PTEN suppresses renal cell carcinoma proliferation and migration via inhibition of the PI3K/AKT pathway by Xu Xu, Yuan-Yue Tang, Xiaohong Liang, Wen Luo, Dong-Mei Jiang, Jie Chen

“…In 786-O cells with low PTEN expression, further induction of PTEN overexpression significantly inhibited PI3K/AKT signaling activity (p < 0.01), accompanied by decreased cell viability and migration ability. …”
Get full text

The Ethical Challenges of Gamification in Iran: Uncovering the Dark Side by Mona Jami Pour, Hamideh Binaei

“…Despite the undeniable advantages of gamification in businesses and its impact on individuals and societies, its implementation is accompanied by a wide range of challenges. There have been limited studies addressing its ethical aspects in Iran; therefore, the present study aims to identify and prioritize the ethical challenges of gamification in Iran to improve the design and application of gamification by understanding its dark aspects. …”
Get full text

Lithuanian exile press during five decades of soviet ban by Silvija Vėlavičienė

“…The main event, which marked the beginning of cultural infiltration by emigrant representatives, was the journey of junior Lithuanian emigrant basketball players and the accompanying delegation to Lithuania, during which particularly large numbers of emigrant publications were brought and distributed. …”
Get full text

Bernardin de Saint-Pierre’s paratexts: ‘j’ai senti, j’ai aimé, j’ai parlé’ by Simon Davies

“…The third edition of this work (1788) featured the first appearance of Paul et Virginie. This was accompanied by another paratext, where Bernardin discusses appropriate book sizes suggested by different social groups (he favours in-12). …”
Get full text

IMPACT OF ENERGY PRICES ON PRICES OF BASIC TOURISM SERVICES IN THE EURO AREA by Lachezar Borisov

“…The period of recovery has been accompanied by significant inflationary processes and a shock increase in the prices of energy products, further provoked by the war on the territory of Ukraine. …”
Get full text

Assessment in education: Current trends, problems and contradictions (review of scientific publications) by I. B. Shmigirilova, A. S. Rvanova, O. V. Grigorenko

“…Global trends in educational assessment are reflected in national education systems, many of which have made the transition to criteria-based assessment. This process is accompanied by a rapid increase in the volume of scientific and methodological publications on this issue, reducing the ability of scientists and practising educators to comprehend the cumulative evidence in this area of research, which is important at the stage of reform. …”
Get full text

Alteration, mineralization, geochemistry and fluid inclusion investigations in Joftrud prospect area, southwest of Birjand by Omid Shareipour, Azadeh Malekzadeh Shafaroudi, Maryam Javidi Moghaddam

“…Extensive magmatic activity in the Lut Block, is accompanied with numerous mineralization events such as porphyry copper, IOCG, vein and skarn (Karimpour et al., 2012). …”
Get full text

Exploring Disparities in Gill Physiological Responses to NaHCO₃-Induced Habitat Stress in Triploid and Diploid Crucian Carp (<i>Carassius auratus</i>): A Comprehensive I... by Shicheng Han, Lin Han, Fangying Yuan, Wenzhi Liu, Jing Wang, Xiaofeng Jin, Yanchun Sun

“…<b>Conclusions</b>: Overall, NaHCO₃-induced stress leads to significant gill tissue damage, accompanied by reactive oxygen species (ROS) production causing oxidative stress and disruptions in lipid metabolism in crucian carp. …”
Get full text

Estrogen-related receptor gamma is a regulator of mitochondrial, autophagy, and immediate-early gene programs in spiny projection neurons: Relevance for transcriptional changes in... by Stephanie N. Fox, Cody H. Savage, Narcy R. Amireddy, Laura J. McMeekin, David K. Crossman, Peter J. Detloff, Michelle Gray, Rita M. Cowell

“…We found an increase in Esrrg expression in HD models, accompanied by a transcriptional profile with similarities to that observed with Esrrg overexpression, suggesting the existence of an ERRγ-dependent, stress-related response. …”
Get full text

Evaluation of the Prognostic Value of Red Cell Distribution Width to Total Serum Calcium Ratio in Patients with Acute Pancreatitis by Tian-Yong Han, Tao Cheng, Bo-Fu Liu, Ya-Rong He, Pan Pan, Wen-Tao Yang, Qiang-Lai, Yu Cao

“…RDW/TSC may be a new method to identify the AP patients who need to be transferred to the ICU, accompanying complications which need surgery treatment, or may be died in hospital at an early stage, and we should pay more attention to RDW/TSC in patients with AP, for they may have a worse prognosis.…”
Get full text

Immune-checkpoint-inhibitor therapy directed against PD-L1 is tolerated in the heart without manifestation of cardiac inflammation in a preclinical reversible melanoma mouse model by Caroline Schoenherr, Caroline Schoenherr, Stefan Pietzsch, Stefan Pietzsch, Cristina Barca, Franziska E. Müller, Frauke S. Bahr, Martina Kasten, Andre Zeug, Sergej Erschow, Christine S. Falk, Evgeni Ponimaskin, James T. Thackeray, Denise Hilfiker-Kleiner, Denise Hilfiker-Kleiner, Melanie Ricke-Hoch

“…ICI-based therapy is frequently accompanied by immune-related adverse side effects (IRAEs). …”
Get full text

Superior liver protection in mice fed total parenteral nutrition containing the novel lipid emulsion Vegaven as compared to a mixed-oil lipid emulsion containing fish oil by Eliana Lucchinetti, Phing-How Lou, Alessandro Quaranta, Craig E. Wheelock, Akash Chakravarty, Martin Hersberger, Stefanie D. Krämer, Michael Zaugg

“…Results: Whole-body insulin resistance as measured by HOMA-IR (Homeostatic Model Assessment for Insulin Resistance) values was lower in VEGA compared with SMOF and accompanied by higher glucagon and lower insulin plasma levels. …”
Get full text

Developmental Proteomics Reveals the Dynamic Expression Profile of Global Proteins of <i>Haemaphysalis longicornis</i> (Parthenogenesis) by Min-Xuan Liu, Xiao-Pei Xu, Fan-Ming Meng, Bing Zhang, Wei-Gang Li, Yuan-Yuan Zhang, Qiao-Ying Zen, Wen-Ge Liu

“…The life cycle of <i>H. longicornis</i> goes through a tightly regulated life cycle to adapt to the changing host and environment, and these stages of transition are also accompanied by proteome changes in the body. Here, we used the isobaric tags for a relative and absolute quantification (iTRAQ) technique to systematically describe and analyze the dynamic expression of the protein and the molecular basis of the proteome of <i>H. longicornis</i> in seven differential developmental stages (eggs, unfed larvae, engorged larvae, unfed nymphs, engorged nymphs unfed adults, and engorged adults). …”
Get full text

Transcutaneous electrical acupoint stimulation for hypertension complicated by anxiety or sleep disorders: A pilot randomized controlled trial by Xue-Ying Bao, Cun-Zhi Liu, Zi-Tong Qian, Lu Wang, Jian-Feng Tu, Bin-Yan Li, Xiao Wang, Fang Wan, Zhi-Han Li, Zhao-Yi Liu, Liang-Xiao Ma, Li-Qiong Wang

“…Background: Hypertension is often accompanied by anxiety and sleep disorders, which further complicate the disease. …”
Get full text

Exercise-induced anxiety impairs local and systemic inflammatory response and glucose metabolism in C57BL/6J mice by I. Gálvez, M.C. Navarro, S. Torres-Piles, L. Martín-Cordero, M.D. Hinchado, E. Ortega

“…Systemic inflammatory alterations are accompanied by detrimental inflammatory responses in tissue macrophage populations. …”
Get full text

The Effect of Cysteine on the Removal of Cadmium in Paddy Soil by Combination with Bioremediation and the Response of the Soil Microbial Community by Emmanuel Konadu Sarkodie, Kewei Li, Ziwen Guo, Jiejie Yang, Yan Deng, Jiaxin Shi, Yulong Peng, Yuli Jiang, Huidan Jiang, Hongwei Liu, Yili Liang, Huaqun Yin, Xueduan Liu, Luhua Jiang

“…However, the Cd removal efficacy achieved through this method remains unsatisfactory and is accompanied by a marginally higher cost. Cysteine has the potential to improve the bioleaching efficiency of Cd from soils and decrease the use cost since it is green, acidic and has a high Cd affinity. …”
Get full text

Decreased expression of LEF1 caused defective decidualization by inhibiting IL-11 expression in patients with adenomyosis by Jingru Duan, Xiaowei Zhou, Hanfei Zhu, Mingjuan Zhou, Mengyu Liu, Yan Zhou, Wenzhu Li, Bufang Xu, Aijun Zhang

“…In the adenomyosis mouse model, we observed a decrease in LEF1 expression and a reduction in implantation sites compared to control mice, accompanied by impaired decidualization and receptivity. …”
Get full text

Non-carbapenem-producing carbapenem-resistant Pseudomonas aeruginosa in children: Risk factors, molecular epidemiology, and resistance mechanism by Lijun Yin, Lu Lu, Leiyan He, Gangfeng Yan, Guoping Lu, Xiaowen Zhai, Chuanqing Wang

“…The primary mechanism driving carbapenem resistance involved the downregulation of outer membrane porin protein oprD, accompanied by oprD mutation inactivation.…”
Get full text

Study of regulated deficit irrigation regime based on individual fruit weight and quality response to water deficit duration: A case study in tomato by Xianbo Zhang, Hui Yang, Taisheng Du

“…In addition, arid and semi-arid regions are often accompanied by soil salinization. This suggests that water-saving irrigation is necessary in salinized soils. …”
Get full text

Accumulation of advanced oxidation protein products aggravates bone-fat imbalance during skeletal aging by Yu-Sheng Huang, Jia-Wen Gao, Rui-Feng Ao, Xin-Yu Liu, Di-Zheng Wu, Jun-Long Huang, Chen Tu, Jing-Shen Zhuang, Si-Yuan Zhu, Zhao-Ming Zhong

“…Age-related accumulation of AOPPs was accompanied by reduced bone formation, increased marrow adiposity and deterioration of bone microstructure. …”
Get full text