Integrated analysis of bioinformatics, mendelian randomization, and experimental validation reveals novel diagnostic and therapeutic targets for osteoarthritis: progesterone as a p... by Ziyu Weng, Chenzhong Wang, Bo Liu, Yi Yang, Yueqi Zhang, Chi Zhang

“…Western blotting also demonstrated the potential therapeutic effects of progesterone on IL-1β-treated chondrocytes. …”
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An inequality for first-order differences by Gord Sinnamon

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The First Described Case of Occupational Anthracofibrosis in the USA by Kamen Rangelov, Sanjay Sethi

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Erratum to “miR-223 Inhibits the Polarization and Recruitment of Macrophages via NLRP3/IL-1β Pathway to Meliorate Neuropathic Pain” by Junsong Zhu, Jinmei Yang, Jianguo Xu

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pryslied vir ’n vreeslose gewete by A. Krog

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Advanced Management in Civil Engineering Projects by Xianbo Zhao, Yingbin Feng, Dujuan Yang, Dong Zhao

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Development and internal validation of the Edmonton Obesity Staging System-2 Risk screening Tool (EOSS-2 Risk Tool) for weight-related health complications: a case-control study in... by Evan Atlantis, P Fahey, Kathryn Williams, Paul Dugdale, James Rufus John, SL Hocking, Kath Peters

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Reconsidering routine admission for children under age 3 undergoing partial tonsillectomy: a prospective study by Ameen Biadsee, Craig Nathanson, Or Dagan, Firas Kassem, Avishai Stahl, Tova Mishali, Yaniv Ebner, Brian Rotenberg

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Exploring the effect of play on heart rate variability as a measure of positive emotional states in pigs by Karolína Steinerová, Annika Krause, Sarah E. Parker, Yolande M. Seddon

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Can verbal autopsies be used on a national scale? Key findings and lessons from South Africa's national cause-of-death validation study by Monique Maqungo, Nadine Nannan, Beatrice Nojilana, Erin Nichols, Diane Morof, Mireille Cheyip, Chalapati Rao, Carl Lombard, Jessica Price, Kathleen Kahn, Lorna J. Martin, Francois Bezuidenhout, Ria Laubscher, Chodziwadziwa Kabudula, Tracy Glass, Oluwatoyin Awotiwon, Nesbert Zinyakatira, Noluntu Funani, Jané Joubert, Debbie Bradshaw, Pamela Groenewald

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Pharmacological Management of Chronic Neuropathic Pain – Consensus Statement and Guidelines from the Canadian Pain Society by DE Moulin, AJ Clark, I Gilron, MA Ware, CPN Watson, BJ Sessle, T Coderre, PK Morley-Forster, J Stinson, A Boulanger, P Peng, GA Finley, P Taenzer, P Squire, D Dion, A Cholkan, A Gilani, A Gordon, J Henry, R Jovey, M Lynch, A Mailis-Gagnon, A Panju, GB Rollman, A Velly

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Human blood cell transcriptomics unveils dynamic systemic immune modulation along colorectal cancer progression by Pedro J Romero, Mauro Delorenzi, Amaia Martínez-Usatorre, Laura Ciarloni, Noushin Hadadi, Eric Durandau, Sylvain Monnier-Benoit, Paolo Angelino, Victoria Wosika, Alessandra Jordano Conforte, Sara S Fonseca Costa, Hector Fabio Satizabal, Jérémie Despraz, Andres Perez-Uribe, Stephan Morgenthaler, Brian Hashemi, Sahar Hosseinian-Ehrensberger

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Composition analysis and mechanism of Guizhi Fuling capsule in anti-cisplatin-resistant ovarian cancer by Lei Dou, Yan Yan, Enting Lu, Fangmei Li, Dongli Tian, Lei Deng, Xue Zhang, Rongjin Zhang, Yin Li, Yi Zhang, Ye Sun

“…Methods: First, differences in cisplatin resistance, PA2G4 gene expression, migration, and invasion in A2780 cells and A2780/DDP cells were analyzed by qRT-PCR, scratch assay, transwell, immunofluorescence, and western blotting. Then, LC-MS/MS analysis of GFC chemical composition. qRT-PCR, scratch tests, transwell, pseudopodium formation, immunofluorescence, and western blotting were used to explore the mechanism by which GFC inhibited A2780/DDP cell migration and invasion. …”
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LncRNA GAS5 inhibits glioma progression through miR-135b-5p/APC axis by ZHANG Jidong, WANG Yutao, JI Jianwen

“…Human glioma T98 and A172 cell lines were subjected for overexpression and knockdown of GAS5, miR-135b-5p and APC by transfection. Western blotting and qRT-PCR were applied to measure the expression of related genes in glioma tissues or cell lines. …”
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Different Effects of Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor-2 on Myogenic Differentiation of Human Mesenchymal Stem Cells by Doaa Aboalola, Victor K. M. Han

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A reference genome for the eastern bettong (Bettongia gaimardi) [version 2; peer review: 2 approved, 1 approved with reservations] by Richard J Edwards, Luke W Silver, Sam Banks, Carolyn J Hogg, Adrian D. Manning, Linda Neaves

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High-resolution fleezers reveal duplex opening and stepwise assembly by an oligomer of the DEAD-box helicase Ded1p by Eric M. Patrick, Rajeev Yadav, Kasun Senanayake, Kyle Cotter, Andrea A. Putnam, Eckhard Jankowsky, Matthew J. Comstock

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BDVCM about the Steel Box Girder Reliability Prediction Based on Monitoring Extreme Stresses by Yuefei Liu, Xueping Fan, Guanghong Yang, Zhipeng Shang, Xiaoxiong Zhao

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Stosunek religii do nauki. Punkt widzenia prawosławnego by Henryk Paprocki

“… Polish astronomer Konrad Rudnicki suggested that the so-called Copernican revolution, with far-reaching consequences for western Christianity, was hardly noticed in orthodoxy. …”
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Maintenance of Synaptic Stability Requires Calcium-Independent Phospholipase A2 Activity by Julie Allyson, Xiaoning Bi, Michel Baudry, Guy Massicotte

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