Enteric-Coated Aspirin Induces Small Intestinal Injury via the Nrf2/Gpx4 Pathway: A Promising Model for Chronic Enteropathy by Zhang M, Xia S, Feng L, Han X, Zhang Y, Huang Y, Liu Y, Zhao K, Guan J, Tian D, Liao J, Yu Y

“…The mRNA and protein levels of inflammatory factors, tight junctions, and antioxidant defense-related genes were measured by qRT-PCR and Western Blot. The MPO activity, SOD activity and MDA content in serum were measured. …”
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Bridging the gap between defossilization and decarbonization to achieve net-zero industry by Steven Griffiths, Benjamin Sovacool, Marfuga Iskandarova, Hans Jakob Walnum

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Diagnostics and treatment of chronic constipation in adults: clinical guidelines of the Russian gastroenterological association by V. T. Ivashkin, I. V. Mayev, A. A. Sheptulin, A. S. Trukhmanov, Ye. A. Poluektova, Ye. K. Baranskaya, O. S. Shifrin, T. L. Lapina, M. F. Osipenko, V. I. Simanenkov, I. B. Khlynov

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Bloodstream infections at a tertiary hospital in the Gambia - a one-year retrospective study by Paul Rahden, Ebrima Barrow, Haddy Bah, Sheikh Omar Bittaye, David Nygren, Abdoulie Badjan

“…Abstract Introduction Antimicrobial resistance is a significant global health concern, particularly in western Sub-Saharan Africa. This study describes causes of bloodstream infections and antimicrobial resistance at a tertiary hospital in The Gambia. …”
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Linking a distal ejecta with its source crater: a probabilistic approach applied to tektites by Rochette, Pierre, Baratoux, David, Braucher, Regis, Cornec, Jean, Debaille, Vinciane, Devouard, Bertrand, Gattacceca, Jerome, Gounelle, Matthieu, Jourdan, Fred, Moustard, Fabien, Nomade, Sébastien

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The effect of a community-based health behaviour intervention on healthcare services use among people with type 2 diabetes in Nepal by Grish Paudel, Corneel Vandelanotte, M Mamun Huda, Padam Kanta Dahal, Lal Rawal

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A computational role of blood nanofluid induced by a stenosed artery with porous medium and thermophoretic particle deposition effects by Shivalila Hangaragi, N. Neelima, N. Beemkumar, Ankur Kulshreshta, Umair Khan, Noreen Sher Akbar, Mohammad Kanan, Mona Mahmoud

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Outcomes of total hip replacement in adults with septic arthritis of the native hip joint: A systematic review by Teddy Cheong, Surya Varma Selvakumar, Ryan Kwang Jin Goh, Ing How Moo

“…Re-infection rate and various functional outcomes, measured in terms of the Harris Hip Score (HHS), Visual Analogue Scale (VAS), Merle D'Aubigne and Postel (MAP), Western Ontario, McMaster Universities Arthritis Index (WOMAC) Short Form 12-Item (SF-12) scores, were analyzed. …”
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Impact of Small-Scale Businesses on Provision of Employment to Informal Labor Force in Kabale Municipality. by Uwibanze, Frank

“…It is about 142 kilometers (88 mi) southwest of Mbarara, the largest city in the Western Region of Uganda. The study employed both exploratory and descriptive study design. …”
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LRP11 promotes stem-like T cells via MAPK13-mediated TCF1 phosphorylation, enhancing anti-PD1 immunotherapy by Zhishui Chen, Gang Chen, Li Chen, Xiangli Zhao, Lingjuan Sun, Zhibo Ma, Xiaosheng Tan, Yuhao Tu, Jingzeng Wang, Peixiang Lan

“…Molecular interactions and TCF1 status were examined using Western blotting. Moreover, we employed RNA sequencing to investigate the effects of LDL stimulation and MAPK13 inhibition in CD8+ T cells.Results By using a tumor-bearing mouse model, we found that LDL-induced tumor-infiltrating TCF1+PD1+CD8+ T cells. …”
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iPSC-derived exosomes as amphotericin B carriers: a promising approach to combat cryptococcal meningitis by Jingyu Zhao, Jingyu Zhao, Wei Fang, Yangjie Gao, Jiquan Chen, Guizhen Wang, Julin Gu

“…Purity was confirmed by Western blotting for markers CD9, CD63, and TSG101. …”
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Hypothermia regulates mitophagy and apoptosis via PINK1/Parkin-VDAC 3 signaling pathway during oxygen-glucose deprivation/recovery injury by Luying Zhang, Song Yang, Hao Cui, Chenchen Hang, Xingsheng Wang, Le An, Zhenyu Shan, Zhen Liang, Rui Shao, Ziren Tang

“…Expression of mitophagy-related proteins (Cleaved PINK1, Parkin, SQSTM1/p62, Beclin-1, LC3B II/LC3B I), apoptosis-related proteins (Bcl-2, Cytochrome C, caspase-3, cleaved caspase3) and VDAC3 were assessed using western blot analysis and quantitative real-time PCR. …”
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How efficient are specialized public health services in China? A data envelopment analysis and geographically weighted regression approach by Qian Bai, Qian Bai, Lieyu Huang, Yan Guo, Xin Xu, Zhouyixin Zhang, Yuan Wang, Hao Chen, Ying Bian, Ying Bian

“…Besides, substantial geographic variations were observed, with the eastern region exhibiting greater levels of technical and pure technical efficiency. Contrarily, the western region appeared to perform better in terms of scale efficiency. …”
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The ground beneath our feet: A critical reflection on 135 years of landscape evolution models for southern Africa by Rivoningo Khosa, Vela Mbele, Kelly Kirsten, Robyn Pickering

“…We also note that the key narratives that have driven research on landscape evolution have been largely shaped by selected prominent Western-based scientists. As we mark the centenary of the Taung discovery, we look toward a new era of landscape evolution research: one characterised by technological advancements and more diverse, local teams that will produce more quantitative, nuanced models for southern Africa and create richer, more dynamic backdrops for our own human evolution. …”
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Evaluation of Ecosystem Services and Tradeoff and Synergy in the Alpine and Canyon Region of Southwest China Based on Multi-source Geographic Data by LIU Jing, XIANG Jiayi, ZHANG Donghai, LAN Mengyao, GUAN Yinghui

“…These synergies were mainly located in the southeastern Tibetan alpine canyon ecological maintenance zone and the eastern Tibetan-western Sichuan alpine canyon ecological maintenance and water retention zone. …”
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Effect of trilaciclib administered before chemotherapy in patients with extensive-stage small-cell lung cancer: A pooled analysis of four randomized studies by Ying Liu, Lin Wu, Dingzhi Huang, Qiming Wang, Chen Yang, Li Zhou, Shuguang Sun, Xiaomei Jiang, Ying Cheng

“…Approach taken, including aspects such as the sample size: This pooled analysis included one study in China and three studies in western countries, and the overall sample size was 325. …”
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Mechanism of melanoma suppression by Prosopis juliflora derived alkaloids: Apoptosis induction and signaling pathway inhibition by Jasoda Choudhari, Snehal K. Nimal, Shridhar Chougule, Trupti Shinde, N.R. Dhatrak, Gopal C. Kundu, Rajesh N. Gacche

“…Mechanistic study of PJLME-AF was explored using ROS generation assay, apoptosis assays (Annexin V) assay, western blot (apoptotic protein, EMT markers, stem cell markers and signalling pathways), qPCR. …”
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NUAK1 acts as a novel regulator of PD-L1 via activating GSK-3β/β-catenin pathway in hepatocellular carcinoma by Chao-Yan Yao, Hang-Tian Tao, Jin-Jin He, Feng-Yi Zhu, Cui-Qing Xie, Yu-Na Cheng, Ji-Qin Li, Zhuang-Zhuang Liu, Chun-Yu Hou, Xue-Li Liu, Yong-Li Fan, Dong Fang, Xin-Rui Lv

“…HCC cell lines were used to validate the role of NUAK1 in regulating the transcription of PD-L1, the diethylnitrosamine-induced HCC model was established and the expression levels of NUAK1 and PD-L1 proteins in the rat livers were detected. Western blotting, immunofluorescence, real time PCR, and immunohistochemical staining were used to investigate the underlying mechanisms by which NUAK1 regulates PD-L1 expression in hepatocellular carcinoma. …”
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Cerebral Cortical Activity During Academic Stress Amongst Undergraduate Medical Students at Kampala International University (Uganda) by Mujinya, Regan, Kalange, Muhamudu, Ochieng, Juma John, Ninsiima, Herbert Izo, Eze, Ejike Daniel, Afodun, Adam Moyosore, Nabirumbi, Ritah, Sulaiman, Sheu Oluwadare, Kairania, Emmanuel, Echoru, Isaac, Okpanachi, Alfred Omachonu, Matama, Kevin, Asiimwe, Oscar Hilary, Nambuya, Grace, Usman, Ibe Michael, Obado, Osuwat Lawrence, Zirintunda, Gerald, Ssempijja, Fred, Nansunga, Miriam, Matovu, Henry, Ayikobua, Emmanuel Tiyo, Nganda, Ponsiano Ernest, Onanyang, David, Ekou, Justine, Musinguzi, Simon Peter, Ssimbwa, Godfrey, Keneth Iceland, Kasozi

“…Methods: This was a cross-sectional study conducted among preclinical (n = 88) and clinical (n = 96) undergraduate medical students at Kampala International University Western Campus. A standard Perceived Stress Scale (PSS) was used to categorize stress into low, moderate, and severe while the ability to cope with stress was categorized into below average, average, above average, and superior stresscoper (SS). …”
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Barriers and facilitators to data-based decision making in Australian early childhood education and care: A qualitative study by Shauna Sherker, Karen Villanueva, Ruth Beatson, Caitlin M. Macmillan, Wan Yi Lee, Olivia Hilton, Carly Molloy, Sharon Goldfeld

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