Immune dysfunction revealed by digital spatial profiling of immuno-oncology markers in progressive stages of renal cell carcinoma and in brain metastases by Wei Wei, Michael Hurwitz, Sabina Signoretti, Lucia Jilaveanu, Toni K Choueiri, David L Rimm, Adebowale Adeniran, Sandra Martínez, Harriet M Kluger, David A Schoenfeld, Myrto Moutafi, Dijana Djureinovic, Ross D Merkin, David A Braun, Fabio Parisi

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Baryon Pasting the Uchuu Light-cone Simulation by Erwin T. Lau, Daisuke Nagai, Arya Farahi, Tomoaki Ishiyama, Hironao Miyatake, Ken Osato, Masato Shirasaki

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The Potential Role of Regulatory B Cells in Idiopathic Membranous Nephropathy by Zhaocheng Dong, Zhiyuan Liu, Haoran Dai, Wenbin Liu, Zhendong Feng, Qihan Zhao, Yu Gao, Fei Liu, Na Zhang, Xuan Dong, Xiaoshan Zhou, Jieli Du, Guangrui Huang, Xuefei Tian, Baoli Liu

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Development of a checklist for cognitive assessment requirements (CARE) based on a Delphi consensus study by Vahid Nejati, Reza Estaji, Vicent Balanzá-Martínez, David A Balota, Suzanne Barker-Collo, Morris Bell, Jacquelyn H Berry, Khatereh Borhani, Munro Cullum, Anthony Feinstein, Charles J Golden, Raul Gonzalez, Jordan Henry Grafman, Steven D Hollon, Petra Jansen, Nicole A Kochan, Ryan Van Patten, Olivier Piguet, Sarah A Raskin, Sean B. Rourke, Andrew Scholey, Yaakov Stern, Steven Paul Woods, Michael I. Posner

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The association between salivary oxytocin, age, and puberty in children with and without OCD by Anna-Rosa Cecilie Mora-Jensen, Line Katrine Harder Clemmensen, Manja Gersholm Grønberg, Eli R. Lebowitz, Daniel S. Quintana, Niklas Rye Jørgensen, Charlotte Sewerin Larsen, Lasse Kristoffer Bak, Gitte Lund Christensen, Linea Pretzmann, Valdemar Uhre, Sofie Heidenheim Christensen, Camilla Uhre, Nicoline Løcke Jepsen Korsbjerg, Christine Lykke Thoustrup, Julie Hagstrøm, Melanie Ritter, Kerstin Jessica Plessen, Anne Katrine Pagsberg, Nicole Nadine Lønfeldt

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The expression landscape and clinical significance of methyltransferase-like 17 in human cancer and hepatocellular carcinoma: a pan-cancer analysis using multiple databases by Yezhou Ding, Mingyang Feng, Wanqing Chi, Xiaoyin Wang, Baoyan An, Kehui Liu, Shike Lou, Xiaolin Wang, Hui Wang

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A novel sensitizer reduces EGFR-TKI resistance by regulating the PI3K/Akt/mTOR pathway and autophagy by Jue Zhang, Zhipeng Qu, Xi Xiao, David L. Adelson, Funeng Wang, Aisheng Wei, Yuka Harata-Lee, Jian Cui, Dongying He, Le Xie, Lingling Sun, Jing Li, Zijing Huang, Thazin Aung, Hong Yao, Lizhu Lin

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Cognitive performance and differentiation of B-SNIP psychosis Biotypes: Algorithmic Diagnostics for Efficient Prescription of Treatments (ADEPT) - 2 by Brett A. Clementz, Ishanu Chattopadhyay, S. Kristian Hill, Jennifer E. McDowell, Sarah K. Keedy, David A. Parker, Rebekah L. Trotti, Elena I. Ivleva, Matcheri S. Keshavan, Elliot S. Gershon, Godfrey D. Pearlson, Carol A. Tamminga, Robert D. Gibbons

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Representation of Hispanic Patients in Clinical Trials for Respiratory Failure: A Systematic Review by Emily A. Harlan, MD, MA, MSc, Kaitlin Malley, BS, Grecia Quiroga, MD, Eman Mubarak, MD, Pema Lama, BS, Amanda Schutz, PhD, Adolfo Cuevas, PhD, Catherine L. Hough, MD MSc, Theodore J. Iwashyna, MD PhD, Mari Armstrong-Hough, PhD, Thomas S. Valley, MD, MSc

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Simons Observatory: Predeployment Performance of a Large Aperture Telescope Optics Tube in the 90 and 150 GHz Spectral Bands by Carlos E. Sierra, Kathleen Harrington, Shreya Sutariya, Thomas Alford, Anna M. Kofman, Grace E. Chesmore, Jason E. Austermann, Andrew Bazarko, James A. Beall, Tanay Bhandarkar, Mark J. Devlin, Simon R. Dicker, Peter N. Dow, Shannon M. Duff, Daniel Dutcher, Nicholas Galitzki, Joseph E. Golec, John C. Groh, Jon E. Gudmundsson, Saianeesh K. Haridas, Erin Healy, Johannes Hubmayr, Jeffrey Iuliano, Bradley R. Johnson, Claire S. Lessler, Richard A. Lew, Michael J. Link, Tammy J. Lucas, Jeffrey J. McMahon, Jenna E. Moore, Federico Nati, Michael D. Niemack, Benjamin L. Schmitt, Max Silva-Feaver, Robinjeet Singh, Rita F. Sonka, Alex Thomas, Robert J. Thornton, Tran Tsan, Joel N. Ullom, Jeffrey L. Van Lanen, Eve M. Vavagiakis, Michael R. Vissers, Yuhan Wang, Kaiwen Zheng

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Cab45G trafficking through the insulin secretory pathway is altered in human type 2 diabetes by Mark Germanos, Belinda Yau, Matthew Taper, Cara Yeoman, Amy Wilson, Yousun An, Jerome Cattin-Ortolá, Drew Masler, Jason Tong, Sheyda Naghiloo, Elise J Needham, A Gabrielle van der Kraan, Kitty Sun, Thomas Loudovaris, Alexis Diaz-Vegas, Mark Larance, Helen Thomas, Helen von Blume, Peter Thorn, Michael Ailion, Cedric Asensio, Melkam Alamerew Kebede

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High-resolution spatiotemporal analysis of chikungunya epidemics between 2019 and 2020 in Salvador, Brazil: a municipality-level transmission dynamics studyResearch in context by Hernan D. Argibay, Cristiane W. Cardoso, William M. de Souza, Raquel L. Souza, Maysa Pellizzaro, Geraldo M. Cunha, Julie Clennon, Scott C. Weaver, Mitermayer G. Reis, Uriel Kitron, Guilherme S. Ribeiro

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Enhanced hydrogen evolution via nano-patterned Pt-based metallic glass and dynamic copper oxide foam formation by Fei-Fan Cai, Baran Sarac, Adnan Akman, Juan J. Londoño, Selin Gümrükcü, Lukas Schweiger, Martin Hantusch, Jan Schroers, Andreas Blatter, Annett Gebert, Florian Spieckermann, Jürgen Eckert

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The association of travel distance and other patient characteristics with breast cancer stage at diagnosis and treatment completion at a rural Rwandan cancer facility by Kayleigh Bhangdia, Abirami Natarajan, Niclas Rudolfson, Stéphane Verguet, Marcia C. Castro, Jean-Marie Vianney Dusengimana, Cyprien Shyirambere, Lauren E. Schleimer, Lawrence N. Shulman, Aline Umwizerwa, Catherine Kigonya, John Butonzi, Emily MacDuffie, Temidayo Fadelu, Daniel S. O’Neil, Cam Nguyen, Tharcisse Mpunga, Nancy L. Keating, Lydia E. Pace

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Effectiveness of using implementation frameworks to facilitate the implementation of a stroke management guideline in the traditional Chinese medicine hospitals in China: protocol... by Zhuo Chen, Yefeng Cai, Wenjun He, Yiyuan Cai, Lingrui Liu, Qing Zhao, Sensen lv, Dong (Roman) Xu, Chun Hao, Lanping Zhang, Pengfei Guo, Yuning Shi

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Anti-PD-1 amplifies costimulation in melanoma-infiltrating Th1-like Foxp3+ regulatory T cells to alleviate local immunosuppression by Fernando Alvarez, Fan Huang, Sonia V Del Rincon, Mikhaël Attias, Tho-Alfakar Al-Aubodah, Roman Istomine, Paige McCallum, Abrahim Sleiman, Tamiko Nishimura, Yasser Riazalhosseini, Ciriaco A Piccirillo

“…As Foxp3+ regulatory T (Treg) cells play an important role in tumor-induced immunosuppression and express PD-1, we hypothesized that anti-PD-1 also increases the functions of melanoma-infiltrating Treg cells, which could be detrimental to treatment efficacy.Methods The cellular and functional dynamics of Treg cells were evaluated in C57Bl/6 Foxp3-reporter mice bearing highly immunogenic and PD-1 blockade-sensitive Yale University Mouse Melanoma Exposed to Radiation 1.7 (YUMMER1.7) tumors. …”
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Impaired creatinine-based estimated glomerular filtration rate in Thai individuals switching to dolutegravir: illustrating the role of cystatin C testing to aid clinical decision m... by Carlo Sacdalan, Curtis Austin, Aswathy Varma, Suteeraporn Pinyakorn, Eugène Kroon, Donn J. Colby, Phillip Chan, Orlanda Goh, Krittaporn Pornpaisakul, Jintana Intasan, Tassanee Luekasemsuk, Merlin L. Robb, Nitiya Chomchey, Nittaya Phanuphak, Jintanat Ananworanich, Sandhya Vasan, Denise Hsu, the SEARCH 010/RV254 study group

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Evaluation of parent reminder-recall letters to promote human papillomavirus vaccination by Joan M. Griffin, Xuan Zhu, Wei Yi Kong, Robert M. Jacobson, Kathy L. MacLaughlin, Jennifer L. St. Sauver, Jeph Herrin, Gregory D. Jenkins, Nicole L. Larson, Lila J. Finney Rutten

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The REpeated ASSEssment of SurvivorS in intracerebral haemorrhage: protocol for a multicentre, prospective observational study by Daniel Woo, Richard Thompson, Carl D Langefeld, Nichol McBee, Daniel Hanley, Matthew L Flaherty, Lauren Sansing, Karen Lane, Lee A Gilkerson, Achala Vagal, Nathan Walborn, Wendy Ziai, Noeleen Ostapkovich, Kevin Triene, Timothy David Howard

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Describing quality of life trajectories in young Hispanic women with breast cancer: 5-year results from a large prospective cohort by Bryan F. Vaca-Cartagena, Ana S. Ferrigno Guajardo, Hatem A. Azim Jr, Federico Rotolo, Antonio Olivas-Martinez, Alejandra Platas, Alan Fonseca, Fernanda Mesa-Chavez, Marlid Cruz-Ramos, Ana Rodriguez, Alejandro Mohar, Cynthia Villarreal-Garza

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