Gut Dysbiosis and Abnormal Bile Acid Metabolism in Colitis-Associated Cancer by Li Liu, Min Yang, Wenxiao Dong, Tianyu Liu, Xueli Song, Yu Gu, Sinan Wang, Yi Liu, Zaripa Abla, Xiaoming Qiao, Wentian Liu, Kui Jiang, Bangmao Wang, Jie Zhang, Hailong Cao

“…Accordingly, fecal bile acids were decreased, accompanied by reduced transformation of primary to secondary bile acids. …”
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The Addition of Pumpkin Flour Impacts the Functional and Bioactive Properties of Soft Wheat Composite Flour Blends by Durim Alija, Remigiusz Olędzki, Daniela Nikolovska Nedelkoska, Agata Wojciechowicz-Budzisz, Gafur Xhabiri, Ewa Pejcz, Eljesa Alija, Joanna Harasym

“…Bioactive properties improved significantly, with TPC increasing up to 0.57 mg/1 g DM and 0.34 GAE mg/1 g DM in water and ethanol extracts, respectively, accompanied by enhanced antioxidant activity. Pumpkin flour incorporation successfully enhanced both functional and bioactive properties of wheat flour blends, with particle size distribution and water interactions serving as fundamental determinants of technological functionality, while contributing to improved nutritional value through increased bioactive compounds.…”
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Clinical characteristics of and growth hormone treatment effects on short stature with type 1 insulin-like growth factor receptor (IGF1R) gene alteration by Yuki Kawashima-Sonoyama, Keisuke Wada, Kei Yamamoto, Masanobu Fujimoto, Noriyuki Namba, Takeshi Taketani

“…Cases with deletions showed a more severe degree of growth impairment (–4.5 ± 0.43 SD) than those caused by pathological variants (–2.71 ± 0.15 SD) and were accompanied by neurodevelopmental delay. However, cases caused by pathological variants lacked distinctive features. …”
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Molecular Insights Into the Sensory Adaption of the Cave‐Dwelling Leech Sinospelaeobdella wulingensis to the Karst Cave Environment by Xi Wen, Haiyang Xiang, Mengqing Zhang, Aoran Yan, Dongqing Xiang, Jie Zou, Yue Zhang, Xinglong Huang, Zhixiao Liu

“…ABSTRACT Karst caves are a unique environment significantly different from the external environment; adaptation of cave‐dwelling animals to the cave environment is often accompanied by shifts in the sensory systems. Aquatic and terrestrial leeches have been found in the karst caves. …”
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Liver transplantation for homozygous familial hypercholesterolemia: a retrospective analysis from Chinese experience by Hao-Su Zhan, Lin Wei, Wei Qu, Zhi-Gui Zeng, Ying Liu, Yu-Le Tan, Jun Wang, Liang Zhang, En-Hui He, Guang-Peng Zhou, Hai-Ming Zhang, Zhi-Jun Zhu, Li-Ying Sun

“…Results Xanthoma and decreased activity tolerance were the primary clinical manifestations in the 7 HoFH children initially assessed (one child died suddenly prior to surgery due to cardiac arrest). Accompanying these symptoms were increased blood total cholesterol (TC) and low density lipoprotein (LDL) levels, along with severe cardiovascular diseases. …”
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Single-cell analyses of intestinal epithelium reveal the dysregulation of gut immune microenvironment in systemic lupus erythematosus by Qiaolin Wang, Yutong Wu, Lianlian Ouyang, Xiaoli Min, Meiling Zheng, Lingyu Gao, Xiaoyun Chen, Zhi Hu, Shuang Yang, Wenjuan Jiang, Sujie Jia, Qianjin Lu, Ming Zhao

“…Results We observed a significant reduction in CD8αα + IELs, accompanied by a marked increase in CD8αβ + IELs in Lpr mice. …”
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Dysmenorrhea Among Women Living in Saudi Arabia: Prevalence, Determinants, and Impact by Mohammad A. Jareebi, Saja A. Almraysi, Dhiyaa A. H. Otayf, Ghadeer A. Alneel, Areej H. Zughaibi, Sarah J. Mobarki, Imtenan A. Oberi, Hayam A. Alzahrani, Shatha A. Aldhowaihi, Zainab A. Alramadhan, Majed A. Ryani, Ahmed A. Bahri, Nuha H. Abutalib, Nada M. Makein, Ahmad Y. Alqassim

“…Dysmenorrhea is highly prevalent among Saudi women and is accompanied by significant menstrual symptoms that adversely affect quality of life. …”
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Fracture behavior of sandstone with partial filling flaw under mixed-mode loading: Three-point bending tests and discrete element method by Dongdong Ma, Yu Wu, Xiao Ma, Xunjian Hu, Wenbao Dong, Decheng Li, Lingyu Li

“…In terms of crack propagation pattern, the increasing filling strength of the partial filling flaw induced the transformation of the fracture mechanism toward deflection, with a tortuosity path, while the filling ratio and inclination of partial filling flaw led to fracture mechanism change from deflection to penetration and attraction, accompanied with a larger AE event source in filler. …”
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Asthma-associated prostate enlargement and bladder smooth muscle hypercontractility: unveiling a potential link to LUTS by Peibin Cen, Ming Chen, Xin Qiu, Wenbin Guo, Hongyu Lan, Xingyu Zhou, Ming Lei, Guohua Zeng, Qingfeng Yu

“…Results Prostate epithelial thickness was significantly increased in asthmatic rats, accompanied by changes in molecular markers, including increased expression of desmin and tropomyosin and decreased expression of vimentin in the prostate tissue. …”
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The Construction of Heterothallic Strains of <i>Komagataella kurtzmanii</i> Using the I-SceI Meganuclease by Daria D. Sokolova, Philipp I. Akentyev, Kristina O. Petrova, Lyudmila V. Lyutova, Aleksei A. Korzhenkov, Irek I. Gubaidullin, Stepan V. Toshchakov, Dmitry G. Kozlov

“…As a result, natural and genetically engineered cultures of these yeasts typically contain a mixture of sexually dimorphic cells that are prone to self-diploidisation and spore formation accompanied by genetic rearrangements. These characteristics pose a significant challenge to the development of genetically stable producers for industrial use. …”
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Case Report: Clinical awareness about the effect of laser interstitial thermal therapy on pediatric high-grade brain tumors after radiotherapy by Sandra Fernandes Dias, Markus F. Oertel, Ana Guerreiro Stücklin, Nicolas U. Gerber, Elisa Colombo, Tristan P. C. van Doormaal, Niklaus Krayenbühl

“…Shortly after the laser ablation, we observed a significant tumor growth along the trajectory of the LITT catheters, accompanied by clinical deterioration. The effect of LITT on pediatric ependymoma and high-grade glioma recurrence after radiotherapy is still unclear. …”
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Functionality of bacterial communities in constructed wetlands used for water purification: influence of root components and seasonality by Yao Huang, Yao Huang, Weili An, Weili An, Tianzhu Ning, Zhiguang Ma, Yuelin Li, Ke Liu, Lingbo Ji, Lingbo Ji, Hongxiao Liu, Dafeng Hui, Hai Ren

“…The abundance and diversity of bacterial communities exhibited a decline from the rhizosphere to the endosphere, accompanied by an increase in the number of distinctive biomarkers from the rhizosphere to the endosphere. …”
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Genetic variability and heritability estimates among nutritional traits of groundnut breeding lines by Richard Adu Amoah, James Yaw Asibuo, Richard Akromah, Kwabena Asare Bediako, Maxwell Lamptey, Collins Yeboah Osei, Samuel Awuah, Richard Boampong

“…Nonetheless, high heritability accompanied by high genetic advance as percent of mean for zinc (Zn) and iron (Fe), indicated that the heritability of these traits is due to additive gene effect and selection for such traits may be effective and rewarding.…”
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Increased TLR4 Expression Aggravates Sepsis by Promoting IFN-γ Expression in CD38−/− Mice by Qi Li, Chenyi Wu, Zhenlong Liu, Huiqing Zhang, Yuna Du, Yuxiang Liu, Kuangyu Song, Qiaofa Shi, Rong Li

“…Our results showed more aggravated kidney damage in CD38−/− mice than in WT mice, accompanied with an increase of proinflammatory cytokine expression. …”
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SEC61 translocon gamma subunit is correlated with glycolytic activity, epithelial mesenchymal transition and the immune suppressive phenotyp... by Zhou Changshuai, Cui Huanhuan, Yang Yuechao, Chen Lei, Feng Mingtao, Gao Yang, Li Deheng, Li Liangdong, Chen Xin, Li Xiaoqiu, Cao Yiqun

“…This inhibitory effect is accompanied by a significant downregulation of key regulators of tumor progression, including hypoxia-inducible factor-1 alpha (HIF-1α), lactate dehydrogenase A, and genes involved in the epithelial-mesenchymal transition pathway. …”
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Establishing rabbit critical-size bone defects to evaluate the bone-regeneration potential of porous calcium phosphate ceramics by Wei Lei, Yan Wu, Yan Wu, Hao Yuan, Ping He, Jingqi Wu, Jingrong Chen, Yuxiao Liu, Hongmei Zhang, Joost D. de Bruijn, Xuerong Xiang, Ping Ji, Huipin Yuan, Huipin Yuan, Mingzheng Li

“…Furthermore, the bone area within the available space of BCP implants increased significantly from 19.3% ± 7.3% at 12 weeks to 37.7% ± 8.5% at 24 weeks (p = 0.0063), accompanied by significant BCP resorption (14.8% at 12 weeks and 30.2% at 24 weeks). …”
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Acupuncture treatment of restless legs syndrome: a randomized clinical controlled study protocol based on PET-CT and fMRI by Lin Tang, Na Zhao, Xiaolin Gao, Jinjin Li, Xintong Yu, Ruilong Liang, Chen Xie, Lutong Li, Qianqian Wang, Wenjia Yang

“…IntroductionRestless legs syndrome (RLS) is a sensorimotor disorder of the nervous system that is mainly characterized by nighttime leg discomfort and can be accompanied by significant anxiety, depression, and other mood disorders. …”
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Diagnosis and treatment of thyroblastoma: a case report and review of literature by Xiting Chen, Xiting Chen, Lijuan Xiong, Lijuan Xiong, Hongling Liu, Haoqiang Wang, Donghai Cheng, Wei Wang, Wenyuan He, Bo Xie, Juan Zhou

“…Next-generation sequencing (NGS) confirmed the presence of germline DICER1 heterozygous pathogenic mutation at p.G1784* in patient, accompanied by the somatic hotspot mutation at p.E1813D of the RNase IIIb domain. …”
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Dihydroporphyrin iron (III) enhances low temperature tolerance by increasing carbon and nitrogen metabolism in Andrographis paniculata by Shao-Fen Jian, Shao-Fen Jian, Shao-Fen Jian, Yan-Fen Huang, Yan-Fen Huang, Yan-Fen Huang, Dong-Liang Chen, Chu Zhong, Chu Zhong, Chu Zhong

“…Soluble protein and proline contents were decreased by DH-Fe, while total N and free amino acids contents were increased, accompanying by the enhancement of the activities of glutamine synthase (GS), glutamic-oxaloacetic transaminase (GOT) and glutamic-pyruvic transaminase (GTP). …”
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The Influence of Gastric Microbiota and Probiotics in <i>Helicobacter pylori</i> Infection and Associated Diseases by Jagriti Verma, Md Tanveer Anwar, Bodo Linz, Steffen Backert, Suneesh Kumar Pachathundikandi

“…While the development of <i>H. pylori</i>-associated intestinal metaplasia is accompanied by an increase in Bacteroides, the stomachs of GC patients are dominated by Firmicutes such as <i>Lactobacillus</i> and <i>Veillonella</i>, constituting up to 40% of the total microbiota, and by Bacteroidetes such as <i>Prevotella</i>, whereas the numbers of <i>H. pylori</i> are decreasing. …”
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