Improvement in Impaired Social Cognition but Not Seizures by Everolimus in a Child with Tuberous Sclerosis-Associated Autism through Increased Serum Antioxidant Proteins and Oxidan... by Kunio Yui, George Imataka, Hitomi Sasaki, Yohei Kawasaki, Tohru Okanshi, Ryoichi Shiroki, Shigemi Yoshihara

“…This study revealed that everolimus treatment improved impaired social cognition with increased serum levels of the copper mediator (Cp) and iron mediator (Tf) via homeostatic control of mTOR activity accompanied by overlap of the oxidant-antioxidant system. …”
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Loss of p53 impairs death receptor expression and confers resistance to CD19 CAR T-cell therapy in BCP-ALL by Willem P. J. Cox, Noël M. M. Dautzenberg, Linde Dekker, Tesa Klenovsek, Annelisa M. Cornel, Marliek van Hoesel, Dorette S. van Ingen Schenau, Reno S. Bladergroen, Roland P. Kuiper, Laurens T. van der Meer, Friso G. Calkoen, Stefan Nierkens, Frank N. van Leeuwen

“…Furthermore, p53 stabilization induced expression of both Fas and DR5, accompanied by increased CAR T–mediated killing. Although these findings provide mechanistic insight into why CAR T therapy fails against TP53Mut BCP-ALL, they may also provide opportunities to enhance the efficacy of CAR T treatment both in patients with TP53Mut and TP53WT BCP-ALL. …”
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Corneal Mucin‐Targeting Liposome Nanoplatforms Enable Effective Treatment of Dry Eye Diseases by Integrated Regulation of Ferroptosis and Inflammation by Yin Zhang, Tinglian Zhou, Kai Wang, Chenqi Luo, Dan Chen, Zeen Lv, Haijie Han, Ke Yao

“…Specifically, CF@SNPs attenuate dry eye pathology by suppressing p53‐SLC7A11‐GSH‐dependent ferroptosis and TNF‐α‐associated inflammatory cascades, accompanied by favorable biocompatibility in vivo. These results underscore the promising potential of this superior nano‐formulation for DED pharmacotherapy.…”
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Effect of the Lipoxygenase Inhibitor Baicalein on Muscles in Ovariectomized Rats by D. Saul, J. H. Kling, R. L. Kosinsky, D. B. Hoffmann, M. Komrakova, M. Wicke, B. Menger, S. Sehmisch

“…Sarcopenia, a loss of muscle mass accompanying osteoporosis, leads to falls and fall-related injuries. …”
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Understanding the formation of a low-pressure pedestal in the presence of a strong internal transport barrier in DIII-D high βp plasmas by X.R. Zhang, X. Jian, Y.R. Zhu, Y.P. Zou, Z.Y. Li, Y.J. Zhou, L.Z. Liu, S. Zheng, Z.X. Wang, W. Chen, S.Y. Ding, A.M. Garofalo, V.S. Chan, G.Q. Li

“…It is frequently observed that in the presence of a strong ITB, the pedestal height is lower and is accompanied by small edge localized modes (ELMs), which further improves the compatibility of a high performance core with an edge solution. …”
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V-ATPase in glioma stem cells: a novel metabolic vulnerability by Alessandra Maria Storaci, Irene Bertolini, Cristina Martelli, Giorgia De Turris, Nadia Mansour, Mariacristina Crosti, Maria Rosaria De Filippo, Luisa Ottobrini, Luca Valenti, Elisa Polledri, Silvia Fustinoni, Manuela Caroli, Claudia Fanizzi, Silvano Bosari, Stefano Ferrero, Giorgia Zadra, Valentina Vaira

“…This metabolic rewiring is accompanied by a higher glycolytic rate and intracellular lactate accumulation, which is not exploited by GSCs for biosynthetic or survival purposes. …”
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Incidental Adrenal Enlargement: An Overview from a Retrospective Study in a Chinese Population by Le-le Li, Wei-jun Gu, Jing-tao Dou, Guo-qing Yang, Zhao-hui Lv, Yi-ming Mu, Ju-ming Lu

“…Incidental adrenal enlargement is a frequent radiographic finding and is accompanied by diverse clinical factors that require proper evaluation and management. …”
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Metallothioneins 1 and 2 Modulate Inflammation and Support Remodeling in Ischemic Cardiomyopathy in Mice by Georg D. Duerr, Daniela Dewald, Eva J. Schmitz, Luise Verfuerth, Katharina Keppel, Christine Peigney, Alexander Ghanem, Armin Welz, Oliver Dewald

“…Expression of MT1/2 mRNA was transiently induced during repetitive I/R in WT-mice, accompanied by a transient inflammation, leading to interstitial fibrosis with left ventricular dysfunction without infarction. …”
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Hyperglycemia Does Not Affect Iron Mediated Toxicity of Cultured Endothelial and Renal Tubular Epithelial Cells: Influence of L-Carnosine by Shiqi Zhang, Emmanouil Ntasis, Sarah Kabtni, Jaap van den Born, Gerjan Navis, Stephan J. L. Bakker, Bernhard K. Krämer, Benito A. Yard, Sibylle J. Hauske

“…Iron has been suggested to affect the clinical course of type 2 diabetes (T2DM) as accompanying increased intracellular iron accumulation may provide an alternative source for reactive oxygen species (ROS). …”
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Palliative Care in Congenital Syndrome of the Zika Virus Associated with Hospitalization and Emergency Consultation: Palliative Care and Congenital Syndrome of Zika by Aline Maria de Oliveira Rocha, Maria Julia Gonçalves de Mello, Juliane Roberta Dias Torres, Natalia de Oliveira Valença, Alessandra Costa de Azevedo Maia, Nara Vasconcelos Cavalcanti

“…Such events happened at an early age and were accompanied by a high number of invasive procedures and interventions. …”
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Effects of Quorum Sensing Systems on Regulatory T Cells in Catheter-Related Pseudomonas aeruginosa Biofilm Infection Rat Models by Lei Feng, Qingqing Xiang, Qing Ai, Zhengli Wang, Yunhui Zhang, Qi Lu

“…QS systems can trigger host immune system, accompanied with the upregulation of Tregs.…”
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How Interpretable Machine Learning Can Benefit Process Understanding in the Geosciences by Shijie Jiang, Lily‐belle Sweet, Georgios Blougouras, Alexander Brenning, Wantong Li, Markus Reichstein, Joachim Denzler, Wei Shangguan, Guo Yu, Feini Huang, Jakob Zscheischler

“…Meanwhile, the rapid proliferation of IML, still in its early stages, has been accompanied by instances of careless application. In response to these challenges, this paper focuses on how IML can effectively and appropriately aid geoscientists in advancing process understanding—areas that are often underexplored in more technical discussions of IML. …”
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Latin America’s Dengue Outbreak Poses a Global Health Threat by Michelle Teixeira de Almeida, Davi Gabriel Salustiano Merighi, Aline Biazola Visnardi, Cauê Augusto Boneto Gonçalves, Vitor Martins de Freitas Amorim, Anielle Salviano de Almeida Ferrari, Anacleto Silva de Souza, Cristiane Rodrigues Guzzo

“…In 2024, Brazil experienced a fourfold increase in dengue cases compared to 2023, accompanied by higher mortality. Conventional control measures, such as vector control, community engagement, and vaccination, proved insufficient as climate change exacerbated mosquito proliferation, challenging containment efforts. …”
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Methicillin-resistant Staphylococcus Aureus Bacteraemia in a Young Boy following Mumps Infection: A Case Report by Jayakanthan Saravanan, AP Krithika, M Geetha

“…In the present case, a nine-year-old boy was brought in with complaints of fever and bilateral swelling in the parotid region for three days, accompanied by pain during chewing. Clinically, patient was diagnosed with a mumps infection. …”
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Shock Breakouts from Compact Circumstellar Medium Surrounding Core-collapse Supernova Progenitors May Contribute Significantly to the Observed ≳10 TeV Neutrino Background by Eli Waxman, Tal Wasserman, Eran O. Ofek, Avishay Gal-Yam

“…The compact size and large UV luminosity imply a pair production optical depth of  ~10 ^4 for  > 100 GeV photons, naturally accounting for the lack of a high-energy gamma-ray background accompanying the neutrino background. SNe producing  >1 neutrino event in a 1 km ^2 detector are expected at a rate of  ≲0.1 yr ^−1 . …”
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FFAR4 (GPR120) Signaling Is Not Required for Anti-Inflammatory and Insulin-Sensitizing Effects of Omega-3 Fatty Acids by Simone Isling Pærregaard, Marianne Agerholm, Annette Karen Serup, Tao Ma, Bente Kiens, Lise Madsen, Karsten Kristiansen, Benjamin Anderschou Holbech Jensen

“…Thus, activation of FFAR4 has been reported to ameliorate chronic low-grade inflammation and insulin resistance accompanying obesity. However, conflicting reports on the role of FFAR4 in mediating the effects of ω3-PUFAs are emerging, suggesting that FFAR4 may not be the sole effector. …”
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Anticolitic Effect of Berberine in Rat Experimental Model: Impact of PGE2/p38 MAPK Pathways by Li Jia, Kuijin Xue, Junheng Liu, Ola A. Habotta, Lianhai Hu, Ahmed E. Abdel Moneim

“…Marked downregulation of Nos2 mRNA expression is accompanied by increased Nrf2 and Hmox-1 expressions in colon specimens treated by BER. …”
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Investigations of MWISP Filaments. I. Filament Identification and Analysis Algorithms, and Source Catalog by Yu Jiang, Xuepeng Chen, Sheng Zheng, Zhibo Jiang, Zhiwei Chen, Yao Huang, Yang Su, Li Sun, Jian-Cheng Feng, Haoran Feng, Ji Yang

“…DPConCFil is openly available on GitHub ( https://github.com/JiangYuTS/DPConCFil ), accompanied by a manual.…”
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Heart in Acromegaly: The Echocardiographic Characteristics of Patients Diagnosed with Acromegaly in Various Stages of the Disease by Agata Popielarz-Grygalewicz, Jakub S. Gąsior, Aleksandra Konwicka, Paweł Grygalewicz, Maria Stelmachowska-Banaś, Wojciech Zgliczyński, Marek Dąbrowski

“…In patients with acromegaly, the following findings were detected: increased left atrial volume index, increased interventricular septum thickness, increased posterior wall thickness, and increased left ventricular mass index, accompanied by reduced diastolic function measured by the following parameters: E’med., E/E’, and E/A. …”
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Case report: JAK inhibitor treatment of immune dysregulation symptoms in a patient with PTPN2 deficiency by Anna Roppelt, Ulyana Markina, Irina Beloglazova, Irina Beloglazova, Vasily Parshin, Dmitry Kanner, Dmitry Pershin, Mariia Fadeeva, Elena Raykina, Maxim Aleksenko, Alexander Karaulov, Mariana Lysenko, Mariana Lysenko, Daria Fomina, Daria Fomina, Daria Fomina

“…We report on a 32-year-old male patient with interstitial lung disease, cytopenia, and lymphadenopathy accompanied by de-novo deletion in PTPN2. The patient has been receiving systemic steroid treatment for decades, which has resulted in hormone dependence as well as therapy-related adverse side effects. …”
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