In Vivo Bioluminescence Imaging Validation of a Human Biopsy–Derived Orthotopic Mouse Model of Glioblastoma Multiforme by Monika A. Jarzabek, Peter C. Huszthy, Kai O. Skaftnesmo, Emmet McCormack, Patrick Dicker, Jochen H.M. Prehn, Rolf Bjerkvig, Annette T. Byrne

“…We have previously shown that a xenograft model based on serial xenotransplantation of human biopsy spheroids in immunodeficient rodents maintains the genotype and phenotype of the original patient tumor. …”
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Deciphering the effect of UM171 on human hematopoietic progenitor cell fate through clonal analysis by Patrick Coulombe, Elisa Tomellini, Jalila Chagraoui, Nadine Mayotte, Guy Sauvageau

“…This differentiation bias can be driven by pro-inflammatory signaling pathways that are activated downstream of UM171 and results in an abundant mast cell population that can be transplanted as part of the graft to populate mice tissues in xenotransplantation studies.…”
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Features of the electrolyte distribution in various tissues in miniature pigs by A. V. Fatianova, V. A. Lavrinenko, O. V.  Trapezov, N. S. Yudin

“…Striking similarities between human and miniature pig anatomy and physiology of the cardiovascular system, skin and digestive organs have made miniature pigs a successful animal model for addressing problems of xenotransplantation. However, despite the widespread interest in this breed of animals, the distribution of water and electrolytes in the tissues of miniature pigs remains poorly understood, which led us to conduct this study. …”
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Human Bone Marrow Mesenchymal Stromal Cells Promote Bone Regeneration in a Xenogeneic Rabbit Model: A Preclinical Study by Juan Francisco Blanco, Jesús García-Briñon, Lorena Benito-Garzón, David Pescador, Sandra Muntión, Fermín Sánchez-Guijo

“…Finally, no inflammatory reaction was detected, besides the xenotransplantation of human cells into an immunocompetent recipient. …”
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Micro–Positron Emission Tomography/Contrast-Enhanced Computed Tomography Imaging of Orthotopic Pancreatic Tumor–Bearing Mice Using the αβ Integrin Tracer Cu-Labeled Cyclam-RAFT-c(-... by Winn Aung, Zhao-Hui Jin, Takako Furukawa, Michael Claron, Didier Boturyn, Chizuru Sogawa, Atsushi B. Tsuji, Hidekatsu Wakizaka, Toshimitsu Fukumura, Yasuhisa Fujibayashi, Pascal Dumy, Tsuneo Saga

“…The purpose of this study was to develop a clinically relevant orthotopic xenotransplantation model of pancreatic cancer and to perform a preclinical evaluation of a new positron emission tomography (PET) imaging probe, 64 Cu-labeled cyclam-RAFT-c(-RGDfK-) 4 peptide ( 64 Cu-RAFT-RGD), using this model. …”
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Somatic Transformations in the Context of Antropotechnogynesis at the Modern Stage by І. Р. Pecheranskyi

“…They are divided into two main groups: intra-structural, substantial, related to techno-modification of the human body directly through biotechnology and genetic engineering, cyborgization, xenotransplantation, Hi-Hume connection with Hi-Tech and others, and external-contextual, when under the influence of pancommunication and hybridization the environment is increasingly mentalized and somatized, and modern technologies are gradually transformed into the social body of man.…”
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Pan-cancer analysis shows that TNFSF4 is a potential prognostic and immunotherapeutic biomarker for multiple cancer types including liver cancer by Zhaoda Deng, Lincheng Li, Zihe Meng, Guineng Zeng, Rui Cao, Rong Liu

“…Furthermore, cell phenotype experiment and tumor xenotransplantation experiment were performed to determine the biological functions of TNFSF4. …”
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ALKBH3-mediated m1A demethylation promotes the malignant progression of acute myeloid leukemia by regulating ferroptosis through the upregulation of ATF4 expression by Xin Liu, Xinghua Pan

“…To investigate the role of ALKBH3 in acute myeloid leukemia (AML), we constructed an animal model of xenotransplantation of AML. Our study demonstrated that ALKBH3-mediated m1A demethylation inhibits ferroptosis in KG-1 cells by increasing ATF4 expression, thus promoting the development of AML. …”
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In vivo MRS study of long-term effects of traumatic intracranial injection of a culture medium in mice by O. B. Shevelev, O. P. Cherkasova, I. A. Razumov, E. L. Zavjalov

“…However, in studying new approaches to the therapy of glioblastoma in the model of orthotopic xenotransplantation of glioma cells into the brain of mice, it is necessary to understand which metabolites are produced by a growing tumor and which are the result of tumor cells injection along the modeling of the pathology. …”
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Long non-coding RNA SNHG17 may function as a competitive endogenous RNA in diffuse large B-cell lymphoma progression by sponging miR-34a-5p. by Shengjuan Lu, Lin Zeng, Guojun Mo, Danqing Lei, Yuanhong Li, Guodi Ou, Hailian Wu, Jie Sun, Chao Rong, Sha He, Dani Zhong, Qing Ke, Qingmei Zhang, Xiaohong Tan, Hong Cen, Xiaoxun Xie, Chengcheng Liao

“…The regulatory function of SNHG17 in DLBCL was investigated using a mouse tumor xenotransplantation model. RNA sequencing was used to analyze the signaling pathways involved in SNHG17 knockdown in B-cell lymphoma cell lines. …”
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Genetically engineered pig heart transplantation in non-human primates by Avneesh K. Singh, Corbin E. Goerlich, Tianshu Zhang, Billeta Lewis, Alena Hershfeld, Gheorghe Braileanu, Kasinath Kurvi, Kathryn Rice, Faith Sentz, Sarah Mudd, Patrick Odonkor, Erik Strauss, Brittney Williams, Allen Burke, Anuj Gupta, Cinthia B. Drachenberg, David Ayares, Bartley P. Griffith, Muhammad M. Mohiuddin

“…However, these 10GE organs may be suitable for clinical cardiac xenotransplantation and have already been utilized in two human cases.…”
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Phenotypic Analysis of BrdU Label-Retaining Cells during the Maturation of Conducting Airway Epithelium in a Porcine Lung by Yuanyuan Jia, Xuehong You, Ningxia Ma, Hui Li, Guopan Liu, Ying Wang, Jing Xue, Juan Shi, Jun Wei, Yong Li, Jiali Yang, Xiaoming Liu

“…Porcine has spurred an increased interest in biomedical research models and xenotransplantation, owing to most of its organs share similarities in physiology, cellular composition and size to humans. …”
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Exosomes derived from syncytia induced by SARS-2-S promote the proliferation and metastasis of hepatocellular carcinoma cells by Huilong Li, Huilong Li, Haotian Lin, Haotian Lin, Tinghui Fan, Linfei Huang, Li Zhou, Xiaoyu Tian, Ruzhou Zhao, Yanhong Zhang, Xiaopan Yang, Luming Wan, Hui Zhong, Nan Jiang, Congwen Wei, Wei Chen, Wei Chen, Lihua Hou, Lihua Hou

“…A patient-derived xenotransplantation (PDX) mouse model was constructed to evaluate the pathological role of the SARS-CoV-2 spike protein (SARS-2-S). …”
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