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    Exploring the Causal Relationship Between Frailty and Chronic Obstructive Pulmonary Disease: Insights From Bidirectional Mendelian Randomization and Mediation Analysis by Cheng Z, Wu J, Xu C, Yan X

    Published 2025-01-01
    “…Zewen Cheng,1 Jian Wu,1 Chun Xu,2 Xiaokun Yan1 1Department of Thoracic Surgery, Suzhou Hospital of Integrated Traditional Chinese and Western Medicine, Suzhou, Jiangsu, 215000, People’s Republic of China; 2Department of Cardio-Thoracic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215000, People’s Republic of ChinaCorrespondence: Xiaokun Yan, Department of Thoracic Surgery, Suzhou Hospital of Integrated Traditional Chinese and Western Medicine, Suzhou, Jiangsu, 215000, People’s Republic of China, Email yanxk2008@126.comBackground: Observational studies have underscored a robust association between frailty and chronic obstructive pulmonary disease (COPD), yet the causality remains equivocal.Methods: This study employed bidirectional two-sample Mendelian randomization (MR) analysis. …”
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