AICpred: Machine Learning-Based Prediction of Potential Anti-Inflammatory Compounds Targeting TLR4-MyD88 Binding Mechanism by Lucindah N. Fry-Nartey, Cyril Akafia, Ursula S. Nkonu, Spencer B. Baiden, Ignatus Nunana Dorvi, Kwasi Agyenkwa-Mawuli, Odame Agyapong, Claude Fiifi Hayford, Michael D. Wilson, Whelton A. Miller, Samuel K. Kwofie

“…This study introduces AICpred, a robust, free, user-friendly, and easily accessible machine learning-based web application for predicting inhibitors against TLR4 by targeting the TLR4-myeloid differentiation primary response 88 (MyD88) interaction. …”
Get full text

The Modulation of Laser Refractive Surgery on Sensory Eye Dominance of Anisometropia by Hongting Liu, Qi Chen, Fangfang Lan, Yan Luo, Enwei Lin, Wuqiang Luo, Ming Kong, Jiangxia Wang, Fengju Zhang

“…Visual acuity, sighting eye dominance, and stereo acuity were also accessed. Results. In experiment one, the mean ODI in the nonanisometropic group and the anisometropic group was 1.48 ± 0.63 and 1.95 ± 1.07, respectively. …”
Get full text

Characterizing populations prioritized for PrEP in 19 African countries: a review of national guidance by Lauren A. Graybill, Caroline N. McKay, Jiayu Wang, Nadia A. Sam‐Agudu, Marcel Yotebieng, Friday Saidi, Linda‐Gail Bekker, Bonnie E. Shook‐Sa, Benjamin H. Chi, Nora E. Rosenberg

“…ABSTRACT Introduction While African countries have expanded access to HIV pre‐exposure prophylaxis (PrEP) since 2015, regional targets for PrEP uptake remain unmet. …”
Get full text

Virtual reality-based cognitive–behavioural therapy for the treatment of anxiety in patients with acute myocardial infarction: a randomised clinical trial by Jiajun Weng, Junbo Ge, Jiajia Liu, Juying Qian, Xiao Huang, Yuanyuan Li, Juan Peng, Yan'e Lu, Dong Huang, Pingyuan Yang, Shikun Xu, Lihua Guan, Qibing Wang, Zexin Zhao, Yabin Wei

“…Providing timely and easily accessible psychological interventions using virtual reality-based cognitive–behavioural therapy (VR-CBT) could potentially improve both acute and long-term symptoms affecting their mental health.Aims We aim to examine the effectiveness of VR-CBT on anxiety symptoms in patients with AMI who were admitted to the intensive care unit (ICU) during the acute stage of their illness.Methods In this single-blind randomised clinical trial, participants with anxiety symptoms who were admitted to the ICU due to AMI were continuously recruited from December 2022 to February 2023. …”
Get full text

Qualitative application of the diffusion of innovation theory to maternity waiting homes in rural Zambia by Jeanette L. Kaiser, Rachel M. Fiorillo, Taryn Vian, Thandiwe Ngoma, Kayla J. Kuhfeldt, Michelle L. Munro-Kramer, Davidson H. Hamer, Misheck Bwalya, Viviane R. Sakanga, Jody R. Lori, Eden Ahmed Mdluli, Peter C. Rockers, Godfrey Biemba, Nancy A. Scott

“…Maternity waiting homes (MWHs) increase access to facility-based delivery in low-resourced settings; yet, quality issues deter utilization of this innovative approach. …”
Get full text

Research on construction of public health system in China – a CiteSpace-based visualization analysis of studies published since the COVID-19 epidemic by Yuntong ZHAO, Ziyi PENG, Shuai DU, Wuqi QIU, Pei DONG, Ayan MAO

“…Recently, however, the focus of research has shifted to underdeveloped areas, with more attention being paid to equity in access to public health services.…”
Get full text

Study protocol: type II hybrid effectiveness-implementation study of routine functional status screening in VA primary care by Francesca M. Nicosia, Kara Zamora, LauraEllen Ashcraft, Gregory Krautner, Marybeth Groot, Bruce Kinosian, Cathy C. Schubert, Sumedha Chhatre, Helene Moriarty, Orna Intrator, Andrea Wershof Schwartz, Ariela R. Orkaby, Jason Prigge, Rebecca T. Brown

“…Improved management includes increasing access to services and supports for veterans and family caregivers, reducing potentially preventable acute care utilization, and allowing veterans to live in the least restrictive setting for as long as possible. …”
Get full text

The associations of physical activity patterns and the triglyceride-glucose index in US adults: a secondary data analysis of NHANES (2007–2018) by JinYe Zhang, YiLin Yang, HaoNan Zheng, BoWen Bai, QianKun Yang, Li Zhang, YuTong Zhao, Jing Luo, Bin Yu

“…Abstract The triglyceride-glucose (TyG) index, a readily accessible surrogate biomarker for insulin resistance and metabolic health, has been extensively investigated across various ethnic populations. …”
Get full text

Alternative psychopharmacologic treatments for pediatric catatonia: a retrospective analysis by Joshua R. Smith, Joshua R. Smith, Isaac Baldwin, Tasia York, Carina Anderson, Trey McGonigle, Simon Vandekar, Lee Wachtel, James Luccarelli, James Luccarelli

“…However, lorazepam may not be readily available, and access to ECT is limited by restrictive legislation and stigma. …”
Get full text

Characteristics and outcomes of out-of-hospital cardiac arrest among students under school supervision in Japan: a descriptive epidemiological study (2008–2021) by Kosuke Kiyohara, Mamoru Ayusawa, Masahiko Nitta, Takeichiro Sudo, Taku Iwami, Ken Nakata, Yuri Kitamura, Tetsuhisa Kitamura

“…The delivery of defibrillation using public-access automated external defibrillators was also significantly less frequent in non-cardiac (3.3%) and traumatic cases (6.2%) than that in cardiac cases (59.8%; p < 0.001). …”
Get full text

Epilepsy care pathway: The Finnish model by Reetta Kälviäinen, Zakarya Hadj‐Allal, Jarkko Kirjavainen, Reina Roivainen, Tarja Linnankivi, Jukka Peltola, Kai Eriksson, Salla Lamusuo, Tuire Lähdesmäki, Johanna Annunen, Päivi Vieira, Virpi Tarkiainen, Leena Jutila, Anni Saarela, Leena Kämppi, Liisa Metsähonkala, Eija Gaily, Niina Lähde, Jaana Antinmaa, Sini Erme, Anna‐Leena Pirttisalo, Jari Virolainen, Milla Ylijoki, Laura Kela, Jonna Komulainen‐Ebrahim, Paula Sorjonen, Finnish Severe Epilepsy Coordination Group

“…Abstract Objective Integrated care pathways are essential for consistent, effective epilepsy care, offering equal access and quality regardless of socioeconomic status. …”
Get full text

The carbon cost of impaired welfare on sheep farms by L. Lanzoni, M.C. Reeves, K. Waxenberg, R. Ramsey, A.S. Atzori, J. Bell, R.M. Rees, G. Vignola, C.M. Dwyer

“…In this study, “high welfare conditions” are defined as situations where animals have access to adequate feeding, suitable housing, good health, and opportunities to express natural behaviours. …”
Get full text

Supporting primary care clinicians in caring for patients with alcohol use disorder: study protocol for Records for Alcohol Care Enhancement (RACE), a factorial four-arm randomized... by Kara M. Magane, Richard Saitz, Sarah Fielman, Marc R. LaRochelle, Christopher W. Shanahan, Christine A. Pace, Michael LaValley, Kaley Penington, Skylar Karzhevsky, Emily Hurstak

“…Methods PCPs from an urban safety-net hospital-based primary care clinic are randomized to one of four groups (1) EHR best practice advisory (BPA) and clinical decision support tools for unhealthy alcohol use (BPA), (2) BPA plus population health manager support, (3) BPA plus clinical care manager support, and (4) all three. All PCPs will have access to the EHR BPA and decision support tools which provide chart-based advisories and order set navigation. …”
Get full text

Clinical outcomes among HIV positive babies below 18 months of age, diagnosed under the Early Infant Diagnosis (EID) programme, India: a mixed-methods studyResearch in context by Suchit Kamble, Nilesh Gawde, Shilpa Bembalkar, Noopur Goel, Mohan Thorwat, Kalyani Nikhare, Sushmita Kamble, Radhika Brahme, Swapna Pawar, Harsh Kubavat, Bhawanisingh Kushwaha, Vinita Verma, Chinmoyee Das, Raman Gangakhedkar

“…Demand-side issues such as stigma and discrimination at family, community, and societal levels, desperation about the survival of the child, supply-side factors such as remote access to paediatric ART centres, and lack of paediatric ART medicine formulations were associated with ART treatment. …”
Get full text

A Systematic Review and Meta-analysis of Randomized Controlled Trials on Comparing Transabdominal Preperitoneal Versus Lichtenstein Operations for Primary Inguinal Hernia Repair by Muhammad Aslam Javed, Muhammad Arshad Abbas, Mudassar Murtaza, Wasif Majeed Chaudhry, Adnan Faisal, Muhammad Mohsin Gillani

“…However, the Lichtenstein technique remains a widely used option, especially in settings where access to advanced Laparoscopic facilities and expertise might not be available. …”
Get full text

Rehabilitation using virtual gaming for Hospital and hOMe-Based training for the Upper limb post Stroke (RHOMBUS II): protocol of a feasibility randomised controlled trial by Cherry Kilbride, Tom Butcher, Meriel Norris, Nana Anokye, Alyson Warland, Karen Baker, Dimitrios A Athanasiou, Guillem Singla-Buxarrais, Jennifer Ryan, Francesca Gowing, Carole Pound, Victoria Stewart, Basaam Aweid, Arul Samiyappan

“…Opportunities for the stroke survivor to engage with UL rehabilitation in a safe, accessible and engaging way are essential to improving UL outcomes following stroke. …”
Get full text

Validation study of synthetic models for esophageal atresia with tracheoesophageal fistula (EA/TEF): A simulation-based training in pediatric surgery by Zahradníková Petra, Hnilicová Silvia, Lindák Martin, Pechanová Rebeka, Števková Dominika, Vitovič Pavol, Laurovičová Miroslava, Horn František, Tvrdoň Tomáš, Babala Jozef

“…Eight participants (18 %) declared weekly access to simulation training, while 49 % had none. …”
Get full text

Biointegration of soft tissue-inspired hydrogels on the chorioallantoic membrane: An experimental characterization by Manuel P. Kainz, Mathias Polz, Daniel Ziesel, Marta Nowakowska, Muammer Üçal, Sabine Kienesberger, Sophie Hasiba-Pappas, Raimund Winter, Nassim Ghaffari Tabrizi-Wizsy, Sarah Kager, Theresa Rienmüller, Julia Fuchs, Michele Terzano, Christian Baumgartner, Gerhard A. Holzapfel

“…This study examines the attachment and integration of soft hydrogels on the CAM using an accessible ex ovo system. Composite hydrogels of polyvinyl alcohol and Phytagel were fabricated by sterile freeze-thawing. …”
Get full text

Realising health justice in Palestine: beyond humanitarian voices by James Smith, Sara el-Solh, Layth Hanbali, Sawsan Abdulrahim, Sali Hafez, Samer Abuzerr, Bram Wispelwey, Mads Gilbert, Mohammed Seyam, Bassam Abu Hamad, Dorotea Gucciardo, Fahd Haddad, Rasha Khoury, Amira Nimerawi, David Mills, Ghassan Abu-Sittah

“…We argue that in relation to the post-genocide reconstruction of the health system in Gaza, the authors have failed to adequately contextualise their analysis, or the health system reconstruction policy proposal as commissioned by the Gaza Health Initiative [Gaza Health Rebuilding Initiative (GHRI), Future of the Gaza health system: Needs assessment. https://static1.squarespace.com/static/656c4ff5b219116063f8099e/t/65c30c4d3e80fd21f1165b57/1707281499127/Final+first+draft+-+Gaza+health+system+report.pdf . Accessed 8 November 2024], and as such have failed to elucidate the root causes of what manifests most immediately as an entirely manufactured humanitarian crisis. …”
Get full text

Cost-effectiveness of decentralising acute malnutrition treatment with a standard or simplified treatment protocol: an economic evaluation in the region of Gao, Mali by Bernardette Cichon, Noemí López-Ejeda, Salimata Samake, Cornelia Aton, Abdias Ogobara Dougnon, Mahamadou N’tji Samake, Aliou Bagayoko, Magloire Bunkembo, Alexandra Rutishauser-Perera, Pilar Charle-Cuellar

“…Decentralisation of treatment to Community Health Worker (CHW) sites has shown to be an effective strategy to improve access and increase coverage, but evidence on the cost and cost-effectiveness of this approach as well the use of simplified treatment protocols in conflict settings is lacking. …”
Get full text