Alveolar Rhabdomyosarcoma of Nasopharynx and Paranasal Sinuses in Children Diagnosis and Treatment—Review of the Literature and Case Report by Cristian Mârțu, Ștefan Dragoș Tîrnovanu, Ioana Mârțu, Dan Ferariu, Dan Mârțu, Alexandra Jităreanu, Luminița Rădulescu

“…This report presents the case of an 8-year-old boy diagnosed with aRMS, accompanied by a literature review. Alveolar rhabdomyosarcoma should be suspected in children presenting with a vegetative tumor in the rhinopharynx or paranasal sinuses. …”
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Biofunctional Characterization of Collagen from Orange-Spotted Grouper, <i>Epinephelus coioides</i>: Maintenance of Cartilage in Aged Zebrafish by Shao-Yang Hu, Chen-Han Tsou, Chung-Chih Tseng, Tai-Wei Han, Chun-Hung Liu

“…After eight weeks of dietary supplementation, zebrafish fed PHC or the combined PHC + GC diets exhibited a significant upregulation of <i>sox9a</i> (<i>jef</i>) expression in spinal tissues, accompanied by a marked downregulation of <i>runx2</i>. …”
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The burden of prostate cancer in the North Africa and Middle East Region from 1990 to 2021 by Saeid Safiri, Ali Shamekh, Kamaleddin Hassanzadeh, Asra Fazlollahi, Mark J. M. Sullman, Mortaza Raeisi, Ali-Asghar Kolahi

“…These metrics were reported as counts and age-standardised rates, each accompanied by 95% uncertainty intervals. In 2021, the age-standardised incidence of prostate cancer in the region was 27.4 per 100,000 population, representing a 125.1% increase from 1990. …”
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Schwann Cell‐Specific Ablation of Beclin 1 Impairs Myelination and Leads to Motor and Sensory Neuropathy in Mice by Lisa Gambarotto, Loris Russo, Silvia Bresolin, Luca Persano, Rachele D'Amore, Giulia Ronchi, Federica Zen, Luisa Muratori, Alice Cani, Samuele Negro, Aram Megighian, Sonia Calabrò, Paola Braghetta, Dario Bizzotto, Matilde Cescon

“…By knocking out Beclin 1 in SCs here a novel mouse model (Becn1 cKO) is generated, developing a severe and progressive neuropathy, accompanied by involuntary tremors, body weight loss, and premature death. …”
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Targeting S100A9 attenuates social dysfunction by modulating neuroinflammation and myelination in a mouse model of autism by Hong Gong, Yao Lu, Shi-Long Deng, Ke-Yi Lv, Jing Luo, Yi Luo, Zhu-Lin Du, Ling-Feng Wu, Tian-Yao Liu, Xia-Qing Wang, Jing-Hui Zhao, Lian Wang, Mei-Ling Xia, Dong-Mei Zhu, Li-Wei Wang, Xiao-Tang Fan

“…Interestingly, the above social dysfunction was attenuated by a pharmacological inhibitor of S100A9, accompanied by a significant reduction in the activated microglia morphological phenotype, inflammatory receptors, and proinflammatory cytokines. …”
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Life Thinning and Gaming Disorder: A Longitudinal Qualitative Registered Report by Karhulahti, Veli-Matti, Siutila, Miia, Vahlo, Jukka, Koskimaa, Raine

“…This registered report addresses the above research gap with a longitudinal design that pursues a comparative descriptive understanding of how intensive gaming experiences evolve in both clinical and non-clinical life situations. Accompanied by a rich health survey, interpretative phenomenological analysis was adapted to understand in-depth interview data from treatment-seeking (n=5) and esports-playing (n=4) participants, the latter of which did not experience any gaming-related health problems. …”
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Blockade of 4-1BB and 4-1BBL Interaction Reduces Obesity-Induced Skeletal Muscle Inflammation by Ngoc Hoan Le, Chu-Sook Kim, Thai Hien Tu, Hye-Sun Choi, Byung-Sam Kim, Teruo Kawada, Tsuyoshi Goto, Taesun Park, Jung Han Yoon Park, Rina Yu

“…Expression of the 4-1BB gene, accompanied by increased levels of inflammatory cytokines, was markedly upregulated in the skeletal muscle of obese mice fed a high-fat diet, in muscle cells treated with obesity factors, and in cocultured muscle cells/macrophages. …”
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Increased Frequency of CD4+ CD25+ FoxP3+ T Regulatory Cells in Pulmonary Tuberculosis Patients Undergoing Specific Treatment and Its Relationship with Their Immune-Endocrine Profil... by Ariana Díaz, Natalia Santucci, Bettina Bongiovanni, Luciano D’Attilio, Claudia Massoni, Susana Lioi, Stella Radcliffe, Griselda Dídoli, Oscar Bottasso, María Luisa Bay

“…Lowered levels of proinflammatory cytokines together with an increased frequency of Tregs of patients undergoing specific treatment might reflect a downmodulatory effect of these cells on the accompanying inflammation.…”
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Partial rejuvenation of the spermatogonial stem cell niche after gender-affirming hormone therapy in trans women by Emily Delgouffe, Samuel Madureira Silva, Frédéric Chalmel, Wilfried Cools, Camille Raets, Kelly Tilleman, Guy T'Sjoen, Yoni Baert, Ellen Goossens

“…The Leydig cells also exhibited a distribution analogous to peripubertal tissue, accompanied by a reduced insulin-like factor 3 expression. …”
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BP-3 exposure at environmentally relevant concentrations induced male developmental reproductive toxicity via ER/CCL27/ROS pathway in mice by Hong-Mei Li, Yan-Rong Gao, Qing Chang, Xiu-Ying Pei, Jia-He Sun, Yu-Jia Lin, Ya-Nan Tian, Qiang-Wang, Bin Zhao, Heidi Qunhui Xie, Hui-Ming Ma, Hai-Ming Xu

“…The results indicated that BP-3 (2.28 and 228 μg/L) led to a decrease in sperm quantity, quality and testosterone level, impaired blood-testis barrier (BTB) integrity and cytoskeleton, accompanied by aggravated oxidative stress in testes of mice on postnatal day 56 (PND 56). …”
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Lunar and Martian gravity alter immune cell interactions with endothelia in parabolic flight by Yu Du, Bing Han, Katharina Biere, Nathalie Abdelmalek, Xinyu Shu, Chaoyang Song, Guangyao Chen, Ning Li, Marina Tuschen, Huan Wu, Shujin Sun, Alexander Choukér, Mian Long, Dominique Moser

“…Floating speed of THP-1 cells was increased in partial gravity, which was accompanied by a successively lower adhesion to the endothelial HUVEC cells. …”
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CD14loCD301b+ macrophages gathering as a proangiogenic marker in adipose tissues by Yibing Lv, Yidan Zheng, Shanshan Su, Junyi Xiao, Jie Yang, Lingyun Xiong, Yanyan Guo, Xiaoqi Zhou, Nengqiang Guo, Ping Lei

“…Gene Ontology enrichment analysis revealed a significant enhancement of angiogenesis-related function in the Cd14−/− epididymal adipose tissues compared to WT counterpart, which was accompanied by an upregulation of Cd301b. Subsequent assays confirmed the enhanced angiogenesis and more accumulation of CD301b+ macrophages in Cd14−/− epididymal adipose tissues. …”
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Maternal Fructose Intake Induces Insulin Resistance and Oxidative Stress in Male, but Not Female, Offspring by Lourdes Rodríguez, Paola Otero, María I. Panadero, Silvia Rodrigo, Juan J. Álvarez-Millán, Carlos Bocos

“…After fasting, HOMA-IR and ISI (estimates of insulin sensitivity) were worse in male descendents from fructose-fed mothers in comparison to the other two groups, and these findings were also accompanied by a higher leptinemia. Interestingly, plasma AOPP and uricemia (oxidative stress markers) were augmented in male rats from fructose-fed mothers compared to the animals from control or glucose-fed mothers. …”
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Impact of Underweight after Treatment on Prognosis of Advanced-Stage Ovarian Cancer by Se Ik Kim, Hee Seung Kim, Tae Hun Kim, Dong Hoon Suh, Kidong Kim, Jae Hong No, Hyun Hoon Chung, Yong Beom Kim, Yong Sang Song

“…In conclusion, underweight status after treatment may be a poor prognostic factor in patients with advanced-stage ovarian cancer, which accompanies increased host inflammation and decreased immunity.…”
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Abnormalities in mitochondrial energy metabolism induced by cryopreservation negatively affect goat sperm motility by Shengqin Zang, Shuqi Zou, Xiangyi Chen, Bo Pan, Ao Ning, Jianpeng Qin, Yaozong Wei, Kunlin Du, Jiangfeng Ye, Qiuxia Liang, Yi Fang, Qiongla, Cirenlamu, Tianzeng Song, Tianzeng Song, Guangbin Zhou

“…The results revealed that goat sperm exhibited mitochondrial vacuolization, reduced matrix density, and significantly decreased levels of high-membrane potential mitochondria and adenosine triphosphate content, accompanied by a substantial increase in reactive oxygen species levels, ultimately leading to a significant decline in sperm viability. …”
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A case report of successful treatment of advanced thymic squamous cell carcinoma with poor performance status using multimodal therapy by Xianhua Xu, Xiang Yan, Yang Qin, Dan Kou, Qi Huang, Qiongcheng Chen, Yejin Li

“…Computed tomography (CT) and positron emission tomography/computed tomography (PET/CT) scans demonstrated a significant mass in the chest, accompanied by metastasis to adjacent lymph nodes. Vascular ultrasound and CT angiography both indicated thrombosis in the jugular, innominate, and left subclavian veins. …”
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Egyptian Novel Goose Parvovirus in Immune Organs of Naturally Infected Ducks: Next-Generation Sequencing, Immunohistochemical Signals, and Comparative Analysis of Pathological Chan... by Mohamed A. Lebdah, Amal A. M. Eid, Reham M. ElBakrey, Abd Elgalil. El-Gohary, Mohamed G. Seadawy, Mohamed R. Mousa, Hagar F. Gouda, Nehal I. A. Goda, Mostafa F. El-Hosseny, Ahmed S. El-tahlawy, Rokayya Sami, Rasha A. Al-Eisa, Sarah S. Helal

“…Microscopically, the pathological impact of the virus was exhibited by a necrotic thymic cortex with Hassall’s corpuscle disintegration, the disappearance of normal bursal histological morphology accompanied by atrophied follicles and lymphocytic depletion, and apoptosis of B-lymphocytes in lymphoid follicles of the spleen. …”
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Effect of Nasal Obstructive Disorders on Sinonasal Symptoms in Children with Different Levels of Bronchial Asthma Control by T. I. Eliseeva, S. V. Krasilnikova, N. A. Geppe, S. Yu. Babaev, E. V. Tush, O. V. Khaletskaya, D. Yu. Ovsyannikov, I. I. Balabolkin, S. K. Ignatov, N. I. Kubysheva

“…Allergic rhinitis (AR) and allergic rhinosinusitis (ARS) are typical upper airway pathologies (UAP) in children with bronchial asthma (BA) frequently accompanied with nasal obstructive diseases (NOD). In order to establish the effect of NOD on correlations between nasal and synonasal symptoms with clinical assessments of asthma control, 82 children, 9.8 [8.9; 10.7] years old, with atopic BA were assessed using ACQ-5 for the BA control level, TNSS for nasal symptoms, and SNOT-20 for synonasal quality of life in combination with rhinovideoendoscopy for NOD. …”
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Saprotrophic Wood Decay Ability and Plant Cell Wall Degrading Enzyme System of the White Rot Fungus <i>Crucibulum laeve</i>: Secretome, Metabolome and Genome Investigations by Alexander V. Shabaev, Olga S. Savinova, Konstantin V. Moiseenko, Olga A. Glazunova, Tatyana V. Fedorova

“…<i>C. laeve</i> produces a unique repertoire of proteins for the saccharification of the plant biomass, including predominantly oxidative enzymes such as laccases (family AA1_1 CAZymes), GMC oxidoreductases (family AA3_2 CAZymes), FAD-oligosaccharide oxidase (family AA7 CAZymes) and lytic polysaccharide monooxygenases (family LPMO X325), as well as accompanying acetyl esterases and loosenine-like expansins. …”
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Effects of limited introgressions from Triticum timopheevii Tausch. into the genome of bread wheat (Triticum aestivum L.) on physiological and biochemical traits under normal water... by T. A. Pshenichnikova, A. V. Permyakov, S. V. Osipova, M. D. Permyakova, E. G. Rudikovskaya, V. V. Verchoturov

“…On the whole, water deficit tolerance was decreased in the line in comparison with the parental cultivar and was accompanied by leaf senescence. Thus, it may be supposed that 2A, 2B and 5A chromosomes of the drought-tolerant cultivar S29 carry important genetic factors responsible for reaction to water stress in wheat plants.…”
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