Driving effect of P16 methylation on telomerase reverse transcriptase-mediated immortalization and transformation of normal human fibroblasts by Xuehong Zhang, Paiyun Li, Ying Gan, Shengyan Xiang, Liankun Gu, Jing Zhou, Xiaorui Zhou, Peihuang Wu, Baozhen Zhang, Dajun Deng, Jing Ni

“…P16 inactivation is frequently accompanied by telomerase reverse transcriptase (TERT) amplification in human cancer genomes. …”
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Comparison of the effects of 3 kinds of oils rich in omega-3 polyunsaturated fatty acids on glycolipid metabolism and lipoprotein subfractions by Hechun Liu, Feng Wang, Hui Xia, Da Pan, Ligang Yang, Shaokang Wang, Feng Zhao, Guiju Sun

“…Patients with type 2 diabetes (T2DM) are frequently accompanied by dyslipidemia, which is closely related to the high-density lipoprotein (HDL-C) subfractions change. …”
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SPIRIT-DEFINE explanation and elaboration: recommendations for enhancing quality and impact of early phase dose-finding clinical trials protocolsResearch in context by Moreno Ursino, Guillermo Villacampa, Jan Rekowski, Munyaradzi Dimairo, Olga Solovyeva, Deborah Ashby, Jordan Berlin, Oliver Boix, Melanie Calvert, An-Wen Chan, Courtney H. Coschi, Thomas R. Jeffry Evans, Elizabeth Garrett-Mayer, Robert M. Golub, Christina Guo, Kathryn S. Hayward, Sally Hopewell, John D. Isaacs, S. Percy Ivy, Thomas Jaki, Olga Kholmanskikh, Andrew Kightley, Shing Lee, Rong Liu, Adrian Mander, Lynley V. Marshall, James Matcham, Dhrusti Patel, Richard Peck, Khadija Rerhou Rantell, Dawn P. Richards, Mahtab Rouhifard, Lesley Seymour, Yoshiya Tanaka, Christopher J. Weir, Johann de Bono, Christina Yap

“…Each new or modified checklist item is accompanied by a detailed description, its rationale with supportive evidence, and examples of good reporting curated from EPDF trial protocols covering a range of therapeutic areas and interventions. …”
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Dietary supplementation of lysozyme can improve growth rate, laying performance, blood biochemistry, and mRNA levels of some related genes in different plumage-colored quails by Ibrahim Elkhaiat, Seham El-Kassas, Karima El-Naggar, Safaa Abdo, Haitham K. Shalaby, Mahmoud M. Azzam, Alessandro Di Cerbo, Mahmoud Alagawany, Reyad Y. Nofal

“…Histologically, the best hepatic histological features were found in both quail’ varieties fed the NLZ1-supplemented diet. Accompanying LZ-induced modulations in the expression levels of GHR, IGF-1, leptin, CCK, FAS, and ACC genes in both quail varieties were reported. …”
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Multiple Gene Deletion Mutants of Equine Herpesvirus 1 Exhibit Strong Protective Efficacy Against Wild Virus Challenge in a Murine Model by Stephanie S. Pradhan, Vekataramireddy Balena, Bidhan Chandra Bera, Taruna Anand, Rhushikesh Khetmalis, Aashwina Madhwal, Supriya Kandasamy, Selvaraj Pavulraj, Manju Bernela, Priya Mor, Bhupendra Nath Tripathi, Nitin Virmani

“…It specifically exhibited less severe clinical disease in terms of clinical signs, body weight reduction, and gross and histopathological lung lesions accompanied by early virus clearance. Conclusions: These studies are suggestive of vToH-QMV EHV1 being a potential vaccine candidate against EHV1 infection, which needs to be finally tested in the main host, i.e., horses.…”
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Inhibition of platelet activation alleviates diabetes-associated cognitive dysfunction via attenuating blood-brain barrier injury by Fuxing Xu, Juan Hu, Xuying Li, Lan Yang, Shiqiu Jiang, Tao Jiang, Bo Cheng, Hailiang Du, Ruiduo Wang, Yingying Deng, Wei Gao, Yansong Li, Yaomin Zhu

“…Inhibition of platelet activation improved cognitive behaviors in diabetic mice, accompanied with reduced BBB permeability, increased tight junction proteins, balanced Aβ transporters, as well as attenuated Aβ deposition and hippocampal neurons damage. …”
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Increase in disturbance-induced canopy gaps leads to reorganization of Central European bird communities by Anne Graser, Claudia Frank, Friederike Kunz, Andreas Schuldt, Cornelius Senf, Christoph Sudfeldt, Sven Trautmann, Johannes Kamp

“…Responses to disturbance were largely species- and trait-specific, with contrasting effects of different canopy gap age not necessarily accompanied by a change in overall bird diversity. Abundance trends of forest birds as well as short-distant migrants were negatively affected by young canopy gaps. …”
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Decrease in phase angle after Roux-en-Y gastric bypass is related to increase of anti-inflammatory status by Amanda Cristina Araújo Gomes, Amanda Machado Fiorotti, Amanda Motta de Bortoli, Beatriz Bobbio de Brito, João Arthur Souza Fiorido, Luciane Bresciani Salaroli, Andressa Bolsoni Lopes, Fabiano Kenji Haraguchi

“…A significant decrease in PhA values accompanied by an improvement in inflammatory parameters were observed post-RYGB (p<0.05). …”
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Genome-wide identification and characterization of WRKYs family involved in responses to Cylindrocarpon destructans in Panax notoginseng by Manqiao Li, Xiaoli Che, Qiwen Liang, Kuixiu Li, Guisheng Xiang, Xuyan Liu, Yan Zhao, Fugang Wei, Shengchao Yang, Guanze Liu

“…Notably, the ectopic expression of PnWRKY35 in tobacco enhanced resistance to C. destructans, accompanied by increased levels of gibberellins (GA24, GA3, GA8), JA, SA, and brassinolide. …”
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Moscatilin inhibits vascular calcification by activating IL13RA2-dependent inhibition of STAT3 and attenuating the WNT3/β-catenin signalling pathway by Tingting Zhang, Mengmeng Zhu, Jialing Ma, Zhenghong Liu, Zhidan Zhang, Meijie Chen, Yaping Zhao, Huaxin Li, Shengnan Wang, Xiaoning Wei, Wenwen Zhang, Xiaoxiao Yang, Peter J. Little, Danielle Kamato, Hao Hu, Yajun Duan, Baotong Zhang, Jianbo Xiao, Suowen Xu, Yuanli Chen

“…Introduction: Vascular calcification, a devastating vascular complication accompanying atherosclerotic cardiovascular disease and chronic kidney disease, increases the incidence of adverse cardiovascular events and compromises the efficacy of vascular interventions. …”
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Melatonin alleviates high temperature exposure induced fetal growth restriction via the gut-placenta-fetus axis in pregnant mice by Jia-Jin Wu, Xiaoyu Zheng, Caichi Wu, Wen Ma, Yibo Wang, Jun Wang, Yulong Wei, Xiangfang Zeng, Shihai Zhang, Wutai Guan, Fang Chen

“…This restoration corresponded to decreased LPS along the maternal gut-placenta-fetus axis, accompanied by enhanced intestinal and placental barrier integrity, safeguarding fetuses from oxidative stress and inflammation, and ultimately improving fetal weight. …”
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Clinical outcomes over 2 years following arthroscopic ankle lateral ligament repair with os subfibulare by Shohei Sano, Noriyuki Kanzaki, Kiminari Kataoka, Koji Nukuto, Tetsuya Yamamoto, Yuta Nakanishi, Kyohei Nishida, Kanto Nagai, Yuichi Hoshino, Takehiko Matsushita, Ryosuke Kuroda

“…In cases where CLAI accompanied by os subfibulare is resistant to conservative treatment, surgery may be necessary; however, there is no consensus on the most appropriate surgical method. …”
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Evaluating the efficacy of carbetocin versus oxytocin for preventing intraoperative blood loss, early postpartum hemorrhage, and maintaining a favorable hemodynamic profile in lowe... by Bisma Fayaz, Raja Suhail Shounthoo, Ajaiz Rasool, Saima Wani, Showkat Ahmad Gurcoo

“…However, their use is compounded by the accompanying side effects, hence the need for uterotonic agents with relatively better pharmacokinetic and pharmacodynamic profile continues. …”
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Bacterial Diversity in Native Heart Valves in Infective Endocarditis by Anna Sinitskaya, Alexander Kostyunin, Maxim Asanov, Maria Khutornaya, Anastasia Klyueva, Alyona Poddubnyak, Alexey Tupikin, Marsel Kabilov, Maxim Sinitsky

“…Histopathological changes accompanied with bacterial invasion were studied by immunohistochemical analysis of pan-leukocyte marker CD45, platelet marker CD41, and neutrophil myeloperoxidase. …”
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Anti-Inflammatory and Healing Activity of the Hydroalcoholic Fruit Extract of Solanum diploconos (Mart.) Bohs by Larissa Benvenutti, Roberta Nunes, Ivonilce Venturi, Silvia Aparecida Ramos, Milena Fronza Broering, Fernanda Capitanio Goldoni, Sarah Eskelsen Pavan, Maria Verônica Dávila Pastor, Angela Malheiros, Nara Lins Meira Quintão, Elizabeth Soares Fernandes, José Roberto Santin

“…An enhanced efferocytosis of apoptotic neutrophils by macrophages was observed and accompanied by higher IL-10 and decreased TNFα secretion (p<0.01). …”
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Epigenetic «probes» for lung cancer monitoring: LINE-1 methylation pattern in blood- circulating DNA by A. A. Ponomaryova, Е. Y. Rykova, N. V. Cherdyntseva, A. A. Bondar, A. Y. Dobrodeev, A. A. Zavyalov, S. A. Tuzikov, L. O. Bryzgalov, T. I. Merkulova, V. V. Vlassov, P. P. Laktionov

“…Malignant cell transformation is accompanied by two processes of DNA methylation changes: promoter hypermethylation of specific genes and hypomethylation of retrotransposons. …”
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The ameliorative effects of melatonin against BDE-47-induced hippocampal neuronal ferroptosis and cognitive dysfunction through Nrf2-Chaperone-mediated autophagy of ACSL4 degradati... by Quan Yuan, Mingwei Wang, Zhaoxiang Zhang, Ruofei Wang, Dechao Wang, Zichun Sang, Pu Zhao, Xiaoli Liu, Xiaoying Zhu, Gaofeng Liang, Hua Fan, Dongmei Wang

“…Acyl-CoA synthetase long-chain family member 4 (ACSL4), a key lipid metabolism enzyme dictating ferroptosis sensitivity, accompanied by higher MDA and lipid reactive oxygen species (ROS), was remarkably increased under BDE-47 stress, while melatonin supplementation could suppress the elevated ACSL4 in vivo and in vitro. …”
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Alteration, mineralization, geochemistry and fluid inclusion investigations in Joftrud prospect area, southwest of Birjand by Omid Shareipour, Azadeh Malekzadeh Shafaroudi, Maryam Javidi Moghaddam

“…Extensive magmatic activity in the Lut Block, is accompanied with numerous mineralization events such as porphyry copper, IOCG, vein and skarn (Karimpour et al., 2012). …”
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Exploring Disparities in Gill Physiological Responses to NaHCO₃-Induced Habitat Stress in Triploid and Diploid Crucian Carp (<i>Carassius auratus</i>): A Comprehensive I... by Shicheng Han, Lin Han, Fangying Yuan, Wenzhi Liu, Jing Wang, Xiaofeng Jin, Yanchun Sun

“…<b>Conclusions</b>: Overall, NaHCO₃-induced stress leads to significant gill tissue damage, accompanied by reactive oxygen species (ROS) production causing oxidative stress and disruptions in lipid metabolism in crucian carp. …”
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Estrogen-related receptor gamma is a regulator of mitochondrial, autophagy, and immediate-early gene programs in spiny projection neurons: Relevance for transcriptional changes in... by Stephanie N. Fox, Cody H. Savage, Narcy R. Amireddy, Laura J. McMeekin, David K. Crossman, Peter J. Detloff, Michelle Gray, Rita M. Cowell

“…We found an increase in Esrrg expression in HD models, accompanied by a transcriptional profile with similarities to that observed with Esrrg overexpression, suggesting the existence of an ERRγ-dependent, stress-related response. …”
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