gadzeto, Paul Ntiamoah, Felix Botchway, Ivan Muanah, Romeo Asumbasiya Aduko

“…Femininity, older age, disease comorbidity with diabetes, Thiazide diuretic and AR Blocker usage, and increasing duration of medication accounted for higher kidney dysfunction. Regular screening and management are therefore recommended to avert progression to end-stage renal failure (ESRD).…”
Get full text

Exploring the association between pro-inflammatory diets and chronic liver diseases: evidence from the UK Biobank by Lili Pan, Lili Pan, Zhengrong Xu, Yining Li, Guoen Cai, Haibing Gao, Shenglong Lin

“…Competing risk analyses, which accounted for cirrhosis, liver cancer, and death, supported these findings. …”
Get full text

Hydrothermal conditions dominated sensitivity and lag effect of grassland productivity in Yunnan Province, China: Implications for climate change by Yan Fang, Long Wan, Jing Tong, Guijing Li, Jing Pang, Enfu Chang, Linglan Chen, Zixuan Shi

“…The areas where grassland productivity with a 3-month lag effects in response to temperature, precipitation, and solar radiation accounted for 25.26 %, 34.52 %, and 16.04 % of the region, respectively. …”
Get full text

Long-Term Outcomes of Mechanical Thrombectomy for Stroke: A Meta-Analysis by David J. McCarthy, Anthony Diaz, Dallas L. Sheinberg, Brian Snelling, Evan M. Luther, Stephanie H. Chen, Dileep R. Yavagal, Eric C. Peterson, Robert M. Starke

“…The study was carried out according to PRISMA guidelines and random effects analysis was carried out to account for heterogeneity. Three trials were included: IMS III, MR CLEAN, and REVASCAT, comprising a total of 1,362 patients. …”
Get full text

Adverse Events of the BCG (Bacillus Calmette–Guérin) and Rotavirus Vaccines in a Young Infant with Inborn Error of Immunity by Suleiman Al-Hammadi, Najla S. Alkuwaiti, Ghassan A. Ghatasheh, Huda Al Dhanhani, Hiba M. Shendi, Abdulghani S. Elomami, Farida Almarzooqi, Abdul-Kader Souid

“…This unguided practice does not account for the children with immunodeficiency, which frequently manifests after the administration of these vaccines. …”
Get full text

Waste ceramic powder for sustainable concrete production as supplementary cementitious material by Yasin Onuralp Özkılıç, Yasin Onuralp Özkılıç, Alireza Bahrami, Yusuf Güzel, Ali Sinan Soğancı, Memduh Karalar, Essam Althaqafi, Ali İhsan Çelik, Özer Zeybek, P. Jagadesh

“…Furthermore, taking into account our experimental research and previous studies on concrete produced utilizing WCP, straightforward equations were provided for practical use to predict CS, STS, and FS. …”
Get full text

A woman’s place is in theatre: women’s perceptions and experiences of working in surgery from the Association of Surgeons of Great Britain and Ireland women in surgery working grou... by Maria Irene Bellini, Yitka Graham, Catherine Hayes, Roxanna Zakeri, Rowan Parks, Vassilios Papalois

“…Orthopaedics was reported as the most sexist surgical specialty by 53% (n=43). Accounts of gendered language in the workplace were reported by 59% (n=47), with 32% (n=25) of surveys participants having used it. …”
Get full text

Molecular Mechanisms of Neurodegeneration Related to C9orf72 Hexanucleotide Repeat Expansion by Mirjana Babić Leko, Vera Župunski, Jason Kirincich, Dinko Smilović, Tibor Hortobágyi, Patrick R. Hof, Goran Šimić

“…Although the exact molecular mechanisms through which C9orf72 repeat expansions account for neurodegeneration have not been elucidated, some potential therapeutics, such as antisense oligonucleotides targeting hexanucleotide GGGGCC repeats in mRNA, were successful in preclinical trials and are awaiting phase 1 clinical trials. …”
Get full text

Specific and common therapeutic factors in psychodynamic psychotherapy for children and adolescents: an overview by Sabine Sammer-Schreckenthaler, Gloria Lagetto, Human-Friedrich Unterrainer, Human-Friedrich Unterrainer, Human-Friedrich Unterrainer, Human-Friedrich Unterrainer, Omar C. G. Gelo, Omar C. G. Gelo

“…Future qualitative and quantitative research should address more in detail the extent to which specific factors, common factors, or both account for the effectiveness of PPCA. Identifying empirically supported specific and common factors and their possible interaction can inform and improve clinical practice and training.…”
Get full text

Global, regional and national epidemiological trends of multiple myeloma from 1990 to 2021: a systematic analysis of the Global Burden of Disease study 2021 by Linmin Zhuge, Xiaowu Lin, Ziwei Fan, Mengxian Jia, Chaowei Lin, Minyu Zhu, Honglin Teng, Guoliang Chen

“…Known epidemiological data suggest that MM accounts for approximately 10% of all hematologic malignancies and remains the second most common hematologic cancer worldwide. …”
Get full text

Exploring genetic associations and drug targets for mitochondrial proteins and schizophrenia risk by Wenxi Sun, Ping Sun, Jin Li, Qun Yang, Qing Tian, Shiting Yuan, Xueying Zhang, Peng Chen, Chuanwei Li, Xiaobin Zhang

“…We conducted bidirectional two-sample Mendelian randomization (MR) analyses, with inverse variance weighting (IVW) as the primary method. To account for multi-directionality and ensure robustness, we included MR-Egger, weighted median (WM), weighted mode, and simple mode methods as supplementary sensitivity analyses. …”
Get full text

Umbilical Cord Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Deliver miR-21 to Promote Corneal Epithelial Wound Healing through PTEN/PI3K/Akt Pathway by Xiaolong Liu, Xuran Li, Guangyuan Wu, Pengfei Qi, Yanyan Zhang, Zhiyu Liu, Xinyue Li, Yu Yu, Xiangmei Ye, Yang Li, Dongguang Yang, Yueqiu Teng, Ce Shi, Xin Jin, Sen Qi, Yuting Liu, Shudan Wang, Ying Liu, Fenglin Cao, Qingran Kong, Zhenkun Wang, Hong Zhang

“…Mesenchymal stem cells (MSCs) can be taken into account as the promising regenerative therapeutics for improvement of wound healing processes based on the variety of the effective components. …”
Get full text