NADPH Oxidase Signaling Pathway Mediates Mesenchymal Stem Cell-Induced Inhibition of Hepatic Stellate Cell Activation by Haowen Qiao, Yu Zhou, Xingping Qin, Jing Cheng, Yun He, Yugang Jiang

“…Moreover, the hBM-MSC-induced decrease in the signaling pathway of NADPH oxidase was accompanied by the decrease of the activated HSC number and liver fibrosis in a mouse model of CCl4-induced liver fibrosis. …”
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Reduced frontotemporal connectivity during a verbal fluency task in patients with anxiety, sleep, and major depressive disorders by Fanxi Ding, Yiyang Ying, Yuqing Jin, Xuanru Guo, Xuanru Guo, You Xu, Zhenghe Yu, Haiteng Jiang, Haiteng Jiang, Haiteng Jiang

“…BackgroundIt has been well established that psychiatric disorders are often accompanied by cognitive dysfunction. Previous studies have investigated the verbal fluency task (VFT) for detecting executive function impairment in different psychiatric disorders, but the sensitivity and specificity of this task in different psychiatric disorders have not been explored. …”
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Revisiting the Ionospheric Disturbances Over Low Latitude Region of China During Super Typhoon Hato by Ke Li, Donghe Zhang, Yi Zeng, Yaoyu Tian, Guofeng Dai, Zhizhao Liu, Guanglin Yang, Shuji Sun, Guozhu Li, Yongqiang Hao, Zuo Xiao

“…Using the ionospheric total electron content (TEC) derived from Global Navigation Satellite System observations, the ionospheric disturbances during the super typhoon Hato in 2017 that was accompanied by a weak geomagnetic storm are revisited, including the ionospheric deviation and traveling ionospheric disturbances (TIDs). …”
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Conversion therapy strategy: A novel GPC3-targeted multimodal organic phototheranostics platform for mid-late-stage hepatocellular carcinoma by Fan Wu, Xin Kuang, Sanlin Deng, Shuo Qi, Jian Xiong, Bibo Zhao, Chuanfu Li, Senyou Tan, Qiang Kang, Hao Xiao, Xiaofeng Tan, Gui-long Wu, Qinglai Yang, Guodong Chen

“…Since traditional therapies are often accompanied by uncertainty of efficacy, there is an urgent need to explore new treatment strategies. …”
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Nitrooleic Acid Attenuates Lipid Metabolic Disorders and Liver Steatosis in DOCA-Salt Hypertensive Mice by Haiping Wang, Jing Sun, Zhanjun Jia, Tianxin Yang, Liang Xu, Bing Zhao, Kezhou Yu, Rong Wang

“…The mice pretreated with OA-NO2 showed reduced liver damage accompanied with low liver lipid content. Moreover, the liver TBARS, together with the expressions of gp91phox and p47phox, were parallelly decreased. …”
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DNA Methylation Profiles of Blood Cells Are Distinct between Early-Onset Obese and Control Individuals by Je-Keun Rhee, Jin-Hee Lee, Hae Kyung Yang, Tae-Min Kim, Kun-Ho Yoon

“…We observed that the hierarchical clustering of DNA methylation, but not gene expression, clearly segregates the obese individuals from the controls, suggesting that the metabolic disturbance that occurs as a result of obesity at a young age may affect the DNA methylation of peripheral blood cells without accompanying transcriptional changes. To examine the genome-wide differences in the DNA methylation profiles of young obese and control individuals, we identified differentially methylated CpG sites and investigated their genomic and epigenomic contexts. …”
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NSUN2 lactylation drives cancer cell resistance to ferroptosis through enhancing GCLC-dependent glutathione synthesis by Kaifeng Niu, Zixiang Chen, Mengge Li, Guannan Ma, Yuchun Deng, Ji Zhang, Di Wei, Jiaqi Wang, Yongliang Zhao

“…The activated GCLC induces higher level of intracellular GSH accompanied by decreased lipid peroxidation and resistant phenotype to ferroptosis induction by doxorubicin (Dox) in gastric cancer cells. …”
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Altered Forebrain Functional Connectivity and Neurotransmission in a Kinase-Inactive Mouse Model of Autism by Shiyu Tang PhD, Elizabeth M. Powell PhD, Wenjun Zhu MS, Fu-Sun Lo MD, Reha S. Erzurumlu PhD, Su Xu PhD

“…Here, we focus on the somatosensory thalamocortical circuitry because distinct somatosensory sensitivity phenotypes accompany ASD, and this system plays a major role in sensorimotor and social behaviors in mice. …”
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Screening for transcriptomic associations with Swine Inflammation and Necrosis Syndrome by Katharina Gerhards, Sabrina Becker, Josef Kuehling, Mirjam Lechner, Hermann Willems, Robert Ringseis, Gerald Reiner

“…The primarily endogenous syndrome is based on vasculitis, thrombosis, and intimal proliferation, involving defence cells, interleukins, chemokines, and acute phase proteins and accompanied by alterations in clinical chemistry, metabolome, and liver transcriptome. …”
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Xenopus laevis neural stem progenitor cells exhibit a transient metabolic shift toward glycolysis during spinal cord regeneration by Paula G. Slater, Paula G. Slater, Miguel E. Domínguez-Romero, Guillermo Campos, Guillermo Campos, Vania Aravena, Vania Aravena, Javier Cavieres-Lepe, Verónica Eisner

“…This morphological shift was accompanied by a transient decrease in the mitochondrial membrane potential and a metabolic switch favoring glycolysis. …”
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Investigating Effects of Solar Proton Events and Forbush Decreases on Ground‐Level Potential Gradient Recorded at Middle and Low Latitudes and Different Altitudes by J. Tacza, A. Odzimek, E. Tueros Cuadros, J.‐P. Raulin, M. Kubicki, G. Fernandez, A. Marun

“…In each situation, we select only events which are not accompanied or followed by the other. Using the superposed epoch analysis, in order to enhance the visualization of small effects, we study the potential gradient data recorded between January 2010 and December 2019 at two stations located at low and middle‐latitudes, and at two different altitudes: the Complejo Astronómico El Leoncito (CASLEO), Argentina: 31.78°S, 2550 m a.s.l., and the Geophysical Observatory in Świder (SWIDER), Poland: 52.12°N, 100 m a.s.l., respectively. …”
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Preventive but Not Curative Efficacy of Celecoxib on Bladder Carcinogenesis in a Rat Model by José Sereno, Belmiro Parada, Flávio Reis, Fernanda X. Cunha, Edite Teixeira-Lemos, Patrícia Garrido, Rui Pinto, Petronila Rocha-Pereira, Paula Neto, José Ruivo, Paulo Rodrigues-Santos, Sara Nunes, Alfredo Mota, Arnaldo Figueiredo, Frederico Teixeira

“…The number and volume of carcinomas were significantly lower in the CEL+BBN-P versus BBN, accompanied by an ample reduction in hyperplasia, dysplasia, and papillary tumors as well as COX-2 immunostaining. …”
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Ultrasound Guidance for Renal Tract Access and Dilation Reduces Radiation Exposure during Percutaneous Nephrolithotomy by Thomas Chi, Selma Masic, Jianxing Li, Manint Usawachintachit

“…To present our series of 38 prone percutaneous nephrolithotomy procedures performed with renal access and tract dilation purely under ultrasound guidance and describe the benefits and challenges accompanying this approach. Methods. Thirty-eight consecutive patients presenting for percutaneous nephrolithotomy for renal stone removal were included in this prospective cohort study. …”
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p53-Dependent Senescence in Mesenchymal Stem Cells under Chronic Normoxia Is Potentiated by Low-Dose γ-Irradiation by Ines Höfig, Yashodhara Ingawale, Michael J. Atkinson, Heidi Hertlein, Peter J. Nelson, Michael Rosemann

“…Long-term observations revealed a decreasing ability of wildtype mMSCs to proliferate and form colonies under extended culture in normoxia. This was accompanied by increased senescence under normoxia but not associated with telomere shortening. …”
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Midlatitude mesosphere and lower thermosphere variations during the extreme gannon geomagnetic storm in May 2024 by Tao Yuan, Tao Yuan, P. D. Pautet, P. D. Pautet, M. J. Taylor, M. J. Taylor

“…Significant warming (as much as ∼50 K) accompanied by fast equatorward flow in the lower thermosphere (up to ∼100 m/s changes in the meridional wind above 100 km altitude) were observed. …”
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S100A9 protein activates microglia and stimulates phagocytosis, resulting in synaptic and neuronal loss by Katryna Pampuscenko, Silvija Jankeviciute, Ramune Morkuniene, Darius Sulskis, Vytautas Smirnovas, Guy C. Brown, Vilmante Borutaite

“…Incubation of cell cultures with 250–500 nM S100A9 caused neuronal loss without signs of apoptosis or necrosis, but accompanied by exposure of the “eat-me” signal - phosphatidylserine on neurons. …”
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Mechanisms of Hearing Loss in a Guinea Pig Model of Superior Semicircular Canal Dehiscence by Bu-Sheng Tong, Zi-Yu He, Chen-Ru Ding, Juan-Mei Yang, Jing Wang, Zhao Han, Yi-Bo Huang, Na Gao, Xian-Hao Jia, Fang-Lu Chi, Dong-Dong Ren

“…Energy leakage from the surgically introduced third window was detected in the range of 300–1500 Hz, accompanied by increased vibration at the umbo, stapes head, and the dehiscence site, while decreased vibration was observed at the round window membrane in the same frequency range. …”
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PKS 2332–017 and PMN J1916–1519: Candidate Blazar Counterparts to Two High-energy Neutrino Events by Shunhao Ji, Zhongxiang Wang, Dong Zheng

“…The two flares, respectively, from PKS 2332–017 and PMN J1916–1519 lasted ~4 yr and ~4 months and showed possible emission hardening by containing high-energy ~2–10 GeV photons in the emissions. Accompanying the flare of PKS 2332–017, optical and mid-infrared brightening variations were also observed. …”
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ЖОРСТКІСТЬ ПАРЕНХІМИ ПЕЧІНКИ ЩУРІВ ПРИ МОДЕЛЮВАННІ СТЕАТОЗУ АЛІМЕНТАРНОГО ГЕНЕЗУ ТА ЙОГО КОРЕКЦІЇ... by В.І. Діденко, Ю.А. Гайдар, І.А. Кленіна, О.О. Галінський, І.С. Коненко, А.І. Руденко, О.І. Грабовська

“…In the course of morphological studies, it was found that in experimental rats development of steatosis with small-drop fat dystrophy, scattered throughout the particle plane and sinusoidal enlargement was observed, which was accompanied by increased stiffness of the liver parenchyma of rats. …”
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Hydration with Mannitol and Dextrose May Promote Cisplatin-Induced Nephrotoxicity: Test of Five Protocols of Hydration during Cisplatin Therapy in Rat Models by Mohammad-Sedigh Khosravi, Alireza Samimiat, Bahar Mazaheri, Farzaneh Ashrafi, Ardeshir Talebi, Mehdi Nematbakhsh

“…Cisplatin (CP) still is a novel choice for solid tumor therapy, but it is accompanied with the side effect of nephrotoxicity. …”
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