De l’agglomération antique de Cassinomagus au village de Chassenon (Charente) : un bilan des connaissances by Lucie Carpentier, Sandra Sicard

“…The natural topography of the land was, in fact, widely exploited by the builders in order to install a monumental complex. On the western terrace, this complex was composed of a vast place of worship, covering an area of approximately 7 ha. …”
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Hybridization-based discovery of novel quinazoline-2-indolinone derivatives as potent and selective PI3Kα inhibitors by Changqun Liu, Yuening Cao, Yi Zuo, Chaozheng Zhang, Senmiao Ren, Xin Zhang, Chuanqi Wang, Yingjie Zeng, Jie Ling, Yilan Liu, Zixian Chen, Xiujun Cao, Zhengzhi Wu, Chuantao Zhang, Jun Lu

“…The biological evaluation of compound 8 was performed by transwell, flow cytometry, laser scanning confocal microscopy, Western blot, CTESA and immunohistochemistry. Results: Here, we employed molecular hybridization methods to construct a series of quinazoline-2-indolinone derivatives as PI3Kα selective inhibitors. …”
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Effect of Three Colostrum Diets on Passive Transfer of Immunity and Preweaning Health in Calves on a California Dairy following Colostrum Management Training by Deniece R. Williams, Patrick Pithua, Angel Garcia, John Champagne, Deborah M. Haines, Sharif S. Aly

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The Wnt/β-Catenin Pathway Regulated Cytokines for Pathological Neuropathic Pain in Chronic Compression of Dorsal Root Ganglion Model by Ye Zhang, Dan Zhao, Xutong Li, Beiyao Gao, Chengcheng Sun, Shaoting Zhou, Yanhong Ma, Xuemei Chen, Dongsheng Xu

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Mechanistic Rationale and Clinical Efficacy of Hyperbaric Oxygen Therapy in Chronic Neuropathic Pain: An Evidence-Based Narrative Review by Simone Schiavo, Julian DeBacker, Carine Djaiani, Anuj Bhatia, Marina Englesakis, Rita Katznelson

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Diet Control and Swimming Exercise Ameliorate HFD-Induced Cognitive Impairment Related to the SIRT1-NF-κB/PGC-1α Pathways in ApoE-/- Mice by Wei Wei, Zhicheng Lin, PeiTao Xu, Xinru Lv, Libin Lin, Yongxu Li, Yangjie Zhou, Taotao Lu, Xiehua Xue

“…The expression of sirtuin-1 (SIRT1), peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), brain-derived neurotrophic factor (BDNF), nuclear factor kappa B p65 (NF-κB p65), interleukin-1β (IL-1β), and tumour necrosis factor-α (TNF-α) in the hippocampus was measured by western blotting. The levels of fractional anisotropy (FA), N-acetylaspartate (NAA)/creatine (Cr) ratio, choline (Cho)/Cr ratio, and myo-inositol (MI)/Cr ratio in the hippocampus were evaluated by diffusion tensor imaging (DTI) and magnetic resonance spectroscopy (MRS) using 7.0-T magnetic resonance imaging (MRI). …”
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«THE CONSCIENCE OF THE WORLD» OR «CONSPIRACY OF SILENCE»? TO THE ANNIVERSARIES OF THE EVIAN AND BERMUDA CONFERENCES by D. V. Ivanov, A. V. Krylov, V. M. Morozov, V. O. Pechatnov, S. A. Sklyarov, E. O. Shebalina

“…The author comes to the conclusion that Roosevelt administration and the president himself were not ardent advocates of the Holocaust victims, but they were not indifferent witnesses to the tragedy, doing for Jewish immigrants more than the governments of other Western countries. In his turn, D. Ivanov carries out a legal analysis of a number of international agreements on forced migration, adopted by states within the framework of the League of Nations, as well as the reasons for their low effectiveness. …”
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Factor structure and longitudinal measurement invariance of Edinburgh Postnatal Depression Scale during the whole perinatal period: a multicenter cohort study in China by Jichun Yang, Yu Jiang, Yimin Qu, Yongle Zhan, Haihui Ma, Xiaoxiu Li, Dongmei Man, Hongguo Wu, Ping Huang

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Assessing the Relationship Between the Type of Internet Use and Internet Addiction in Early and Middle Adolescents: Cross-Sectional Study From Qatar by Khansa Chemnad, Maryam Aziz, Sanaa Al- Harahsheh, Azza Abdelmoneium, Ahmed Baghdady, Diana Alsayed Hassan, Raian Ali

“…Conducted among adolescents of Arab origin, our study addressed the limitations of the literature, which predominantly focuses on Western, educated, industrialized, rich, and democratic populations. …”
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A Methodological and Reporting Quality Assessment of Systematic Reviews/Meta-Analyses about Chinese Medical Treatment for Gastroesophageal Reflux Disease by Zipan Lyu, Zhongyu Huang, Fengbin Liu, Zhengkun Hou

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Poldip2/Nox4 Mediates Lipopolysaccharide-Induced Oxidative Stress and Inflammation in Human Lung Epithelial Cells by Yueguo Wang, Zhenxing Ding, Youhui Tu, Xu Wu, Wenying Zhang, Shuang Ji, Jilong Shen, Li Zhang, Huimei Wu, Guanghe Fei

“…The expression of Poldip2, Nox4, heme oxygenase-1 (HO-1), cyclooxygenase-2 (COX-2), AKT, and p-AKT was detected by Western blotting and/or immunofluorescence. Poldip2 and Nox4 interaction was analyzed via coimmunoprecipitation (Co-IP) assay. …”
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Impact of time-varying exposure on estimated effects in observational studies using routinely collected data: protocol for a cross-sectional study by Ling Li, Xin Sun, Jing Tan, Mei Liu, Wen Wang, Kevin Lu, Guowei Li, Jiayue Xu, Jeff Jianfei Guo

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Treatment of a mutant KRAS lung cancer cell line with polyisoprenylated cysteinyl amide inhibitors activates the MAPK pathway, inhibits cell migration and induces apoptosis. by Matthew D Gregory, Kweku Ofosu-Asante, Jassy Mary S Lazarte, Pablo E Puente, Nada Tawfeeq, Nadine Belony, Yong Huang, Ite A Offringa, Nazarius S Lamango

“…Of the 17 PCAIs tested, compounds NSL-YHJ-2-27 and NSL-YHJ-2-46 showed the most potency with EC50 values of 2.7 and 3.3 μM, respectively. Western blotting was used to determine the effect of the PCAIs on the phosphorylation levels of MAPK pathway enzymes. …”
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Effectiveness of interventions for middle-aged and ageing population with neck pain: a systematic review and network meta-analysis protocol by Alison B Rushton, Nicola R Heneghan, Taweewat Wiangkham, Uchukarn Boonyapo, Piyameth Dilokthornsakul, Nattawan Phungwattanakul

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Biologic Therapies for Chronic Obstructive Pulmonary Disease: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials by Tyler Pitre, Daniel Lupas, Jasmine Mah, Matthew Stanbrook, Alina Blazer, Dena Zeraatkar, Terence Ho

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Effects of physical activity on brain function: Mechanisms, adaptations and clinical implications by Dariusz Fabian, Klaudia Maria Kufel, Mateusz Teofilak, Natalia Maria Smyl, Olga Śpiołek, Jan Siwiec, Aleksandra Słowikowska, Julia Szatkowska, Marcelina Paula Sztyler-Krąkowska, Agnieszka Alicja Wąsowicz, Franciszek Kędziora

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lncRNA-KCNQ1OT1: A Potential Target in Exosomes Derived from Adipose-Derived Stem Cells for the Treatment of Osteoporosis by Shan-zheng Wang, Jun Jia, Chang-hong Chen

“…The protein expression of cleaved-caspase-3, caspase-3, and Bax was determined by Western blot. Cell viability and apoptosis were assessed by Cell Counting Kit-8 (CCK-8) and flow cytometry analysis, respectively. …”
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Creation and study of emmer (<i>Triticum dicoccum</i>) × triticale hybrids by O. G. Silkova, Y. N. Ivanova, P. I. Stepochkin

“…Triticale (× Triticosecale Wittmack) is of great interest as an insurance crop that can ensure the stability of the gross harvest of feed and food grains at a lower cost. In Western Siberia, only winter triticale varieties are cultivated, however, spring triticales are important for cultivation in regions not suitable for winter crops. …”
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Morphological and phylogenetic features of the Crimean population of <i>Juniperus deltoids</i> R.P. Adams by A. O. Lantushenko, O. O. Korenkova, A. A. Syrovets, Ya. V. Meger, P. A. Korenkov, O. M. Shevchuk

“…A similar phenomenon is characteristic of the Western Mediterranean populations of J. oxycedrus. …”
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A Canadian Perspective on Systemic Therapy for Recurrent or Metastatic Nasopharyngeal Carcinoma by Anna Spreafico, Eric Winquist, Cheryl Ho, Brian O’Sullivan, Nathaniel Bouganim, Neil Chua, Sarah Doucette, Lillian L. Siu, Desiree Hao

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